Article
Immunology
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Summary: Immune function changes with age, and infection with CMV accelerates these changes, resulting in increased mortality and impaired responses in elderly individuals. Following organ transplantation, CMV+ recipients show accelerated aging of CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hannah N. Imlay, Daniel R. Kaul
Summary: Until recently, available drugs for CMV prevention and treatment in transplant patients have been limited by toxicity and resistance issues, with letermovir being the first new drug approved for CMV prevention since 2003. The efficacy of letermovir in treating established CMV infection or disease remains largely unstudied, while the investigational agent maribavir shows promise as a preemptive treatment option with unique mechanisms of action. Ongoing studies will define the efficacy of these drugs in patients with refractory or resistant CMV disease.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Yanis Tamzali, V. Pourcher, L. Azoyan, N. Ouali, B. Barrou, F. Conti, G. Coutance, F. Gay, J. Tourret, D. Boutolleau
Summary: In this study, we investigated the factors associated with CMV genotypic resistance in refractory infections in solid organ transplant recipients (SOTRs). We found that age, underdosing or low plasma concentration of valganciclovir (VGCV), VGCV prophylaxis at infection onset, and recipient's CMV negative serostatus were independently associated with CMV genotypic resistance. We also observed a poorer outcome in the resistant CMV group.
TRANSPLANT INTERNATIONAL
(2023)
Article
Oncology
Jennifer M. Geris, Logan G. Spector, Ruth M. Pfeiffer, Ajit P. Limaye, Kelly J. Yu, Eric A. Engels
Summary: The study found that CMV status was not associated with the risk of most cancers among SOT recipients, but the inverse association with DLBCL may reflect the protective effects of CMV prophylaxis or treatment against EBV infection.
Review
Infectious Diseases
Benoit Pilmis, Emmanuel Weiss, Anne Scemla, Alban Le Monnier, Paolo Antonio Grossi, Monica A. Slavin, Christian Van Delden, Olivier Lortholary, Catherine Paugam-Burtz, Jean-Ralph Zahar
Summary: Transplant recipients are highly susceptible to multidrug-resistant (MDR) related infections, especially those caused by metallo-β-lactamases. It is important to develop control strategies to manage MDR Gram-negative bacilli infections in transplant recipients. Understanding the clinical microbiology and infectious diseases is crucial for reducing the risk of infection in transplant recipients and the appropriate use of antibiotics.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Virology
S. Reshwan K. Malahe, Jeroen J. A. van Kampen, Olivier C. C. Manintveld, Rogier A. S. Hoek, Caroline M. M. den Hoed, Carla C. C. Baan, Marcia M. L. Kho, Georges M. G. M. Verjans
Summary: Solid organ transplant recipients (SOTRs) face a high risk of human herpesvirus (HHV)-related morbidity and mortality due to immunosuppressive therapy. We aim to increase awareness of the HHV disease burden in SOTRs by providing an overview of current prevention and management strategies from the literature and guidelines. We discuss challenges in prevention, treatment, and future perspectives.
Review
Pediatrics
Marjan Moghadamnia, Hamid Eshaghi, Hosein Alimadadi, Simin Dashti-Khavidaki
Summary: Viral infections are common complications following pediatric solid organ transplantation, leading to increased morbidity and mortality. Prevention strategies include vaccination, post-transplant prophylaxis, and preemptive therapy. Treatment options vary depending on the virus and may include antiviral therapy and immunosuppression modification.
FRONTIERS IN PEDIATRICS
(2023)
Article
Virology
Lynne Li, Christopher F. Lowe, Elizabeth McLachlan, Marc G. Romney, Alissa Wright, Nancy Matic
Summary: This study investigated CMV antiviral drug resistance (AVDR) frequencies in transplant patients in British Columbia, Canada from 2011 to 2019. The results showed that over half of the samples had AVDR mutations detected, with higher occurrence in solid organ transplant patients. Previous resistance testing was identified as a significant risk factor for AVDR. These findings can guide clinicians in selecting empiric antiviral therapy.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Immunology
Hannah Rafferty, Matthew J. Murray, Jerry C. H. Tam, Alastair Macfarlane, Colette Smith, Sheila F. Lumley, Sowsan Atabani, Jane A. McKeating, Dinesh Sharma, Matthew Reeves, David Whitmore, Paul Griffiths
Summary: Using a large data set on preemptive cytomegalovirus therapy for solid-organ transplant recipients, the study found no association between time of day of transplantation and CMV viremia, but observed increased viremia in recipients of deceased-donor transplants compared with live-donor transplants. These findings provide important insights into the factors influencing CMV infection after transplantation.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Maria Serrano-Alonso, Paloma Martin-Moreno, Gregorio Rabago, Francisco Guillen-Grima, Jose Herrero, Mirian Fernandez-Alonso
Summary: This study compared the efficacy and safety of standard and extended primary cytomegalovirus (CMV) prophylaxis in solid organ transplantation. The results showed that extending the prophylaxis did not prevent late-onset infection, but was associated with hematological toxicity.
Article
Surgery
Kristen G. Valencia Deray, Kathleen E. Hosek, Divya Chilukuri, Jordan R. Dunson, David R. Spielberg, Sarah J. Swartz, Joseph A. Spinner, Daniel H. Leung, Elizabeth A. Moulton, Flor M. Munoz, Gail J. Demmler-Harrison, Claire E. Bocchini
Summary: This study aimed to determine the frequency of CMV DNAemia in pediatric solid organ transplant recipients and found associations with high-risk CMV status and lung transplantation. The study showed that universal prophylaxis is effective in preventing CMV disease after SOTR, but further research is needed to optimize prevention strategies and reduce morbidity and mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Anesthesiology
Dmitri Bezinover, Gianni Biancofiore, Marco Falcone, Costantine Karvellas, Shaid Husain, Fuat H. Saner
Summary: Solid organ transplantation is the best therapeutic option for patients with end-stage organ disease. However, infections remain a serious complication, with an increasing incidence of episodes due to antibiotic-resistant bacteria and opportunistic agents.
MINERVA ANESTESIOLOGICA
(2022)
Article
Immunology
Sara Belga, Clayton MacDonald, Diana Chiang, Dima Kabbani, Soroush Shojai, Juan G. Abraldes, Carlos Cervera
Summary: The study found that patients exposed to CMV at transplantation have a higher risk of posttransplant thrombotic events, independent of pretransplant cardiovascular risk factors and thrombotic events.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Arnau Monforte, Ibai Los-Arcos, Maria Teresa Martin-Gomez, David Campany-Herrero, Judith Sacanell, Cristina Berastegui, Ester Marquez-Algaba, Abiu Sempere, Xavier Nuvials, Maria Deu, Lluis Castells, Francesc Moreso, Carles Bravo, Joan Gavalda, Oscar Len
Summary: We describe 53 solid organ transplant recipients treated with isavuconazole for fungal infections. There is scarce data of its use in solid organ transplant recipients, where interactions with calcineurin inhibitors and mTOR and adverse drug events have limited the use of other triazoles. To the best of our knowledge, this is the first article describing the safety regarding adverse events and drug interactions of isavuconazole for the treatment of fungal infections in a cohort of solid organ transplant recipients. Also, although this is a noncomparative study, we report some real world effectivity data of these patients, including treatment of non-Aspergillus fungal infections.
MICROBIOLOGY SPECTRUM
(2022)
Review
Oncology
Rosario Mazzola, Francesco Cuccia, Alessandro Bertani, Slavisa Tubin, Pier Giulio Conaldi, Stefanie Corradini, Maria Tolia, Markus Guba, Filippo Alongi
Summary: Radiotherapy in cancer patients with prior organ transplants poses challenges due to potential effects on immunosuppressive therapy and organ tolerance. This systematic review aims to assess the safety and efficacy of radiotherapy in these patients, focusing on modern treatment techniques.
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Elizabeth Roosma, Johanna P. Van Gemert, Auke E. S. De Zwart, Coretta C. Van Leer-Buter, Merel E. Hellemons, Elize M. Berg, Bart Luijk, Rogier A. S. Hoek, Diana A. Van Kessel, Onno W. Akkerman, Huib A. M. Kerstjens, Erik A. M. Verschuuren, C. Tji Gan
Summary: This study retrospectively analyzed the impact of COVID-19 on transplant function in LTx patients, showing high mortality in hospitalized patients, decline in lung function 3 months post infection, gradual improvement at 6 months but still lower than pre-infection levels.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Schwarz, Christian Lang, Matevz Harlander, Tomaz Stupnik, Jan Van Slambrouck, Laurens J. Ceulemans, Fabio Ius, Jens Gottlieb, Stefan Kuhnert, Matthias Hecker, Clemens Aigner, Nikolaus Kneidinger, Erik AM. Verschuuren, Jacqueline M. Smits, Edda Tschernko, Eva Schaden, Peter Faybik, Klaus Markstaller, Michael Trauner, Peter Jaksch, Konrad Hoetzenecker
Summary: SSC-CIP is a severe late complication after lung transplantation for COVID-19 ARDS, leading to significant morbidity and mortality. GGT appears to be a sensitive parameter able to predict SSC-CIP even at the time of listing.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Geriatrics & Gerontology
Joanna Sophia J. Vinke, Hanneke J. C. M. Wouters, Suzanne P. Stam, Rianne M. Douwes, Adrian Post, Antonio W. Gomes-Neto, Melanie M. Klauw, Stefan P. Berger, Stephan J. L. Bakker, Martin H. De Borst, Michele F. Eisenga
Summary: The study revealed a negative correlation between hemoglobin levels and muscle mass and strength in kidney transplant recipients, indicating that lower hemoglobin levels are closely associated with decreased muscle mass and strength in this population.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Immunology
Siqi Liu, Nicolaas A. Bos, Erik A. M. Verschuuren, Debbie van Baarle, Johanna Westra
Summary: The article discusses the importance and significance of HLA-G in transplantation as a crucial molecule in combating rejection reactions. During pregnancy, it also helps maintain immune tolerance between mother and fetus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J. G. Melchers, Adriaan J. C. van den Brule, Anco Molijn, John W. J. Hinrichs, Hubert G. M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M. C. M. de Kok
Summary: In the Netherlands, self-collected samples have lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection compared to clinician-collected samples. The differences between the two sampling methods are likely related to sociodemographic factors as well as differences in screening test accuracy and background risk. Self-sampling can be used as a more convenient screening tool for underscreened women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Infectious Diseases
Jelte Helfferich, Marit M. A. de Lange, Kimberley S. M. Benschop, Bart C. Jacobs, Coretta C. Van Leer-Buter, Adam Meijer, Dewi P. Bakker, Eva de Bie, Hilde M. H. Braakman, Rick Brandsma, Rinze F. Neuteboom, Erik H. Niks, Jikke-Mien Niermeijer, Vincent Roelfsema, Niels Schoenmaker, Lilian T. Sie, Hubert G. Niesters, Oebele F. Brouwer, Margreet J. M. Te Wierik
Summary: AFM is rare in children in the Netherlands, with a strong association with non-polio enterovirus EV-D68. Increased awareness among clinicians, proper diagnosis, and case registration are important for monitoring the incidence of AFM.
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Pharmacology & Pharmacy
Jeroen J. Koomen, Tim R. Knobbe, Tanja Zijp, Daan Kremer, C. Tji Gan, Erik A. M. Verschuuren, Stephan J. L. J. Bakker, Daan J. Touw, Pieter Colin, TransplantLines Investigators
Summary: This study aimed to establish plasma concentration ranges reflecting the currently used target ranges of whole blood tacrolimus concentrations. By developing a pharmacokinetic model and performing simulations, it was found that the whole blood target ranges for kidney and lung transplant recipients corresponded to plasma concentration ranges of 0.06-0.26 ng/mL and 0.10-0.93 ng/mL, respectively.
CLINICAL PHARMACOKINETICS
(2023)
Article
Medicine, General & Internal
Johanna van Gemert, Fleur Steenberg, Coretta van Leer-Buter, Huib Kerstjens, Willie Steenhuis, Onno Akkerman, Erik Verschuuren, Tji Gan
Summary: COVID-19 causes high mortality in LTx patients, so vaccination in this population is crucial. However, the antibody response is impaired after multiple vaccinations. This study aims to investigate the possibility of increasing this response and identify risk factors for non-response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Oncology
Nick Veltmaat, Yujie Zhong, Filipe Montes de Jesus, Geok Wee Tan, Johanna A. A. Bult, Martijn M. Terpstra, Pim G. N. J. Mutsaers, Wendy B. C. Stevens, Rogier Mous, Joost S. P. Vermaat, Martine E. D. Chamuleau, Walter Noordzij, Erik A. M. Verschuuren, Klaas Kok, Joost L. Kluiver, Arjan Diepstra, Wouter J. Plattel, Anke Van den Berg, Marcel Nijland
Summary: The study investigates the use of cfDNA for genomic profiling of PTLD, and explores its potential as a screening tool. Analysis showed that 41% of patients had EBV-positive tumors and 76% had stage IV disease. The study provides important insights into the genetic variations and EBV infection in PTLD.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Erley Lizarazo Forero, Marjolein Knoester, Lilli Gard, Alewijn Ott, Afke H. Brandenburg, Matthew B. B. Mccall, Hubert G. M. Niesters, Coretta Van Leer-Buter
Summary: The study found that during the lockdown measures for SARS-CoV-2, there was a decreased transmission of enteroviruses in the Netherlands, which led to a decrease in genetic diversity of the five most commonly detected enterovirus serotypes.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Surgery
R. van Pel, C. T. Gan, W. van der Bij, E. A. M. Verschuuren, J. P. A. van Gemert, C. van de Wauwer, M. E. Erasmus, D. J. Slebos
Summary: Post lung transplantation airway complications, especially stenosis, significantly affect survival. Risk factors for the development of airway complications are unclear.
TRANSPLANT INTERNATIONAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Luong, F. P. Silveira, O. Morrissey, L. Danziger-Isakov, E. Verschuuren, C. R. Wolfe, D. Hadjiliadis, D. Chambers, J. K. Patel, G. Dellgren, M. So, G. M. Verleden, E. A. Blumberg, R. Vos, M. Perch, A. M. Holm, N. Muller, C. Chaparro, S. Husain
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)