Journal
FUTURE ONCOLOGY
Volume 15, Issue 15, Pages 1771-1780Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0606
Keywords
biomarker; hepatocellular carcinoma; immunohistochemistry; prognosis
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Funding
- National Natural Science Foundation of China [81472278, 81472769, 81201937]
- Funds for Creative Research Groups of the National Natural Science Foundation of China [81521091]
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Aim: MTHFD1 was the enzyme providing one-carbon derivatives of tetrahydrofolate. We sought to investigate the impact of MTHFD1 on hepatocellular carcinoma (HCC). Methods: Bioinformatic analysis, western blot and immunohistochemistry were conducted to detect MTHFD1 expression in HCC. The relationships between MTHFD1 and prognosis of 172 HCCs were analyzed by Kaplan-Meier method and Cox proportional hazards model. Results: High MTHFD1 expression in HCC represented poor prognosis (overall survival p =0.025; time to recurrence p =0.044). Combining MTHFD1 with serum AFP, survival analysis demonstrated the prognosis of the MTHFD1 low expression and AFP <= 20ng/ml group was better than that of the MTHFD1 high expression or AFP >20ng/ml group and the MTHFD1 high expression and AFP >20ng/ml group (overall survival p<0.0001; time to recurrence p<0.0001). Conclusion: High MTHFD1 expression in HCC indicated poorer prognosis. Combining MTHFD1 with serum AFP improved the accuracy of prognostic prediction.
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