Article
Immunology
Ruiqiang Sun, Nan Zhao, Yuzun Wang, Yanchao Su, Jiayan Zhang, Yaoqi Wang, Yonghao Yu, Guolin Wang, Zhen Wang, Keliang Xie
Summary: The study demonstrated that high concentration hydrogen gas can effectively treat LPS-induced acute lung injury by activating the Nrf2 signaling pathway and inhibiting the inflammatory and cell apoptosis responses mediated by NF-kappa B.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jianhua Li, Jiamin Ma, Mengyu Li, Jing Tao, Jiayi Chen, Chengye Yao, Shanglong Yao
Summary: The study demonstrates that GYY4137 inhibits the activation of the NLRP3 inflammasome by blocking the PDGFR beta/Akt/NF-kappa B pathway, which contributes to the treatment of CLP-induced ALI in mice.
Article
Immunology
Xu Wu, Weixia Xuan, Xiaoping Yang, Wei Liu, Hui Zhang, Gang Jiang, Bin Cao, Yongliang Jiang
Summary: This study aimed to investigate whether Ficolin A (FcnA) modulated the gut microbiota to affect the progression of sepsis-induced severe acute lung injury (ALI). The results showed that knockout of FcnA alleviated sepsis-induced severe ALI by regulating the gut microbiota to protect against lung damage. This study provides new therapeutic targets for treating sepsis-induced severe lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Surgery
Kohei Ageta, Takahiro Hirayama, Toshiyuki Aokage, Mizuki Seya, Ying Meng, Tsuyoshi Nojima, Hirotsugu Yamamoto, Takafumi Obara, Atsunori Nakao, Tetsuya Yumoto, Kohei Tsukahara, Hiromichi Naito
Summary: Inhalation of hydrogen gas can alleviate pulmonary inflammation and acute lung injury caused by lung contusion. It mitigates histopathological changes, reduces inflammatory cytokine levels, and improves lung oxygenation, making it a potential supplemental therapeutic strategy for treating lung contusion.
Article
Health Care Sciences & Services
Nan Zhao, Ruiqiang Sun, Yan Cui, Yu Song, Wanjie Ma, Yingning Li, Jing Liang, Guolin Wang, Yonghao Yu, Jiange Han, Keliang Xie
Summary: This study aimed to explore the therapeutic effect of high concentration (67%) hydrogen on acute lung injury in septic mice and its mechanism. The inhalation of 2% or 67% hydrogen improves the 7-day survival rate and reduces acute lung injury as well as liver and kidney injury in sepsis. The therapeutic effect of 67% hydrogen inhalation on sepsis was related to increasing antioxidant enzyme activity, reducing oxidation products and pro-inflammatory cytokines in lungs and serums.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhang Qiongyue, Yang Xin, Peng Meng, Mi Sulin, Wang Yanlin, Li Xinyi, Song Xuemin
Summary: This study demonstrates the involvement of ferroptosis, a new type of cell death, in the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). The results show that post-treatment with irisin can inhibit ferroptosis and alleviate SA-AKI through the activation of the SIRT1/Nrf2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ping Han, Xia Wang, Tianqiu Zhou, Jinmei Cheng, Chengniu Wang, Fei Sun, Xi Zhao
Summary: Expression of Nrf2 in sperm is reduced in oligospermia patients, but the mechanism is unclear. This study found that Nrf2 and GPX4 protein expressions in sperm of oligospermia men were significantly decreased. Animal experiments showed that Nrf2 knockout in mice led to the occurrence of ferroptosis in spermatogenic cells, resulting in oligospermia. Treatment with a ferroptosis inhibitor reversed the decrease in sperm concentration and motility.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biology
Veronika Lang, Sebastian Ferencik, Bharath Ananthasubramaniam, Achim Kramer, Bert Maier
Summary: Local circadian clocks play a role in the body's immune response, with light affecting susceptibility to endotoxic shock. Conditional knockout mice showed rhythmic patterns of immune response even without a myeloid clock. This suggests that systemic time cues can orchestrate immune functions.
Article
Pharmacology & Pharmacy
Yue Wang, Fengyi Deng, Xing Zhong, Yijun Du, Xingyu Fan, Hong Su, Tianrong Pan
Summary: This study investigated the effects and mechanism of action of dulaglutide in lipopolysaccharide-induced lung injury in mice with sepsis. The results showed that dulaglutide improved weight loss, reduced lung injury, reversed the increase in inflammatory cytokine expression, and reduced the infiltration of immune cells in the lung tissues. Additionally, dulaglutide reduced the expression of STAT3 and NLRP3, suggesting their potential as therapeutic targets for sepsis-induced lung injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Liping Li, Qianwen Zhang, Xi Zhang, Xiaoting Xu, Xinzhi Wang, Xin Huang, Tao Wang, Zhenzhou Jiang, Li Xiao, Luyong Zhang, Lixin Sun
Summary: The study found that Nrf2 plays a crucial role in decreasing inflammatory cytokine levels and counteracting oxidative stress to alleviate sepsis-induced hepatic injury.
Article
Biochemistry & Molecular Biology
Kuo Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, Liang Luo, Weixia Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Dahai Hu
Summary: This study explored the protective effect and mechanism of ADSCs exosomes on excessive inflammation-induced injury in pulmonary microvascular endothelial cells (PMVECs). ADSCs exosomes reduced ROS accumulation and cell injury in PMVECs by inhibiting excessive inflammatory response. They also alleviated ferroptosis induced by excessive inflammatory response and upregulated GPX4 expression. Furthermore, specific delivery of miR-125b-5p by ADSCs exosomes inhibited Keap1 and alleviated ferroptosis. In a sepsis model, ADSCs exosomes relieved lung tissue injury, reduced the death rate, and alleviated oxidative stress injury and ferroptosis of lung tissue.
Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Critical Care Medicine
Yuanyuan Zhang, Jia Zhang, Yifan Ren, Teng Li, Jianbin Bi, Zhaoqing Du, Rongqian Wu
Summary: Luteolin can suppress CIRP production and attenuate lung injury in neonatal sepsis, potentially through downregulation of HIF-1 alpha and NLRP3 expression in neonatal macrophages.
Article
Critical Care Medicine
Keliang Xie, Yaoqi Wang, Lijun Yin, Yuzun Wang, Hongguang Chen, Xing Mao, Guolin Wang
Summary: Hydrogen gas therapy improves mitochondrial function and cognitive function in septic mice with SAE by activating PGC-1 alpha, thereby increasing survival rates.
Article
Neurosciences
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, Hongguang Chen, Yonghao Yu
Summary: The study found that treatment with molecular hydrogen can improve the functional outcome of sepsis-associated encephalopathy (SAE) in mice by increasing beneficial bacteria, repressing harmful bacteria, improving metabolic disorder, and reducing inflammation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Qing Li, Yang Jiao, Yang Yu, Guolin Wang, Yonghao Yu
MOLECULAR MEDICINE REPORTS
(2019)
Article
Neurosciences
Chunyan Wang, Rubin Xu, Xueling Wang, Qing Li, Yize Li, Yang Jiao, Qi Zhao, Suqian Guo, Lin Su, Yang Yu, Yonghao Yu
NEUROSCIENCE RESEARCH
(2020)
Article
Oncology
Yang Jiao, Yang Yu, Bo Li, Xiyan Gu, Keliang Xie, Guolin Wang, Yonghao Yu
MOLECULAR MEDICINE REPORTS
(2020)
Article
Neurosciences
Chunyan Wang, Qing Li, Zhen Jia, Haifang Zhang, Yize Li, Qi Zhao, Lin Su, Yang Yu, Rubin Xu
NEUROSCIENCE LETTERS
(2020)
Article
Immunology
Xinqi Zhuang, Yang Yu, Yi Jiang, Sen Zhao, Yuzun Wang, Lin Su, Keliang Xie, Yonghao Yu, Yuechun Lu, Guoyi Lv
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Developmental Biology
Man Yang, Hong Tan, Kai Zhang, Naqi Lian, Yang Yu, Yonghao Yu
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2020)
Article
Neurosciences
Yi Jiang, Kai Zhang, Yang Yu, Yaoqi Wang, Naqi Lian, Keliang Xie, Yonghao Yu
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Clinical Neurology
Naqi Lian, Mengxi Shen, Kai Zhang, Jiacheng Pan, Yi Jiang, Yang Yu, Yonghao Yu
Summary: The study found that hydrogen-rich water can alleviate pain caused by oxaliplatin, alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Behavioral Sciences
Yang Yu, Man Yang, Xiaoli Zhuang, Jiacheng Pan, Yue Zhao, Yonghao Yu
Summary: Anesthesia-induced Tau phosphorylation and cognitive impairment in young mice, but not adults. Elevated levels of ApoE fragments, rather than full-length ApoE, may contribute to age-dependent cognitive impairment in young mice following sevoflurane anesthesia.
BRAIN AND BEHAVIOR
(2022)
Article
Immunology
Jing Tian, Yanan Li, Xing Mao, Keliang Xie, Yuxin Zheng, Yang Yu, Yonghao Yu
Summary: This study found that HO-1 plays a protective role in sepsis-induced lung injury in mice by regulating autophagy and activating the PI3K/Akt signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Jing Chu, Hong Li, Zhihao Yuan, Wenyu Zhou, Yang Yu, Yonghao Yu
Summary: This study found that a low dose of acetaminophen (APAP) can prevent neuronal ferroptosis in the hippocampal tissue by inhibiting the GPX4 and FSP1 pathways, thereby improving cognitive impairment and mortality in patients with sepsis-associated encephalopathy (SAE).
BRAIN AND BEHAVIOR
(2023)
Article
Toxicology
Jing Chu, Yi Jiang, Wenyu Zhou, Jialei Zhang, Hong Li, Yang Yu, Yonghao Yu
Summary: The study shows that acetaminophen (APAP) alleviates sepsis-associated encephalopathy (SAE) by attenuating ferroptosis and mediating the glutathione peroxidase (GPX4) pathway. APAP improves survival rates, reduces hippocampal and mitochondrial damage, and improves cognitive impairment. The findings suggest that APAP reduces sepsis-induced cognitive impairment by reducing ferroptosis, mediated by the GPX4 signaling pathway.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Toxicology
Yang Yu, M. Yang, X. Zhuang, J. Pan, J. Feng, J. Yu, Yonghao Yu
Summary: Anesthesia may cause neuronal tau phosphorylation and neurotoxicity in the developing brain. Apolipoprotein E (ApoE) has a protective role in neuronal activity and injury repair, while its 18-kDa fragments can induce neurodegeneration and neuroinflammation. This study suggests that the presence of 18-kDa ApoE fragments in primary mouse neurons is associated with differences in tau phosphorylation and neuroinflammation.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Neurosciences
Keliang Xie, Naqi Lian, Yufei Kan, Man Yang, Jiacheng Pan, Yang Yu, Yonghao Yu
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)