Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice

Optimization of sample preparation and chromatography for the determination of perfluoroalkyl acids in sediments from the Yangtze Estuary and East China Sea

(2018) Qian-wen Wang et al.   CHEMOSPHERE

Elevated concentrations of perfluorohexanesulfonate and other per- and polyfluoroalkyl substances in Baiyangdian Lake (China): Source characterization and exposure assessment

(2018) Qianqian Cui et al.   ENVIRONMENTAL POLLUTION

Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks

(2017) Kan Li et al.   ENVIRONMENT INTERNATIONAL

Molecular Mechanisms of Perfluorooctanoate-Induced Hepatocyte Apoptosis in Mice Using Proteomic Techniques

(2017) Kan Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse bioeffect of perfluorooctanoic acid on liver metabolic function in mice

(2017) Xinmou Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The impact of exposure to environmental contaminant on hepatocellular lipid metabolism

(2017) Zongguang Hui et al.   GENE

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

Acot1 is a sensitive indicator for PPARα activation after perfluorooctanoic acid exposure in primary hepatocytes of Sprague-Dawley rats

(2017) Hui Liu et al.   TOXICOLOGY IN VITRO

Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)

(2016) Shuji Tsuda   JOURNAL OF TOXICOLOGICAL SCIENCES

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Hydroxamate-Based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via a Histone Deacetylase-Independent Catalase-Like Mechanism

(2015) David E. Olson et al.   CHEMISTRY & BIOLOGY

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Oxidative stress alters global histone modification and DNA methylation

(2015) Yingmei Niu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes

(2015) Thorsten Buhrke et al.   TOXICOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA)

(2014) Erin M. Quist et al.   TOXICOLOGIC PATHOLOGY

PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

(2014) Ling Wang et al.   Scientific Reports

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

(2013) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

Histone deacetylase inhibitors in the treatment for multiple myeloma

(2013) Teru Hideshima et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid

(2013) Siyuan Peng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Perfluorooctanoic acid induces apoptosis through the p53-dependent mitochondrial pathway in human hepatic cells: A proteomic study

(2013) Qingyu Huang et al.   TOXICOLOGY LETTERS

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Polyfluorinated Compounds: Past, Present, and Future

(2011) Andrew B. Lindstrom et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy

(2011) S Spiegel et al.   ONCOGENE

Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues

(2011) Barbara D. Abbott et al.   REPRODUCTIVE TOXICOLOGY

Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring

(2011) Tian Chen et al.   REPRODUCTIVE TOXICOLOGY

Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low-Dose Developmental Effects and Internal Dosimetry

(2011) Madisa B. Macon et al.   TOXICOLOGICAL SCIENCES

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

(2010) Jessica M. Ellis et al.   Cell Metabolism

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

(2010) Maryam Rakhshandehroo et al.   PPAR Research

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Chromatin-modifying enzymes as therapeutic targets – Part 2

(2008) Brian R Keppler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Chromatin-modifying enzymes as therapeutic targets – Part 1

(2008) Brian R Keppler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS