Article
Cell Biology
Kangkai Xia, Shujing Li, Yuxi Yang, Xiaoxia Shi, Binggong Zhao, Linlin Lv, Zhiqiang Xin, Jie Kang, Ping Ren, Huijian Wu
Summary: Breast cancer is a global health issue with rising incidence. Disruption of the internal circadian clock, including the genetic dysregulation of Cry2, can contribute to the development of diseases, such as tumors. This study focuses on understanding the post-translational modifications of Cry2 and its role in breast cancer pathogenesis.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Zhihong Yang, Rana V. Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A. Delker, Nicholas J. Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul
Summary: This study identified a role for the SHP/REV-ERB alpha/CYP4A axis in the pathogenesis of ALD, highlighting REV-ERB alpha or CYP4A as potential therapeutic targets for ALD.
Article
Dermatology
Hyunjin Yeo, Sung Shin Ahn, Euitaek Jung, Yoongho Lim, Young Han Lee, Soon Young Shin
Summary: This study identifies the transcription factor EGR1 as a key regulator of PER2 expression in skin inflammation. IL-4, an inflammatory cytokine, enhances PER2 expression through the MAPK and Jak signaling pathways. These findings provide further insights into the molecular mechanisms underlying the relationship between inflammation and the circadian clock.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shani Tsameret, Daniela Jakubowicz, Zohar Landau, Julio Wainstein, Tali Ganz, Itamar Raz, Nava Chapnik, Oren Froy
Summary: The study found that soluble factors present in the serum of type 2 diabetes patients consuming a three-meal diet can reset circadian rhythms in the liver, leading to a gene expression pattern similar to that of healthy individuals, which contributes to improved glucose metabolism.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Rongfeng Huang, Jianghui Chen, Meiyu Zhou, Haoran Xin, Sin Man Lam, Xiaoqing Jiang, Jie Li, Fang Deng, Guanghou Shui, Zhihui Zhang, Min-Dian Li
Summary: This study systematically profiles the daily rhythms of the proteome, four post-translational modifications (PTMs), and the lipidome in mouse livers under time-restricted feeding. It provides a comprehensive resource detailing the rhythmic liver functions shaped by meal timing.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Biology
Ann Louise Hunter, Charlotte E. Pelekanou, Nichola J. Barron, Rebecca C. Northeast, Magdalena Grudzien, Antony D. Adamson, Polly Downton, Thomas Cornfield, Peter S. Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew S. Loudon, Richard D. Unwin, Mudassar Iqbal, David W. Ray, David A. Bechtold
Summary: The circadian clock component NR1D1 plays a crucial role in regulating lipid metabolism and can drive dysregulation of white adipose tissue (WAT) lipogenesis and obesity when globally deleted. However, adipocyte-selective deletion does not lead to the same phenotype. Under high-fat diet conditions, NR1D1 in adipocytes controls metabolic processes and plays a critical role in obesity-related WAT pathology and insulin resistance.
Article
Biochemistry & Molecular Biology
Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen, Weiming Tian
Summary: In this study, we discovered the involvement of klf7 in regulating circadian rhythm. Knocking down klf7 disrupted circadian rhythm and led to autism-like behavior. We also observed downregulation of the Clock gene and disturbance of its downstream rhythm genes in the brain of klf7 knockout mice. Melatonin, a circadian regulation drug, was able to regulate the expression of rhythm genes in klf7 knockout cells and rescue the autistic behavior of klf7 knockout mice.
CELL AND BIOSCIENCE
(2022)
Article
Fisheries
Fei Kong, Jiazheng Shang, Zhaoshou Ran, Mengqi Zhang, Kai Liao, Jilin Xu, Xiaojun Yan
Summary: This study investigates the light entrainment of the molecular circadian clock in Sinonovacula constricta, an important bivalve species. The results reveal the presence of a clock system consisting of seven closely related genes. These genes are expressed in all tissues, with high expression in the labial palps and hepatopancreas. Different clock genes display daily or circadian rhythms under different light conditions, indicating the adaptation of the circadian system to various light environments. Differences in gene expression patterns between the labial palps and hepatopancreas suggest tissue-specific regulation of the circadian system. Overall, this study provides insights into how the circadian oscillators of S. constricta respond to light and may have implications for optimizing light environments in the farming industry.
Article
Biochemistry & Molecular Biology
Shani Tsameret, Nava Chapnik, Oren Froy
Summary: We investigated the effects of fructose with or without fatty acids on circadian metabolism in AML-12 hepatocytes. Fructose treatment under steatosis conditions led to increased fat synthesis and inflammatory marker expression. Fructose also inhibited the AMPK signaling pathway and altered the expression of the BMAL1-ROR alpha-REV-ERB alpha axis. Our findings suggest that the presence of fatty acids modulates the response of hepatocytes to fructose, influencing metabolism and circadian rhythms by regulating BMAL1 activity and expression.
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Article
Fisheries
Shiori Murakami, Natsuki Morimoto, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2019)
Article
Fisheries
Natsuki Morimoto, Masakazu Kondo, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
FISH & SHELLFISH IMMUNOLOGY
(2019)
Meeting Abstract
Fisheries
T. Onoue, G. Nishi, J. Hikima, M. Sakai, T. Kono
FISH & SHELLFISH IMMUNOLOGY
(2019)
Meeting Abstract
Fisheries
Natsuki Morimoto, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
FISH & SHELLFISH IMMUNOLOGY
(2019)
Meeting Abstract
Fisheries
Yo Okamura, Natsuki Morimoto, Masato Kinoshita, Takashi Aoki, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yo Okamura, Natsuki Morimoto, Shuzo Sawada, Tomoya Kono, Jun-ichi Hikima, Masahiro Sakai
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Natsuki Morimoto, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: PRRs, including NLRs, play important roles in inducing inflammatory responses through recognizing various patterns. The activation of inflammasome leads to the maturation of proinflammatory cytokines and pyroptosis, which play protective roles against pathogen infection in mammals and teleosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Nanaki Harada, Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study identified three IL-17RC transcripts in the Japanese medaka, with il17rca1 showing significantly higher expression in adult tissues and il17rcb showing higher expression in embryos and larvae. Infections with specific pathogens led to changes in gene expression patterns. Additionally, immunoprecipitation assays suggested that three ligands could signal through two IL17RCs in teleosts.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Aki Nishihara, Natsuki Morimoto, Takechiyo Sumiyoshi, Shinya Yasumoto, Masakazu Kondo, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: The Ivy gene in the plasmid of Pdp may help the bacteria evade lysozyme-mediated lysis during interaction with an animal host. This study found that Ivy-Pdp is a temperature- and pH-stable lysozyme inhibitor, and it inhibits the lytic activity of lysozyme involved in host biophylaxis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: Interleukin (IL)-17 is an important proinflammatory cytokine involved in immune responses against bacterial and fungal infections. Although little research has been conducted on IL-17 in teleosts, recent studies have reported interesting findings about its functions in teleost species. This review focuses on teleost IL-17 and compares its signaling with that of mammals, particularly in intestinal immunity. It aims to provide further understanding of the roles and importance of IL-17 signaling in teleosts.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Akito Tsuchiya, Yo Okamura, Tomoya Kono, Jun-ichi Hikima, Masahiro Sakai
Summary: The lack of immortalized shrimp cell lines has hindered the progress of virology research in shrimp, and stable primary cell cultures have not been achieved. Transcriptomic analysis of primary lymphoid cells in kuruma shrimp Marsupenaeus japonicus was performed to understand gene expression changes. The analysis revealed three groups of genes with different expression changes, including a downregulation in platelet-derived growth factor receptor alpha and vascular endothelial growth factor 3 (MjVEGF3). Supplementation of VEGF signaling at the appropriate time is important for the long-term and stable culture of shrimp lymphoid organ cells.
Article
Fisheries
Mika Watanabe, Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study analyzed the functional significance of IL-22 in fish gills and found that IL-22 may be involved in immune responses through the production of inflammatory cytokines and antimicrobial peptides in fish gills.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)