Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 5, Pages 474-488Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1588888
Keywords
Rauvolfia reflexa; indole alkaloids; reflexin A; apoptosis; HCT-116 cells; acute toxicity
Funding
- Universiti Malaya Research Grants [RG388-17AFR, BKP069-2016]
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One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 +/- 0.75 mu M. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. [GRAPHICS] .
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