Article
Peripheral Vascular Disease
Vincent Dupont, Rida Al-Rifai, Gael Poitevin, Jeremy Ortillon, Laura Jayyosi, Christine Terryn, Caroline Francois, Philippe Rieu, Guenter Fritz, Camile Boulagnon-Rombi, Caroline Fichel, Ann Marie Schmidt, Claire Tournois, Philippe Nguyen, Fatouma Toure
Summary: Patients with chronic kidney disease (CKD) are more likely to develop peripheral arterial disease (PAD) with a worse prognosis. The receptor for advanced glycation end products (RAGE) plays a critical role in uremia-associated vasculopathy. Deleting the RAGE gene may reduce sFlt1 production and improve post-ischemic revascularization in uremic conditions, suggesting it as a potential therapeutic target for improving outcomes in CKD patients with PAD.
Article
Medicine, Research & Experimental
Qin Jiang, Dong-Yuan Su, Zhen-Zhen Wang, Chang Liu, Ya-Nan Sun, Hong Cheng, Xiu-Miao Li, Biao Yan
Summary: This study provides molecular evidence that the retina is a window of the brain from the circRNA perspective. cGLIS3 is a common regulator and diagnostic marker of cerebral neurodegeneration and retinal neurodegeneration.
Article
Genetics & Heredity
Xia Liu, Miao Ren, Anqi Zhang, Changshun Huang, Junlu Wang
Summary: This study investigated the potential role of ciprofol in cerebral ischemia-reperfusion injury (CIRI) and found that it can alleviate neurological deficits and reduce damage through the Nrf2-xCT-GPX4 signaling pathway.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Cell Biology
Weifeng Shan, Huifeng Ge, Bingquan Chen, Linger Huang, Shaojun Zhu, Yanfeng Zhou
Summary: MiR-499a-5p is downregulated in ischemic stroke patients, and overexpression can reduce cell apoptosis, mainly through inhibiting PDCD4-mediated apoptosis to exert neuroprotective effects.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Jin -Yi Hou, Xiao-Ling Zhou, Xiao-Yuan Wang, Jia Liang, Qun Xue
Summary: PRDX6, a member of the peroxiredoxin family, has been identified as a potential therapeutic target for brain diseases, particularly Alzheimer's disease and ischemic stroke. However, its role in neurons under ischemic conditions was unclear. This study revealed that astrocytes can release PRDX6 extracellularly after OGD/R, exacerbating neuroapoptosis. The PRDX6/RAGE/JNK signaling pathway was found to contribute to this effect. The inhibition of the RAGE signaling pathway showed significant changes in animal behavior in a mouse MCAO model. These findings highlight the crucial role of astrocyte-released PRDX6 in neuroapoptosis caused by OGD/R and provide insights into the molecular mechanism of protecting brain function from ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Xixi Jiang, Kaina Zhang, Chenying Gao, Wenzhuo Ma, Mengqing Liu, Xinyu Guo, Gaowa Bao, Bing Han, Hao Hu, Zhenghang Zhao
Summary: This study investigates the role of Flt3 activation in sympathetic hyperactivity-induced cardiac hypertrophy and its mechanisms of action through autophagy and mitochondrial dynamics. The results suggest that activation of Flt3 may attenuate isoprenaline-induced cardiac hypertrophy by promoting autophagy and balancing mitochondrial dynamics.
Article
Biochemistry & Molecular Biology
Daria Monogiou Belik, Riccardo Bernasconi, Lifen Xu, Giacomo Della Verde, Vera Lorenz, Vivienne Gruterich, Melania Balzarolo, Michika Mochizuki, Otmar Pfister, Gabriela M. Kuster
Summary: This study aimed to test whether Flt3-targeting TKI treatment aggravates cardiac injury after myocardial infarction (MI). The results showed that quizartinib did not alter cardiac dimensions or function in healthy mice, but significantly enhanced ventricular dilatation and apoptotic cell death in MI mice. In vitro studies further confirmed that quizartinib increased cell death and apoptosis, potentially through a p38-dependent mechanism.
Article
Biochemistry & Molecular Biology
Yumei Liao, Jun-Ya Wang, Yan Pan, Xueyi Zou, Chaoqun Wang, Yinghui Peng, Yun-Lin Ao, Mei Fong Lam, Xiaoshen Zhang, Xiao-Qi Zhang, Lei Shi, Shiqing Zhang
Summary: In this study, THA was isolated from Alstonia scholaris and examined for its neuroprotective effect against OGD/R-induced neuronal damage. It was found that THA increased cell viability and ameliorated autophagy-lysosomal dysfunction induced by OGD/R. THA also activated the Akt/mTOR pathway.
Article
Biochemistry & Molecular Biology
Zengxin Qi, Yusheng Tong, Hao Luo, Ming Chen, Nan Zhou, Liang Chen
Summary: Oxidative stress has a close relationship with cerebral ischemic/reperfusion (I/R) injury. The Keap1-Nrf2 pathway is a defensive system to maintain cellular redox homeostasis. In this study, compound 6 K was found to be a promising antioxidant treatment for cerebral I/R injury through activation of Nrf2 and suppression of oxidative stress.
BIOORGANIC CHEMISTRY
(2023)
Article
Cell Biology
Haoran Hu, Xuyu Cheng, Fei Li, Zhu Guan, Jian Xu, Dongming Wu, Yiyun Gao, Xinyu Zhan, Ping Wang, Haoming Zhou, Zhuqing Rao, Feng Cheng
Summary: Aging impairs efferocytosis of macrophages, leading to increased liver ischemia and reperfusion injury. Activation of MerTK can improve efferocytosis and reduce inflammation and liver injury. This study provides a new mechanism and potential therapy for promoting inflammation resolution and efferocytosis in aged livers.
CELL DEATH DISCOVERY
(2023)
Article
Obstetrics & Gynecology
Jessica R. Zolton, Lindsey A. Sjaarda, Sunni L. Mumford, Elizabeth A. DeVilbiss, Keewan Kim, Kerry S. Flannagan, Jeannie G. Radoc, Neil J. Perkins, Robert M. Silver, Jean Wactawski-Wende, Micah J. Hill, Alan H. DeCherney, Enrique F. Schisterman
Summary: Circulating VEGF and sFLT-1 did not vary significantly across the menstrual cycle in normal ovulating women, and may not be useful as peripheral biomarkers of endometrial changes during the menstrual cycle. Plasma may be the preferred medium for measuring circulating VEGF in reproductive-age women, regardless of menstrual cycle phase.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Wanying Cheng, Lingling Wang, Xin Gao, Guangli Yin, Jujuan Wang, Yongqian Shu, Hongxia Qiu, Limin Duan
Summary: sFLt-1 is a reliable immune biomarker for predicting the inflammatory status and prognosis of secondary hemophagocytic lymphohistiocytosis (sHLH).
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Annika Schulz, Carolin Christina Drost, Bettina Hesse, Katrin Beul, Marcus Brand, Giovana Seno Di Marco
Summary: sFlt-1 has damaging effects on endothelial cell structure and function. Its levels are correlated with endothelial cell cortex stiffening, which is accompanied by cytoskeleton reorganization and changes in endothelial barrier function, mediated by p38 MAPK activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.