Article
Biochemistry & Molecular Biology
Jerad Dumolt, Theresa L. Powell, Thomas Jansson, Fredrick J. Rosario
Summary: Infants born to obese mothers have a higher risk of childhood obesity and insulin resistance. Lower levels of maternal adiponectin, a hormone associated with placental nutrient transport and fetal overgrowth, contribute to these risks. Previous research showed that supplementing adiponectin in obese mice during pregnancy prevented obesity and metabolic dysfunction in their offspring. This study further demonstrates the importance of maternal adiponectin levels in the development of metabolic diseases in offspring and suggests that improving these levels could prevent long-term metabolic dysfunction in children of obese mothers.
Article
Endocrinology & Metabolism
Yuan Wu, Qiao Yu, Mingyan Dai, Jing Wang, Ling Shu, Dilin Dai, Jie Chen, Junxia Zhang, Mingwei Bao
Summary: Carotid baroreceptor stimulation (CBS) suppresses sympathetic nervous system activity and oxidative stress mediated by monoamine oxidase A (MAO-A) in obese rats, preventing cardiac remodeling and improving heart function.
Article
Reproductive Biology
Meng Zuo, Guotao Liao, Wenqian Zhang, Dan Xu, Juan Lu, Manhong Tang, Yue Yan, Chenghao Hong, Yuxia Wang
Summary: The study aimed to investigate the impact of adiponectin intervention during early pregnancy of obese mice with PCOS on the metabolic phenotype of adult female offspring. Results showed that adiponectin intervention significantly reduced the adverse effects of maternal obesity and high androgen levels during pregnancy on female offspring, correcting the PCOS-like endocrine phenotype and metabolic disorders in adult female offspring. This effect may be mediated by the activation of the AMPK/PI3K-Akt signaling pathway in PCOS offspring mice.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Daniel E. Radford-Smith, Fay Probert, Philip W. J. Burnet, Daniel C. Anthony
Summary: Maternal obesity has a negative impact on the emotional behavior of offspring. However, perinatal intake of a multispecies probiotic can mitigate this effect. The probiotic treatment improves gut and brain metabolism, increases neuroplasticity, and enhances resilience to emotional dysfunction induced by maternal obesity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, Andrya J. Durr, Andrew D. Taylor, William T. Goldsmith, Krista L. Garner, Timothy R. Nurkiewicz, John M. Hollander
Summary: Maternal exposure to engineered nanomaterials (ENM) during gestation has been linked to negative cardiovascular effects in offspring. This study investigates the epitranscriptomic mechanism and the potential of overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase (mPHGPx) to preserve cardiovascular function in offspring following gestational exposure to nano-titanium dioxide (TiO2) inhalation. Results suggest that m(6)A hypermethylation of mPHGPx may be responsible for diminished antioxidant capacity and mitochondrial/cardiac deficits in adult offspring following gestational ENM exposure.
Article
Nutrition & Dietetics
Roger Marine-Casado, Cristina Domenech-Coca, Anna Crescenti, Miguel Angel Rodriguez Gomez, Josep Maria Del Bas, Lluis Arola, Noemi Boque, Antoni Caimari
Summary: Maternal supplementation with high-flavan-3-ol cocoa extract during lactation has beneficial effects on dams and their offspring, including increased circulating levels of adiponectin and decreased mammary gland lipid content in dams. It also leads to increased energy expenditure, circulating free fatty acids, and expression of lipogenic and adiponectin-related genes in mammary glands. Furthermore, it programs the offspring towards increased plasma total adiponectin levels, decreased liver weight, and an improvement in the inflammatory profile.
Article
Cell Biology
Bhavisha A. Bakrania, Ana C. Palei, Umesh Bhattarai, Yingjie Chen, Joey P. Granger, Sajid Shahul
Summary: This study found that chronic excess levels of Activin A during pregnancy can lead to cardiac dysfunction, supporting the concept that Activin A may serve as a mediator of preeclampsia-induced cardiac dysfunction.
Review
Multidisciplinary Sciences
Tahereh Raeisi, Hossein Rezaie, Mina Darand, Akram Taheri, Nazila Garousi, Bahman Razi, Leonardo Roever, Reza Mohseni, Shimels Hussien Mohammed, Shahab Alizadeh
Summary: This meta-analysis showed that resistin and follistatin levels are significantly higher in women with PCOS compared to controls, regardless of obesity status. The findings suggest that resistin and follistatin may play a crucial role in the pathology of PCOS.
Article
Pharmacology & Pharmacy
Nataliia Hula, Floor Spaans, Jennie Vu, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Tom J. Phillips, C. Patrick Case, Sandra T. Davidge
Summary: Offspring born from pregnancies complicated by prenatal hypoxia are at higher risk of cardiovascular disease in adulthood. Cardiac tolerance to ischemia/reperfusion (I/R) insult is decreased in both male and female offspring exposed to hypoxia during fetal life, but can be improved by maternal treatment with nMitoQ. The molecular mechanisms underlying the improved cardiac tolerance to I/R may involve changes in the levels/phosphorylation of proteins important for intracellular Ca2+ cycling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Guadalupe L. Rodriguez-Gonzalez, Lilia Vargas-Hernandez, Luis A. Reyes-Castro, Carlos A. Ibanez, Claudia J. Bautista, Consuelo Lomas-Soria, Nozomi Itani, Guadalupe Estrada-Gutierrez, Aurora Espejel-Nunez, Arturo Flores-Pliego, Araceli Montoya-Estrada, Enrique Reyes-Munoz, Paul D. Taylor, Peter W. Nathanielsz, Elena Zambrano
Summary: Maternal obesity leads to oxidative stress and metabolic dysfunction. Supplementation of obese mothers with resveratrol improves maternal metabolic alterations and reduces oxidative stress in the placenta and maternal and fetal liver, with a sex-dependent effect.
Article
Cardiac & Cardiovascular Systems
Youyang Shi, Feifei Li, Man Shen, Chenpin Sun, Wei Hao, Chunyu Wu, Ying Xie, Shuai Zhang, Hongzhi Gao, Jianfeng Yang, Zhongyan Zhou, Dongwen Gao, Yuenong Qin, Xianghui Han, Sheng Liu
Summary: Luteolin can mitigate Doxorubicin-induced toxicity in cardiomyocytes by reducing oxidative stress, decreasing mitochondrial fission, and lowering levels of apoptosis. In addition, Luteolin exhibits protective effects in zebrafish and enhances the cytotoxicity of Doxorubicin in triple-negative breast cancer by inhibiting proliferation, metastasis, and inducing apoptosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Alexandre Ribault, Mohamed Amine Benadjaoud, Claire Squiban, Laurent Arnaud, Coralie Judicone, Aurelie S. Leroyer, Alexandra Rousseau, Christelle Huet, Chandan Guha, Marc Benderitter, Romaric Lacroix, Stephane Flamant, Emily I. Chen, Jean-Marc Simon, Radia Tamarat
Summary: In a retrospective study on 208 patients with prostate adenocarcinoma, circulating microvesicles (MVs) were investigated as potential biomarkers for radiation toxicity. The level of platelet (P)-, monocyte (M)- and endothelial (E)-derived MVs was assessed, and it was found that increased numbers of P-derived MVs were associated with higher toxicity grades. Furthermore, a correlation between P-derived MVs and M-derived MVs was observed, indicating their potential as biomarkers for radiation therapy complications.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Hsing Hung, Chih-Yao Hou, Chi- Chang, You-Lin Tain
Summary: The study found that perinatal resveratrol supplementation can prevent offspring hypertension programmed by TCDD exposure in mothers, with mechanisms involving reshaping gut microbiota and antagonizing AHR-mediated TH17 cell responses.
Review
Pharmacology & Pharmacy
Abhipree Sharma, Michael Mah, Rebecca H. Ritchie, Miles J. De Blasio
Summary: Diabetes is associated with an increased risk of heart failure known as diabetic cardiomyopathy. Adiponectin, a cardioprotective adipokine, is downregulated in diabetes and obesity, leading to reduced cardioprotection. This review summarizes the evidence linking suppressed adiponectin signaling pathway to cardiac dysfunction in diabetes and discusses potential therapeutic approaches for diabetic cardiomyopathy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Katrin Schmitz, Eva-Maria Turnwald, Tobias Kretschmer, Ruth Janoschek, Inga Bae-Gartz, Kathrin Vossbrecher, Merlin D. Kammerer, Angela Koeninger, Alexandra Gellhaus, Marion Handwerk, Maria Wohlfarth, Dirk Gruendemann, Eva Hucklenbruch-Rother, Joerg Doetsch, Sarah Appel
Summary: With the increasing prevalence of obesity, the risks associated with pregnancy are also rising. Inflammation and oxidative stress are identified as key mechanisms in white adipose tissue (WAT) that contribute to obesity-associated complications and diseases. The anti-diabetic drug metformin has known systemic effects, but its effects on WAT are not well understood. This study investigated the effects of metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. The results showed that metformin treatment reduced weight gain and visceral fat accumulation, and regulated several potential adipokines to mediate anti-diabetic, anti-inflammatory, and oxidative stress-modulating effects.