Compartmentalization of dendritic cell and T‐cell interactions in the lymph node: Anatomy of T‐cell fate decisions

BIM determines the number of merocytic dendritic cells, a cell type that breaks immune tolerance

(2018) Cindy Audiger et al.   IMMUNOLOGY AND CELL BIOLOGY

Human dendritic cells

(2018) Matthew Collin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

(2018) Caroline L. Sokol et al.   IMMUNITY

Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology

(2018) Lei Qin et al.   Frontiers in Immunology

Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life

(2017) Tomer Granot et al.   IMMUNITY

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4–dependent dermal dendritic cells

(2017) Julie Deckers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

House dust mite–driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting

(2017) Melissa Dullaers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

(2016) Salvador Iborra et al.   IMMUNITY

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite

(2016) André Ballesteros-Tato et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma

(2016) Brian D. Hondowicz et al.   IMMUNITY

The transcription factor NR4A3 controls CD103+ dendritic cell migration

(2016) Kiwon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

(2016) Jianhua Li et al.   NATURE

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response

(2016) Victoria Fang et al.   NATURE IMMUNOLOGY

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

(2016) Erica Russo et al.   Cell Reports

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

(2016) Samuele Calabro et al.   Cell Reports

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses

(2015) Roxane Tussiwand et al.   IMMUNITY

Interleukin-21-Producing CD4+ T Cells Promote Type 2 Immunity to House Dust Mites

(2015) Jonathan M. Coquet et al.   IMMUNITY

Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory

(2015) Joanna R Groom   IMMUNOLOGY AND CELL BIOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

Exit Strategies: S1P Signaling and T Cell Migration

(2015) Audrey Baeyens et al.   TRENDS IN IMMUNOLOGY

PKC-Theta in Regulatory and Effector T-cell Functions

(2015) Vedran Brezar et al.   Frontiers in Immunology

Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism

(2014) Taeg S. Kim et al.   IMMUNITY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine

(2014) Matthew C. Woodruff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leishmania major-Specific B Cells Are Necessary for Th2 Cell Development and Susceptibility to L. major LV39 in BALB/c Mice

(2014) C. Ronet et al.   JOURNAL OF IMMUNOLOGY

Arrestin 3 Mediates Endocytosis of CCR7 following Ligation of CCL19 but Not CCL21

(2014) M. A. Byers et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells and B Cells: Unexpected Partners in Th2 Development

(2014) Beatriz León et al.   JOURNAL OF IMMUNOLOGY

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

(2014) Menna R Clatworthy et al.   NATURE MEDICINE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions

(2013) Sarah E. Henrickson et al.   IMMUNITY

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

(2013) Wolfgang Kastenmüller et al.   IMMUNITY

The Spleen in Local and Systemic Regulation of Immunity

(2013) Vincenzo Bronte et al.   IMMUNITY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity

(2013) Yosuke Kumamoto et al.   IMMUNITY

Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

(2013) Yan Gao et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Priming of T follicular helper cells by dendritic cells

(2013) André Ballesteros-Tato et al.   IMMUNOLOGY AND CELL BIOLOGY

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

(2013) Dominique Gatto et al.   NATURE IMMUNOLOGY

Resident CD11b+Ly6C− Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice

(2013) Claire Mesnil et al.   PLoS One

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

(2013) Jesse W. Williams et al.   Nature Communications

Complement Mediated Signaling on Pulmonary CD103+ Dendritic Cells Is Critical for Their Migratory Function in Response to Influenza Infection

(2013) Matheswaran Kandasamy et al.   PLoS Pathogens

EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

(2013) Tangsheng Yi et al.   eLife

Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes

(2012) Jung Hwan Sung et al.   CELL

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5

(2012) Rubén Barroso et al.   FASEB JOURNAL

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

Migratory properties of pulmonary dendritic cells are determined by their developmental lineage

(2012) H Nakano et al.   Mucosal Immunology

Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells

(2012) Beatriz León et al.   NATURE IMMUNOLOGY

Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo

(2012) T. Fukaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histological Study and LYVE-1 Immunolocalization of Mouse Mesenteric Lymph Nodes with “In Vivo Cryotechnique”

(2011) Yuqin Bai et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo

(2011) G. L. Moschovakis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling

(2011) Orna Tal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration

(2011) Asolina Braun et al.   NATURE IMMUNOLOGY

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse

(2010) Julian Pulecio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD11c depletion severely disrupts Th2 induction and development in vivo

(2010) Alexander T. Phythian-Adams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

(2010) Hamida Hammad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biochemical and Genetic Evidence for a SAP-PKC-  Interaction Contributing to IL-4 Regulation

(2010) J. L. Cannons et al.   JOURNAL OF IMMUNOLOGY

The Origin and Maturity of Dendritic Cells Determine the Pattern of Sphingosine 1-Phosphate Receptors Expressed and Required for Efficient Migration

(2010) A. Rathinasamy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Lack of High Affinity Competition for Peptide in Polyclonal CD4+ Responses Unmasks IL-4 Production

(2010) J. D. Milner et al.   JOURNAL OF IMMUNOLOGY

Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza

(2010) André Ballesteros-Tato et al.   NATURE IMMUNOLOGY

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

(2009) K. Gollmer et al.   BLOOD

Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

(2009) Wojciech Wojciechowski et al.   IMMUNITY

Regulatory B Cells Shape the Development of Th2 Immune Responses in BALB/c Mice Infected with Leishmania major Through IL-10 Production

(2009) C. Ronet et al.   JOURNAL OF IMMUNOLOGY

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

(2009) David Sancho et al.   NATURE

MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity

(2009) Jacqueline G Perrigoue et al.   NATURE IMMUNOLOGY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

MGL2+ Dermal Dendritic Cells Are Sufficient to Initiate Contact Hypersensitivity In Vivo

(2009) Yosuke Kumamoto et al.   PLoS One

Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells

(2009) Marieke Bax et al.   PLoS One

Mechanisms and Consequences of Dendritic Cell Migration

(2008) David Alvarez et al.   IMMUNITY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

B Cell Antigen Presentation Promotes Th2 Responses and Immunopathology during Chronic Allergic Lung Disease

(2008) Dennis M. Lindell et al.   PLoS One

Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice

(2008) M. Tomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE