Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Acoustics
JiaYi Li, WeiMing Guo, Fei Yu, Lu Liu, XiaoTing Wang, LvYuan Li, Bing Fang, Lunguo Xia
Summary: The study demonstrated that LIPUS could promote the proliferation and angiogenic differentiation of endothelial cells (ECs) via the activation of the AKT signaling pathway. Additionally, LIPUS could alter the DNA methylation of ECs through the AKT signaling pathway activation, which in turn affected biomolecular changes in the cells.
Article
Immunology
Jin-Li Guo, Xiang Han, Xian-Yan Yan, Juan-Juan Wang, Ya-Qiong Chang, Bei-Lei Zhang, Xiu-Juan Guo
Summary: This study investigates the efficacy and mechanism of action of isoliquiritigenin (ISL) in treating phlebitis induced by amiodarone (AM). The results show that ISL pretreatment promotes cell proliferation and migration, inhibits cell apoptosis, increases angiogenesis, and downregulates p-NF-kappa Bp65 expression.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Cell Biology
Sandra Dienemann, Vanessa Schmidt, Tabea Fleischhammer, Julia H. H. Mueller, Antonina Lavrentieva
Summary: In vitro cultivation conditions are important for understanding cell physiology and responses to external stimuli. Oxygen concentrations are crucial in influencing cell behaviors in both 2D and 3D cultures. This study genetically modified two types of human endothelial cells and monitored their responses to different oxygen concentrations. The findings demonstrated different hypoxic signatures for these cells in both 2D and 3D culture systems.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou, Ming-Jyh Sheu
Summary: Curcumin and demethoxycurcumin demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Combination treatment with curcuminoids and semaxanib is expected to reverse semaxanib resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Situo Zhou, Pengfei Liang, Pihong Zhang, Minghua Zhang, Xiaoyuan Huang
Summary: In this study, it was found that PDK1-AS plays a crucial role in modulating angiogenesis of HDMEC and HUVEC after thermal injury by relieving the inhibition of miR-125b-5p on VEGFA. Inhibition of miR-125b-5p increases VEGFA expression and enhances cell viability and invasive ability.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Zhaohui Wang, Ziwei Zeng, Vytaute Starkuviene, Holger Erfle, Kejia Kan, Jian Zhang, Manuel Gunkel, Carsten Sticht, Nuh Rahbari, Michael Keese
Summary: By using RNA sequencing and text mining, this study identified miRNAs involved in cell migration in human umbilical vein endothelial cells (HUVECs), and analyzed their regulatory role and affected pathways in HUVEC migration.
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Food Science & Technology
Ho-Jeong Bang, Eunju Yoon, Sun Wook Kim, Mok-Ryeon Ahn
Summary: Benzyl caffeate significantly inhibits angiogenesis by inducing apoptosis and anti-proliferative effects on endothelial cells, showing potential antiangiogenic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biotechnology & Applied Microbiology
Yan Huang, Bo Liang, Xiangjuan Chen
Summary: In this study, it was found that the expression of circ_0074673 was upregulated in GDM patients' exosomes and silencing circ_0074673 promoted proliferation, migration, and angiogenesis of HG-HUVECs via the miR-1200/MEOX2 axis affecting biological functions.
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
Article
Biotechnology & Applied Microbiology
Jia Xia, Xiaoying Song, Jing Meng, Danfei Lou
Summary: EPCs-Exos inhibit Erastin-induced HUVEC ferroptosis by upregulating miR-30e-5p, inhibiting SP1, and activating the AMPK pathway.