Article
Polymer Science
Gabriela Kaufmann, Manuela Poletto Klein, Marcia Ines Goettert, Tanira Alessandra Silveira Aguirre
Summary: A hydrogel composed of chitosan and genipin was developed for the oral delivery of diclofenac sodium. The hydrogel exhibited pH-dependent swelling and release profiles. The release of the drug was observed to be different at different pH levels. In vitro cytotoxicity tests showed that the hydrogel components did not induce any toxic effects on cells.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Nicola Antonio Di Spirito, Nino Grizzuti, Mose Casalegno, Franca Castiglione, Rossana Pasquino
Summary: The study focuses on the effect of diclofenac sodium on the self-assembly and thermoresponsive crystallization of Pluronic F68 in water solutions. Experimental rheology and Nuclear Magnetic Resonance (NMR) techniques were used to investigate the morphological transitions and structural characteristics of the systems. The study provides insights into the interactions between Pluronic F68 and diclofenac sodium in the colloidal system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Kristina Grigorova, Bistra Kostova, Dilyana Georgieva, Anton Apostolov, Elena Vassileva
Summary: Nowadays, modern pharmaceutical investigations focus on designing and producing drug delivery systems that achieve prolonged and controlled drug delivery. This paper describes the synthesis and characterization of novel interpenetrating polymer networks (IPNs) for diclofenac sodium delivery.
Review
Biochemistry & Molecular Biology
Phuong H L Tran, Thao T D Tran
Summary: Recent studies have shown a growing interest in colon-targeted oral delivery systems, with film coatings serving as effective components for integrating multiple release strategies. These strategies include pH-controlled release, time-controlled release, and enzyme-triggered release. Modulations in coating layers, the use of natural film materials, and nanoparticle coatings are currently being vigorously investigated for their promising applications.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Yasmeena Thabet, Mahmoud Elsabahy, Noura G. Eissa
Summary: The development of nanocarriers has opened up new possibilities for drug delivery with improved targeting and reduced side effects. Niosomes, a type of non-ionic vesicles, have gained significant attention in biomedical applications due to their unique characteristics and ability to encapsulate hydrophilic and lipophilic drugs. Different methods for preparing niosomes have been described, each impacting the size and characteristics of the resulting niosomes.
Review
Biochemistry & Molecular Biology
Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
Summary: This review provides an overview of natural materials in film coating for oral drug delivery, focusing on their classification and potential combinations for adjusting desired properties. Discussing these materials can benefit the optimization of processes and strategies for future utilization.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ana C. Q. Silva, Barbara Pereira, Nicole S. Lameirinhas, Paulo C. Costa, Isabel F. Almeida, Patricia Dias-Pereira, Ines Correia-Sa, Helena Oliveira, Armando J. D. Silvestre, Carla Vilela, Carmen S. R. Freire
Summary: The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC) for the transdermal delivery of diclofenac sodium salt (DCF). The MNs showed adequate morphology, thermal stability, and the required mechanical strength for skin insertion. Experiments demonstrated the insertion capability and dissolution of the patches, as well as their noncytotoxicity.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Environmental
Keshireddy AnjiReddy, Subramanian Karpagam
Summary: Hyperbranched chitosan nanofiber formulations show faster drug release and higher absorption rates in vitro, with in vivo studies demonstrating faster absorption rates and higher peak plasma concentrations. The results suggest that chitosan blended/hyperbranched chitosan nanofiber formulation is a promising alternative to commercial formulations for the treatment of Alzheimer's disease.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Md Rakib Hasan Khan, Raj Shankar Hazra, Gauthami Nair, Jiyan Mohammad, Long Jiang, Katie Reindl, Mohammad Khalid Jawed, Sabha Ganai, Mohiuddin Quadir
Summary: The potential of cellulose nanofiber (CNF) for designing thin-film drug delivery systems (TF-DDS) with prolonged-release properties was explored. CNF-based TF-DDS prepared via solvent casting method showed optimized performance in terms of drug loading and sustained release. The system exhibited therapeutic activity against pancreatic cancer cells in vitro and in patient-derived xenograft models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Jakub Wlodarczyk, Monika Musial-Kulik, Katarzyna Jelonek, Mateusz Stojko, Paulina Karpeta-Jarzabek, Malgorzata Pastusiak, Henryk Janeczek, Piotr Dobrzynski, Michal Sobota, Janusz Kasperczyk
Summary: Dual-jet electrospinning was used to produce two-component, partially degradable drug releasing non-wovens with interlacing of PDLGA and PCUs. The study focused on drug release profiles and the influence of drug incorporation on material degradation and mechanical properties. In vitro cell tests showed that introduction of sirolimus reduced fibroblast viability and limited their capability to colonize the fiber surface. Due to improved mechanical strength and controlled drug release, the material may be considered as a prospective surgical mesh implant for hernia treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Yangqi Zhou, Menglong Wang, Chao Yan, Hui Liu, Deng-Guang Yu
Summary: Oral ulcers have significant impact on oral and systemic health, with individual differences in etiology and extent of the disease. Electrospinning technology is effective for preparing nanofiber films for the treatment of oral ulcers, offering advantages of long-term local administration.
Article
Biochemistry & Molecular Biology
Joseph Jose, Hemalatha Kanniyappan, Vignesh Muthuvijayan
Summary: This study presents a novel approach for separating drugs from liposomes using solvents with varying dielectric constants. The method proves to be cost-effective and efficient, with a significantly higher recovery rate compared to conventional techniques.
PROCESS BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Sagar R. Pardeshi, Eknath B. Kole, Harshad S. Kapare, Sachin M. Chandankar, Prashant J. Shinde, Ganesh S. Boisa, Sanjana S. Salgaonkar, Prabhanjan S. Giram, Mahesh P. More, Praveen Kolimi, Dinesh Nyavanandi, Sathish Dyawanapelly, Vijayabhaskarreddy Junnuthula
Summary: The surface drying process is crucial in pharmaceutical, biomedical, and food industries. Thin film freezing (TFF) is a promising freeze-drying technique that has been utilized in drug delivery and pharmaceutical development. TFF has various therapeutic applications in the development of nanoformulations, dry powder inhalations, and vaccines.
Article
Energy & Fuels
Han-xin Mei, Paolo Piccardo, Giovanni Carraro, Marco Smerieri, Roberto Spotorno
Summary: All-solid-state batteries (ASSBs) with solid-state electrolytes (SSEs) have gained attention due to their high energy density and safety. However, achieving mass production of SSEs while maintaining quality control is a challenge in current research.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Pharmacology & Pharmacy
Fatima Akbar Sheikh, Muhammad Naeem Aamir, Muhammad Tahir Haseeb, Syed Nasir Abbas Bukhari, Muhammad Farid ul Haq, Naveed Akhtar
Summary: The study aimed to prepare fast dissolving ODFs for simultaneous delivery of BCS class II drugs using synthetic, semisynthetic, and natural polymers. The results showed that the prepared ODFs had appropriate physico-chemical parameters, drug release properties, and good stability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ayman Gebril, Mohammad A. Obeid, Ewan M. Bennett, Anairis Pujol, Mario L. Chovel, Tatiana Mahy, Reinaldo Acevedo, Valerie A. Ferro
Summary: This study investigated the use of a microwave reactor to prepare lipid nanoparticles (LNPs) and optimize the formulation process for reducing manufacturing time. The results showed that bilosomes administered orally had higher antigen entrapment efficiency and stronger immune response.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Alaa A. A. Aljabali, Mohammad A. Obeid, Hamid A. Bakshi, Walhan Alshaer, Raed M. Ennab, Bahaa Al-Trad, Wesam Al Khateeb, Khalid M. Al-Batayneh, Abdulfattah Al-Kadash, Shrouq Alsotari, Hamdi Nsairat, Murtaza M. Tambuwala
Summary: The study demonstrates the chemical effectiveness of zinc oxide nanoparticles in combating aggressive breast cancer and drug resistance. The synthesized nanoparticles showed a hexagonal wurtzite crystal arrangement and strong absorbance at 374 nm. The cytotoxic effect of the nanoparticles was tested on wild-type and doxorubicin-resistant breast cancer cell lines, showing their ability to induce apoptosis without significant differences in drug resistance.
Review
Pharmacology & Pharmacy
Adedapo Adesokan, Mohammad A. Obeid, Aisha F. Lawal
Summary: This article discusses the variants of SARS-CoV-2 and the reduced neutralising ability of antibodies against them, highlighting the need for efficacy studies before mass vaccination. It also explores the potential of nanoparticles as carrier vehicles for vaccines and investigates emerging prophylactics and therapeutics for severe and critical cases of COVID-19.
THERAPEUTIC DELIVERY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad A. Obeid, Manal Alsaadi, Alaa A. Aljabali
Summary: Curcumin, a natural component extracted from turmeric, has received considerable attention due to its antioxidant and anti-inflammatory effects. However, its clinical application is limited by its poor solubility, rapid metabolism, and photosensitivity. Nanoparticles have been used to improve the solubility and bioavailability of curcumin.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Alaa A. A. Aljabali, Rasha M. Bashatwah, Mohammad A. Obeid, Vijay Mishra, Yachana Mishra, Angel Serrano-Aroca, Kenneth Lundstrom, Murtaza M. Tambuwala
Summary: mRNA vaccines are an attractive alternative to conventional vaccination technologies due to their superior efficacy, rapid engineering, low-cost manufacturing, and safe delivery prospects. They have shown promising results in targeting infectious diseases and various types of cancer in both in vivo and in vitro studies. Issues related to mRNA stability and immunogenicity have been addressed, and current mRNA vaccines can generate robust immune responses without being constrained by the recipient's major histocompatibility complex haplotype.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromic-Jahjefendic, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala
Summary: Nanomaterials have been extensively studied in the medical and industrial sectors, but their potential toxicities have raised concerns. Researchers are interested in how nanoparticles interact with the immune system and their biomolecules. This review examines literature on the immunostimulatory and immunosuppressive effects of nanomaterials and their interactions with immune cells, as well as the possibility of creating stealth nanomaterials that evade the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Natalie Maclean, Ibrahim Khadra, James Mann, Alexander Abbott, Heather Mead, Daniel Markl
Summary: Stability studies are crucial in drug product development to ensure the safety and efficacy of the product. This study investigated the changes in dissolution performance and physical properties of three griseofulvin formulations under different storage conditions. The results showed a decrease in dissolution rate after storage, which correlated with humidity. The changes in physical properties were attributed to either premature swelling or dissolution of particles during storage.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Hind Ashraf Hassan, Omnia Hesham Abdelhafez, Nourhan Hisham Shady, Ramadan Yahia, Nada M. Mohamed, Mostafa E. Rateb, Lina Akil, Ibrahim Khadra, Stefanie P. Glaeser, Peter Kampfer, Usama Ramadan Abdelmohsen, Mo'men Hamed El-Katatny
Summary: Endophytic fungi in Allium cepa were investigated for their potential as a source of anti-infective drugs. One isolate, Penicillium sp. LCEF10, showed significant anti-infective activity against several tested microbes and was identified as Penicillium oxalicum NRRL 787. Metabolomic analysis revealed the presence of various bioactive compounds in the ethyl acetate extract of Penicillium sp. LCEF10, including polyketides, macrolides, phenolics, and terpenoids. Molecular docking study predicted the compounds most likely responsible for the anti-infective activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mohammad A. Obeid, Saja Haifawi, Ibrahim Khadra
Summary: The study aimed to assess the impact of solvent selection on the characteristics of niosomes prepared by microfluidic mixing. Niosomes were manufactured using different solvents to investigate their physiochemical characteristics. The type of organic solvent significantly affected the size of the niosomes, while changing the aqueous solvent affected particle size, distribution, and surface charge. The encapsulation efficiency of hydrophobic drug quinine was significantly influenced by the organic solvent used.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Pharmacology & Pharmacy
Maria Ines Silva, Ibrahim Khadra, Kate Pyper, Gavin W. Halbert
Summary: The solubility of drugs in intestinal fluid is an essential factor for the performance and bioavailability of oral dosage forms. Both solubility and permeability are used in the Biopharmaceutics and Developability Classification Systems (DCS) to evaluate the potential of drugs for oral administration. This study introduces a novel fed state simulated media system consisting of nine media to measure the solubility of seven drugs previously studied in the fasted state DCS. The results demonstrate that the fed nine media system provides consistent solubility behavior and can be used for assessing the drug's position on the DCS grid.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Heba A. S. El-Nashar, Ahmed M. Sayed, Hany A. M. El-Sherief, Mostafa E. Rateb, Lina Akil, Ibrahim Khadra, Taghreed A. Majrashi, Sara T. Al-Rashood, Faizah A. Binjubair, Mahmoud A. El Hassab, Wagdy M. Eldehna, Usama Ramadan Abdelmohsen, Nada M. Mostafa
Summary: This study investigated the metabolic profile and anti-trypanosomal effect of the methanol extract of Thunbergia grandifolia leaves. Fifteen compounds of different classes were identified using LC-HRESIMS. The extract showed a strong inhibitory activity against T. brucei TC 221 and two compounds were identified as potential targets. Both compounds showed acceptable drug-like properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Review
Virology
Alaa A. A. Aljabali, Mohammad A. Obeid, Mohamed El-Tanani, Murtaza M. Tambuwala
Summary: Respiratory syncytial virus (RSV) is a major cause of respiratory diseases, particularly in children under 2 years old and adults. RSV spreads through respiratory droplets from coughing or sneezing. Extensive research has been conducted on RSV, including treatment strategies, potential vaccines, and diagnostic techniques, to develop appropriate management and control measures.
Review
Oncology
Ahmed A. Abdulhussein Al-Ali, Nameer Al Ward, Mohammad A. Obeid, Carsten Uhd Nielsen, Paul A. Mulheran, Mohammed M. Al Qaraghuli
Summary: Recently, research has been focused on the use of photothermal therapy (PTT) as an advanced method to treat various types of cancer. The PTT approach primarily utilizes nanoparticles (NPs) made from metals, carbon, or semiconductors that can convert near-infrared laser irradiation into local heat, inducing cancer cell death. An alternative approach is to utilize NPs like liposomes to carry suitable dye molecules to achieve the same effect.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Adel Alghamdi, Amr S. S. Abouzied, Abdulwahab Alamri, Sirajudheen Anwar, Mukhtar Ansari, Ibrahim Khadra, Yasser H. H. Zaki, Sobhi M. M. Gomha
Summary: In this study, a novel series of N-aminothiazole-hydrazineethyl-pyridines were designed, synthesized, and characterized. Molecular docking and molecular dynamics simulation were applied to investigate their binding energy with the SARS-CoV-2 main protease. The results obtained from in vitro and in vivo research on these synthesized compounds are expected to make a significant contribution to the fight against COVID-19.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
