Article
Obstetrics & Gynecology
Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: A review found that assessing endometrial receptivity is difficult in natural conception due to adenomyosis and endometriosis affecting fertility. However, recent data from assisted reproductive technology has allowed the study of endometrial receptivity in affected women, challenging previous beliefs about the disorders' effects on embryo implantation. The existence of altered receptivity in assisted reproductive technology is now being questioned, as frozen euploid blastocyst transfers in estradiol and progesterone cycles have shown unchanged outcomes in both disorders.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Bin He, Xiao-Ming Teng, Fan Hao, Mei Zhao, Zhi-Qin Chen, Kun-Ming Li, Qiang Yan
Summary: This study found that intracellular protein level of IL-33 was downregulated in the endometrium of patients with adenomyosis, and IL-33 expression status was positively correlated with that of HOXA10. In vitro experiments demonstrated that IL-33 overexpression enhanced embryo implantation through induction of STAT3 phosphorylation, which was inhibited by the STAT3 inhibitor cryptotanshinone. Validation in an adenomyosis mouse model confirmed the positive relationship between IL33 and HOXA10 expression in the endometrium.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman, Adila A. Hamid, Norhazlina Abdul Wahab, Mohd Helmy Mokhtar
Summary: Endometrial receptivity refers to the readiness of the endometrium for embryo implantation. Impairment of endometrial receptivity due to hyperandrogenism or androgen excess can lead to pregnancy loss or infertility. Various clinical conditions are associated with hyperandrogenism, including polycystic ovary syndrome (PCOS), hirsutism, congenital adrenal hyperplasia, and hyperprolactinemia. Elevated testosterone levels have been linked to recurrent miscarriages by altering the endometrial milieu. Mechanisms such as the HOXA gene, aV & beta;3 integrin, CDK signaling pathway, MECA-79, and MAGEA-11 are involved in the modulation of endometrial receptivity in the presence of hyperandrogenic state. This review aims to explore the manifestations of androgen excess other than PCOS and understand the potential mechanisms underlying endometrial receptivity impairment caused by androgen excess leading to pregnancy loss or infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Yaoming Peng, Zhixing Jin, Haiou Liu, Congjian Xu
Summary: The endometrial stromal cells of adenomyosis exhibit a defective ability for full decidualization, which may result in a nonreceptive endometrium. Changes in the secretion of cytokines and matrix metalloproteinases were also observed, indicating an aberrant decidualization response in adenomyosis.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Iwona Scheliga, Dunja M. Baston-Buest, Gereon Poschmann, Kai Stuehler, Jan-Steffen Kruessel, Alexandra P. Bielfeld
Summary: Endometrial scratching has been widely used in assisted reproductive technology to improve pregnancy rates, but its mechanism and benefits are still not fully understood or investigated. Proteomic analysis suggests that the scratching procedure may impact proteins involved in immune response pathways and cytoskeleton formation, potentially increasing endometrial receptivity and enhancing embryo implantation. This pilot study provides data that explain the possible benefits of endometrial scratching for patients in infertility treatment and highlights potential changes in the endometrium due to the procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Song Guo, Di Zhang, Xiaowei Lu, Qian Zhang, Ruihuan Gu, Binghui Sun, Yijuan Sun
Summary: The study found that patients with Adenomyosis (AM) have lower levels of endometrial HOXA10 and HOXA11 expression, but higher levels of HIF-2 alpha. Administering an HIF-2 alpha antagonist increased the expression levels of Hoxa10 and Hoxa11 in AM model mice. This suggests that HIF-2 alpha overexpression may contribute to decreased endometrial receptivity in AM.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yue Zhang, Xinman Du, Xuemei Chen, Hongyu Tang, Qin Zhou, Junlin He, Yubin Ding, Yingxiong Wang, Xueqing Liu, Yanqing Geng
Summary: This study demonstrates the important role of Rictor in regulating uterine receptivity, which is crucial for both mice and humans. Loss of Rictor leads to impaired fertility and altered expression in the endometrium of women with infertility.
Article
Immunology
Bohan Li, Hua Duan, Sha Wang, Jiajing Wu, Yazhu Li
Summary: The level of immune infiltration is closely associated with successful embryo implantation. Macrophage-endometrium interaction modules play a critical role in reproductive outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Jin-xiang Wu, Shu Lin, Shuang-bo Kong
Summary: Psychological stress can adversely affect endometrial function, leading to female infertility, which significantly impacts quality of life and psychological well-being.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Fei Guo, Yufan Huang, Taniya Fernando, Yingli Shi
Summary: Impaired endometrial development and receptivity in PCOS patients contribute to lower pregnancy rates and higher miscarriage rates, but are often overlooked in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, Research & Experimental
George-Alexandru Rosu, Cringu Antoniu Ionescu, Florin Daniel Calin, Mihai Dimitriu, Liana Ples, Alexandra Matei, Dan-Bogdan Navolan
Summary: The location and size of submucosal fibroids are predictive factors of impaired fertility, with different types of fibroids having varying effects on fertility. Uterine cavity distortion is an important factor that alters the normal development of a pregnancy and the birth rate.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Reproductive Biology
Jiao Tian, Chunxue Zhang, Nannan Kang, Junxia Wang, Na Kong, Jidong Zhou, Min Wu, Lijun Ding, Haixiang Sun, Guijun Yan, Xiaoqiang Sheng
Summary: The establishment of endometrial receptivity is crucial for successful pregnancy, and women with adenomyosis have lower chances of clinical pregnancy after assisted reproductive technology due to impaired endometrial receptivity. The study found that attenuated MAOA can impair endometrial receptivity by promoting inappropriate proliferation of EECs through the downregulation of FOXO1, highlighting the vital role of MAOA in female reproduction.
BIOLOGY OF REPRODUCTION
(2021)
Article
Oncology
Xiaohong Guan, Dan Liu, Hong Zhou, Chaoqun Dai, Tao Wang, Yuan Fang, Yanping Jia, Kunming Li
Summary: In this study, the effect of melatonin on uterine receptivity and pregnancy outcomes in an adenomyosis mouse model was investigated. The results showed that melatonin significantly improved implantation rates and restored impaired uterine development and endometrial receptivity in the adenomyosis mice. Melatonin also mitigated adenomyosis-induced changes in the uterine microenvironment and improved pregnancy outcomes by inhibiting the NF-kappa B signaling pathway and decreasing endometrial cell apoptosis. These findings provide new insight into melatonin-based therapy for adenomyosis-related infertility.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
David Kuzel, Zdenka Lisa, Michael Fanta, Zdenek Zizka, Barbora Boudova, Tereza Cindrova-Davies, Michal Mara
Summary: This study demonstrates that hysteroscopy in women using LNG-IUS is an effective method for managing symptoms related to endometrial polyps and submucous leiomyomas, with an 82.6% postoperative symptom relief rate. The successful resection of intrauterine pathology was achieved in all cases, with some procedures performed without general anesthesia.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Immunology
Zhanhu Zhang, Tianqi Li, Lili Xu, Qiuhong Wang, Haibo Li, Xingmin Wang
Summary: This study found that the extracellular superoxide produced by Enterococcus faecalis can induce the expression of inflammatory cytokines, promote apoptosis, and reduce the expression of receptivity biomarkers in endometrial epithelial cells, suggesting that it is an important virulence factor for E. faecalis-induced endometritis.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)