Article
Gastroenterology & Hepatology
Allon Kahn, Julia Crook, Michael G. Heckman, Mikolaj A. Wieczorek, Sarmed Sami, Diana Snyder, Siddharth Agarwal, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, W. Keith Tan, Ramona Lansing, Kenneth K. Wang, Krish Ragunath, Massimiliano DiPietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Cadman L. Leggett, Prasad G. Iyer
Summary: This study proposes optimal surveillance intervals after complete eradication of intestinal metaplasia (CE-IM) based on a multicenter international cohort, aiming to reduce the endoscopic burden for patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tony He, Vijaya Sundararajan, Nicholas J. Clark, John Slavin, Edward H. Tsoi, Alexander J. Thompson, Bronte A. Holt, Paul V. Desmond, Andrew C. F. Taylor
Summary: Routine surveillance biopsy sampling of normal-appearing tubular esophageal neosquamous epithelium has no yield for detecting recurrent nondysplastic BE or dysplasia after CRIM. Dysplastic recurrences are predominantly visible and located in BE islands, while dysplastic recurrences at the gastroesophageal junction are less visible. Endoscopic features can help identify recurrent advanced dysplasia or neoplasia.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Quinn S. Solfisburg, Sarmed S. Sami, Joel Gabre, Ali Soroush, Lovekirat Dhaliwal, Claire Beveridge, Zhezhen Jin, John M. Poneros, Gary W. Falk, Gregory G. Ginsberg, Kenneth K. Wang, Charles J. Lightdale, Prasad G. Iyer, Julian A. Abrams
Summary: Recurrence of intestinal metaplasia at the gastroesophageal junction (GEJIM) after endoscopic eradication of Barrett's esophagus (BE) is common, but not associated with an increased risk of subsequent dysplasia. Older age and longer initial BE length are independently associated with recurrence.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Swathi Eluri, Anna Paterson, Brianna N. Lauren, Maria O'Donovan, Pradeep Bhandari, Massimiliano di Pietro, Minyi Lee, Rehan Haidry, Laurence Lovat, Krish Ragunath, Chin Hur, Rebecca C. Fitzgerald, Nicholas J. Shaheen
Summary: This study assessed the application value of Cytosponge in BE patients after RFA. The results showed that Cytosponge testing is a cost-effective surveillance method and is strongly associated with residual BE after ablation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Arvind J. Trindade, Jianying Zhang, Kara L. Raphael, Jiejing Qiu, John Hauschild, Petros C. Benias
Summary: This retrospective observational study examined the utilization of endoscopic ablation therapy and esophagectomy in patients with Barrett's esophagus. The study found an increasing trend in the utilization of ablation therapy, while esophagectomy showed a decreasing trend. These findings suggest that endoscopic ablation therapy has become the predominant method of treatment for Barrett's esophagus with dysplasia.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Kazuaki Norita, Tomoyuki Koike, Masahiro Saito, Hirohiko Shinkai, Reiko Ami, Yasuhiko Abe, Naohiro Dairaku, Yoshifumi Inomata, Shoichi Kayaba, Fumitake Ishiyama, Tomoyuki Oikawa, Motoki Ohyauchi, Hirotaka Ito, Sho Asonuma, Tatsuya Hoshi, Katsuaki Kato, Shuichi Ohara, Yosuke Shimodaira, Kenta Watanabe, Tooru Shimosegawa, Atsushi Masamune, Katsunori Iijima
Summary: This study followed 98 patients with Barrett's esophagus (BE) of maximum length ≥ 2 cm in Japan for over 5 years and found that the incidence of esophageal adenocarcinoma (EAC) was 0.47% per year, lower than the previously reported 1.2% per year. Further large-scale studies are needed to validate these results.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Esther A. Nieuwenhuis, Sanne N. van Munster, Wouter L. Curvers, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, B. Ed Schenk, Arjun D. Koch, Manon C. W. Spaander, Thjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Jacques J. G. H. M. Bergman, Erik J. Schoon, Roos E. Pouw
Summary: One quarter of patients with confirmed low grade dysplasia (LGD) in Barrett's esophagus (BE) diagnosed in a community hospital had high grade dysplasia (HGD) or cancer after re-staging at an expert center. Referral of patients with confirmed LGD, even without visible lesions, for re-staging endoscopy at an expert center is necessary.
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Surgery
Ravi Vissapragada, Norma B. Bulamu, Christine Brumfitt, Jonathan Karnon, Roger Yazbeck, David I. Watson
Summary: Studies revealed that guideline-specified endoscopic surveillance for patients with non-dysplastic Barrett's esophagus (NDBE) was not cost-effective. Instead, a strategy of deselecting low-risk NDBE patients from surveillance may be a cost-effective approach.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Zachary L. Smith, Abigail M. Thorgerson, Aprill Z. Dawson, Sachin Wani
Summary: This study provides real-world data on critical outcomes for Barrett's esophagus patients undergoing endoscopic eradication therapy (EET), demonstrating a low risk of incident esophageal adenocarcinoma, all-cause mortality, and the need for esophagectomy.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Paul Wolfson, Kai Man Alexander Ho, Ash Wilson, Hazel McBain, Aine Hogan, Gideon Lipman, Jason Dunn, Rehan Haidry, Marco Novelli, Alessandro Olivo, Laurence B. Lovat
Summary: Radiofrequency ablation (RFA) treatment is effective and durable in preventing esophageal adenocarcinoma. Most relapses occur early but can be successfully retreated.
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Shashank Garg, Jesse Xie, Sumant Inamdar, Sheila L. Thomas, Arvind J. Trindade
Summary: Dysplasia in Barrett's esophagus is predominantly located in the right half of the esophagus before ablation therapy. Post-ablation recurrence of dysplasia is more commonly found at the top of the gastric folds and is non-visible compared to the tubular esophagus.
Article
Surgery
Ryosuke Kobayashi, Natalia Causada Calo, Norman Marcon, Yugo Iwaya, Yuto Shimamura, Hirokazu Honda, Catherine Streutker, Jeffrey Mosko, Gary May, Christopher Teshima
Summary: This study found that achieving complete eradication of intestinal metaplasia (CE-IM) following the complete eradication of neoplasia (CE-N) can reduce the risk of recurrent dysplasia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Immunology
Samah Mohamed Awad, Mohammed Taha, Mahmoud Omar, Ashraf Khalil
TRANSPLANT IMMUNOLOGY
(2020)
Article
Transplantation
Kristen M. Kidson, Jeieung Park, Marthe K. Charles, Mahmoud Omar, Mel Krajden, Alissa J. Wright, Trana Hussaini, Peter T. W. Kim, Stephen W. Chung, Eric M. Yoshida
Summary: In cases where urgent liver transplantation is needed for patients with active COVID-19 infection, successful transplantation has been reported, saving the patient's life. This case is only the second of its kind worldwide and the first in Canada.
TRANSPLANTATION DIRECT
(2021)