Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 31-32, Pages 5196-5200Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900570
Keywords
Arynes; Insertion; Nitrogen heterocycles; Ring expansion; Synthetic methods
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Funding
- EPSRC [EP/M026221/1] Funding Source: UKRI
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Arynes have been found to undergo formal sigma-bond insertion into a C(sp3)-N bond for the first time. This transformation is utilized in the ring expansion of 1,3-diaza-heterocycles to afford benzofused medium-ring N-heterocycles in a single step. This represents a novel route to biologically relevant 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepines, prepared directly from easily accessible imidazolidines. An example of the ring expansion of a 1,3-diazetidine is also reported, which affords the corresponding 1,2,3,4-tetrahydroquinazoline.
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