Review
Cardiac & Cardiovascular Systems
Bo Xiong, Dan Nie, Jun Qian, Yuanqing Yao, Gang Yang, Shunkang Rong, Que Zhu, Yun Du, Yonghong Jiang, Jing Huang
Summary: This meta-analysis suggests that early administration of sacubitril-valsartan may be superior to conventional ACEI/ARB to decrease the risk of hospitalization for HF, improve the cardiac function, and reverse the LV remodelling in patients following AMI.
Review
Cardiac & Cardiovascular Systems
Bo Xiong, Dan Nie, Jun Qian, Yuanqing Yao, Gang Yang, Shunkang Rong, Que Zhu, Yun Du, Yonghong Jiang, Jing Huang
Summary: Sacubitril-valsartan may be superior to conventional ACEI/ARB in reducing the risk of hospitalization for HF, improving cardiac function, and reversing LV remodelling in patients following AMI, without increasing the risk of adverse events such as hypotension, hyperkalaemia, angioedema, and cough.
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Xiao-Ce Dai, Zhuo-Yu An, Zi-Yang Wang, Zi-Zhen Wang, Yi-Ren Wang
Summary: The use of ACEIs/ARBs does not appear to have a significant impact on mortality, disease severity, or duration of hospitalization in COVID-19 patients. Based on the findings of this meta-analysis, there is no support for discontinuing treatment with ACEIs or ARBs in patients with COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
Summary: Studies suggest that blood-brain barrier crossing renin-angiotensin drugs may be linked to less memory decline, while nonpenetrant medications may help improve attention.
Article
Respiratory System
Federico Angriman, Laura C. Rosella, Patrick R. Lawler, Dennis T. Ko, Claudio M. Martin, Hannah Wunsch, Damon C. Scales
Summary: Adult sepsis survivors have an increased risk of long-term cardiovascular events, but this risk can be reduced by renin-angiotensin system inhibitors (RASi).
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Cell Biology
Zheng Ma, Mei-Ping Wang, Lian Liu, Shuang Yu, Tian-Ran Wu, Lei Zhao, Ye-Ping Zhang, Hai-Feng Liang, Xin-Chun Yang
Summary: The meta-analysis suggests that the use of ACEI/ARB may increase the risk of COVID-19 infection in the general population, but not in hypertensive individuals. Additionally, ACEI/ARB usage was not associated with adverse outcomes in COVID-19 patients.
Article
Medicine, General & Internal
Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney Fletcher, Andrew M. South, Thomas A. Murray, Christopher Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: This study found that oral administration of losartan did not improve the PaO2:FiO(2) ratio at 7 days in hospitalized patients with COVID-19 and acute lung injury. The use of losartan also did not improve secondary clinical outcomes and resulted in fewer vasopressor-free days compared to placebo.
Article
Multidisciplinary Sciences
Mohitosh Biswas, Most. Sumaiya Khatun Kali
Summary: The use of ACE inhibitors and ARBs in COVID-19 patients was not associated with increased risk of mortality, severe clinical manifestations, or positive SARS-CoV-2 tests compared to patients not taking these medications. The findings suggest that discontinuation of ACE inhibitors or ARBs in treating COVID-19 patients may not be necessary based on current evidence.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jaejin An, Rong Wei, Hui Zhou, Tiffany Q. Luong, Michael K. Gould, Matthew T. Mefford, Teresa N. Harrison, Beth Creekmur, Ming-Sum Lee, John J. Sim, Jeffrey W. Brettler, John P. Martin, Angeline L. Ong-Su, Kristi Reynolds
Summary: The study found that the use of ACEIs or ARBs was not significantly associated with COVID-19 infection among patients with hypertension. However, there was a lower odds of COVID-19 infection among adults over 85 years old using ACEIs, suggesting that further investigation is warranted.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Rohan Khera, Callahan Clark, Yuan Lu, Yinglong Guo, Sheng Ren, Brandon Truax, Erica S. Spatz, Karthik Murugiah, Zhenqiu Lin, Saad B. Omer, Deneen Vojta, Harlan M. Krumholz
Summary: The study found that ACE inhibitors and ARBs were not significantly associated with the risk of COVID-19 hospitalization or mortality. Despite some tendency to lower hospitalization risk in older individuals, recent data consistency supports this conclusion.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Multidisciplinary Sciences
Ilke Sipahi
Summary: This analysis reveals for the first time that the risk of cancer, especially lung cancer, increases with increasing cumulative exposure to ARBs. The long-term use of ARBs has significant implications on public health.
Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Seiya Izumida, Hiroaki Kawano, Takahiro Muroya, Tetsufumi Motokawa, Ryohei Akashi, Tsuyoshi Yonekura, Yosuke Morimoto, Yudai Yano, Satoshi Ikeda, Koji Maemura
Article
Surgery
Saburo Kusumoto, Takahiro Muroya, Yuji Matsumoto, Shiro Hata, Hiroaki Kawano, Koji Maemura
ANNALS OF VASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Takahiro Muroya, Hiroaki Kawano, Shiro Hata, Hiroki Shinboku, Koichiro Sonoda, Saburo Kusumoto, Ryo Eto, Kaishi Otsuka, Koji Maemura
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Tomoyuki Hasuwa, Hiroaki Kawano, Satoki Fukae, Shuji Arakawa, Koji Maemura
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Article
Medicine, General & Internal
Serina Koto, Masataka Umeda, Hiroaki Kawano, Yushiro Endo, Toshimasa Shimizu, Tomohiro Koga, Kunihiro Ichinose, Hideki Nakamura, Akihiro Mukaino, Osamu Higuchi, Shunya Nakane, Atsushi Kawakami
Article
Pathology
Hiroaki Kawano, Keita Iyama, Kuniko Abe, Mitsuaki Ishijima, Tsuyoshi Yonekura, Seiji Koga, Satoshi Ikeda, Koji Maemura
PATHOLOGY INTERNATIONAL
(2020)
Letter
Pathology
Kentaro Furukawa, Hiroaki Kawano, Mitsuru Futakuchi, Mitsuaki Ishijima, Yuki Yamgataga, Yuki Ueno, Seiji Koga, Satoshi Ikeda, Kiyohiku Eishi, Koji Maemura
PATHOLOGY INTERNATIONAL
(2021)
Article
Biology
Hiroaki Kawano, Koichi Kawamura, Masaki Kohno, Mitsuaki Ishijima, Satoki Fukae, Taisuke Ishikawa, Naomasa Makita, Koji Maemura
Summary: A 16-year-old Japanese boy was admitted to the hospital due to cardiac issues, diagnosed with a cardiac conduction defect and found to have a genetic mutation related to cardiomyopathy and arrhythmia in family genetic analysis. After further examinations and surgery, he successfully received permanent pacemaker implantation.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Biology
Hiroaki Kawano, Koichi Kawamura, Munetake Kanda, Mitsuaki Ishijima, Kuniko Abe, Tomayoshi Hayashi, Yuji Matsumoto, Akinori Kimura, Koji Maemura
Summary: Restrictive cardiomyopathy is a rare primary myocardial disease with unclear pathological features. A 65-year-old Japanese woman was diagnosed with MHY7 mutation-related RCM, with electron microscopy of a myocardial biopsy revealing specific features possibly associated with the pathogenesis of the disease.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Takako Minami, Hiroaki Kawano, Tsuyoshi Yoshimuta, Koji Maemura
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Biology
Hiroaki Kawano, Koichi Kawamura, Mitsuaki Ishijima, Kuniko Abe, Tomayoshi Hayashi, Masamichi Eguchi, Kiyonori Miura, Koji Maemura
Summary: The etiology of peripartum cardiomyopathy (PPCM) is varied and related to myocarditis and myocardial overload due to hypertension, as revealed by endomyocardial biopsy.
MEDICAL MOLECULAR MORPHOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hiroaki Kawano, Jumpei Watanabe, Yuri Akiyama-Uchida, Koji Maemura
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroaki Kawano, Masataka Umeda, Shinji Okano, Takashi Kudo
Summary: Complications, including pericarditis, myocarditis, and myocardial ischemia, have been reported after COVID-19 vaccination. A case study of a 28-year-old Japanese woman with systemic lupus erythematosus and antiphospholipid syndrome showed myocardial microangiopathy after receiving the COVID-19 vaccine. Immunostaining revealed the presence of SARS-CoV/SARS-CoV-2 spike protein in small intramural coronary arteries. The patient's symptoms improved with medication.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Takahiro Muroya, Hiroaki Kawano, Shiro Hata, Hiroki Shinboku, Koichiro Sonoda, Kentaro Furukawa, Kazuki Matsumura, Koji Maemura
Summary: This study investigated the midterm clinical outcomes of 137 patients with deferred revascularization based on resting full cycle ratio (RFR) and fractional flow reserve (FFR). The results showed that concordant abnormal, current or history of cancer, body mass index (BMI), and left ventricular ejection fraction were associated with increased risks of adverse outcomes.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Takahiro Muroya, Hiroaki Kawano, Fumi Yamamoto, Koji Maemura
Summary: This study investigated the relationship between coronary arteries of different diameters and hyperemic microvascular resistance index (hMVRI). The results showed that hMVRI was significantly higher for the right coronary artery compared to the left anterior descending artery, and there was a correlation between coronary arteries of different diameters.
HEALTH SCIENCE REPORTS
(2023)