Review
Medicine, General & Internal
Qinyi Bao, Shuxin Lei, Shitian Guo, Zhuo Wang, Jiaye Yu, Yayu You, Ning Zhang, Xiaojie Xie
Summary: Exercise-based cardiac rehabilitation is safe and effective for chronic heart failure (CHF) patients. Traditional Chinese exercise (TCE) significantly improves exercise capacity, cardiac function, and quality of life in CHF patients. Increasing the duration and combining TCE with conventional aerobic exercise further enhances the benefits.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Gregg C. Fonarow, Lee R. Goldberg, Maya Guglin, Richard A. Josephson, Daniel E. Forman, Grace Lin, JoAnn Lindenfeld, Chris O'Connor, Gurusher Panjrath, Ileana L. Pina, Tina Shah, Shashank S. Sinha, Eugene Wolfel
Summary: Cardiac rehabilitation, which includes exercise training, risk factor modification, and outcomes assessment, is safe and beneficial for patients with HF. Despite its effectiveness and cost-efficiency, it is currently underused and should be prioritized as part of standard care for HF patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Nursing
Yingtong Meng, Wei Zhuge, Hanjun Huang, Tingting Zhang, Xiaohua Ge
Summary: The study found that early exercise has significant benefits on cardiac rehabilitation-related outcomes in acute heart failure patients, including improvements in physical capacity, physiological outcomes, and clinical outcomes, with no adverse events reported during the intervention.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Rehabilitation
Yoichiro Aoyagi, Etsuko Mori, Hideki Ishii, Yuji Kono, Ayako Sato, Yuki Okochi, Reisuke Funahashi, Hitoshi Kagaya
Summary: This study compared the effects of cardiac rehabilitation therapies performed in wards and rehabilitation units during the COVID-19 pandemic. The results showed that patients receiving ward-based rehabilitation had lower walking distance and speed at discharge compared to those admitted before the outbreak, and they also had shorter exercise time.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Medicine, General & Internal
Pasquale Ambrosino, Antimo Papa, Agostino Buonauro, Marco Mosella, Ilenia Calcaterra, Giorgio Alfredo Spedicato, Mauro Maniscalco, Matteo Nicola Dario Di Minno
Summary: Endothelial dysfunction is documented in patients with HFpEF, with a direct association between the severity of diastolic dysfunction and endothelial dysfunction. Strategies targeting endothelial dysfunction may provide a promising therapeutic option.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Catherine Giuliano, Don Vicendese, Sara Vogrin, Rebecca Lane, Andrea Driscoll, Diem Dinh, Katie Palmer, Itamar Levinger, Christopher Neil
Summary: This study investigated the rate and factors associated with referral to cardiac rehabilitation (CR) among patients hospitalized with heart failure (HF). The results showed a low rate of referral, particularly among females, older patients, and those with chronic obstructive pulmonary disease or anemia. Future studies should focus on improving referral processes and implementing strategies to increase referrals to CR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Grace O. Dibben, James Faulkner, Neil Oldridge, Karen Rees, David R. Thompson, Ann-Dorthe Zwisler, Rod S. Taylor
Summary: Participation in exercise-based cardiac rehabilitation by patients with coronary heart disease can reduce cardiovascular mortality, recurrent cardiac events, and hospitalizations, improve health-related quality of life (HRQoL), and be cost-effective.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Cal D. Molloy, Linda Long, Ify R. Mordi, Charlene Bridges, Viral A. Sagar, Edward J. Davies, Andrew J. S. Coats, Hasnain Dalal, Karen Rees, Sally J. Singh, Rod S. Taylor
Summary: Exercise-based cardiac rehabilitation (ExCR) has significant benefits for heart failure (HF) patients in reducing hospitalization rates and improving quality of life. Global healthcare systems should routinely recommend ExCR and offer different delivery modes for patients to choose.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Medicine, General & Internal
Ran Guo, Yi Wen, Ying Xu, Ruikun Jia, Song Zou, Sijie Lu, Guobin Liu, Kaijun Cui
Summary: This study systematically reviewed the effects of exercise training in chronic heart failure patients with cardiac resynchronization therapy. The results indicated that in the short term, non-high intensity training could improve exercise capacity, cardiac function, and quality of life, with no significant statistical difference found in high intensity training.
Review
Cardiac & Cardiovascular Systems
Andrea Passantino, Laura Adelaide Dalla Vecchia, Ugo Corra, Simonetta Scalvini, Massimo Pistono, Maurizio Bussotti, Fabiana Isabella Gambarin, Domenico Scrutinio, Maria Teresa La Rovere
Summary: Cardiac rehabilitation (CR) is a comprehensive program that includes multiple components and can lead to significant physical and psychological benefits. Exercise-based CR for heart failure patients is a recommended treatment that should be personalized and optimized for each individual.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Pharmacological interventions have shown limited efficacy, while exercise-based interventions consistently improve symptoms and quality of life. This may be attributed to the pleiotropic effects of exercise, which positively influence the various abnormalities contributing to exercise intolerance in HFpEF. This article critically examines the effects of exercise-based therapies, compares them with other cardiovascular conditions, and highlights gaps in implementation for future research.
Article
Cardiac & Cardiovascular Systems
Benjamin J. R. Buckley, Stephanie L. Harrison, Elnara Fazio-Eynullayeva, Paula Underhill, Rajiv Sankaranarayanan, David J. Wright, Dick H. J. Thijssen, Gregory Y. H. Lip
Summary: Exercise-based cardiac rehabilitation was associated with lower odds of all-cause mortality, hospitalization, incident stroke, and incident atrial fibrillation at 2-year follow-up for patients with heart failure (including patients with reduced ejection fraction and preserved ejection fraction).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuta Nagatomi, Tomomi Ide, Tae Higuchi, Tomoyuki Nezu, Takeo Fujino, Takeshi Tohyama, Takuya Nagata, Taiki Higo, Toru Hashimoto, Shouji Matsushima, Keisuke Shinohara, Tomiko Yokoyama, Aika Eguchi, Ayumi Ogusu, Masataka Ikeda, Yusuke Ishikawa, Fumika Yamashita, Shintaro Kinugawa, Hiroyuki Tsutsui
Summary: This study investigated the efficacy and safety of a comprehensive home-based cardiac rehabilitation programme that combines patient education, exercise guidance, and nutritional guidance using information and communication technology (ICT). The results showed that the programme improved exercise tolerance and lower extremity muscle strength in patients with heart failure and physical frailty.
Review
Medicine, General & Internal
Lingjun Jiang, Ruixuan Wan, Bohan Li, XuHui Huang, Yaning Xu, Kaisong Wu, Jie Xu, Yan Lu
Summary: This study aims to use network meta-analysis to investigate the relative efficacy and safety of different modes of exercise-based cardiac rehabilitation delivery for individuals with heart failure. The study will assess primary outcomes such as functional capacity and health-related quality of life, as well as secondary outcomes including hospital admissions, mortality, and adverse events.
Editorial Material
Cardiac & Cardiovascular Systems
Tim Kambic, Borut Jug, Massimo Francesco Piepoli, Mitja Lainscak
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Federica Toto, Elisabetta Salvioni, Damiano Magri, Susanna Sciomer, Massimo Piepoli, Roberto Badagliacca, Arianna Galotta, Nikita Baracchini, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Pasquale Perrone Filardi, Annamaria Iorio, Michele Senni, Michele Correale, Mariantonietta Cicoira, Enrico Perna, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Francesco Bandera, Maurizio Bussotti, Massimo Mapelli, Manlio Cipriani, Alice Bonomi, Goncalo Cunha, Federica Re, Carlo Vignati, Andrea Garascia, Carlo Lombardi, Angela B. Scardovi, Andrea Passantino, Michele Emdin, Claudio Passino, Caterina Santolamazza, Davide Girola, Denise Zaffalon, Dario Vizza, Fabiana De Martino, Piergiuseppe Agostoni
Summary: This study aimed to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF patients and found that it does not influence patients' outcome.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Letter
Medicine, General & Internal
Oriana Ciani, Michela Meregaglia, Francesco De Lorenzo, Francesco Perrone, Carmine Pinto
Article
Medicine, General & Internal
Izabella Uchmanowicz, Giuseppe Rosano, Massimo Francesco Piepoli, Ercole Vellone, Michal Czapla, Magdalena Lisiak, Dorota Diakowska, Anna Prokopowicz, Krzysztof Aleksandrowicz, Bernadetta Nowak, Marta Wleklik, Kenneth M. Faulkner
Summary: Pathological processes associated with ageing increase the risk of cognitive deficits and dementia. Frailty syndrome, also known as weakness or reserve depletion syndrome, may significantly accelerate these pathological processes in the elderly population. The co-occurrence of cognitive impairment and frailty syndrome significantly increases the risk of dementia and other adverse outcomes, including mortality, in the heart failure population.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Francesco Bandera, Guido Giacalone, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Surgery
Luca Bertolaccini, Oriana Ciani
FRONTIERS IN SURGERY
(2023)
Review
Oncology
Vittoria Ardito, Georgi Golubev, Oriana Ciani, Rosanna Tarricone
Summary: This study aimed to explore barriers and enablers to the uptake of mHealth solutions used by patients with cancer undergoing treatment. A scoping literature review was conducted, and the Consolidated Framework for Implementation Research (CFIR) was used to guide data collection. The study found that multistakeholder co-design and testing of mHealth interventions, as well as addressing patient needs and ensuring technology interoperability, were key enablers for mHealth uptake.
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Attanasio, Massimo F. Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gianfranci Parati, Massimo Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Attanasio, Geza Halasz, Massimo F. Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Oriana Ciani, Anthony M. Manyara, Philippa Davies, Derek Stewart, Christopher J. Weir, Amber E. Young, Jane Blazeby, Nancy J. Butcher, Sylwia Bujkiewicz, An-Wen Chan, Dalia Dawoud, Martin Offringa, Mario Ouwens, Asbjorn Hrobjartssson, Alain Amstutz, Luca Bertolaccini, Vito Domenico Bruno, Declan Devane, Christina D. C. M. Faria, Peter B. Gilbert, Ray Harris, Marissa Lassere, Lucio Marinelli, Sarah Markham, John H. Powers, Yousef Rezaei, Laura Richert, Falk Schwendicke, Larisa G. Tereshchenko, Achilles Thoma, Alparslan Turan, Andrew Worrall, Robin Christensen, Gary S. Collins, Joseph S. Ross, Rod S. Taylor
Summary: Interventional trials that use surrogate endpoints to evaluate treatment effects are increasingly common. However, there is currently inconsistency and lack of clarity in the definition and interpretation of surrogate endpoints. Surrogate endpoints are used as substitutes for the treatment effects on ultimate outcomes of interest. While traditionally biomarkers have been the focus of surrogate endpoint consideration, intermediate outcomes that include measures of function or symptoms can also act as surrogate endpoints. However, there is a lack of consensus among stakeholders on accepting and interpreting intermediate outcomes as surrogate endpoints. Better understanding and reporting on the use of surrogate endpoints in interventional trials is urgently needed.
Article
Multidisciplinary Sciences
Filippo Trentini, Oriana Ciani, Elena Vanni, Simone Ghislandi, Aleksandra Torbica, Elena Azzolini, Alessia Melegaro
Summary: Italy was the first European country affected by SARS-CoV-2, and little research has been done on the economic impact of caring for COVID-19 patients. This study quantifies the additional healthcare costs for hospitalizations related to the timing and status of SARS-CoV-2 cases in Italy. The study found that the overall costs of hospitalizations increased during the pandemic, particularly for SARS-CoV-2 positive patients with non-COVID-19 related diagnoses.
SCIENTIFIC REPORTS
(2023)
Correction
Cardiac & Cardiovascular Systems
M. Riccardi, A. M. Sammartino, M. Piepoli, M. Adamo, M. Pagnesi, G. Rosano, M. Metra, S. von Haehling, D. Tomasoni
Correction
Cardiac & Cardiovascular Systems
Massimo F. Piepoli, Marianna Adamo, Andrea Barison, Reinaldo B. Bestetti, Jan Biegus, Michael Bohm, Javed Butler, Jonathan Carapetis, Claudio Ceconi, Ovidiu Chioncel, Andrew Coats, Maria G. Crespo-Leiro, Giovanni de Simone, Heinz Drexel, Michele Emdin, Dimitros Farmakis, Martin Halle, Stephane Heymans, Tiny Jaarsma, Ewa Jankowska, Mitja Lainscak, Carolyn S. P. Lam, Maja-Lisa Lochen, Yuri Lopatin, Aldo Maggioni, Benedetta Matrone, Marco Metra, Katharine Noonan, Ileana Pina, Eva Prescott, Giuseppe Rosano, Petar M. Seferovic, Karen Sliwa, Simon Stewart, Alicia Uijl, Ilonca Vaartjes, Roel Vermeulen, W. M. Verschuren, Maurizio Volterrani, Stephan Von Haehling, Arno Hoes
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)