Journal
FITOTERAPIA
Volume 136, Issue -, Pages -Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.104186
Keywords
Delphinium brunonianum; Acetylcholinesterase; Butyrylcholinesterase; Amide alkaloids
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Funding
- National Natural Science Foundation of China [81873091, 81573566, 81673872, 81460659]
- Department of Education Guangdong of Province [YQ2013043]
- Department of Science and Technology of Tibet autonomous region
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Five new amide alkaloids, named delamide A-E (1-5), along with five known ones, methyl-N-(3-carboxy-2-methylpropanoyl) anthranilate (6), benzoic acid, 2-[(1-oxodecyl) amino]-methylester (7), puberline (8), benzoic acid, 2- [(4-methoxy-2-methyl-1, 4-dioxobutyl) amino]-methylester (9) and benzoic acid, 2- [(4-methoxy-3-methyl-1, 4-dioxobutyl) amino]-methylester (10) were isolated from the extract of Delphinium brunonianum. Their structures were elucidated by extensive spectroscopic analyses (including 1D-, 2D-NMR, and HR-ESI-MS). 1-10 were also evaluated for their acetylcholinesterase (AChE) inhibiting activity by the Ellman's method. Delamide A (1) showed highly selective AChE inhibition activity. The kinetic analysis revealed that 1 was a mixed-type reversible inhibitor of AChE.
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