Journal
FEBS LETTERS
Volume 593, Issue 10, Pages 1089-1101Publisher
WILEY
DOI: 10.1002/1873-3468.13387
Keywords
invasion; matrix metalloproteinases; metastasis; miR-134; osteosarcoma
Funding
- Natural Science Foundation of China [81772867]
- Applied Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province [201801D121215]
- Key Research and Development Program of Shanxi Province [201603D321051]
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miR-134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR-134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR-134 directly targets the 3 '-UTRs of MMP1 and MMP3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. We propose miR-134 as an attractive novel therapeutic target for the treatment of osteosarcoma.
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