Article
Immunology
Naohiko Akimoto, Juha P. Vayrynen, Melissa Zhao, Tomotaka Ugai, Kenji Fujiyoshi, Jennifer Borowsky, Rong Zhong, Koichiro Haruki, Kota Arima, Mai Chan Lau, Junko Kishikawa, Tyler S. Twombly, Yasutoshi Takashima, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Summary: Immature desmoplastic reaction and myxoid stroma are associated with lower densities of immune cells in the colorectal tumor microenvironment, which may influence cancer survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Mark A. Glaire, Neil A. J. Ryan, Marieke E. Ijsselsteijn, Katarzyna Kedzierska, Sofia Obolenski, Reem Ali, Emma J. Crosbie, Tjalling Bosse, Noel F. C. C. de Miranda, David N. Church
Summary: Defective DNA mismatch repair (dMMR) leads to elevated tumour mutational burden (TMB) and microsatellite instability (MSI), which is associated with better prognosis in colorectal cancer (CRC) but not in endometrial cancer (EC). The study reveals that CRC has a more robust immune response to dMMR/MSI compared to EC, as evidenced by increased density of tumor-infiltrating T cells.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Daniel A. Fox, Deepak Bhamidipati, Tsuyoshi Konishi, Harmeet Kaur, Nancy You, Kanwal P. S. Raghav, Phillip S. Ge, Craig Messick, Benny Johnson, Van K. Morris, Jane V. Thomas, Preksha Shah, Brian K. Bednarski, Scott Kopetz, George J. Chang, Kaysia Ludford, Victoria Serpas Higbie, Michael J. Overman
Summary: This study retrospectively analyzed the endoscopic and imaging response of patients with localized dMMR CRC who received neoadjuvant immune checkpoint blockade therapy. It found discrepancies between imaging and endoscopy were common, and abnormalities could be identified despite pathological remission. Improved clinical response criteria are needed.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Immunology
Jiahao Zhu, Jie Lian, Benjie Xu, Xiangyi Pang, Shengjun Ji, Yutian Zhao, Haibo Lu
Summary: Neoadjuvant chemoradiotherapy or chemotherapy, radical resection, and adjuvant therapy are the optimal treatment model for locally advanced colorectal cancer. Total neoadjuvant therapy further improved preoperative tumor regression rate and reduced local-regional recurrence in locally advanced rectal cancer. However, distant metastasis remains high, and overall survival benefit is limited.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yan Sun, Hongping Li, Zhiming Ma, Jianfei Wang, Huiyu Yang, Xiaopeng Zhang, Bingrong Liu
Summary: This study identified three immune subtypes (high, moderate, and low) in colorectal cancer samples and investigated their associations with patient prognosis. Differential gene expression and immunomodulators were also analyzed between the subtypes.
Article
Oncology
Sudhir B. Malla, David J. Fisher, Enric Domingo, Andrew Blake, Sylvana Hassanieh, Keara L. Redmond, Susan D. Richman, Michael Youdell, Steven M. Walker, Gemma E. Logan, Aikaterina Chatzipli, Raheleh Amirkhah, Matthew P. Humphries, Stephanie G. Craig, Ultan McDermott, Matthew T. Seymour, Dion G. Morton, Philip Quirke, Nicholas P. West, Manuel Salto-Tellez, Richard D. Kennedy, Patrick G. Johnston, Ian Tomlinson, Viktor H. Koelzer, Letitia Campo, Richard S. Kaplan, Daniel B. Longley, Mark Lawler, Timothy S. Maughan, Louise C. Brown, Philip D. Dunne
Summary: Positivity of DDIR does not predict improved response to oxaliplatin treatment in colorectal cancer, with DDIR-negative patients showing a trend towards better outcomes. The DDIR assay may have potential in identifying immune-rich tumors that could benefit from immune checkpoint blockade therapies, beyond the current use of MSI status.
CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Jiao-Ting Chen, Yu-Wen Zhou, Ting-Rui Han, Jun-Lun Wei, Meng Qiu
Summary: Surgical resection is essential for achieving good prognoses in colorectal cancer (CRC), but some patients fail to meet surgical indications or achieve pathological complete response after surgery. Perioperative therapy can effectively decrease tumor staging and reduce recurrence and metastasis. Immune checkpoint inhibitors (ICIs) have shown satisfactory efficacy and safety in patients with high microsatellite instability/deficient mismatch repair (MSI-H/dMMR), while the therapeutic effect is minimal in patients with mismatch repair-proficient or microsatellite stable (pMMR/MSS). Additional predictors are needed to screen patients with potential clinical benefits. Different combinations of immunotherapy in perioperative clinical trials for CRC have been comprehensively summarized in this review, focusing on efficacy and safety, and pointing out future directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Cell Biology
Gayathri Anandappa, Michael J. Overman
Summary: In a recent study, Amodio and colleagues discovered a method to modulate immunosurveillance in colorectal tumors by manipulating DNA mismatch repair heterogeneity. They found that enriching the MMR deficient component using 6-thioguanine can improve tumor control in murine models.
CELL REPORTS MEDICINE
(2023)
Article
Immunology
Ning Liu, Fengping Shan, Mingxing Ma
Summary: Colorectal cancer is a common and deadly disease, with conventional therapies having limited effectiveness. Immune checkpoint inhibition has shown promise for some CRC patients but not all, highlighting the need for new treatment approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Bomiao Zhang, Yien Li, Liqiang Song, Hua Xi, Shaoke Wang, Chenfeng Yu, Binbin Cui
Summary: This study investigated the expression characteristics of copper-related genes in colon cancer using bioinformatics approaches and established a Cu_riskScore model based on these genes. The results showed that Cu_riskScore was associated with tumor stage, MSI-H subtype, and several biological processes. The model also predicted the response to immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Sofia Edin, Bjorn Gylling, Xingru Li, Asa Stenberg, Anna Lofgren-Burstrom, Carl Zingmark, Bethany van Guelpen, Ingrid Ljuslinder, Agnes Ling, Richard Palmqvist
Summary: This study investigates the tumor immune cell infiltration in relation to well-established molecular markers of colorectal cancer (CRC). The results show an association between higher immune cell infiltration and microsatellite instability, and opposite relationships of BRAF and KRAS mutations with tumor infiltration of cytotoxic T cells. The positive prognostic importance of cytotoxic T cells is found in wild-type as well as KRAS and BRAF-mutated CRCs in both cohorts.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Vitaly Shubin, Yury Shelygin, Sergey Achkasov, Oleg Sushkov, Ilya Nazarov, Alexey Ponomarenko, Iuliia Alimova, Anna Loginova, Aleksey Tsukanov
Summary: The aim of this study was to determine the characteristics of Russian patients with microsatellite instability (MSI) tumors. The results showed that patients with MSI tumors differed in the age of diagnosis, tumor localization, time of cancer recurrence, and stage of the disease. Patients whose tumors had MSI status had higher overall and disease-free survival rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Paulina Rzasa, Sarah Whelan, Pooyeh Farahmand, Hong Cai, Inna Guterman, Raquel Palacios-Gallego, Shanthi S. Undru, Lauren Sandford, Caleb Green, Catherine Andreadi, Maria Mintseva, Emma Parrott, Hong Jin, Fiona Hey, Susan Giblett, Nicolas B. Sylvius, Natalie S. Allcock, Anna Straatman-Iwanowska, Roberto Feuda, Cristina Tufarelli, Karen Brown, Catrin Pritchard, Alessandro Rufini
Summary: BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. Short-term and long-term expression of Braf(V600E) in the intestinal tissue perturbs the homeostasis of intestinal epithelial cells, impairs differentiation of enterocytes, and leads to persistent transcriptional reprogramming.
COMMUNICATIONS BIOLOGY
(2023)
Review
Oncology
Romain Cohen, Raphael Colle, Thomas Pudlarz, Maximilien Heran, Alex Duval, Magali Svrcek, Thierry Andre
Summary: Microsatellite instability (MSI) is a tumor phenotype related to a deficient DNA mismatch repair system (dMMR). This phenotype, observed in 5% of metastatic mCRC but 10-18% of localized CRC, is associated with high tumor mutational burden with highly immunogenic neoantigens. It has emerged as a major predictive biomarker for the efficacy of ICIs.
Article
Oncology
Quang Loc Bui, Leo Mas, Antoine Hollebecque, David Tougeron, Christelle de la Fouchardiere, Thomas Pudlarz, Emily Alouani, Rosine Guimbaud, Julien Taieb, Thierry Andre, Raphael Colle, Romain Cohen
Summary: This study retrospectively collected clinical data from 31 patients with dMMR/MSI mCRC. The results showed that there was no improved outcome with CT after ICI failure, but prolonged disease control was observed in some cases.
Correction
Cell & Tissue Engineering
Imelda Ontoria-Oviedo, Itziar Palacios, Joaquin Panadero, Belen Sanchez, Francisco Garcia-Garcia, Adolfo Lopez-Cerdan, Akaitz Dorronsoro, Delia Castellano, Luis Rodriguez-Borlado, Antonio Bernad, Pilar Sepulveda
STEM CELLS INTERNATIONAL
(2022)
Article
Education & Educational Research
Antonio Rodriguez-Fuentes, Lineth Alain-Botaccio, Francisco Garcia-Garcia
Summary: This research addresses the communication problem between people with deafness and the general population in terms of learning and using sign language. It proposes an accessible platform for both deaf and non-deaf individuals. The EnSenias platform, developed using a design-based research model and software engineering methodology, offers 1,253 interactive objects through videos, braille lines, and screen readers. The effectiveness of the platform was validated through focus groups and content analysis, resulting in three categories of validation: general, learning, and teaching. EnSenias fills a gap in digital resources for its specific context and language.
CULTURE AND EDUCATION
(2022)
Editorial Material
Biochemical Research Methods
Salvador Capella-Gutierrez, Eva Alloza, Laura Rubinat-Ripoll, Ana Conesa, Alfonso Valencia
Article
Biology
Nicolas J. Pillon, Laura Sardon Puig, Ali Altintas, Prasad G. Kamble, Salvador Casani-Galdon, Brendan M. Gabriel, Romain Barres, Ana Conesa, Alexander Chibalin, Erik Naslund, Anna Krook, Juleen R. Zierath
Summary: Obesity and elevated circulating lipids can disrupt the molecular circadian clock and impair metabolism. This study shows that lipid overload interacts with the circadian clock in skeletal muscle and alters the rhythmicity of gene expression through epigenomic mechanisms. Specific histone modifications are responsive to lipid overload and contribute to the reprogramming of circadian genes and pathways involved in lipid biosynthesis.
LIFE SCIENCE ALLIANCE
(2022)
Article
Neurosciences
Jose Francisco Catala-Senent, Zoraida Andreu, Marta R. Hidalgo, Irene Soler-Saez, Francisco Jose Roig, Natalia Yanguas-Casas, Almudena Neva-Alejo, Adolfo Lopez-Cerdan, Maria de la Iglesia-Vaya, Barbara E. Stranger, Francisco Garcia-Garcia
Summary: This study provides insights into the molecular mechanisms underlying gender differences in multiple sclerosis (MS) by conducting a systematic review and analysis of genome-wide transcriptome studies. The results reveal differential gene expression patterns between male and female patients in various brain and blood tissues, guiding potential personalized treatments for MS based on gender.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Microbiology
Salvador Meseguer, Mari-Paz Rubio, Begona Lainez, Beatriz Perez-Benavente, Raul Perez-Moraga, Sergio Romera-Giner, Francisco Garcia-Garcia, Olalla Martinez-Macias, Antonio Cremades, Francisco J. Iborra, Oscar Candelas-Rivera, Fernando Almazan, Enric Esplugues
Summary: It has been found that levels of SERINC5 are reduced in COVID-19 patients, and the repression of SERINC5 expression may be caused by viral non-coding small RNAs (svRNAs).
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maria Guaita-Cespedes, Ruben Grillo-Risco, Marta R. Hidalgo, Sonia Fernandez-Veledo, Deborah Jane Burks, Maria de la Iglesia-Vaya, Amparo Galan, Francisco Garcia-Garcia
Summary: The expression stability of classical housekeeping genes in human adipose tissue varies by sex, indicating that they are not suitable as internal controls. Some new potential housekeeping genes that are not affected by sex bias are proposed.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Carla Perpina-Clerigues, Susana Mellado, Jose F. Catala-Senent, Francesc Ibanez, Pilar Costa, Miguel Marcos, Consuelo Guerri, Francisco Garcia-Garcia, Maria Pascual
Summary: The study shows that drinking alcohol leads to the enrichment of plasma EV lipid species in female adolescents, which is associated with the propagation of neuroinflammatory responses. Gender differences in lipid abundance were also observed in wild-type mice and Toll-like receptor 4 deficient mice. These findings support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Oncology
Irene Perez-Diez, Zoraida Andreu, Marta R. Hidalgo, Carla Perpina-Clerigues, Lucia Fantin, Antonio Fernandez-Serra, Maria de la Iglesia-Vaya, Jose A. Lopez-Guerrero, Francisco Garcia-Garcia
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with limited treatment options. The desmoplastic stroma and immune system evasion in PDAC pose challenges to therapeutic strategies. Characterizing the PDAC microenvironment is crucial for developing effective therapies. A meta-analysis identified 1153 dysregulated genes involved in extracellular matrix remodeling and the immune system. The study also identified immune gene signatures and stromal gene signatures associated with PDAC patients' survival, and discovered new immune genes associated with PDAC prognosis.
Article
Biophysics
Maria del Mar Alvarez-Torres, Adolfo Lopez-Cerdan, Zoraida Andreu, Maria de la Iglesia Vaya, Elies Fuster-Garcia, Francisco Garcia-Garcia, Juan M. Garcia-Gomez
Summary: Global agreement in CNS tumor classification is crucial for patient prognosis, treatment decisions, and international clinical trials. The latest update by the World Health Organization recognized IDH-wildtype glioblastoma and astrocytoma IDH-mutant grade 4 as distinct tumors. IDH mutations contribute to gliomagenesis by affecting tumor cell metabolism and hypoxia processes. Alternative biomarkers, such as MRI-perfusion biomarkers, could provide a reliable and cost-effective classification for CNS tumors.
NMR IN BIOMEDICINE
(2023)
Article
Cell Biology
Marian Leon, Javier Prieto, Maria Micaela Molina-Navarro, Francisco Garcia-Garcia, Manuela Barneo-Munoz, Xavier Ponsoda, Rosana Saez, Francesc Palau, Joaquin Dopazo, Juan Carlos Izpisua Belmonte, Josema Torres
Summary: Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy affecting Schwann cells and motor neurons. The loss of function of the GDAP1 gene leads to altered mitochondrial morphology, activation of autophagy, abnormal metabolism, increased reactive oxygen species, and an elevated innate immune response. Understanding these cellular and molecular phenotypes could lead to the development of therapies for this disease.
CELL DEATH DISCOVERY
(2023)
Article
Art
Francisco Jose Gil-Ruiz, Francisco Garcia-Garcia
Summary: The article examines the representation of scientific communicators in the film Don't Look Up (Adam McKay, 2021). It analyzes the relationships between cinema, science, and pragmatics, and focuses on the roles of scientists, technological producers, communicators, politicians, and citizens. The study uses a model of pragmatic obligations to analyze the interactions between these agents and presents the findings in a relationship map. The results suggest that scientists are more likely to fulfill their obligations to the truth, while political power and producer-technology have a weaker connection to it. Communicators and citizens generally only partially fulfill their respective obligations. Furthermore, except for two scientists, all roles face challenges in effectively communicating the truth, and the influence of political power on truth administration is highlighted.
FOTOCINEMA-REVISTA CIENTIFICA DE CINE Y FOTOGRAFIA
(2023)
Letter
Biochemistry & Molecular Biology
Francisco J. Iborra, Cristina Marti, Virtu Calabuig-Navarro, Petros Papadopoulos, Salvador Meseguer, Pedro M. Iborra, Francisco Garcia, Antonio Martinez-Lorente, Fernando Almazan, Juana Calabuig
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Jorge Mestre-Tomas, Tianyuan Liu, Francisco Pardo-Palacios, Ana Conesa
Summary: SQANTI-SIM is a versatile tool that wraps around popular long-read simulators, allowing precise management of transcript novelty based on the structural categories defined by SQANTI3. It effectively emulates scenarios involving unannotated transcripts and supports the simulation of additional types of data, making it the first multi-omics simulation tool for the lrRNA-seq field.
Article
Computer Science, Information Systems
Jesus Alejandro Alzate-Grisales, Alejandro Mora-Rubio, Francisco Garcia-Garcia, Reinel Tabares-Soto, Maria de la Iglesia-Vaya
Summary: This study presents a novel model, SAM-UNETR, for segmenting clinically significant prostate cancer regions from MRI images. SAM-UNETR combines the features of Segment Anything Model and UNETR, and uses multiple image modalities and preprocessing steps to improve accuracy. Compared with three other models, SAM-UNETR achieves higher reliability and accuracy in csPCa segmentation.