Review
Microbiology
Sayanta Mondal, Krishnendu Pramanik, Sudip Kumar Ghosh, Priyanka Pal, Tanushree Mondal, Tithi Soren, Tushar Kanti Maiti
Summary: Arsenic is a major pollutant of soil and water, posing serious health concerns to human lives as it enters the food chain through contaminated crops. Indigenous, free-living As-resistant plant growth-promoting rhizobacteria (PGPR) play a crucial role in As immobilization and increasing As tolerance in host plants. They also impact the antioxidative defense system in plants and reduce membrane damage and electrolyte leakage, salvaging As-induced photosynthetic damage.
MICROBIOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Chandramohan Muthu Lakshmi Bavithra, Marimuthu Murugan, Shanmugasundaram Pavithran, Kathirvel Naveena
Summary: Insecticide resistance in insects is a major threat to human health and agriculture, leading to pest management failures, increased costs, decreased crop yields, and public health disasters. The resistance is caused by factors such as indiscriminate insecticide usage and selection pressure on insect populations. Insects respond to insecticide stress at the cellular level through genetic propagations, transcriptional and post-transcriptional regulatory signals, and physiological changes. Understanding these cellular intricacies can help develop alternative pest control methods targeting insect vulnerabilities and using technologies like RNA interference to manage resistance-related genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Engineering, Environmental
Balasubramanian Sriram, Jeena N. Baby, Yung -Fu Hsu, Sea-Fue Wang, Mary George
Summary: In the wake of the COVID-19 pandemic, the increased use of antibiotics worldwide has raised concerns about pharmaceutical pollution and antimicrobial resistance. This study investigates the use of rare earth vanadates as electrochemical probes for the detection of pharmaceutical compounds. Through a comparative study of different rare earth vanadates, it is discovered that the composition of the cationic site affects the electrochemical properties, with dysprosium-based vanadate showing superior conductivity and charge transfer characteristics. This research provides an efficient method for the simultaneous detection of nitrofurazone and roxarsone residues and offers insights into the relationship between cationic site composition and electrochemical behavior.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Agronomy
Debora Boaventura, Benjamin Buer, Niklas Hamaekers, Frank Maiwald, Ralf Nauen
Summary: The study found that the Bt-resistant Brazilian strain Sf_Des has medium resistance to deltamethrin and chlorpyrifos, high cross-resistance to Cry1 toxins but high susceptibility to Vip3A. In comparison to the susceptible strain Sf_Bra, Sf_Des exhibited up to 19-fold increased cytochrome P450 activity and upregulation of multiple P450 transcripts. Gene Ontology analysis categorized most differentially expressed genes into oxidation-reduction and metabolic processes.
PEST MANAGEMENT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Di Ju, David Mota-Sanchez, Eduardo Fuentes-Contreras, Ya-Lin Zhang, Xiao-Qi Wang, Xue-Qing Yang
Summary: Despite the implementation of environmentally compatible integrated control strategies, such as mating disruption and attract-kill strategies, the management of codling moth still heavily relies on insecticides. There have been varying levels of insecticide resistance towards different types of insecticides in codling moth populations worldwide, involving both metabolic and target-site mechanisms.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Engineering, Environmental
Caide Huang, Xiaoling Zhang, Kun Wang, Shizhong Yue, Yuhui Qiao
Summary: The study indicates that earthworm offspring can develop metal resistance despite suffering more severe toxicity effects under cross-generation exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Meng Ma, Xiao-Di Zhai, Hui-Qian Xu, Peng-Yu Guo, Jin-Jun Wang, Dong Wei
Summary: In this study, 34 GST genes were identified from the melon fly, Zeugodacus cucurbitae, and classified into six classes. The expression of these genes showed dynamic changes during the developmental stage and were mainly expressed in anti-stress-related tissues. When exposed to insecticides, some genes were significantly up-regulated, indicating their involvement in detoxification. One gene, ZcGSTe4, was found to confer tolerance to fl-cypermethrin when over-expressed, and its suppression increased the sensitivity of the melon fly to this agent.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhiming Yang, Tianxiang Xiao, Kai Lu
Summary: In this study, it was found that inhibiting the activity of UGT enzyme effectively increased the toxicity of chlorpyrifos to the chlorpyrifos-resistant strain of Nilaparvata lugens. The resistant strain showed higher content of UGT compared to the susceptible strain. Four UGT genes (UGT386H2, UGT386J2, UGT386N2, and UGT386P1) were significantly overexpressed in the resistant strain and could be induced by chlorpyrifos. Knockdown of UGT386H2 or UGT386P1 increased the susceptibility of the resistant strain to chlorpyrifos. These findings suggest that overexpression of these two UGT genes contributes to chlorpyrifos resistance in N. lugens.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anis Aboutalebian-Soureshjani, Hooshang Rafiee-Dastjerdi, Bahram Naseri, Mahdi Hassanpour, Jahangir Khajehali
Summary: This study investigated the occurrence of resistance to indoxacarb and the underlying mechanisms in Iranian populations of T. absoluta. The results showed that the populations have developed resistance primarily through changes at the target site.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Engineering, Environmental
Jie-wen Ma, Ya-qing Wu, Chen-Lu Xu, Zhuan-xi Luo, Rui-lian Yu, Gong-ren Hu, Yu Yan
Summary: A study was conducted to investigate the effects of microplastics on the degradation of Rox(V) in soil. It was found that microplastics inhibited the degradation of Rox(V) and also influenced the composition and function of soil bacterial communities. The study highlights the role of microplastics in the risk assessment and remediation of Rox(V)-contaminated soils.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chunmei You, Lulu Zhang, Jiajia Song, Lei Zhang, Congai Zhen, Xiwu Gao
Summary: Long-term and excessive use of insecticides has led to environmental problems and insecticide resistance in pests. The variation in a P450 gene, CYP6G4, is found to be the main driver of carbamate resistance in house flies. Understanding the molecular mechanisms of insecticide resistance is crucial for effective resistance management strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Multidisciplinary
Jiayu Liu, Yangyang Zhao, Zheng Qing Fu, Fengquan Liu
Summary: The research uncovered a self-defense strategy featuring the antibiotic biosynthesis monooxygenase (ABM) family protein LaPhzX for myxin degradation, demonstrating an increased resistance and reduced derivative accumulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Mathieu Schwartz, Valentin Boichot, Stephane Fraichard, Mariam Muradova, Patrick Senet, Adrien Nicolai, Frederic Lirussi, Mathilde Bas, Francis Canon, Jean-Marie Heydel, Fabrice Neiers
Summary: Glutathione transferases (GSTs) are key enzymes that have a wide range of activities as transferases or isomerases. They play important roles in both detoxification and modulation of the perception process in chemosensory organs. By metabolizing exogenous molecules, GSTs contribute to signal termination and modulate receptor activation, ultimately affecting the perception of these molecules. This review provides insights into the involvement of GSTs in chemoperception, discussing their localization and enzymatic capacity in insects and mammals.
Article
Engineering, Environmental
Xia Li, Jie He, Jian Lu, Yi Zhou, Yanbo Zhou
Summary: FeS2-RFR catalyst was successfully prepared for in-situ production of H2O2 and efficient removal of ROX under solar light illumination. This catalyst degraded more than 97% of ROX within 2 hours and selectively transformed ROX into low-toxic As(V) without inhibition effect from cations, anions, or humic acid. FeS2-RFR showed good stability and efficiency in degrading organoarsenic compounds, providing a sustainable and eco-friendly method.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
B. K. Sonu Koirala, Timothy Moural, Fang Zhu
Summary: This article provides a comprehensive overview of the versatile functions and diverse structures of insect GSTs in detoxifying chemical compounds. Recent advancements in technology have greatly enhanced our understanding of the functional and structural diversity of these enzymes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Microbiology
Jun Zhang, Jian Chen, Yi-Fei Wu, Zi-Ping Wang, Ji-Guo Qiu, Xiao-Long Li, Feng Cai, Ke-Qing Xiao, Xiao-Xu Sun, Barry P. Rosen, Fang-Jie Zhao
Summary: Arsenic can be biomethylated to form various organic arsenicals with different toxicities and environmental mobilities. The trivalent methylarsenite (MAs(III)) produced in this process is more toxic than inorganic arsenite (As(III) and can also act as a primitive antibiotic. A new enzyme, ArsV, has been identified in Ensifer adhaerens ST2, which plays a role in detoxifying MAs(III) and Sb(III) by oxidizing them to MAs(V) and Sb(V). Genes encoding ArsV are widely present in soil bacteria according to metagenomic analysis.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Jian Chen, Jun Zhang, Barry P. Rosen
Summary: Organoarsenicals enter the environment from biogenic and anthropogenic sources. Microorganisms can methylate trivalent inorganic arsenite to more toxic methylarsenite and oxidize them. Sources include herbicides and antimicrobial growth promoters, with microorganisms such as Sphingobacterium wenxiniae showing resistance and detoxification abilities.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ngozi P. Paul, Adriana E. Galvan, Kunie Yoshinaga-Sakurai, Barry P. Rosen, Masafumi Yoshinaga
Summary: Arsenicals, one of the oldest treatments for various human disorders, have been paradoxically used as therapeutic agents since ancient times despite their toxicity. After the discovery of antibiotics, most arsenic-based drugs were abandoned, but recent years have seen a renewed interest in their clinical use. The current applications of arsenicals include antimicrobial, antiviral, antiparasitic, and anticancer uses. With the rise of antibiotic resistance and emerging pathogens, revisiting arsenicals as an effective treatment option is suggested.
Article
Microbiology
Jun Zhang, Jian Chen, Yi-Fei Wu, Xia Liu, Charles Packianathan, Venkadesh S. Nadar, Barry P. Rosen, Fang-Jie Zhao
Summary: This study identified an arsRM operon in Noviherbaspirillum denitrificans HC18, which can detoxify MAs(III) via further methylation.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Y. Tong, E. Orang'o, M. Nakalembe, P. Tonui, P. Itsura, K. Muthoka, M. Titus, S. Kiptoo, A. Mwangi, J. Ong'echa, R. Tonui, B. Odongo, C. Mpamani, B. Rosen, A. Moormann, S. Cu-Uvin, J. A. Bailey, C. Oduor, A. Ermel, C. Yiannoutsos, B. Musick, E. Sang, A. Ngeresa, G. Banturaki, A. Kiragga, J. Zhang, Y. Song, S. Chintala, R. Katzenellenbogen, P. Loehrer, D. R. Brown
Summary: The East Africa Consortium was established to study the epidemiology of HPV infections and cervical cancer, as well as the influence of HIV infection on HPV and cervical cancer. Collaborations between researchers in North America and East African countries have led to a better understanding of the impact of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on HPV detection, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia. Future research will focus on how HPV testing can be integrated into cervical cancer screening programs, the influence of aflatoxin on the immunological control of HIV, and how HPV alters certain genes involved in tumor growth in HIV-infected women.
ANNALS OF MEDICINE
(2022)
Article
Oncology
Joanne Kotsopoulos, Jan Lubinski, Jacek Gronwald, Janusz Menkiszak, Jeanna McCuaig, Kelly Metcalfe, William D. Foulkes, Susan L. Neuhausen, Sophie Sun, Beth Y. Karlan, Andrea Eisen, Nadine Tung, Olufunmilayo Olopade, Fergus J. Couch, Tomasz Huzarski, Leigha Senter, Louise Bordeleau, Christian F. Singer, Charis Eng, Robert Fruscio, Tuya Pal, Ping Sun, Steven A. Narod
Summary: The study suggests that bilateral oophorectomy is unlikely to determine the risk of breast cancer in BRCA1 mutation carriers, but it should be offered at age 35 to reduce the risk of ovarian and fallopian tube cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Microbiology
Yi-Fei Wu, Jian Chen, Wan-Ying Xie, Chao Peng, Shi-Tong Tang, Barry P. P. Rosen, Andreas Kappler, Jun Zhang, Fang-Jie Zhao
Summary: We isolated a photosynthetic purple bacteria, Rhodobacter strain CZR27, from an arsenic-contaminated paddy soil and demonstrated its capacity to oxidize As(III) to As(V) using malate as a carbon source photosynthetically. Our study revealed the presence of anaerobic photosynthesis-coupled As(III) oxidation in paddy soils, highlighting the importance of light-dependent, microbe-mediated arsenic redox changes in paddy arsenic biogeochemistry.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Jian Chen, Barry P. Rosen
Summary: In this study, the broad diversity of structural domains in ArsMs was revealed through comparative analysis. The differences in the ArsM structure lead to variations in methylation efficiency and substrate selectivity. The C-terminal domain was found to play a role in modulating the rate of catalysis. Additionally, the relationship between arsenite efflux systems and methylation was examined.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ngozi P. P. Paul, Thiruselvam Viswanathan, Jian Chen, Masafumi Yoshinaga, Barry P. P. Rosen
Summary: AST is a pentavalent organoarsenical synthesized by Burkholderia gladioli GSRB05, which is effective against carbapenem-resistant Enterobacter cloacae. It inhibits bacterial glutamine synthetase and is a non-proteogenic amino acid and glutamate mimetic. ArsQ is an efflux permease that is proposed to transport AST or related species out of the cells, but the chemical nature of the actual transport substrate is unclear.
MOLECULAR MICROBIOLOGY
(2023)
Article
Microbiology
Masafumi Yoshinaga, Guodong Niu, Kunie Yoshinaga-Sakurai, Venkadesh S. S. Nadar, Xiaohong Wang, Barry P. P. Rosen, Jun Li
Summary: Malaria caused by Plasmodium parasites is a major disease with high morbidity and mortality rates. The Plasmodium parasite has a complex life cycle involving both human and mosquito hosts. Most current antimalarials only target the blood stage of the parasite, requiring the development of new drugs that can target multiple stages of the life cycle.
Article
Engineering, Environmental
Shi-Tong Tang, Xin-Wei Song, Jian Chen, Jie Shen, Bin Ma, Barry P. Rosen, Jun Zhang, Fang-Jie Zhao
Summary: This study identified a previously unknown gene, arsO, which encodes an enzyme called ArsO that oxidizes Sb(III) to Sb(V) under aerobic conditions. The enzyme plays a significant role in the detoxification of Sb(III) in the environment. The arsO gene is widely distributed and abundant in various environments affected by human activities.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Microbiology
Jun Zhang, Yan-Ning Li, Jie Shen, Venkadesh Sarkarai Nadar, Jian Chen
Summary: Microbes have evolved resistance genes to cope with arsenic toxicity, which are commonly regulated by transcriptional repressors. In the bacteria Ensifer adhaerens strain ST2, a novel transcriptional repressor called EaArsR has been found to regulate the expression of methylarsenite resistance genes. The binding site of EaArsR is different from other ArsR regulators, demonstrating the diverse evolution of arsenic binding sites.
FEMS MICROBIOLOGY LETTERS
(2023)