Article
Biochemistry & Molecular Biology
Xin Weng, Yun-Yun Lou, Yun-Shan Wang, Ya-Ping Huang, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: Gynostemma pentaphyllum has a long history as a food and dietary supplement in China. Research has found that compounds from G. pentaphyllum can serve as PCSK9 inhibitors and play a role in the treatment of hyperlipidemia.
BIOORGANIC CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Shiwei Li, Yingna Wang, Weipeng Dun, Wanqing Han, Tao Ning, Qi Sun, Zichao Wang
Summary: Researchers have explored the use of Gynostemma pentaphyllum polysaccharide (GPP) in disease treatment through gut microbiota regulation. However, this study highlights the potential of GPP in disease prevention and physique enhancement. The findings suggest that GPP has the ability to prevent or mitigate obesity by modulating the gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Ying Li, Qiong Ouyang, Xu Li, Raphael N. N. Alolgal, Yuanming Fan, Yangyang Sun, Hang Gong, Pingxi Xiao, Gaoxiang Ma
Summary: In this study, the lipid-lowering effects of Gynostemma pentaphyllum (GP) were investigated using a meta-analysis, animal experiments, and metabolomic analysis. The results showed that GP can effectively reduce triglyceride levels and improve blood lipid metabolism by regulating the intestinal microbiota and tryptophan metabolism.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yun-Yun Lou, Xian Zheng, Ya-Ping Huang, Long Mu, Xiao-Gai Zhang, Zhi-Wei Zhao, Zhe Song, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: This study isolated and structurally characterized novel, minor gypenosides from Gynostemma pentaphyllum, and evaluated their Sirt1 agonist activity. Results showed satisfactory Sirt1 agonist activity in four saponins, indicating the potential for further research on G. pentaphyllum as a source of Sirt1 agonists.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Ping Huang, Yun-Shan Wang, Bi-Wen Liu, Zhe Song, Xiao-Shuang Liang, Yuan Teng, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: Seven undescribed dammarane-type saponins, along with four known compounds, were isolated from the whole herb of Gynostemma pentaphyllum. The newly discovered compounds showed inhibitory activities against PCSK9, with some compounds exhibiting this activity at different concentrations. Notably, gypenoside LXXXII retained its inhibitory activity against PCSK9 even at a lower concentration of 5 mu M.
Article
Biochemistry & Molecular Biology
Hai-Zhen Liang, Peng-Xin Lu, Li-Li Chu, Gang Li, Chuan-Biao Li, Xiao-Juan Chen, Jie Zhang, Juan Song, Tao Zhang, Ying Luo, Ying Hu, Bai-Ping Ma
Summary: RNA sequencing analysis revealed that Gynostemma pentaphyllum extract can up-regulate genes involved in oxidative phosphorylation and SIRT signaling pathways, improving mitochondrial functions and promoting cell viability. Sixteen undescribed dammarane-type saponins and twenty-eight known analogues were isolated from the extract, with thirteen compounds showing satisfactory agonist activities on SIRT3 and TOM20. These findings suggest the potential of Gynostemma pentaphyllum and its bioactive saponins in developing natural drugs for aging-related diseases.
Review
Pharmacology & Pharmacy
Ning Dai, Fang-fang Zhao, Min Fang, Feng-lan Pu, Ling-yao Kong, Jian-ping Liu
Summary: This study evaluated the lipid-lowering effect and safety of Gynostemma pentaphyllum (GP) used alone or as adjunctive therapy for dyslipidemia. The findings suggest that GP has a similar effect as lipid-lowering agents in regulating serum lipids, but is inferior to red yeast rice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Weilin Liao, Imran Khan, Guoxin Huang, Shengshuang Chen, Liang Liu, Wai Kit Leong, Xiao Ang Li, Jianlin Wu, W. L. Wendy Hsiao
Summary: Colorectal cancer ranks the third most common cancer type in both men and women, with disturbed gut microbes potentially contributing to its onset and progression. Maintaining a balanced gut microbiota has become a novel pursuit in the medical field, particularly in gastrointestinal disorders. Gynostemma pentaphyllum saponins have shown prebiotic and cancer-preventive properties through modulation of gut microbiota, with the specific bacteria Bifidobacterium animalis demonstrating anticancer and cancer-preventive activities.
Article
Biochemistry & Molecular Biology
Duc Duy Le, Woohyun Kim, Soohwan Lim, Sun Chang Kim, Giltsu Choi
Summary: Ginsenosides, glycosylated dammarene-type triterpenes found in Panax ginseng and Gynostemma pentaphyllum, share common UGT families for biosynthesis despite belonging to different subfamilies, indicating independent evolutionary selection for their synthesis.
Article
Plant Sciences
Yunyi Zhou, Lixiang Yao, Xueyan Huang, Ying Li, Chunli Wang, Qinfen Huang, Liying Yu, Chunliu Pan
Summary: Through physiological response analysis, transcriptomics, and metabolomics, this study reveals the stress response mechanisms and metabolic changes in Gynostemma pentaphyllum under cadmium stress. It is found that G. pentaphyllum enhances antioxidant enzyme activity and accumulation of proline and polysaccharides under cadmium stress. Transcriptomics and metabolomics analysis identify genes and metabolic pathways associated with cadmium stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Applied
Wei-Ye Cui, Yulian Jin, Hui Liu, Ma-Li Zu, Xin-Fang Zhai, Ce Yang, Yu-Long Gu, Yong Cheng, Xiang-Lan Piao
Summary: Two dammarane-type saponins were isolated from the heat-processed Gynostemma pentaphyllum, showing moderate activity against human lung carcinoma A549 cells. In vitro assays revealed that damulin E and damulin F exhibited moderate activity against various cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daopeng Tan, Jianmei Wang, Xianting Wang, Lin Qin, Yimei Du, Changkuo Zhao, Peijun Liu, Qianru Zhang, Feifei Ma, Jian Xie, Di Wu, Yuqi He
Summary: This study evaluated the inhibitory activity of five new and four known compounds isolated from Gynostemma pentaphyllum on PTP1B, a key factor and regulator of glucose and lipid metabolism. The results showed that all the compounds exhibited significant inhibitory activity against PTP1B. The structure-activity relationship indicated that the strength of PTP1B inhibitory activity was mainly related to the presence of an electron-donating group on its side chain.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Chao Su, Nan Li, Ruru Ren, Yingli Wang, Xiaojuan Su, Fangfang Lu, Rong Zong, Lingling Yang, Xueqin Ma
Summary: Gynostemma pentaphyllum, also known as Jiaogulan, is a tea traditionally consumed for its taste and weight loss benefits, but is now recognized for its various bioactive compounds with medicinal properties. Studies have shown that it possesses anti-cancer, anti-atherogenic, anti-dementia, and anti-Parkinson's disease effects, as well as lipid-regulating, neuroprotective, hepatoprotective, and hypoglycemic properties. Ongoing research on its chemical constituents and pharmacological activities has shown promising potential for treating various human diseases.
Article
Biochemistry & Molecular Biology
Yumeng Zhang, Guohui Shi, Zhonghua Luo, Jiewen Wang, Shao Wu, Xiaoshu Zhang, Yuqing Zhao
Summary: In this study, nineteen compounds were extracted from Gynostemma pentaphyllum and compound 19 showed the best anti-proliferation activity against t-HSC/Cl-6 cells. Further network pharmacology study demonstrated that compound 19 mainly plays an anti-fibrosis role by regulating the EGFR signaling pathway and the PI3K-Akt signaling pathway.
Article
Chemistry, Applied
Nani Wang, Pingcui Xu, Weixuan Yao, Jiali Zhang, Shufen Liu, Yongjun Wang, Yan Zhang
Summary: PPCP-1, an arabinogalactan isolated from Phellodendron chinense Schneid., shows potential in protecting against diabetic osteoporosis through various mechanisms, making it a potential functional food or drug for bone health.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Xincheng Sun, Chengxin Zhao, Xuyang Hu, Jingnan Zhang, Suyue Xu, XiaYing Li, Yanhong Bai, Xiaogen Zhang, Jinqiang Hu, Qi Sun, Zichao Wang
Summary: The research found that low molecular weight xanthan gum has a positive effect on weight gain in mice, increasing the content of short-chain fatty acids and enhancing the diversity of gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Minjie Gao, Hongyu Li, Tianyi Yang, Zhitao Li, Xiuyu Hu, Zichao Wang, Yun Jiang, Li Zhu, Xiaobei Zhan
Summary: Biologically active gellan oligosaccharides (GOSs) are newly discovered plant elicitors and biostimulants produced from the hydrolysis of gellan gum. Traditional hydrolysis methods suffer from pollution and low functional oligosaccharide yield. In this study, irradiation was used to efficiently degrade gellan gum into low molecular weight gellan, which was further hydrolyzed to produce GOSs with antioxidant and prebiotic activities.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Minjie Gao, Zhilei Liu, Zhongsheng Zhao, Zichao Wang, Xiuyu Hu, Yun Jiang, Jiajun Yan, Zhitao Li, Zhiyong Zheng, Xiaobei Zhan
Summary: This study explored the roles of exoR and exoX genes in curdlan biosynthesis in Agrobacterium sp. ATCC 31749. The results showed that the curdlan yields and glucose utilization increased in delta exoR and delta exoX strains compared with the wild-type strain during batch fermentation. However, the curdlan yields and gel strength decreased in exoR and exoX overexpression strains.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Shiwei Li, Yingna Wang, Weipeng Dun, Wanqing Han, Tao Ning, Qi Sun, Zichao Wang
Summary: Researchers have explored the use of Gynostemma pentaphyllum polysaccharide (GPP) in disease treatment through gut microbiota regulation. However, this study highlights the potential of GPP in disease prevention and physique enhancement. The findings suggest that GPP has the ability to prevent or mitigate obesity by modulating the gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Zexin Gao, Chuanchao Wu, Jianrong Wu, Li Zhu, Minjie Gao, Zichao Wang, Zhitao Li, Xiaobei Zhan
Summary: This study extracted the exopolysaccharide BPS-2 from Bacillus thuringiensis and found that it has strong anti-digestive capacity, as well as anti-inflammatory and antioxidant effects in vitro. These findings provide a basis for biopharmaceutical applications of BPS-2.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Xuyang Chen, Haizhen Tao, Yuqi Guo, Zichao Wang, Ruifang Li, Yingyuan Zhao, Chuan Liu, Xuanping Zhao, Xueqin Wang, Shaofeng Duan
Summary: In this study, an innovative immunoaffinity nanozyme aided CELISA was developed for the specific detection of triple-negative breast cancer MDA-MB-231 cells. The CD44FM nanozymes replaced unstable HRP and H2O2, and exhibited remarkable oxidase-like activities. By bioconjugating CD44 mAbs, the CD44FM nanozymes selectively entered MDA-MB-231 cells and catalyzed the oxidation of chromogenic substrate TMB for specific detection.
ANALYTICA CHIMICA ACTA
(2023)
Review
Biotechnology & Applied Microbiology
Zichao Wang, Lu Wang, Yaping Pan, Xinxin Zheng, Xiaona Liang, Lili Sheng, Di Zhang, Qi Sun, Qi Wang
Summary: Endophytic fungi, living in healthy plant tissues and organs, are important sources of natural bioactive products and new microbial resources. Exploring and utilizing these fungi can alleviate resource shortage, ecological imbalance, and benefit the protection of rare and endangered plant resources.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Ruifang Li, Xuxia Wang, Kedong Yin, Qingpeng Xu, Shiming Ren, Xueqin Wang, Zichao Wang, Yanjie Yi
Summary: In this study, fatty acid modification was used to enhance the antimicrobial activity of the peptide CGA-N9 against Candida albicans. The optimized peptide CGA-N9-C8 showed high anti-Candida activity and biosafety, making it a promising candidate for the treatment of Candida albicans infection and drug resistance.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Zichao Wang, Lu Wang, Hongtao Huang, Qiuyan Li, Xiaoyuan Wang, Qi Sun, Qi Wang, Na Li
Summary: In this study, flavonoids were successfully extracted from Artemisia argyi stem, with a yield of 15.3 mg/g dry A. argyi stem. The flavonoid extract had a purity of 88.58% (w/w) and contained carbohydrates, proteins, and polyphenols. It demonstrated concentration-dependent scavenging effects on various radicals and exerted protective effects on stimulated macrophages. This research provides guidance for utilizing A. argyi as a plant-based diet and its flavonoid extract as antioxidant and anti-inflammatory ingredients to enhance the function and nutrition of foods.
Review
Biochemistry & Molecular Biology
Zichao Wang, Xueyan Zhou, Lili Sheng, Di Zhang, Xinxin Zheng, Yaping Pan, Xiaoxue Yu, Xiaona Liang, Qi Wang, Baoshi Wang, Na Li
Summary: With their bioactivities including antioxidant, anti-bacterial, anti-inflammatory, immune regulation, antitumor and anti-coagulation properties, plant and microbial polysaccharides are widely used in the fields of food, medicine and cosmetics. However, the relationship between structure features and physicochemical properties as well as bioactivities of these polysaccharides remains unclear. Ultrasonic degradation, through mechanical bond breaking and cavitation effects, has the potential to modify the chemical or spatial structures of plant and microbial polysaccharides, thus affecting their physicochemical properties and bioactivities. This review provides an overview of the influence of ultrasonic degradation on the structure features, physicochemical properties and bioactivities of plant and microbial polysaccharides, and highlights the need for attention in the application of ultrasonication for polysaccharide degradation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zichao Wang, Xueyan Zhou, Xiaona Liang, Xinxin Zheng, Zhihan Shu, Qi Sun, Qi Wang, Na Li
Summary: In this study, a polysaccharide (GCP-TS) derived from tapioca starch by the endophytic fungus Chaetomium globosum CGMCC 6882 in Gynostemma pentaphyllum herb was analyzed. GCP-TS exhibited concentration-dependent scavenging ability against various radicals and enhanced antibacterial activity against Staphylococcus aureus and Escherichia coli with increasing concentrations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemical Research Methods
Yan Hui Yang, Hao Wei Song, Jun Yi Lai, Rui Fang Li, Zi Chao Wang, Hui Cong Jia, Yong Yang
Summary: This study reconstructed the ferulic acid (FA) biosynthetic pathway from Rehmannia glutinosa in Saccharomyces cerevisiae and identified the functional activity of the RgCOMT enzyme involved in FA production. It was found that several other genes in R. glutinosa also participate in the FA biosynthetic pathway. By introducing these genes into yeast, the entire biosynthesis process from phenylalanine metabolism to FA was successfully achieved in vitro, resulting in an engineered strain with an FA titer of 148.34 mg/L.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Applied
Zhilei Liu, Ying Xu, Zichao Wang, Li Zhu, Zhitao Li, Yun Jiang, Xiaobei Zhan, Minjie Gao
Summary: During curdlan production, the encapsulation of Agrobacterium sp. by secreted exopolysaccharide (EPS) inhibits substrate uptake and curdlan synthesis. This study found that the addition of endo-ss-1,3-glucanase (BGN) effectively alleviated the EPS encapsulation effect and improved glucose consumption and curdlan yield. The upregulation of related genes and enhanced metabolic activity contributed to the increased production of curdlan.
CARBOHYDRATE POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Zichao Wang, Xueyan Zhou, Zhihan Shu, Yi Zheng, Xilei Hu, Peiyao Zhang, Hongtao Huang, Lili Sheng, Pengshuai Zhang, Qi Wang, Xueqin Wang, Na Li
Summary: Structural features play a crucial role in the bioactivity, physical properties, and applications of plant and microbial polysaccharides. However, the complex structure-function relationship hinders the production, preparation, and utilization of these polysaccharides. Molecular weight, as a easily regulated structural feature, significantly impacts the bioactivity and physical properties of plant and microbial polysaccharides, and polysaccharides with specific molecular weights are essential for their optimal function. This review provides an overview of the regulation strategies for controlling molecular weight, including metabolic regulation, degradation by physical, chemical, and enzymatic methods, and explores the influence of molecular weight on the bioactivity and physical properties of plant and microbial polysaccharides. Furthermore, the study highlights the need for attention to potential problems and offers suggestions for the analysis of polysaccharide molecular weights. The findings of this work will contribute to the production, preparation, utilization, and investigation of the structure-function relationship of plant and microbial polysaccharides based on their molecular weights.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Qi Wang, Xueyan Zhou, Haiqin Gou, He Chang, Junyi Lan, Jia Li, Zhitao Li, Minjie Gao, Zichao Wang, Yanjie Yi, Na Li
Summary: This study analyzed the chemical composition of Artemisia argyi leaf polysaccharide (AALP) and its inhibitory effect on Staphylococcus aureus. The results showed that AALP could inhibit the growth of S. aureus by disrupting the cell wall and depolarizing the inner membrane potential. This research provides new insights for the search for alternative antibiotics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
