A patent review of bisphosphonates in treating bone disease

Pharmacology of Bisphosphonates

(2019) Serge Cremers et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

(2019) Staci L. Haney et al.   ONCOGENE

Pharmacometrics and systems pharmacology for metabolic bone diseases

(2019) Matthew M. Riggs et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

(2018) Robert A. Matthiesen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT)

(2018) Łukasz Joachimiak et al.   ChemMedChem

Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor

(2018) Staci L. Haney et al.   INVESTIGATIONAL NEW DRUGS

Role of Bone-Modifying Agents in Multiple Myeloma: American Society of Clinical Oncology Clinical Practice Guideline Update

(2018) Kenneth Anderson et al.   JOURNAL OF CLINICAL ONCOLOGY

Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors

(2018) Cyrus M. Lacbay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study

(2018) Noopur Raje et al.   LANCET ONCOLOGY

Rab GTPases in Osteoclastic Endomembrane Systems

(2018) Michèle Roy et al.   Biomed Research International

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases

(2017) Andrew L. Himelstein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)

(2017) Michelle A Lawson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors

(2017) Aleksandra Kaźmierczak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase

(2017) Cheryl Allen et al.   MOLECULAR PHARMACOLOGY

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

(2017) Staci Haney et al.   MOLECULES

Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1–34)

(2017) Jacquelin Jolette et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice

(2016) Naomi O. Hodgins et al.   JOURNAL OF CONTROLLED RELEASE

Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates

(2016) Robert A. Matthiesen et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation

(2015) Xiang Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase

(2015) Veronica S. Wills et al.   ACS Medicinal Chemistry Letters

Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages

(2015) Manabu Ueno et al.   Nature Communications

Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase

(2014) Xiang Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nanoparticles for the delivery of zoledronic acid to prostate cancer cells: A comparative analysis through time lapse video-microscopy technique

(2014) Chiara Schiraldi et al.   CANCER BIOLOGY & THERAPY

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT

(2014) Fraser P. Coxon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Recent Prevalence of Osteoporosis and Low Bone Mass in the United States Based on Bone Mineral Density at the Femoral Neck or Lumbar Spine

(2014) Nicole C Wright et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Long-term Follow-up of MRC Myeloma IX Trial: Survival Outcomes with Bisphosphonate and Thalidomide Treatment

(2013) G. J. Morgan et al.   CLINICAL CANCER RESEARCH

Liposome encapsulation of zoledronic acid results in major changes in tissue distribution and increase in toxicity

(2013) Hilary Shmeeda et al.   JOURNAL OF CONTROLLED RELEASE

The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets

(2012) Andrew Wiemer et al.   Anti-Cancer Agents in Medicinal Chemistry

Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study

(2012) M. Varenna et al.   RHEUMATOLOGY

Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors

(2011) Katarzyna M. Błażewska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Randomized, Double-Blind Study of Denosumab Versus Zoledronic Acid in the Treatment of Bone Metastases in Patients With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma

(2011) David H. Henry et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes

(2011) Monica Marra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Human protein tyrosine phosphatase-σ: Alternative splicing and inhibition by bisphosphonates

(2010) Naoto Endo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lasofoxifene in Postmenopausal Women with Osteoporosis

(2010) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography–electrospray ionization mass spectrometry

(2009) Marjo Jauhiainen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer

(2009) Michael Gnant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease

(2008) Michelle A. Lawson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

(2008) Fraser P. Coxon et al.   BONE

Structures of RabGGTase–substrate/product complexes provide insights into the evolution of protein prenylation

(2008) Zhong Guo et al.   EMBO JOURNAL

Rho GTPases in osteoclasts: Orchestrators of podosome arrangement

(2008) S ORY et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase

(2008) Rudi A. Baron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Is Required for the Anti-Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo

(2008) Lilian I Plotkin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

(2007) Andrew J. Wiemer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prevalence of Pelvic Paget's Disease of Bone in the United States

(2006) R. D. Altman et al.   JOURNAL OF BONE AND MINERAL RESEARCH