Article
Clinical Neurology
Jana Freff, Eva C. Beins, Lisa Broeker, Kathrin Schwarte, Rafael Leite Dantas, Carlo Maj, Volker Arolt, Udo Dannlowski, Markus M. Noethen, Bernhard T. Baune, Andreas J. Forstner, Judith Alferink
Summary: This study characterizes the expression pattern of CCR4 and its ligands CCL17 and CCL22 in major depressive disorder (MDD) and explores their clinical relevance in predicting disease severity. The results show that decreased CCR4 expression and increased CCL17/CCL22 levels are associated with MDD. CCR4 expression on CD4(+) T cells is correlated with depression severity and specific symptoms. Additionally, CCR4 and polygenic risk score (PRS) have predictive capacity for disease severity.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Nina Vindegaard Sorensen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Sonja Orlovska-Waast, Rose Jeppesen, Kristin Skogstrand, Michael Eriksen Benros
Summary: By analyzing the cytokine levels in the cerebrospinal fluid (CSF) of patients with recent-onset depression and healthy controls, this study found that IL-4, MCP-1, and MIP-1 beta levels were significantly higher in patients with depression compared to healthy controls, while IL-6 and IL-8 levels showed no significant differences.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Chemistry, Medicinal
Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Atapol Sughondhabirom, Kitiporn Plaimas, Apichat Suratanee, Michael Maes
Summary: This study examines the effects of cannabidiol (CBD) on the immune-inflammatory response and immune-regulatory system in patients with depression and healthy controls. The results suggest that higher concentrations of CBD may worsen inflammatory processes.
Article
Psychiatry
Yiyue Yang, Kaiqi Gu, Changyang Meng, Jia Li, Qiao Lu, Xiaobo Zhou, Deping Yan, Dongxiao Li, Changzhen Pei, Yue Lu, Shenglan Ran, Jing Li
Summary: There is a relationship between sleep and inflammatory factors, and the quality of sleep in MDD patients is associated with specific inflammatory factors. Poor sleep quality is negatively correlated with IL-2 and IL-8 levels, and positively correlated with IL-6, IL-10, CRP, TNF-alpha, CXCL-1, CXCL-2, and IFN-gamma levels.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study found significantly higher levels of urinary cytokines and chemokines in patients with IC/BPS, which were closely associated with bladder conditions and treatment outcomes.
Article
Immunology
Luba Sominsky, Martin O'Hely, Katherine Drummond, Sifan Cao, Fiona Collier, Poshmaal Dhar, Amy Loughman, Samantha Dawson, Mimi LK. Tang, Toby Mansell, Richard Saffery, David Burgner, Anne-Louise Ponsonby, Peter Vuillermin, Barwon Infant Study Investigator Group Barwon Infant Study Investigator Grp
Summary: In this study, the association between pre-pregnancy body mass index (BMI) and perinatal depressive symptoms was investigated, as well as the potential mediation of circulating inflammatory markers during pregnancy. The findings suggest that pre-pregnancy obesity increases the risk of antenatal depressive symptoms and is associated with systemic inflammation. However, further research is needed to understand the role of specific inflammatory markers in mediating the effects of pre-pregnancy obesity on antenatal depression.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
M. Ishrat Husain, Jane. A. A. Foster, Brittany. L. L. Mason, Sheng Chen, Haoyu Zhao, Wei Wang, Susan Rotzinger, Sakina Rizvi, Keith Ho, Raymond Lam, Glenda MacQueen, Roumen Milev, Benicio. N. N. Frey, Daniel Mueller, Gustavo Turecki, Manish Jha, Madhukar Trivedi, Sidney. H. H. Kennedy
Summary: This study investigates the association between inflammatory tone and response to sequential pharmacotherapies in major depressive disorder. The findings suggest that higher pre-treatment levels of IFN-Gamma and CCL-2 are associated with non-response to escitalopram, and increasing levels of these pro-inflammatory markers may be associated with non-response to adjunctive aripiprazole.
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wail M. Hassan, Nashwa Othman, Maha Daghestani, Arjumand Warsy, Maha A. Omair, Eman Alqurtas, Shireen Amin, Abdulaziz Ismail, Afaf El-Ansary, Ramesa Shafi Bhat, Mohammed A. Omair
Summary: This study aimed to explore the role of cytokines in the early diagnosis of rheumatoid arthritis (RA). By analyzing the levels of cytokines in the serum, we found that multiple cytokine profiles were able to successfully distinguish RA patients from healthy controls. Additionally, the use of gender-specific models may have some benefits in clinical diagnosis.
Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Galecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Summary: This study examines the association between the reoccurrence of illness (ROI), the phenome of depression, and major dysmood disorder (MDMD) features and immune response in major depressive disorder and a major depressive episode (MDD/MDE). The results show that MDMD is characterized by heightened immune responses, which are a consequence of ROI-associated sensitization combined with immunostimulatory triggers.
Review
Biochemistry & Molecular Biology
Vilim Molnar, Vid Matisic, Ivan Kodvanj, Roko Bjelica, Zeljko Jelec, Damir Hudetz, Eduard Rod, Fabijan Cukelj, Trpimir Vrdoljak, Dinko Vidovic, Mario Staresinic, Srecko Sabalic, Borut Dobricic, Tadija Petrovic, Darko Anticevic, Igor Boric, Rok Kosir, Ursula Prosenc Zmrzljak, Dragan Primorac
Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
M. Paula Gomez Hernandez, Emily E. Starman, Andrew B. Davis, Miyuraj Harishchandra Hikkaduwa Withanage, Erliang Zeng, Scott M. Lieberman, Kim A. Brogden, Emily A. Lanzel
Summary: The study aimed to evaluate the presence of CCBMs in saliva from children with SS and their association with immune system diseases. Elevated CCBMs were found to be related to autoimmune diseases and leukocyte activities. ROC analysis showed promising potential for certain CCBMs in diagnosing SS, with 8 previously unreported CCBMs warranting further investigation.
Review
Immunology
Tong Yue, Yu Shi, Sihui Luo, Jianping Weng, Yali Wu, Xueying Zheng
Summary: Diabetic retinopathy is a common complication of diabetes mellitus that is largely driven by inflammation. Understanding and elucidating the inflammation-related mechanisms is crucial for prevention and management of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Leile Camila Jacob-Nascimento, Caroline Xavier Carvalho, Monaise Madalena Oliveira Silva, Mariana Kikuti, Rosangela Oliveira Anjos, Jordana Rodrigues Barbosa Fradico, Ana Carolina Campi-Azevedo, Laura Beatriz Tauro, Gubio Soares Campos, Patricia Sousa dos Santos Moreira, Moyra Machado Portilho, Olindo Assis Martins-Filho, Guilherme Sousa Ribeiro, Mitermayer Galvao Reis
Summary: The study found that CHIKV-infected patients had significantly higher levels of chemokines compared to HC, and CCL2, CCL5, and CXCL10 levels were also significantly higher compared to patients with OAFD. Among patients with arthralgia lasting more than 3 months, CXCL8 levels were significantly increased. Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting more than 3 months.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Vincenzo Oliva, Giuseppe Fanelli, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Chiara Fabbri, Alessandro Serretti
Summary: This study found that different clinical subtypes of major depressive disorder (MDD), particularly melancholic features and typical neurovegetative symptoms, may be associated with distinct underlying genetics. These findings contribute to a better understanding of the genetic heterogeneity of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Raffaella Zanardi, Matteo Carminati, Francesco Attanasio, Chiara Fabbri, Alessandro Serretti
Summary: Nonpharmacological treatments for depression show effectiveness and tolerability in certain patients with diverse response. Genetic variables associated with treatment efficacy need to be examined to assist treatment selection. Most studies using candidate gene approach yielded poorly replicated findings due to small sample sizes, while a few methylome-wide and genome-wide association studies (GWASs) provided interesting results with the use of polygenic risk scores in small samples of electroconvulsive therapy (ECT) and cognitive-behavioral therapy. Further GWAS with larger sample sizes, such as the gen-ECT-ic consortium, can enhance our understanding of the genetic factors underlying treatment response in nonpharmacological therapies for depression.
PSYCHIATRIC GENETICS
(2023)
Article
Pharmacology & Pharmacy
Paolo Olgiati, Giuseppe Fanelli, Alessandro Serretti
Summary: This study analyzed the clinical correlates and prognostic impact of severe suicidal ideation in 249 outpatients with major depressive disorder (MDD). The results showed that patients with severe suicidal ideation were younger, more severely depressed, had more lifetime suicidal behavior and psychiatric comorbidities. Severe suicidal ideation was also positively associated with childhood maltreatment and bipolar liability, and inversely associated with age of onset and sleep-onset insomnia. These findings emphasize the importance of assessing childhood maltreatment and bipolar liability in estimating suicidal behavior risk in MDD.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Paolo Olgiati, Giuseppe Fanelli, Alessandro Serretti
Summary: In late-life depression (LLD), there are differences between patients with late-onset depression (LOD) and early-onset depression (EOD) that may be due to the effects of brain aging. To test this hypothesis, the study analyzed the clinical and cognitive manifestations of 438 outpatients aged >60 years with major depressive disorder. Compared to the EOD group, the LOD group had older patients with lower depression severity, lower global cognitive functioning, and more dyskinesias. Current age and age of onset were found to be correlated with various clinical and cognitive measures. LOD may be a separate diagnostic entity characterized by memory dysfunction and increased liability to movement disorders.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Martina Chiera, Stefano Draghetti, Diana De Ronchi, Anna Rosa Scaramelli, Chiara Fabbri, Giuseppe Fanelli, Alessandro Serretti
Summary: The relationship between psychiatric symptoms and thyroid function has been studied since antiquity. Generally, clinical hypothyroidism is associated with depressive symptoms, while hyperthyroidism is associated with agitation, emotional lability, and hyperexcitability. However, a case study of a 73-year-old Italian woman with lab-induced hyperthyroidism and severe major depressive episode challenges this conventional knowledge. The resolution of the hyperthyroid state improved the patient's psychiatric symptoms. This insight may contribute to the early diagnosis and treatment of thyroid disease.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Mariagrazia Palladini, Mario Gennaro Mazza, Andrea Scalabrini, Patrizia Rovere Querini, Sara Poletti, Francesco Benedetti
Summary: COVID-19 survivors experience intense depressive and post-traumatic symptoms in the sub-acute stages. Survivor guilt may contribute to the development of post-COVID psychiatric implications. This study aims to uncover the affective mechanism behind these implications by examining the association between survivor guilt, psychopathology, and maladaptive attributional style. The study evaluated symptoms of depression, post-traumatic distress, and sleep disturbances in 195 COVID-19 survivors one month after discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mauro Scala, Giuseppe Fanelli, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: Mood disorders are chronic diseases with low remission rates and treatment options have limitations. New antidepressants targeting different receptors have been developed to provide rapid action, tolerability, and effectiveness on specific symptoms. This review discusses the clinical profile and efficacy/tolerability of new antidepressants, such as AV-101, dextromethorphan-bupropion, PH-10, pimavanserin, PRAX-114, psilocybin, REL-1017/dextromethadone, JNJ-42847922/MIN-202, and SAGE-217, in patients with mood disorders, aiming to help clinicians optimize the risk/benefit ratio when prescribing these drugs.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Christoph Kraus, Alexander Kautzky, Victoria Watzal, Anna Gramser, Bashkim Kadriu, Zhi-De Deng, Lucie Bartova, Rupert Lanzenberger, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Giuseppe Fanelli, Alessandro Serretti, Siegfried Kasper
Summary: Individuals with major depressive disorder (MDD) are at higher risk for obesity, and weight gain is a predisposing factor for depression. Clinical data suggest that suicide risk is also elevated in obese patients. Monitoring weight gain in individuals with MDD should be a priority in clinical practice.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Chiara Possidente, Giuseppe Fanelli, Alessandro Serretti, Chiara Fabbri
Summary: Mood disorders and type 2 diabetes mellitus (T2DM) often co-occur, with T2DM leading to more severe depression and depression being associated with more complications and higher mortality in T2DM. There is a bidirectional association between mood disorders and T2DM. Mendelian randomisation studies showed a causal effect of MDD on T2DM in Europeans and a suggestive causal association in the opposite direction in East Asians. Antidepressants may increase the long-term risk of T2DM, while certain oral antidiabetics could be effective for depressive and cognitive symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Neurosciences
Alessandro Serretti
Summary: Anhedonia is a core symptom of depression and other psychiatric disorders, referring to a lack of pleasure or reward. It is not only a psychological distress but also encompasses a range of reward processing deficits. Anhedonia is a relevant risk factor for suicidal behaviors and may operate independently of the severity of depressive episodes. It has also been associated with inflammation, which can have a reciprocal detrimental effect on depression. The neurophysiological bases of anhedonia mainly involve changes in striatal and prefrontal areas, with dopamine playing a key role as the neurotransmitter involved. Anhedonia is believed to have a significant genetic component and polygenic risk scores may be a tool for predicting an individual's risk for developing anhedonia. Traditional antidepressants have shown limited benefit in treating anhedonia, also considering their potential to worsen anhedonia in some individuals. Other treatments such as agomelatine, vortioxetine, ketamine, and transcranial magnetic stimulation may be more effective. Psychotherapy, particularly cognitive-behavioral therapy and behavioral activation, is widely supported as beneficial for anhedonia. In conclusion, evidence suggests that anhedonia is partially independent from depression and requires careful evaluation and targeted treatment.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Alexander Kautzky, Lucie Bartova, Gernot Fugger, Markus Dold, Daniel Souery, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz, Chiara Fabbri, Alessandro Serretti, Dan Rujescu, Siegfried Kasper
Summary: This study investigates the differences in presentation and treatment outcomes of treatment-resistant depression (TRD) among different age groups. It finds that age has an impact on depressive symptoms and treatment outcomes. In TRD patients, symptom load and hospitalization time increase with age, while treatment responders do not show this trend. Older patients are more likely to have symptoms such as inner tension, reduced appetite, concentration difficulties, and lassitude.
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
