Review
Biochemistry & Molecular Biology
David Muallah, Jan Matschke, Matthias Kappler, Lysann Michaela Kroschwald, Gunter Lauer, Alexander W. Eckert
Summary: Xerostomia, or dry mouth, is mainly caused by hypofunction of the salivary glands due to various factors. Current treatment methods are not very effective and regenerative medicine using dental pulp stem cells shows promise. Dental pulp stem cells can differentiate into different cell types and have immunomodulatory effects. However, more clinical studies are needed to fully understand their potential for salivary gland regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mohammad Samiei, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Jaleh Barar, Yadollah Omidi
Summary: In this study, chitosan-based hydrogels were used to improve the proliferation and differentiation of dental pulp stem cells (DPSCs), with CS/GN hydrogel showing better features in enhancing DPSCs viability and osteogenic differentiation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nela Pilbauerova, Jan Schmidt, Tomas Soukup, Romana Koberova Ivancakova, Jakub Suchanek
Summary: This study aimed to observe the effect of uncontrolled-rate freezing on DPSCs stored for 6 and 12 months. It was found that DPSCs retained their stemness markers and low-level expression of hematopoietic markers even after one year of cryopreservation at -80 degrees C, suggesting that DPSCs can still be successfully used in potential clinical applications after a year of uncontrolled cryopreservation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zhuo Xie, Zongshan Shen, Peimeng Zhan, Jiayu Yang, Qiting Huang, Shuheng Huang, Lingling Chen, Zhengmei Lin
Summary: Treatment of pulpal and periapical diseases faces challenges, but significant progress has been made in achieving true pulp tissue regeneration through technologies such as stem cells, biomaterials, and growth factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Agnese Gugliandolo, Luigia Fonticoli, Oriana Trubiani, Thangavelu S. Rajan, Guya D. Marconi, Placido Bramanti, Emanuela Mazzon, Jacopo Pizzicannella, Francesca Diomede
Summary: Tissue engineering has become a major focus of research, with the potential of biomaterials and mesenchymal stem cells (MSCs) showing promise for bone regeneration, particularly in oral bone regeneration. Combining MSCs with biomaterials enhances bone regenerative power, and utilizing the MSC secretome also presents a promising future for bone tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Qiulin He, Junxin Lin, Fanghao Zhou, Dandan Cai, Yiyang Yan, Yejie Shan, Shufang Zhang, Tiefeng Li, Xudong Yao, Hongwei Ouyang
Summary: Nonuniform microstretching (NUMS), a natural phenomenon in bone tissues, promotes osteogenic differentiation and has potential positive effects on bone healing.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Mohammed Mashyakhy, Ahmed Alkahtani, Abdulaziz S. Abumelha, Reham Jamal Sharroufna, Mazen F. Alkahtany, Mohamed Jamal, Ali Robaian, Sultan Binalrimal, Hitesh Chohan, Vikrant R. Patil, A. Thirumal Raj, Shilpa Bhandi, Rodolfo Reda, Luca Testarelli, Shankargouda Patil
Summary: The study investigated the effects of taurine on DPSC chondrogenic differentiation, demonstrating a significant increase in the expression of chondrogenesis-related genes and an increase in glycosaminoglycan production by the cells.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Engineering, Biomedical
B. Christie, N. Musri, N. Djustiana, V. Takarini, N. Tuygunov, M. N. Zakaria, A. Cahyanto
Summary: This systematic review investigates the effects of calcium phosphate (CaP) and silicate-based materials on human dental pulp stem cells (hDPSCs). The findings demonstrate that CaP and silicate-based materials have positive effects on the viability, adhesion, migration, proliferation, and differentiation of hDPSCs. However, the limited number of studies and methodological heterogeneity pose challenges for quantitative research.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Julia K. Bar, Anna Lis-Nawara, Piotr Grzegorz Grelewski
Summary: The secretome derived from dental pulp stem cells and human exfoliated deciduous teeth has therapeutic potential in regenerating bone, cartilage, and nerve tissue. By secreting bioactive factors, these cells can modulate processes such as neuroprotection, anti-inflammatory, antiapoptotic, and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Fernando J. Aguilar-Ayala, Fernando J. Aguilar-Perez, Geovanny Nic-Can, Rafael Rojas-Herrera, Gabriela Chuc-Gamboa, David Aguilar-Perez, Beatriz A. Rodas-Junco
Summary: Biomaterials and stem cells are crucial in regenerative medicine, particularly in the development of autologous therapies. While progress has been made, challenges remain in understanding the characteristics of biomaterials and the molecular mechanisms regulating stem cell behavior.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Victor J. Costela-Ruiz, Lucia Melguizo-Rodriguez, Chiara Bellotti, Rebeca Illescas-Montes, Deborah Stanco, Carla Renata Arciola, Enrico Lucarelli
Summary: The success of regenerative medicine depends on the appropriate selection of mesenchymal stem cell (MSC) sources, as they influence the regenerative milieu. MSCs from bone marrow, adipose tissue, and dental tissue are all potential candidates for oral and dental regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jan Schmidt, Vojtech Pavlik, Jakub Suchanek, Kristina Nesporova, Tomas Soukup, Martin Kapitan, Nela Pilbauerova
Summary: Hyaluronic acid (HA), a widely present biopolymer in the human body, can be used as a scaffold material for cells. It has been found that different molecular weights of HA have negligible effects on the viability and differentiation potential of human dental pulp stem cells (hDPSCs). Therefore, HA is a suitable component for hDPSCs-containing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Tullio Genova, Davide Cavagnetto, Fabio Tasinato, Sara Petrillo, Federico Alessandro Ruffinatti, Luca Mela, Massimo Carossa, Luca Munaron, Ilaria Roato, Federico Mussano
Summary: Mesenchymal stem cells (MSCs) from third molar dental pulp and buccal fat pads of patients were compared for osteoinductive potential. The study found higher yield and proliferation of cells in BFPSCs compared to DPSCs, although both could differentiate into osteoblast-like cells and release a mineralized matrix. The release of osteocalcin did not significantly differ between the two types of stem cells.
Review
Veterinary Sciences
Hussein M. M. El-Husseiny, Eman A. A. Mady, Mahmoud A. Y. Helal, Ryou Tanaka
Summary: The use of stem cells in veterinary practice is rapidly evolving, with significant research efforts focused on both experimental animals and clinical cases. Stem cells, particularly mesenchymal stem cells (MSCs), are promising for therapeutic applications due to their immunomodulatory capabilities and ease of isolation. However, challenges remain in their clinical implementation for treating various animal diseases, driving further advancements in stem cell therapies.
VETERINARY SCIENCES
(2022)
Review
Cell & Tissue Engineering
Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. M. Galler, Mohammad-Hossein Nekoofar, Paul M. H. Dummer
Summary: This systematic review investigated the mechanisms regulating the differentiation of hDP-MSCs and identified several miRNAs involved in this process. Bioinformatic analysis revealed target genes, signaling pathways, and gene ontologies associated with these miRNAs. The findings support the potential application of these specific miRNAs in regulating the directed differentiation of hDP-MSCs in regenerative therapies.
STEM CELL RESEARCH & THERAPY
(2023)
Editorial Material
Medicine, General & Internal
Marco Tatullo, Gianrico Spagnuolo
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cell Biology
Marco Tatullo, Maria Giovanna Gandolfi
Editorial Material
Biochemistry & Molecular Biology
Marco Tatullo, Maria Giovanna Gandolfi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Marco Tatullo, Adriano Piattelli, Barbara Zavan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Francesco Paduano, Emma Colao, Fernanda Fabiani, Valentina Rocca, Francesca Dinatolo, Adele Dattola, Lucia D'Antona, Rosario Amato, Francesco Trapasso, Francesco Baudi, Nicola Perrotti, Rodolfo Iuliano
Summary: The study revealed that germline pathogenic variants accounted for a certain proportion in some patients, and multi-gene panel testing can be an effective diagnostic approach for individuals at high risk of hereditary cancers.
Review
Biochemistry & Molecular Biology
Mariacristina Amato, Simona Santonocito, Gaia Viglianisi, Marco Tatullo, Gaetano Isola
Summary: Periodontal disease is a common chronic inflammatory condition that lacks effective treatment options. Utilizing stem cells for periodontal tissue regeneration shows promise as a potential therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francesco Paduano, Eugenio Gaudio, Francesco Trapasso
Summary: Fhit protein is often reduced in human tumors, and its restoration can trigger apoptosis of cancer cells and suppress tumor formation. In this study, Fhit expression was found to be significantly reduced in human melanoma cells, and the use of a recombinant adenovirus carrying the FHIT gene blocked their in vivo growth. It was also discovered that Fhit physically interacts with Hsp90, a chaperone that plays a crucial role in the conformational maturation and stabilization of C-Raf. Furthermore, the combination of Hsp90 inhibitor 17-AAG and Fhit protein overexpression in melanoma cells led to increased C-Raf ubiquitination and degradation.
Article
Anatomy & Morphology
Priscilla Pelaez-Cruz, Pia Lopez Jornet, Marco Tatullo, Eduardo Pons-Fuster Lopez
Summary: This study evaluated the in vitro effect of bovine, porcine, and beta-tricalcium phosphate bone substitutes, and their combination with polyphenol epigallocatechin-3-gallate (EGCG), on cultured dental pulp stem cells (DPSCs). The addition of EGCG reversed the cytotoxic effect of certain biomaterials and improved cell adhesion, migration, and alkaline phosphatase activity. EGCG shows potential as a strategy for enhancing the biocompatibility and osteoconductive properties of bone substitutes in bone regeneration treatments.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2023)
Article
Biochemistry & Molecular Biology
Bruno Lamanna, Marina Vinciguerra, Miriam Dellino, Gabriele Cascella, Gerardo Cazzato, Enrica Macorano, Antonio Malvasi, Salvatore Scacco, Ettore Cicinelli, Vera Loizzi, Antonella Vimercati, Gennaro Cormio, Francesco Paduano, Eliano Cascardi, Marco Tatullo
Summary: Turner syndrome is a chromosomal disorder characterized by short stature and infertility. It can be accompanied by Duchenne muscular dystrophy, a neuromuscular disease that primarily affects males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Marco Tatullo, Barbara Zavan, Adriano Piattelli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Marco Tatullo, Sandro Rengo, Gilberto Sammartino, Gaetano Marenzi
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Chemistry, Physical
Marco Tatullo, Giuseppina Ambrogio, Gilberto Sammartino
Article
Oncology
Eliano Cascardi, Gerardo Cazzato, Giuseppe Ingravallo, Miriam Dellino, Carmelo Lupo, Nadia Casatta, Andrea Ballini, Andrea Pacifici, Gaetano Marenzi, Gilberto Sammartino, Eugenio Maiorano, Marco Tatullo
Summary: Oral malignant melanoma (OMM), accounting for less than 1% of all melanomas, commonly develops on the oral mucosa and often faces a diagnostic delay. This study explored the use of PRAME as a tool to investigate and differentiate OMM from other dysplastic pigmented lesions. The findings showed that PRAME could accurately differentiate Melanoma cases from other melanocytic nevi, leading to better differential diagnosis, early diagnosis, and clinical/surgical management of oncological lesions.
Review
Cell & Tissue Engineering
Marco Tatullo
Summary: Aging is characterized by physiological changes that increase susceptibility to age-related diseases. This review summarizes the alterations affecting MSCs during aging and the role of inflammation in age-related syndromes.
