Article
Public, Environmental & Occupational Health
Mandy Goldberg, Mary Diaz-Santana, Katie M. O'Brien, Shanshan Zhao, Clarice R. Weinberg, Dale P. Sandler
Summary: This study examined the association between gestational hypertensive disorders and breast cancer in a cohort of women with a family history of breast cancer. The results showed that a history of gestational hypertensive disorder was not associated with breast cancer risk.
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Marija Majda Perisic, Klemo Vladimir, Sarah Karpov, Mario Storga, Ali Mostashari, Raya Khanin
Summary: Preeclampsia and gestational hypertensive disorders are common complications of pregnancy with long-term consequences. This study developed a risk score using machine learning to screen for GHD early. It confirmed that high BMI is a risk factor for GHD and explored the relationship between GHD and genetically constructed anthropometric measures and biomarkers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Obstetrics & Gynecology
Kelly S. Gibson, C. Andrew Combs, Samuel Bauer, Rebecca Feldman Hamm, Andrew Healy, Jamie Morgan, Lorraine Toner, Amy Whitsel
Summary: Hypertensive disorders of pregnancy are a major cause of maternal morbidity and mortality, so it is necessary to establish corresponding follow-up metrics to improve the timely follow-up rate of patients with severe hypertension.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Cecilie Holm Christiansen, Stinne Hogh, Line Rode, Jeppe Bennekou Schroll, Hanne Kristine Hegaard, Hanne Trap Wolf
Summary: This systematic review and meta-analysis examined the association between multivitamin use and the risk of preeclampsia. The results showed very weak evidence suggesting that multivitamin use might reduce the risk of preeclampsia. However, due to limited and low-quality studies, further large-scale randomized controlled trials are needed to confirm these findings. Therefore, no final conclusions can be drawn regarding the preventive effect of multivitamin use in relation to preeclampsia based on the results of this review.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Sarka Lisonkova, Jeffrey N. Bone, Giulia M. Muraca, Neda Razaz, Li Qing Wang, Yasser Sabr, Amelie Boutin, Chantal Mayer, K. S. Joseph
Summary: This population-based study aimed to assess the gestational age-specific incidence rates and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, as well as eclampsia. The results showed different rates and risk factors for these severe pregnancy complications based on gestational age. Younger maternal age was associated with an increased risk for eclampsia and term-onset severe preeclampsia, while older mothers had elevated risks for severe preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Yossi Tzur, Eli Rimon, Gil Geva, Jacky Herzlich, Michael J. Kupferminc
Summary: This study found that a higher level of isolated gestational proteinuria was associated with an increased risk of developing preeclampsia with severe features among pregnant women past 24 weeks of gestation.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
Matthew H. Mossayebi, Neel S. Iyer, Rodney A. McLaren, Hind N. Moussa, Baha M. Sibai, Huda B. Al-Kouatly
Summary: Early-onset HELLP syndrome in pregnancy presents with symptoms similar to later gestation, with high risks of maternal complications, including hepatic, central nervous system-related, and respiratory complications. Fetal outcomes are poor in cases of early-onset HELLP syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Peripheral Vascular Disease
Natalie A. Cameron, Ian K. Everitt, Kristen A. Lee, Lynn M. Yee, Sadiya S. Khan
Summary: Hypertension is a significant risk factor for cardiovascular disease in the US, and its prevalence during pregnancy has almost doubled in the past decade. High blood pressure during pregnancy is concerning due to increased risks of maternal and fetal complications and long-term cardiovascular risks. Identifying chronic hypertension during pregnancy can provide insights into cardiovascular disease risk and offer opportunities for risk reduction. Equitable healthcare interventions during the peripartum period can have a significant impact on preventing chronic hypertension and reducing lifetime cardiovascular disease risk.
Review
Biochemistry & Molecular Biology
Nidhi Chawla, Hinal Shah, Kathleen Huynh, Alex Braun, Hanna Wollocko, Nilank. C. C. Shah
Summary: Clinical hypertension is a complex cardiovascular disease that affects the body's ability to maintain homeostasis. High blood pressure is classified as systolic pressure above 130-139 and diastolic pressure above 80-89, indicating stage 1 hypertension. Pregnant women with hypertension are at risk of developing pre-eclampsia, which can progress to HELLP syndrome if not controlled. Magnesium is commonly used in the treatment of clinical hypertension, pre-eclampsia, and HELLP syndrome due to its role in vascular smooth muscle and myocardial excitability. Platelet-activating factor (PAF) exacerbates hypertension by causing platelet aggregation.
Article
Emergency Medicine
Nathaniel Coggins, Steven Lai
Summary: Hypertensive disorders in pregnancy, including chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia, are a major cause of morbidity for pregnant women and their babies worldwide. A comprehensive evaluation, including medical history, physical examination, and laboratory analysis, is crucial for distinguishing between these disorders and determining the severity, which has important implications for disease management.
EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
(2023)
Article
Environmental Sciences
Sumonthip Leelawai, Chitkasaem Suwanrath, Nannapat Pruphetkaew, Pensri Chongphattararot, Pornchai Sathirapanya
Summary: This study investigated the association between gestational Bell's palsy and late obstetric complications, revealing a potential relationship between gestational Bell's palsy and lower birth weight in newborns, although the association with other complications remains inconclusive.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Jason Raina, Amira El-Messidi, Ahmad Badeghiesh, Togas Tulandi, Tuong-Vi Nguyen, Eva Suarthana
Summary: This population-based retrospective study of over 9 million pregnant women in the United States found increasing rates of maternal mental disorders, with anxiety showing the greatest increase. Only anxiety was consistently associated with an increased risk of gestational hypertension, preeclampsia, and eclampsia. Targeted screening for mental disorders in pregnant women, particularly anxiety, may aid in timely prevention and surveillance of hypertensive disorders of pregnancy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Obstetrics & Gynecology
Zhaoqi Li, Ying Dai, Lin Yun, Wei Guo
Summary: This study aimed to establish a prediction model for PE complicated with HELLP syndrome using multiple-factor logistic regression analysis. MAP, APRI, CHE, FDP, and Ca were identified as independent factors affecting PE complicated with HELLP syndrome, and a prediction model based on these factors was constructed.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Steven L. Clark, George A. Saade, Mary C. Tolcher, Michael A. Belfort, Dwight J. Rouse, John R. Barton, Robert M. Silver, Baha M. Sibai
Summary: Our understanding and management of gestational hypertension are hindered by outdated terminology and non-evidence-based practices. This has resulted in little improvement in maternal and neonatal morbidity and mortality rates. To improve the situation, it is necessary to abandon current misleading terminology and traditional practices, and instead focus on evidence-based management approaches.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Engineering, Biomedical
R. Gentry Wilkerson, Aliaksei Pustavoitau, Howard Carolan, Nolan Benner, Clark Fischer, Daniel J. Sheets, Peggy I. Wang, Steven Tropello
JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME
(2019)
Article
Emergency Medicine
Matthew Li, Ashley N. Martinelli, Wesley D. Oliver, R. Gentry Wilkerson
JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Emergency Medicine
R. Gentry Wilkerson, Jason D. Adler, Nirav G. Shah, Robert Brown
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Brandon R. Allen, Robert H. Christenson, Scott A. Cohen, Richard Nowak, R. Gentry Wilkerson, Bryn Mumma, Troy Madsen, James McCord, Maite Huis In't Veld, Michael Massoomi, Jason P. Stopyra, Cindy Montero, Michael T. Weaver, Kai Yang, Simon A. Mahler
Summary: In a prospective multisite US cohort, an initial hs-cTnT below the LOQ combined with a low-risk HEART score has a 99% NPV for 30-day MACEs. The 0/1-h hs-cTnT algorithm did not achieve an NPV >99% for 30-day MACEs when used alone or with a HEART score.
Article
Medicine, Research & Experimental
Stephanie O. Ibemere, Sarah B. Dubbs, Huiman X. Barnhart, Jacqueline L. Brown, Caroline E. Freiermuth, Patricia Kavanagh, Judith A. Paice, John J. Strouse, R. Gentry Wilkerson, Paula Tanabe
Summary: This study aims to compare the impact of different pain management protocols on pain scores in SCD patients during emergency department visits and evaluate their effectiveness. Through a rigorous randomized controlled trial design, the study results will provide important clinical guidance for improving VOE treatment.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Emergency Medicine
Steven Rosenbaum, R. Gentry Wilkerson, Michael E. Winters, Gary M. Vilke, Marie Yung Chen
Summary: Angioedema induced by ACE inhibitors is a complex complication that may lead to airway compromise. The optimal treatment remains uncertain, with discontinuation of ACE inhibitors being the primary focus of management.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
J. David Gatz, Daniel B. Gingold, Daniel L. Lemkin, R. Gentry Wilkerson
Summary: The complication rates of procedures performed by emergency medicine residents were higher during the last 4 hours of a 12-hour shift compared to the first 8 hours. Training programs should take into consideration the impact of resident fatigue on patient safety when creating work schedules.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Kenneth W. Dodd, Deborah L. Zvosec, Michael A. Hart, George Glass, Laura E. Bannister, Richard M. Body, Brett A. Boggust, William J. Brady, Anna M. Chang, Louise Cullen Mbbs, Rafael Gomez-Vicente, Maite A. Huis In't Veld, Rehan M. Karim, Pendell Meyers, David F. Miranda, Gary J. Mitchell, Charles Reynard, Clifford Rice, Bayert J. Salverda, Samuel J. Stellpflug, Vaishal M. Tolia, Brooks M. Walsh, Jennifer L. White, Stephen W. Smith
Summary: The modified Sgarbossa criteria (MSC) demonstrated higher sensitivity than the original Sgarbossa criteria for diagnosing occlusion myocardial infarction in patients with ventricular paced rhythm. Specificity was high for both criteria, suggesting that MSC may aid in clinical decision-making for these patients.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Robert M. Rodriguez, Jesus R. Torres, Anna Marie Chang, Adrianne N. Haggins, Stephanie A. Eucker, Kelli N. O'Laughlin, Erik Anderson, Daniel G. Miller, Gentry Wilkerson, Martina Caldwell, Stephen C. Lim, Ali S. Raja, Brigitte M. Baumann, Joseph Graterol, Vidya Eswaran, Brian Chinnock
Summary: Emergency department patients who lack a regular source of medical care are more hesitant towards COVID-19 vaccination, while the majority of vaccine acceptors are willing to receive the vaccine as part of their care in the ED.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
R. Gentry Wilkerson
EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
(2022)
Article
Emergency Medicine
R. Gentry Wilkerson, Joseph J. Moellman
EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
(2022)
Article
Emergency Medicine
R. Gentry Wilkerson, Michael E. Winters
EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
(2022)
Article
Emergency Medicine
Bryan P. McNeilly, R. Gentry Wilkerson
Summary: With the mass immunization campaign against COVID-19, more patients are presenting to the emergency department with concerns about vaccine reactions. This case report highlights the importance of thorough examination and broad differential diagnosis as patients may misattribute symptoms to vaccine reactions when they are actually experiencing underlying diseases.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Elizabeth Ford, R. Gentry Wilkerson
Summary: Resistance bands commonly used in strength training exercise may lead to ocular trauma, particularly traumatic hyphema. Emergency physicians should be aware of this potential risk and be able to recognize and treat it promptly to prevent severe consequences.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Health Policy & Services
R. Gentry Wilkerson, Youssef Annous, Eli Farhy, Jonathan Hurst, Angela D. Smedley
Summary: This study aimed to evaluate patient engagement and compliance with a home SpO(2) monitoring program. The results showed that nearly half of the patients completed the 14-day monitoring period without loss to follow-up, and there was no significant difference in engagement and compliance between those who tested positive and those who tested negative for SARS-CoV-2.
HEALTH POLICY AND TECHNOLOGY
(2023)
