Journal
FITOTERAPIA
Volume 134, Issue -, Pages 250-255Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.02.021
Keywords
Ganoderma australe; Meroterpenoids; Neuroprotection
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Funding
- Shenzhen Science and Technology Innovation Committee for Basic Research [JCYJ20170307170742519]
- National Science Fund for Distinguished Young Scholars [81525026]
- National Key Research and Development Program of China [2017YFA0503900]
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Six new meroterpenoids, australeols A - F (1-6), together with nineteen known compounds (7-25), were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13, (-)-19, and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells.
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