Article
Oncology
Mengli Zhao, Zhongrong Gao, Xiaowei Gu, Xiaojing Yang, Shanshan Wang, Jie Fu
Summary: The research focuses on analyzing the prognostic significance of minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil-to-lymphocyte (NLR) in cervical cancer patients receiving radiotherapy. The study found that patients with higher LY levels and lower NLR values during radiotherapy had better survival prognosis. Factors such as FIGO stage I, absence of lymph node metastasis, and lower NLR values were associated with poorer overall survival and progression-free survival.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jeong Won Lee, Ki Ho Seol
Summary: The study found that high NLR-PLR is associated with poor clinical outcomes, while increases in both NLR and PLR are correlated with lower survival rates for patients. Elevation in both NLR and PLR before initiation of CCRT may be a useful biomarker for predicting clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Jun-Qiang Du, Fan Zhang, Chao-Qun Wang, Ju-Fan Zhu, Li-Xia Xu, Yi-Heng Yang, Meng-Fei Han, Yan Hu
Summary: This study analyzed the levels of peripheral blood NLR in 203 patients with early cervical cancer and evaluated the relationship between NLR changes, clinicopathological characteristics, and patient prognosis. The study found that high preoperative NLR was associated with shorter overall survival and high postoperative NLR was associated with lower progression-free survival. Postmenopausal patients and those without vascular infiltration had higher rates of NLR increase. Further multicenter studies are needed to verify the effect of NLR changes on the prognosis of cervical cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Giovanni Salzano, Francesco Perri, Fabio Maglitto, Giulia Togo, Gianluca Renato De Fazio, Michela Apolito, Federica Calabria, Claudia Laface, Luigi Angelo Vaira, Umberto Committeri, Mario Balia, Ettore Pavone, Corrado Aversa, Francesco Antonio Salzano, Vincenzo Abbate, Alessandro Ottaiano, Marco Cascella, Mariachiara Santorsola, Roberta Fusco, Luigi Califano, Franco Ionna
Summary: This study retrospectively reviewed data of LSCC patients and found a significant correlation between high NLR values and neck occult metastasis, with an NLR value of 2.26 corresponding to a 20% probability of OM.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Guangyu Zhang, Youzhong Zhang, Fangfang He, Haijian Wu, Cong Wang, Chunli Fu
Summary: This study aimed to confirm whether preoperative controlling nutritional status (CONUT) was a prognostic factor in early-stage cervical cancer patients and found that a high CONUT score was associated with poor prognosis. Therefore, patients with high CONUT scores should be considered for consolidation chemotherapy in clinical practice.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Wentao Wang, Yilin Tong, Shulan Sun, Yuen Tan, Zexing Shan, Fan Sun, Chengyao Jiang, Yanmei Zhu, Jianjun Zhang
Summary: This study found that pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can independently predict tumor regression grade (TRG) after neoadjuvant chemotherapy in patients with locally advanced gastric cancer. Patients with high NLR and PLR values may benefit from alternative treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Ahmet Bilgehan Sahin, Erdem Cubukcu, Birol Ocak, Adem Deligonul, Sibel Oyucu Orhan, Sahsine Tolunay, Mustafa Sehsuvar Gokgoz, Sibel Cetintas, Gorkem Yarbas, Kazim Senol, Mehmet Refik Goktug, Zeki Burak Yanasma, Ulviyya Hasanzade, Turkkan Evrensel
Summary: The study indicates that PIV is a better predictor for predicting the efficacy of neoadjuvant chemotherapy and survival in breast cancer patients, outperforming NLR, MLR, and PLR.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Tibera K. Rugambwa, Omar Abdihamid, Xiangyang Zhang, Yinghui Peng, Changjing Cai, Hong Shen, Shan Zeng, Wei Qiu
Summary: This study aimed to investigate the correlation between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and the treatment outcomes of immune checkpoint inhibitors (ICIs). The results showed that patients with lower NLR and PLR were more likely to achieve clinical benefit and better treatment response, while higher NLR and PLR were associated with poorer treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Agnieszka Pikula, Magdalena Skorzewska, Zuzanna Pelc, Radoslaw Mlak, Katarzyna Geca, Katarzyna Sedlak, Bogumila Cisel, Magdalena Kwietniewska, Karol Rawicz-Pruszynski, Wojciech P. Polkowski
Summary: The study confirmed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in advanced gastric cancer patients, serving as significant prognostic factors.
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Ji-Hoon Sim, Ju-Seung Lee, Dong-Min Jang, Hwa Jung Kim, Shin-Wha Lee, Hyun-Seok Cho, Woo-Jong Choi
Summary: Surgical patients with cervical cancer in the laparoscopic group had significantly lower postoperative changes in neutrophil to lymphocyte ratio (NLR), but the extent of these changes was not associated with 5-year mortality. In contrast, preoperative NLR was related to 5-year mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ayumi Taguchi, Yujiro Nakajima, Akiko Furusawa, Yasunori Yoshino, Maki Takao, Tomoko Kashiyama, Nao Kino, Toshiharu Yasugi
Summary: This study aimed to explore predictive biomarkers for the outcomes of patients with recurrent cervical cancer post radiotherapy, demonstrating that definitive local treatment can provide long-term survival while high NLRs are predictive of short-term survival.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Oncology
Gowoon Yang, Jee Suk Chang, Jeong Eun Choi, Eun Sil Baek, Seung-Seob Kim, Hwa Kyung Byun, Yeona Cho, Woong Sub Koom, Seung Yoon Yang, Byung Soh Min, Sang Joon Shin
Summary: The study investigated the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) in locally advanced rectal cancer (LARC) patients and whether modifiable factors in radiotherapy (RT) influenced the NLR. The results showed that increased NLR after neoadjuvant RT is associated with increased distant metastasis risk and poor survival outcome in patients with LARC. Moreover, high NLR following RT is directly related to RT fractionation, delivery modality, and tumor characteristics.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Kyung Hwan Kim, Hongryull Pyo, Hoyoung Lee, Dongryul Oh, Jae Myoung Noh, Yong Chan Ahn, Chang Gon Kim, Hong In Yoon, Jiyun Lee, Sehhoon Park, Hyun-Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Bo mi Ku, Eui-Cheol Shin, Myung-Ju Ahn
Summary: The association between immunosenescence and radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) was investigated. It was found that the higher baseline frequencies of CD57+CD28-CD8+ T cells were correlated with increased risks of severe RP. Further research is needed to understand the role of T cell senescence in radiation-induced organ damage.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Kangpyo Kim, Seung Yeun Chung, Caleb Oh, Iksung Cho, Kyung Hwan Kim, Hwa Kyung Byun, Hong In Yoon, Jaewon Oh, Jee Suk Chang
Summary: Coronary artery calcium (CAC) scores are significant predictors of acute coronary events (ACE) in breast cancer patients, which may help identify high-risk patients.
Article
Biotechnology & Applied Microbiology
Woojung Lee, Min-Hee Kim, Juyeon Park, You Jin Kim, Eiseul Kim, Eun Jeong Heo, Seung Hwan Kim, Gyungcheon Kim, Hakdong Shin, Soon Han Kim, Hae-Yeong Kim
Summary: In this study, the changes in bacterial community and prevalence of foodborne pathogens on lettuce in different seasons were investigated using 16S rRNA gene-based sequencing. The results revealed significant differences in microbial communities and relative abundance of potential pathogens among different seasons. In addition, seasonal biomarkers and microbial association networks of microbiota on lettuce samples were detected. These findings provide basic data for food safety management to predict and prevent future outbreaks.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Surgery
Hong Bae Jeon, Ji Hyuk Jung, Sang Hee Im, Yong Bae Kim, Jee Suk Chang, Seung Yong Song, Dae Hyun Lew, Tai Suk Roh, Won Jai Lee, Dong Won Lee
Summary: This study aimed to investigate the impact of immediate breast reconstruction on the risk of breast cancer-related lymphedema. The results showed that immediate breast reconstruction can reduce the incidence of lymphedema.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Medicine, General & Internal
Mi Youn Seol, Seo Hee Choi, Ik Jae Lee, Hyung Soon Park, Hye Ryun Kim, Sang Kyum Kim, Hong In Yoon
Summary: This study investigated whether selective inhibition of PI3K isoforms could enhance radiosensitivity in GBM. The results from cell experiments and a mouse model demonstrated that inhibition of PI3K-alpha isoform increased radiosensitivity in GBM cells, leading to tumor growth suppression and extended survival in vivo.
YONSEI MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Won Ick Chang, Hwa Kyung Byun, Joo Ho Lee, Chul-Kee Park, In Ah Kim, Chae-Yong Kim, Jong Hee Chang, Seok-Gu Kang, Sang Hyung Lee, Yuki Kuranari, Ryota Tamura, Masahiro Toda, Chan Woo Wee, Hong In Yoon
Summary: This study investigated the prognostic impact of serum biomarkers in patients with newly diagnosed atypical meningiomas. The findings revealed that tumor size, surgical resection, and postoperative serum markers were associated with the progression/recurrence rate. Further studies are needed to validate their clinical significance and biological background.
Article
Oncology
Yeseul Kim, Kyung Hwan Kim, Junyoung Park, Hong In Yoon, Wonmo Sung
Summary: The study aimed to develop a prognosis prediction model for glioblastoma multiforme (GBM) patients, which accurately predicts overall survival (OS) and progression-free survival (PFS). Four algorithms were developed based on clinical variables, and random survival forest (RSF) outperformed the other algorithms in both OS and PFS predictions. Important prognostic factors for OS and PFS were identified, and the models accurately stratified patients into risk groups. The final models were clinically applicable for newly diagnosed GBM patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Yejin Kim, Ibrahim Chamseddine, Yeona Cho, Jin Sung Kim, Radhe Mohan, Nadya Shusharina, Harald Paganetti, Steven Lin, Hong In Yoon, Seungryong Cho, Clemens Grassberger
Summary: The study aims to develop a novel neural network approach that integrates patient characteristics, treatment related variables, and differential dose volume histograms (dDVH) of lung and heart to predict the incidence of radiation-induced lymphopenia (RIL) at the end of treatment. The study shows that clinical factors combined with dDVHs can be used to predict the risk of RIL for an individual patient and provides a path toward preventing lymphopenia using patient-specific modifications of the radiotherapy plan.
Article
Oncology
Gowoon Yang, Chang Young Lee, Eun Young Kim, Chang Geol Lee, Min Hee Hong, Byung Jo Park, Hong In Yoon, Kyung Hwan Kim, Sang Hoon Lee, Hwa Kyung Byun, Jaeho Cho
Summary: This study aimed to determine the role of radiotherapy (RT) and the optimal RT target volume in the treatment of thymic carcinoma. A total of 116 patients who received multimodal treatment were included. The target volume was defined as the tumor bed or gross tumor with margin, and selective irradiation of the regional nodal area was performed when involved. The results showed a high local control rate with RT, and a target volume confined to the tumor bed or gross tumor plus margin with the involved lymph node stations seems reasonable.
Article
Oncology
Seung Yeun Chung, Jee Suk Chang, Yong Bae Kim
Summary: This study aimed to train a deep learning-based auto-segmentation model for OAR/CTVs for patients with cervical cancer undergoing radiotherapy and to evaluate the model's feasibility and efficacy. The results showed that the deep learning model can reduce heterogeneity and save contouring time.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Joongyo Lee, Sang Kyun Yoo, Kangpyo Kim, Byung Min Lee, Vivian Youngjean Park, Jin Sung Kim, Yong Bae Kim
Summary: The study aimed to develop machine learning-based radiomics models using preoperative magnetic resonance imaging (MRI) data to predict locoregional recurrence (LRR) in breast cancer patients. The stacking model demonstrated superior performance in feature selection and performance compared to other models. An ongoing external validation study is being conducted to investigate the efficacy of the stacking model in this study.
Article
Oncology
Jee Suk Chang, Heejoo Ko, Sang Hee Im, Jin Sung Kim, Hwa Kyung Byun, Yong Bae Kim, Wonguen Jung, Goeun Park, Hye Sun Lee, Wonmo Sung, Robert Olsen, Chae-Seon Hong, Kyubo Kim
Summary: This study aimed to validate the relationship between the dose at the axillary-lateral thoracic vessel juncture (ALTJ) and the rate of lymphedema in patients with breast cancer, and explore whether incorporating ALTJ dose-distribution parameters improves the accuracy of the prediction model. The results showed that adding dose parameters to the prediction model can improve its accuracy in predicting lymphedema development.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ja Ho Koo, Myeongjee Lee, Eun Hwa Kim, Hyung Jung Oh, Joon Seok Lim, Woo Jin Hyung, Hong In Yoon, Inkyung Jung, Yong Eun Chung
Summary: This retrospective study investigated the impact of repetitive exposure to intravenous iodinated contrast media on long-term renal function in patients who underwent curative surgery for gastric cancer. The study found that the frequency of CT scans using ICM slightly increased the odds of developing chronic kidney disease.
SCIENTIFIC REPORTS
(2023)