Article
Hematology
Wenli Zhang, Ruirui Gui, Yingling Zu, Binglei Zhang, Zhen Li, Yanli Zhang, Xianjing Wang, Shuli Guo, Xinrong Zhan, Yuewen Fu, Yongping Song, Jian Zhou
Summary: This study demonstrates that the combination of reduced-dose post-transplant cyclophosphamide (PTCy) and low-dose post-transplant anti-thymocyte globulin (ATG) in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) significantly reduces the incidence of graft-versus-host disease (GVHD) and improves overall survival and disease-free survival.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biophysics
Ali Bazarbachi, Myriam Labopin, Didier Blaise, Edouard Forcade, Gerard Socie, Ana Berceanu, Emanuele Angelucci, Claude Eric Bulabois, Nicolaus Kroeger, Alessandro Rambaldi, Patrice Ceballos, Stephan Mielke, Jean El Cheikh, Ibrahim Yakoub-Agha, Bipin Savani, Alexandros Spyridonidis, Arnon Nagler, Mohamad Mohty
Summary: The study compared the outcomes of haploidentical allogeneic hematopoietic-cell transplantation and matched unrelated donor transplantation for AML patients in different risk groups and remission statuses. The results showed that haploidentical transplantation increased nonrelapse mortality and decreased relapse incidence in high-risk AML in CR, leading to similar leukemia-free survival, overall survival, and graft-versus-host disease-free, relapse-free survival compared to matched unrelated donor transplantation. This suggests the potential benefits of using haploidentical family donors for high-risk AML patients without matched sibling donors.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Diego Medina-Valencia, Daniela Cleves, Estefania Beltran, Natalia Builes, Alexis A. Franco, Andres Felipe Escobar-Gonzalez, Manuela Olaya
Summary: Primary hemophagocytic lymphohistiocytosis is a severe and uncommon disease affecting pediatric patients, with genetic abnormalities linked to altered apoptosis and exaggerated inflammatory reactions. This study describes a novel treatment strategy involving haploidentical hematopoietic stem cell transplantation, yielding positive outcomes for all pediatric patients treated. The results suggest this strategy could be a promising alternative in cases where other donor options are limited.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Hematology
Shigeo Fuji, Junichi Sugita, Yuho Najima, Tatsuya Konishi, Takashi Tanaka, Hiroyuki Ohigashi, Tetsuya Eto, Koji Nagafuji, Nobuhiro Hiramoto, Ken-ichi Matsuoka, Yumiko Maruyama, Shuichi Ota, Jun Ishikawa, Toshiro Kawakita, Takashi Akasaka, Tomohiko Kamimura, Masayuki Hino, Takahiro Fukuda, Yoshiko Atsuta, Kimikazu Yakushijin
Summary: Reduced- and standard-dose PTCY were found to have comparable major clinical outcomes in patients undergoing haplo-HCT for haematological malignancies.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biophysics
Eugenio Galli, Elisabetta Metafuni, Sabrina Giammarco, Maria Assunta Limongiello, Idanna Innocenti, Francesco Autore, Luca Laurenti, Federica Sora, Patrizia Chiusolo, Luciana Teofili, Andrea Bacigalupo, Simona Sica
Summary: In this retrospective analysis of allogeneic hematopoietic stem cell transplant recipients, the use of post-transplant cyclophosphamide, cyclosporine, and mycophenolate mophetil as graft-versus-host-disease prophylaxis showed differences in outcomes between HLA-matched and haploidentical grafts, with higher rates of acute and chronic GVHD in the HLA-mismatched group. However, disease-free survival was comparable between the two groups.
BONE MARROW TRANSPLANTATION
(2022)
Article
Oncology
Amandine Le Bourgeois, Maxime Jullien, Alice Garnier, Pierre Peterlin, Marie C. Bene, Thierry Guillaume, Patrice Chevallier
Summary: This study aimed to assess the feasibility and safety of using PTCY as the sole prophylaxis for GVHD in adult patients. However, the study had to be stopped due to an unacceptable rate of severe acute GVHD. Despite this, overall survival and GVHD-free relapse-free survival remained good.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biophysics
Michael H. Albert, Mehtap Sirin, Manfred Hoenig, Fabian Hauck, Catharina Schuetz, Rajat Bhattacharyya, Polina Stepensky, Elad Jacoby, Tayfun Gungor, Rita Beier, Ansgar Schulz
Summary: The study found that a post-transplantation cyclophosphamide-based HLA-haploidentical salvage HSCT after irradiation-free conditioning resulted in excellent engraftment and overall survival in children with non-malignant diseases.
BONE MARROW TRANSPLANTATION
(2021)
Article
Biophysics
Raynier Devillier, Jacques-Emmanuel Galimard, Myriam Labopin, Didier Blaise, Anna Maria Raiola, Jiri Pavlu, Luca Castagna, Gerard Socie, Yves Chalandon, Massimo Martino, Friedrich Stolzel, Gesine Bug, Benedetto Bruno, Radovan Vrhovac, Amandine Charbonnier, Attilio Olivieri, Jacques-Olivier Bay, Herrera Arroyo, Ibrahim Yakoub-Agha, Daniele Avenoso, Andreas Neubauer, Stephanie Nguyen, Edouard Forcade, Eolia Brissot, Bipin Savani, Arnon Nagler, Mohamad Mohty
Summary: The optimal conditioning regimen prior to haploidentical stem cell transplantation for acute myeloid leukemia remains uncertain. In younger patients, intensifying the conditioning from CyFluTBI to TBF may reduce relapse risk, while in older patients, the conditioning regimen does not significantly influence survival but can lower the risk of non-relapse mortality.
BONE MARROW TRANSPLANTATION
(2022)
Article
Biophysics
Remy Dulery, Florent Malard, Eolia Brissot, Anne Banet, Simona Sestili, Ramdane Belhocine, Martina Calabro, Zoe van de Wyngaert, Agnes Bonnin, Tounes Ledraa, Ollivier Legrand, Myriam Labopin, Elodie Capderou, Ariel Cohen, Stephane Ederhy, Mohamad Mohty
Summary: Reducing PT-Cy total dose to 70 mg/kg is a safe and valid approach for elderly patients and those with cardiac comorbidities undergoing haploidentical HCT with PBSCs and low-dose antithymocyte globulin. The reduced PT-Cy dose is associated with improved hematological count recovery, lower incidence of toxicities, and higher GVHD-free, relapse-free survival.
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Ignacio Gomez-Centurion, Reyes Maria Martin Rojas, Rebeca Bailen, Cristina Munoz, Santiago Sabell, Gillen Oarbeascoa, Paula Fernandez-Caldas, Diego Carbonell, Jorge Gayoso, Carolina Martinez-Laperche, Ismael Buno, Javier Anguita, Jose Luis Diez-Martin, Mi Kwon
Summary: This retrospective cohort study investigated adult patients who underwent haploidentical-SCT with post-transplant cyclophosphamide (PT-Cy) in a single center. Poor graft function (PGF) was observed in 27.5% of the patients, and CMV reactivation was found to be significantly associated with PGF development. Thrombopoietin-receptor agonists (TRA) and donor CD34 + selected boost were effective treatment options for patients with persistent cytopenias.
ANNALS OF HEMATOLOGY
(2023)
Article
Biophysics
Dipenkumar Modi, Seongho Kim, Abhinav Deol, Lois Ayash, Voravit Ratanatharathorn, Joseph P. Uberti
Summary: Our study found no significant difference in outcomes between myeloablative conditioning (MAC) and reduced intensity conditioning (RIC) regimens in haploidentical peripheral blood stem cell transplant (haploPBSCT).
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Motoi Yamashita, Shiori Eguchi, Dan Tomomasa, Takahiro Kamiya, Daiki Niizato, Noriko Mitsuiki, Takeshi Isoda, Hanako Funakoshi, Yuki Mizuno, Kentaro Okamoto, Tuan Minh Nguyen, Hidetoshi Takada, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane
Summary: Leukocyte adhesion deficiency type I (LAD-I) is a rare genetic immune disorder that can be cured with allogeneic hematopoietic cell transplant (HCT). In cases where ideal donors are unavailable, HLA-haploidentical HCT with posttransplant cyclophosphamide (PT-CY) can be a safe and effective alternative.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaodi Ma, Zhengli Xu, Tingting Han, Yuanyuan Zhang, Wei Han, Haixia Fu, Xiaohui Zhang, Fan Lin, Xiaojun Huang, Lanping Xu
Summary: This study modified the Beijing Protocol for haplo-HSCT in SAA patients, achieving successful and stable engraftment while reducing the incidence of severe acute GVHD. In the first batch of 17 patients who received the novel regimen, all patients achieved transplantation without primary graft failure, resulting in a 100% survival rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jaroslaw Dybko, Malgorzata Sobczyk-Kruszelnicka, Sebastian Makuch, Siddarth Agrawal, Krzysztof Dudek, Sebatian Giebel, Lidia Gil
Summary: This study compared the outcomes of patients who received post-transplant cyclophosphamide (PTCy) or conventional immunosuppressants after allogeneic hematopoietic cell transplantation. The study found that patients receiving PTCy had lower rates of acute graft-versus-host disease and cytomegalovirus reactivation, and higher survival rates. Further research with a larger sample size is needed to confirm these results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hasan Hashem, Rula Najjar, Mayada Abu-Shanap, Eman Khattab, Rawad Rihani, Abdelghani Tbakhi, Iyad Sultan
Summary: Haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamide (PTCy) is a valuable curative option for children with non-malignant diseases when an HLA-matched donor is not available. Younger age at HCT (<4 years) and primary immunodeficiency are significantly associated with better survival outcomes. Early diagnosis, timely treatment, and referral can further improve outcomes for these children.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Oncology
Yuriko N. Koyanagi, Isao Oze, Yumiko Kasugai, Yukino Kawakatsu, Yukari Taniyama, Kazuo Hara, Yasuhiro Shimizu, Issei Imoto, Hidemi Ito, Keitaro Matsuo
Summary: A functional variant on ALDH2 rs671 (G>A) protects against alcohol-induced carcinogenesis by decreasing alcohol consumption, but also contributes to the accumulation of carcinogens, resulting in a direct carcinogenic effect. This study quantified the opposing effects of the rs671 A allele on pancreatic cancer risk and explored the impact of the rs671 A allele and alcohol consumption on pancreatic carcinogenesis. The results showed that alcohol consumption was associated with an increased risk of pancreatic cancer, but the effect did not vary by genotype. This study supports the association between alcohol consumption and pancreatic cancer risk and suggests the potential contribution of the rs671 A allele to pancreatic carcinogenesis through impaired metabolism.
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Oncology
Xiang Shu, Zhishan Chen, Jirong Long, Xingyi Guo, Yaohua Yang, Conghui Qu, Yoon-Ok Ahn, Qiuyin Cai, Graham Casey, Stephen B. Gruber, Jeroen R. Huyghe, Sun Ha Jee, Mark A. Jenkins, Wei-Hua Jia, Keum Ji Jung, Yoichiro Kamatani, Dong-Hyun Kim, Jeongseon Kim, Sun-Seog Kweon, Loic Le Marchand, Koichi Matsuda, Keitaro Matsuo, Polly A. Newcomb, Jae Hwan Oh, Jennifer Ose, Isao Oze, Rish K. Pai, Zhi-Zhong Pan, Paul D. P. Pharoah, Mary C. Playdon, Ze-Fang Ren, Robert E. Schoen, Aesun Shin, Min-Ho Shin, Xiao-Ou Shu, Xiaohui Sun, Catherine M. Tangen, Chizu Tanikawa, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Wei Zheng
Summary: This study identified potential novel risk biomarkers for colorectal cancer by integrating genetics and circulating metabolomics data. The results highlight the importance of lipids, especially certain glycerophospholipids and triacylglycerols, in the etiology of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Ophthalmology
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki
Summary: This study conducted a Mendelian randomization analysis to assess the causal association between genetically predicted glycemic traits and the risk of primary open-angle glaucoma (POAG). The results did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Hasegawa, Haruyuki Takaki, Hiroshi Kodama, Keitaro Matsuo, Takashi Yamanaka, Atsuhiro Nakatsuka, Motoshi Takao, Hideo Gobara, Sadao Hayashi, Yoshitaka Inaba, Koichiro Yamakado
Summary: The purpose of this study was to explore the impact of ablative margin depicted by CT immediately after RF ablation on reducing LTP for CRC lung metastases. A retrospective study was conducted on 70 patients who underwent RF ablation for CRC lung metastases. The results indicated that an ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Rheumatology
Yu Toyoda, Masahiro Nakatochi, Akiyoshi Nakayama, Yusuke Kawamura, Hirofumi Nakaoka, Kenji Wakai, Keitaro Matsuo, Hirotaka Matsuo
Article
Rheumatology
Ai Yaku, Yuki Ishikawa, Takeshi Iwasaki, Ryosuke Hiwa, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Moritoshi Furu, Hiromu Ito, Takao Fujii, Taira Maekawa, Motomu Hashimoto, Koichiro Ohmura, Tsuneyo Mimori, Chikashi Terao
Summary: Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. However, the genetic architecture underlying IgG-RF, which is associated with rheumatoid vasculitis, is not well understood.
Article
Oncology
Yukari Taniyama, Isao Oze, Yuriko N. Koyanagi, Yukino Kawakatsu, Yuri Ito, Tomohiro Matsuda, Keitaro Matsuo, Tetsuya Mitsudomi, Hidemi Ito
Summary: Introduction of EGFR-TKIs and EGFR mutation testing has led to improved survival in NSCLC patients, particularly in women with adenocarcinoma and at advanced stages.
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki-Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Summary: The ALDH2 enzyme's ability to break down aldehydes is impaired by a specific gene polymorphism, leading to alcohol flushing and an increased risk of esophageal cancer in East Asians. Recent studies suggest that this gene variant may result in higher levels of DNA damage caused by naturally occurring aldehydes. However, in breast epithelial cells, this loss of function does not appear to have an impact on the initiation and development of cancer.
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Oncology
Yoshiaki Usui, Hidemi Ito, Kota Katanoda, Tomohiro Matsuda, Yoshinobu Maeda, Keitaro Matsuo
Summary: The introduction of rituximab has led to a decline in mortality rates of non-Hodgkin lymphoma in both Japan and the United States, despite an increase in incidence. However, the trends in mortality rates have differed between the two countries, with the mortality rate declining continuously in the United States but stopping in Japan.
Article
Multidisciplinary Sciences
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, Kei Muro, Makoto Mark Taketo, Tomoyoshi Soga, Masahiro Aoki
Summary: Cancer cachexia is a metabolic disorder characterized by a decrease in B vitamin-related liver enzymes. The relationship between enzymes and their associated metabolites may depend on protein abundance and cofactor subtype. These metabolic/proteomic changes can be utilized for the diagnosis of cancer cachexia through blood samples.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.