Zizhines G-O, AchE inhibitory meroterpenoids from Ganoderma sinensis

Zizhines G-O (1-9), nine new meroterpenoids, and seven known analogs (10-16) were isolated from the dried fruiting bodies of Ganoderma sinensis. Their structures were identified by using spectroscopic data and CD curve comparison. The inhibitory activities of the selected new meroterpenoids toward AchE were assessed in vitro. Compounds 1-6 and 10-14 were found to exhibit AchE inhibitory activities at the concentration of 50 mu M.