Article
Chemistry, Multidisciplinary
Hang Li, Mian Jiang, Shu-ya Zhao, Shu-qin Zhang, Lu Lu, Xin He, Guo-xing Feng, Xin Wu, Sai-jun Fan
Summary: This study revealed the involvement of exosomes in TBI-induced intestinal injury in mice, providing a new target for protecting patients against irradiation-induced intestinal injury during radiotherapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Birgitte V. Offersen, Jan Alsner, Hanne M. Nielsen, Erik H. Jakobsen, Mette H. Nielsen, Lars Stenbygaard, Anders N. Pedersen, Mette S. Thomsen, Esben Yates, Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mirjana Josipovic, Maj-Britt Jensen, Jens Overgaard
Summary: External-beam PBI is noninferior to WBI in terms of breast induration for patients with low-risk breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kimberly J. Jurgensen, William K. J. Skinner, Bryan Oronsky, Nacer D. Abrouk, Andrew E. Graff, Reid D. Landes, William E. Culp, Thomas A. Summers, Lynnette H. Cary
Summary: The present studies demonstrate that systemic administration of RRx-001 prior to total body irradiation significantly improves overall survival and bone marrow regeneration in mice, suggesting potential applications in radiation protection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physics, Applied
Zenghua Cai, Yuning Wu, Shiyou Chen
Summary: First-principles calculations show significant knock-on atomic displacement damage in the organic-inorganic hybrid perovskite CH3NH3PbI3, with displacement of H, C, N, and I atoms dependent on incident energy. High-energy irradiation can cause simultaneous loss of CH3NH3 and I due to knock-on displacements, which may impact experimental conclusions.
APPLIED PHYSICS LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Masaru Yamaguchi, Yota Tatara, Eka Djatnika Nugraha, Yoshiaki Sato, Tomisato Miura, Masahiro Hosoda, Mukh Syaifudin, Shinji Tokonami, Ikuo Kashiwakura
Summary: Proteomic analysis of serum components from mice exposed to ionizing radiation revealed dose-dependent protein variations and oxidative modifications in albumin. It also detected variations in other proteins that correlated with radiation dose. These findings suggest that protein variations and serum albumin oxidative modification responses may serve as important indicators for the effects of radiation on living organisms and as potential biomarkers for radiation dose estimation.
Article
Optics
Yue Zhou, Dawei Bi, Songlin Wang, Longsheng Wu, Yi Huang, Enxia Zhang, Daniel M. Fleetwood, Aimin Wu
Summary: In this study, the radiation responses of silicon photonic passive devices in silicon-on-insulator technology were investigated. High-energy neutron and Co-60 gamma-ray irradiation caused blue shifts in the wavelengths of micro-ring resonators and Mach-Zehnder interferometers. The devices with SiO2 upper cladding layer exhibited strong tolerance to irradiation.
Article
Engineering, Mechanical
Liangwei Ke, Zhimin Xu, Yifan Liu, Fengxian Xin
Summary: This study proposes a theoretical model for analyzing the time-dependent deformation of poroelastic materials under ultrasonic fields, showing that the material can be stretched or compressed depending on the ratio of thickness to acoustic wavelength. The relaxation process of acoustic deformation is explored, shedding light on the mechanical properties of the material.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Pradeep Bhartiya, Sohail Mumtaz, Jun Sup Lim, Neha Kaushik, Pradeep Lamichhane, Linh Nhat Nguyen, Jung Hyun Jang, Sang Ho Yoon, Jin Joo Choi, Nagendra Kumar Kaushik, Eun Ha Choi
Summary: The study revealed that microwave-irradiated water can significantly alter cellular physiology, while irradiated media and buffered saline solutions have negligible impact on cellular health.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sung Bo Lee, Heung Nam Han
Summary: This study investigated the structural evolution of the grain boundary in a Cu bicrystal at room temperature under beam-irradiation using a C-s-corrected, monochromated transmission electron microscope. The faceting of the grain boundary was observed at low current density but became defaceted at higher current density, with the transition being reversible upon decreasing the current density. The structural transition is attributed to inelastic scattering effects by electron-beam irradiation.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Jianshi Yu, Weiliang Huang, Tian Liu, Amy E. Defnet, Stephanie Zalesak-Kravec, Ann M. Farese, Thomas J. MacVittie, Maureen A. Kane
Summary: High-dose radiation exposure can lead to hematopoietic and gastrointestinal acute radiation syndromes, followed by delayed effects such as damage to various tissues and inflammation. Radiation may disrupt retinoid metabolism, playing a crucial role in inhibiting inflammation and fibrosis development.
Article
Multidisciplinary Sciences
Tai-Sing Wu, Sheng-Fu Chen, Shih-Chang Weng, Yun-Liang Soo
Summary: In this study, an unconventional effect of synchrotron X-ray irradiation on thermally annealed (Y, Co)-codoped CeO2 nanocrystal samples was reported. The experimental data indicated that instead of breaking the Co-O bonds, the X-ray irradiation formed new Co-O bonds by capturing escaping oxygen atoms from the X-ray-broken Ce-O bonds. This effect caused a transition of Co dopant atoms from the energetically-favored Co-O4 structure to the metastable Co-O6 environment, resulting in a fine-tuning of the band gap of the material.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kento Igarashi, Haruki Iwai, Koh-ichi Tanaka, Yoshikazu Kuwahara, Junichi Kitanaka, Nobue Kitanaka, Akihiro Kurimasa, Kazuo Tomita, Tomoaki Sato
Summary: This study found that nasal oxytocin administration after cranial irradiation can protect the neurological function of mice, alleviate cognitive dysfunction, and exert multifaceted neuroprotective effects on DNA damage, while maintaining the chloride ion concentration in neuronal cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Chirag Shah, Xuefei Jia, Brian P. Hobbs, Rahul D. Tendulkar, Sarah M. C. Sittenfeld, Zahraa Al-Hilli, Douglas W. Arthur, Martin E. Keisch, Atif J. Khan, Simona F. Shaitelman, John Boyages, David Wazer, Neilendu Kundu, Frank A. Vicini
Summary: The study found that at 5 years, there was no significant difference in ipsilateral breast tumor recurrence rate between partial breast irradiation (PBI) and whole breast irradiation (WBI), with PBI having lower acute toxicities. Different PBI techniques, such as external beam radiation and brachytherapy, showed varying rates of IBTR.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Adam Institoris, Ciaran Murphy-Royal, Stefano Tarantini, Andriy Yabluchanskiy, Jordan N. Haidey, Anna Csiszar, Zoltan Ungvari, Grant R. Gordon
Summary: Whole brain irradiation (WBI) therapy is a key treatment for brain metastases, but can lead to cognitive decline. This study investigated the impact of WBI on astrocytic Ca2+ signaling and gap junctional coupling, finding that while the latter remained unaffected, there was a long-lasting reduction in synaptic-evoked astrocyte Ca2+ signals, potentially contributing to cognitive impairment post-WBI.
Article
Materials Science, Multidisciplinary
J. Wu, F. Granberg
Summary: Tungsten is chosen as the material for demanding parts in fusion test reactors and power plants. Material degradation due to irradiation necessitates component replacement. Understanding how defects are formed is crucial for predicting replacement needs. Low energy simulations and Frenkel-pair insertion method are compared to investigate the potential of the latter in accelerating cascade simulations. Results show similarities qualitatively, but differences quantitatively, particularly at higher energies.
JOURNAL OF NUCLEAR MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Stephanie J. Shiffka, Jace W. Jones, Linhao Li, Ann M. Farese, Thomas J. MacVittie, Hongbing Wang, Peter W. Swaan, Maureen A. Kane
JOURNAL OF LIPID RESEARCH
(2020)
Article
Cell & Tissue Engineering
Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman
Summary: Gaucher disease is caused by mutations in the GBA1 gene, leading to the accumulation of GlcSph which activates an mTORC1-dependent pathogenic mechanism in neurons. Inhibition of acid ceramidase can prevent mTOR hyperactivity and lysosomal dysfunction, suggesting a potential therapeutic target for GBA1-associated neurodegeneration. Incubation with exogenous GlcSph in wild-type neurons can recapitulate the abnormalities observed in mutant neurons, highlighting the role of GlcSph in the pathogenesis of Gaucher disease.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Biochemical Research Methods
Anh Tran, I. Abrrey Monreal, Eugene Moskovets, Hector C. Aguilar, Jace W. Jones
Summary: An unmet need exists for analytical strategies that can characterize the lipid composition of viral envelopes and do so on a high-throughput scale. The use of atmospheric pressure MALDI with lithium adduct consolidation allows for rapid and confident profiling of total lipid extracts from enveloped viruses, specifically geared towards sphingolipid detection. This approach provides a robust and high-throughput lipid detection platform for structural characterization of lipid extracts from viruses.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Medicine, Research & Experimental
Ni Yang, Lauren E. Parker, Jianshi Yu, Jace W. Jones, Ting Liu, Kyriakos N. Papanicolaou, C. Conover Talbot, Kenneth B. Margulies, Brian O'Rourke, Maureen A. Kane, D. Brian Foster
Summary: The study showed that there is a decline in cardiac ATRA in heart failure, despite sufficient reserves of cardiac vitamin A. Strategies to normalize ATRA metabolism, such as CYP26 inhibition, may have therapeutic potential in preventing cardiac remodeling and functional decline. This suggests that low cardiac ATRA attenuates critical gene expression programs in heart failure.
Article
Chemistry, Analytical
Yulemni Morel, Nivedita Hegdekar, Chinmoy Sarkar, Marta M. Lipinski, Maureen A. Kane, Jace W. Jones
Summary: The study developed a targeted, quantitative method using HILIC separation and selective reaction monitoring mass spectrometry for specific and sensitive quantitation of 100 PE-P structures. Application of this assay to a TBI mouse model demonstrated distinct temporal profiles for plasma PE-P up to 28 days post injury, showing a significant increase 24 hours after induced TBI followed by a gradual reduction to sham concentrations by day 28.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Carballal, Victor Vitvitsky, Roshan Kumar, David A. Hanna, Marouane Libiad, Aditi Gupta, Jace W. Jones, Ruma Banerjee
Summary: This study demonstrates that H2S increases lipid synthesis in cells by affecting mitochondrial NAD(P)H pools and enabling reductive carboxylation of alpha-ketoglutarate. H2S also leads to time-dependent changes in various lipid classes, upregulating triglycerides while downregulating phosphatidylcholine.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Ludovic Muller, Weiliang Huang, Jace W. Jones, Ann M. Farese, Thomas J. MacVittie, Maureen A. Kane
Summary: Radiation exposure leads to dysregulation of lipid and protein composition in the mesenteric lymph node (MLN), affecting pathways regulating lipids and acute phase response. The study demonstrates molecular alterations in MLN after acute radiation exposure, potentially informing on injury mechanism in a non-human primate model of acute radiation syndrome of the gastrointestinal tract.
Article
Biochemistry & Molecular Biology
Owen B. Becette, Anh Tran, Jace W. Jones, John P. Marino, Robert G. Brinson
Summary: Nucleic acids are a popular platform for developing biotherapeutics. There are currently 14 short oligonucleotide therapeutics and 2 mRNA vaccines approved by the FDA. However, there is a lack of high-resolution structural techniques for characterizing these molecules. In this study, nuclear magnetic resonance (NMR) methods were used to structurally fingerprint short oligonucleotide therapeutics, demonstrating their utility and broad applicability.
NUCLEIC ACID THERAPEUTICS
(2022)
Article
Cell Biology
Jianshi Yu, Mariarita Perri, Jace W. Jones, Keely Pierzchalski, Natalia Ceaicovscaia, Erika Cione, Maureen A. Kane
Summary: The study investigated the relationship between RBP1 expression and atRA, finding that RBP1 and atRA are reduced in mammary tumor tissue and tumorigenic epithelial cell lines. Increasing atRA levels could activate direct atRA targets, inhibit proliferation, and collagen deposition. Conditions in tumor microenvironments reduced RBP1 expression and atRA, while treatments with specific agonists or agents could restore RBP1 expression and atRA levels. This work highlights the potential therapeutic benefit of restoring RBP1 expression and endogenous atRA in diseases with reduced RBP1.
Article
Substance Abuse
Bryan Mackowiak, Mingjiang Xu, Yuhong Lin, Yukun Guan, Wonhyo Seo, Ruixue Ren, Dechun Feng, Jace W. Jones, Hongbing Wang, Bin Gao
Summary: The study found that mice chronically fed with ethanol responded less severely to multiple binge ethanol consumption compared to a single binge. The upregulation of the Cyp2b10 gene after binge ethanol intake can indirectly modify ethanol metabolism and reduce acute-on-chronic ethanol-induced liver injury.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Physics, Atomic, Molecular & Chemical
Owen B. Becette, Anh Tran, John P. Marino, Jace W. Jones, Robert G. Brinson
Summary: In this study, a simplified and quick method for identification and assessment of a known impurity in nucleic acid drugs was developed using lithium adduct consolidation combined with mass spectrometry and nuclear magnetic resonance spectroscopy. The method is believed to have broad applicability in academic and industrial laboratories.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Genetics & Heredity
Clorissa L. Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S. Karuppagounder, Yulemni Morel, Jace W. Jones, Alex Zak, Tong Xiao, Tatiana N. Boronina, Robert N. Cole, Namandje N. Bumpus, Christopher J. Chang, Ted M. Dawson, Svetlana Lutsenko
Summary: This study reveals the importance of Cu transporter Atp7b in maintaining Cu homeostasis in the brain during postnatal development. Loss of Atp7b function leads to morphological changes in choroid plexus and affects Cu transporters Atp7a and Slc31a, resulting in Cu deficit and associated imbalance of catecholamines and lipids. These findings contribute to our understanding of the neuropathology of Wilson disease.
Article
Biochemical Research Methods
Yulemni Morel, Jace W. Jones
Summary: Lipid peroxidation is crucial in the development of various diseases, as it causes oxidative damage to lipids, leading to dysfunction and death of cells. This study presents an analytical approach for characterizing the structure of oxidized products of specific types of phospholipids, providing insights into the initial impact of lipid peroxidation on cellular membranes and their role in redox biology.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Zalesak-Kravec, Weiliang Huang, Jace W. Jones, Jianshi Yu, Jenna Alloush, Amy E. Defnet, Alexander R. Moise, Maureen A. Kane
Summary: This study investigated the impact of CRBP1 loss on the adult mouse heart using a multi-omics approach. The results showed that RA levels were decreased in Rbp1(-/-) mouse heart tissue, and metabolomics and proteomics analyses revealed disrupted pathways related to cellular metabolism and cardiac metabolism. These findings characterize the effect of CRBP1 loss and reduced RA in the adult heart.
Article
Biochemical Research Methods
Anh Tran, Liting Wan, Zhenbo Xu, Janette M. Haro, Bing Li, Jace W. Jones
Summary: The research team utilized lithium adduct consolidation to enhance mass-spectrometry-based sphingolipid analysis and implemented an optimized MALDI matrix system for high-throughput detection. They successfully applied the technology to detect differentially expressed sphingolipids in liver, brain, and plasma matrices, validating the method's efficacy.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)