Article
Immunology
Rebeca Bailen, Raquel Alenda, Beatriz Herruzo-Delgado, Cynthia Acosta-Fleitas, Ana Valles, Albert Esquirol, Marta Fonseca, Laura Solan, Irene Sanchez-Vadillo, Guiomar Bautista, Leyre Bento, Oriana Lopez-Godino, Ariadna Perez-Martinez, Anna Torrent, Joud Zanabili, Maria Calbacho, Miguel Angel Moreno, Maria Jesus Pascual-Cascon, Luisa Guerra-Dominguez, Anabelle Chinea, Irene Garcia-Cadenas, Lucia Lopez-Corral, Francisco Boix-Giner, Jose Luis Lopez Lorenzo, Karem Humala, Rafael Duarte, Antonia Sampol, Inmaculada Heras, Jose Luis Vicario, Antonio Balas, Gillen Oarbeascoa, Paula Fernandez-Caldas, Javier Anguita, Mi Kwon
Summary: The Spanish Group of Hematopoietic Transplant (GETH-TC) reported their experience in DSA-positive patients who underwent haplo-HSCT. It was found that baseline MFI >20,000 and increased DSA intensity after infusion were independent risk factors for survival and graft failure.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Claudia M. M. Munoz-Herrera, Juan Francisco Gutierrez-Bautista, Miguel Angel Lopez-Nevot
Summary: This study evaluated the association between complement-fixing dnDSA antibodies and graft loss, as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. The presence of C1q-binding dnDSA was significantly associated with rejection frequency and renal graft loss. These findings suggest that classifying dnDSA based on their ability to activate the complement and detecting complement-binding capacity could serve as prognostic markers for predicting AMR outcome and graft survival in kidney transplant patients who develop dnDSA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Nizar Joher, Marie Matignon, Philippe Grimbert
Summary: The presence of anti-HLA antibodies is a major barrier to solid organ transplantation. Desensitization protocols have shown improvements in transplantation rates but limitations still exist, prompting interest in new desensitization approaches focused on targeting alloimmune pathways beyond antibodies. Targeting CD38 to desensitize in the field of transplantation is an emerging concept worth further exploration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Florian Kaelble, Caner Suesal, Luiza Pego da Silva, Claudius Speer, Louise Benning, Christian Nusshag, Lien Pham, Hien Tran, Matthias Schaier, Claudia Sommerer, Joerg Beimler, Arianeb Mehrabi, Martin Zeier, Christian Morath
Summary: Living donor kidney transplant recipients with pre-existing sensitization can achieve good graft outcomes with desensitization protocols, comparable to standard-risk recipients. Adequate patient selection and close immunological monitoring are crucial to minimize rejection episodes and graft loss.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Guillaume Baudry, Matteo Pozzi, Matthieu Aubry, Elisabeth Hugon-Vallet, Raluca Mocan, Lara Chalabreysse, Philippe Portran, Jean-Francois Obadia, Olivier Thaunat, Nicolas Girerd, Valerie Dubois, Laurent Sebbag
Summary: In heart transplant patients, the presence of donor specific antibodies with C3d-binding ability is associated with increased risk of severe CAV or mortality, while those without this binding ability do not show the same impact.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Scott M. Krummey, Alison J. Gareau
Summary: Advances in hematopoietic stem cell transplant have led to changes in donor selection approach, including the use of haploidentical donors or permissive HLA mismatches. However, this may increase the risk of donor-specific HLA antibodies, which can limit engraftment. Desensitization treatments can effectively reduce HLA antibodies and improve transplant outcomes. The consideration and management of HLA antibodies in donor selection are increasingly important in HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Jennifer D. Motter, Kyle R. Jackson, Jane J. Long, Madeleine M. Waldram, Babak J. Orandi, Robert A. Montgomery, Mark D. Stegall, Stanley C. Jordan, Enrico Benedetti, Ty B. Dunn, Lloyd E. Ratner, Sandip Kapur, Ronald P. Pelletier, John P. Roberts, Marc L. Melcher, Pooja Singh, Debra L. Sudan, Marc P. Posner, Jose M. El-Amm, Ron Shapiro, Matthew Cooper, Jennifer E. Verbesey, George S. Lipkowitz, Michael A. Rees, Christopher L. Marsh, Bashir R. Sankari, David A. Gerber, Jason R. Wellen, Adel Bozorgzadeh, A. Osama Gaber, Eliot C. Heher, Francis L. Weng, Arjang Djamali, J. Harold Helderman, Beatrice P. Concepcion, Kenneth L. Brayman, Jose Oberholzer, Tomasz Kozlowski, Karina Covarrubias, Allan B. Massie, Dorry L. Segev, Jacqueline M. Garonzik-Wang
Summary: Incompatible living donor kidney transplant recipients have a higher risk of DGF and AR, but the impact on survival and DCGF risk is not significantly different from compatible recipients. Providers should consider these risks during preoperative counseling, and strategies to mitigate them should be considered.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe
Summary: Antibody-mediated allograft rejection is a major cause of kidney transplant failure, with research focusing on identifying antibodies and optimizing therapies. New reagents and techniques have been used to measure MHC sensitization and isolate HLA-specific B cells from sensitized patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Ashlee M. Webber, Tara R. Bradstreet, Xiaoli Wang, Hongjie Guo, Christopher A. Nelson, Daved H. Fremont, Brian T. Edelson, Chang Liu
Summary: HLA-Fc is a novel strategy for antigen-specific humoral suppression to improve transfusion and transplantation outcomes.
Article
Immunology
Tetsuya Tajima, Koichiro Hata, Jiro Kusakabe, Hidetaka Miyauchi, Joshua Sam Badshah, Shoichi Kageyama, Xiangdong Zhao, Sung-Kwon Kim, Tatsuaki Tsuruyama, Varvara A. Kirchner, Takeshi Watanabe, Shinji Uemoto, Etsuro Hatano
Summary: We developed a rat model of liver transplantation antibody-mediated rejection (AMR) and demonstrated the effectiveness of anti-C5 antibody for treating this rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jasmin Mucha, Ara Cho, Anna Marianne Weijler, Moritz Muckenhuber, Amun Georg Hofmann, Markus Wahrmann, Andreas Heinzel, Birgit Linhart, Pia Gattinger, Rudolf Valenta, Gabriela Berlakovich, Andreas Zuckermann, Peter Jaksch, Rainer Oberbauer, Thomas Wekerle
Summary: This study aims to determine the frequency of pre-existing and de novo anti-HLA IgE antibodies in solid organ transplant recipients. The study found that anti-HLA IgE antibodies occur at low frequency in kidney, liver, heart, and lung transplant recipients and are associated with sensitization at the IgG level.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Solaf Al-Awadhi, Marc Raynaud, Kevin Louis, Antoine Bouquegneau, Jean-Luc Taupin, Olivier Aubert, Alexandre Loupy, Carmen Lefaucheur
Summary: In this systematic review, meta-analysis, and critical appraisal, the impact of complement-activating anti-HLA DSAs on solid organ transplant outcomes was investigated. The study found that complement-activating anti-HLA DSAs were associated with an increased risk of allograft loss and rejection. These findings demonstrate the significant deleterious impact and independent prognostic value of circulating complement-activating anti-HLA DSAs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ajay Kumar Baranwal, Sanjeev Goswami, Sanjay Kumar Agarwal, Gurvinder Kaur, Narinder Kumar Mehra
Summary: Not all anti-HLA donor-specific antibodies are harmful to renal allografts. The ability of antibodies to activate the C1q complement seems to be a crucial factor in determining whether DSAs are clinically inert or detrimental. Those DSAs that were able to fixate C1q were associated with a significantly higher risk of antibody-mediated rejection compared to those that did not show C1q fixation.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarah Nabulsi, Afolarin A. Otunla, Justin Salciccioli, Dominic C. Marshall, Vincenzo Villani, Kumaran Shanmugarajah, Joseph Shalhoub
Summary: This study aimed to determine the relationship between HLA matching and liver graft survival using a large-scale multi-centre database and multivariate logistic analysis. The results showed that HLA mismatch significantly reduced graft survival and increased the risk of acute rejection, particularly in certain indications. The relationship between HLA mismatch and graft survival was also influenced by donor status.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Michal Gniewkiewicz, Katarzyna Czerwinska, Katarzyna Zielniok, Magdalena Durlik
Summary: This study investigated the association between circulating DSAs and their characteristics with renal allograft long-term outcomes. The detection of DSAs at the time of biopsy and their C1q-binding capacity were found to be independent predictors of inferior renal allograft function and graft failure in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Vivian E. Saper, Michael J. Ombrello, Adriana H. Tremoulet, Gonzalo Montero-Martin, Sampath Prahalad, Scott Canna, Chisato Shimizu, Gail Deutsch, Serena Y. Tan, Elaine F. Remmers, Dimitri Monos, Timothy Hahn, Omkar K. Phadke, Elaine Cassidy, Ian Ferguson, Vamsee Mallajosyula, Jianpeng Xu, Jaime S. Rosa Duque, Gilbert T. Chua, Debopam Ghosh, Ann Marie Szymanski, Danielle Rubin, Jane C. Burns, Lu Tian, Marcelo A. Fernandez-Vina, Elizabeth D. Mellins, Jill A. Hollenbach
Summary: Drug reaction with eosinophilia and systemic symptoms (DRESS) can occur in Still's disease patients treated with IL-1/IL-6 inhibitors, with features such as eosinophilia, liver enzyme elevation, and persistent rash. HLA-DRB1*15 haplotypes are significantly enriched in Still's disease with DRESS. Pre-prescription HLA typing and vigilance for serious reactions to these drugs are recommended.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Luciana de Brito Vargas, Marcia H. Beltrame, Brenda Ho, Wesley M. Marin, Ravi Dandekar, Gonzalo Montero-Martin, Marcelo A. Fernandez-Vina, A. Magdalena Hurtado, Kim R. Hill, Luiza T. Tsuneto, Mara H. Hutz, Francisco M. Salzano, Maria Luiza Petzl-Erler, Jill A. Hollenbach, Danillo G. Augusto
Summary: The KIR genes in humans exhibit high diversity, particularly in South American populations, and play a regulatory role in HLA interactions. Studies show that indigenous populations in South America have lower numbers of KIR-HLA interactions, with most relying on a few HLA-C molecules.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Review
Hematology
Pongthep Vittayawacharin, Piyanuch Kongtim, Stefan O. Ciurea
Summary: Myelodysplastic syndromes (MDS) are a group of diverse hematopoietic stem cell tumors primarily affecting older individuals, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the only curative treatment. In recent years, the use of reduce-intensity conditioning regimens and haploidentical donors for transplantation has improved treatment outcomes. However, treatment-related mortality remains a limitation, highlighting the importance of pre-transplant evaluation for older patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Alexandre Chan, Susan O'Brien, Deepa Jeyakumar, Stefan O. Ciurea, Pamela S. Becker, Piyanuch Kongtim
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Immunology
Alin L. Girnita, Lin Wang, Adriana Colovai, Patrick Ahearn, Yorg Azzi, Madhav C. Menon, Marcelo Fernandez-Vina, Howard M. Gebel, E. Steve Woodle, Paolo Cravedi, Jonathan S. Maltzman, Enver Akalin
Summary: This study investigated the changes in anti-HLA antibodies in kidney transplant recipients after COVID-19 and compared them with anti-SARS-CoV-2 antibodies. The results showed that anti-HLA antibodies were mainly IgG, while anti-SARS-CoV-2 antibodies had a high IgA/IgM profile.
Article
Multidisciplinary Sciences
Victoria N. Parikh, Alexander G. Ioannidis, David Jimenez-Morales, John E. Gorzynski, Hannah N. De Jong, Xiran Liu, Jonasel Roque, Victoria P. Cepeda-Espinoza, Kazutoyo Osoegawa, Chris Hughes, Shirley C. Sutton, Nathan Youlton, Ruchi Joshi, David Amar, Yosuke Tanigawa, Douglas Russo, Justin Wong, Jessie T. Lauzon, Jacob Edelson, Daniel Mas Montserrat, Yongchan Kwon, Simone Rubinacci, Olivier Delaneau, Lorenzo Cappello, Jaehee Kim, Massa J. Shoura, Archana N. Raja, Nathaniel Watson, Nathan Hammond, Elizabeth Spiteri, Kalyan C. Mallempati, Gonzalo Montero-Martin, Jeffrey Christle, Jennifer Kim, Anna Kirillova, Kinya Seo, Yong Huang, Chunli Zhao, Sonia Moreno-Grau, Steven G. Hershman, Karen P. Dalton, Jimmy Zhen, Jack Kamm, Karan D. Bhatt, Alina Isakova, Maurizio Morri, Thanmayi Ranganath, Catherine A. Blish, Angela J. Rogers, Kari Nadeau, Samuel Yang, Andra Blomkalns, Ruth O'Hara, Norma F. Neff, Christopher DeBoever, Sandor Szalma, Matthew T. Wheeler, Christian M. Gates, Kyle Farh, Gary P. Schroth, Phil Febbo, Francis DeSouza, Omar E. Cornejo, Marcelo Fernandez-Vina, Amy Kistler, Julia A. Palacios, Benjamin A. Pinsky, Carlos D. Bustamante, Manuel A. Rivas, Euan A. Ashley
Summary: This study investigates the impact of the SARS-CoV-2 pandemic on different populations based on race and ethnicity. Using a multi-omic approach, the researchers analyze viral and host genomes and transcriptomes from individuals in Northern California. The findings reveal genetic factors associated with COVID-19 severity and provide insights into the epidemiological and biological associations for individuals at the highest risk.
NATURE COMMUNICATIONS
(2022)
Letter
Hematology
Benjamin J. J. Lee, Shawn P. P. Griffin, Jean Doh, Piyanuch Kongtim, Alexandre Chan, Susan O'Brien, Deepa Jeyakumar, Stefan O. O. Ciurea
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Benjamin J. Lee, Piyanuch Kongtim, Jean Doh, Shawn P. Griffin, Alexandre Chan, Susan O'Brien, Stefan O. Ciurea, Deepa Jeyakumar
Summary: The use of triple intrathecal (IT) chemotherapy during HyperCVAD is a feasible alternative to standard of care (SOC) CNS prophylaxis for the treatment of acute lymphoblastic leukemia (ALL). It does not result in differences in CNS relapse-free survival, cumulative incidence of relapse, or overall survival compared to SOC. However, it significantly reduces the number of IT doses administered and the need for additional outpatient appointments.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Ute V. Solloch, Anette S. Giani, Maria Ignacia Pattillo Garnham, Juergen Sauter, Stefanie N. Bernas, Vinzenz Lange, Francisco Barriga, Marcelo A. Fernandez-Vina, Alexander H. Schmidt
Summary: Hematopoietic stem cell transplantation often requires unrelated stem cell donors matched in HLA genes. The extensive allelic variability of the HLA system complicates donor search, hence the need for large registries. This study analyzed HLA allele and haplotype frequencies of DKMS Chile donors, identifying alleles more abundant in the Chilean subpopulations, particularly in the Mapuche. The study also revealed limited benefits for Chilean patients from non-Chilean donor registries, emphasizing the need for ongoing donor recruitment efforts in Chile.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Maneesh Kumar Misra, Jerome G. Weidner, Rebecca L. Upchurch, Arianne M. Mankey, Marcelo A. Fernandez-Vina, Susana G. Marino
Summary: This study presents a novel approach of using SPT-EDTA serum treatment to reduce background interference in Luminex HLA antibody testing. The effectiveness of SPT-EDTA treatment was compared with ADS and SC-treated sera, and SPT-EDTA treatment showed better results in reducing high background.
Meeting Abstract
Cell Biology
Kerry Kizer, Danillo Augusto, Gonzalo Montero-Martin, Noelle Schlenk, Jacquelyn Horgan, Kristen Wade, Jorge Oksenberg, Marcelo Fernandez-Vina, Jennifer Frankovich, Jill A. Hollenbach
Meeting Abstract
Cell Biology
Katerina Sikorova, Martina Doubkova, Adam Strnad, Lenka Kocourkova, Jana Petrkova, Kazutoyo Osoegawa, Marcelo A. Fernandez-Vina, Martin Petrek
Meeting Abstract
Cell Biology
Kazutoyo Osoegawa, Steven G. E. Marsh, Rhonda Holdsworth, Sebastiaan Heidt, Gottfried Fischer, Cathi Murphey, Martin Maiers, Marcelo Fernandez-Vina
Meeting Abstract
Cell Biology
Katerina Sikorova, Adriana Gavronova, Jana Petrkova, Lenka Kocourkova, Kazutoyo Osoegawa, Marcelo A. Fernandez-Vina, Martin Petrek
Article
Surgery
Vaka K. Sigurjonsdottir, Natasha Purington, Abanti Chaudhuri, Bing M. Zhang, Marcelo Fernandez-Vina, Runolfur Palsson, Neeraja Kambham, Vivek Charu, Kim Piburn, Lynn Maestretti, Anika Shah, Amy Gallo, Waldo Concepcion, Paul C. Grimm
Summary: This retrospective study assessed the performance of risk stratification using systematic donor-specific antibody (DSA) monitoring. The results showed that C1q-dnDSA is more reliable than standard dnDSA in identifying patients at high risk of graft failure.
TRANSPLANT INTERNATIONAL
(2022)