Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer

(2018) C Massard et al.   ANNALS OF ONCOLOGY

Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours

(2018) Olivier Mir et al.   EUROPEAN JOURNAL OF CANCER

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

(2017) Renata Ferrarotto et al.   JOURNAL OF CLINICAL ONCOLOGY

Taking it up a NOTCH: anovel subgroup of ACC is identified

(2017) Renata Ferrarotto et al.   Oncotarget

Prognostic impact of expression Notch-1 in invasive bladder transitional cell carcinoma.

(2017) Nasser Ghaly Yousif et al.   JOURNAL OF CLINICAL ONCOLOGY

Abstract 1133: Prevalence of activated NOTCH receptor in solid tumors and chronic lymphocytic leukemia

(2016) Gerard Oakley et al.   CANCER RESEARCH

NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma

(2015) Bo-Hua Su et al.   Oncotarget

Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma

(2013) Diana Bell et al.   Annals of Diagnostic Pathology

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming

(2013) Henry F. Frierson et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

The mutational landscape of adenoid cystic carcinoma

(2013) Allen S Ho et al.   NATURE GENETICS

Docetaxel and capecitabine for advanced gastric cancer: investigating dose-dependent efficacy in two patient cohorts

(2011) P C Thuss-Patience et al.   BRITISH JOURNAL OF CANCER

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.

(2011) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review

(2010) Scott A Laurie et al.   LANCET ONCOLOGY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER