Review
Medicine, Research & Experimental
Stephanie N. N. Johnson, Spencer D. D. Brucks, Kyle D. D. Apley, Mark P. P. Farrell, Cory J. J. Berkland
Summary: Autoimmune diseases occur when the immune system mistakenly attacks its own antigens. Current treatments lack specificity and often result in adverse effects. Multivalent immunotherapies that specifically target immune cells responsible for disease are a promising strategy to mitigate adverse effects. This article reviews the architectural properties and functional mechanisms of multivalent ligands, and evaluates four different multivalent scaffolds for autoimmune treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Sonja Scharf, Joerg Ackermann, Leonie Bender, Patrick Wurzel, Hendrik Schaefer, Martin-Leo Hansmann, Ina Koch
Summary: In this study, a semi-quantitative mathematical model of lymph nodes is constructed using the Petri net formalism. The model encompasses the major cellular processes of the immune response and fulfills the formal requirements of Petri net models. Through simulations, the model describes the dynamic modes of the immune response, its adaption to antigens, and its loss of memory.
Article
Immunology
Yiying Yang, Muyuan Li, Yaxi Zhu, Ke Liu, Meidong Liu, Yanjuan Liu, Ganqian Zhu, Hui Luo, Xiaoxia Zuo, Huali Zhang, Muyao Guo
Summary: The aim of this study was to elucidate the role of enhancer of zeste homolog 2 (EZH2) in the breakdown of B cell immune tolerance and production of autoantibodies in systemic lupus erythematosus (SLE), and to explore the therapeutic effects of EZH2 inhibition on lupus. EZH2 expression was elevated in diverse B-cell subsets in both SLE patients and pristane-induced lupus mice. The EZH2 inhibitor attenuated lupus-like symptoms and dampened autoantibody production in pristane-induced lupus mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Lauren M. F. Merlo, Weidan Peng, Laura Mandik-Nayak
Summary: Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are closely related enzymes that modulate T cell and B cell function. IDO1 inhibits inflammatory B cell responses while IDO2 drives them. Targeting IDO1 and/or IDO2 shows promise as a therapeutic approach for inflammatory autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Corrine Ying Xuan Chua, Allen Yujie Jiang, Tatiane Eufrasio-da-Silva, Alireza Dolatshahi-Pirouz, Robert Langer, Gorka Orive, Alessandro Grattoni
Summary: Cellular therapies have the potential to revolutionize medicine by repairing dysfunctional tissues and treating various diseases in a dynamic way. However, the immune response poses a significant challenge to the widespread adoption and success of these therapies. This review explores current research and clinical advances in immune-modulatory strategies to overcome immune rejection and promote immune tolerance for cellular therapies, aiming to enhance therapeutic outcomes and clinical success.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiajia Xu, Zhao Li, Robert J. Tower, Stefano Negri, Yiyun Wang, Carolyn A. Meyers, Takashi Sono, Qizhi Qin, Amy Lu, Xin Xing, Edward F. McCarthy, Thomas L. Clemens, Aaron W. James
Summary: Bone regeneration following injury is coordinated by inflammatory signals and sensory nerve infiltration. This study demonstrates that nerve growth factor (NGF) signals through p75 to affect migration of mesenchymal osteogenic precursors, thereby impacting bone healing. Lack of NGF or p75 results in delayed bone repair.
Article
Biochemistry & Molecular Biology
Zhiming Shen, Min Chen, Yang Gao, Fangfang Dong, Changhuo Cen, Haowei Wu, Nan Wang, Xiuhong Cui, Chunsheng Han, Fei Gao
Summary: This study found that inactivation of Foxo1 after birth leads to germ cell loss and male infertility. Foxo1 is involved in the development of spermatogonia after birth, and its function is probably not regulated by the PI3K/PTEN signaling pathway.
Article
Immunology
Otto Castro Nogueira, Mariana Gandini, Natasha Cabral, Vilma de Figueiredo, Rodrigo Nunes Rodrigues-da-Silva, Josue da Costa Lima-Junior, Roberta Olmo Pinheiro, Geraldo Moura Batista Pereira, Maria Cristina Vidal Pessolani, Cristiana Santos de Macedo
Summary: This study analyzed the profile of B cell subpopulations in leprosy patients and found that Mycobacterium leprae infection could alter the proportions of B cell subpopulations. The modulation in B cell subpopulations was associated with an increase in total IgG levels and the patient's clinical condition, indicating that circulating B cells may be involved in modulating the immune response to M. leprae in patients with leprosy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Yan-Wei Wu, Wan-Yu Wang, Yu-Hung Chen
Summary: This study demonstrates that a positively charged nanocomplex can drive the Th1 immune response and modulate dendritic cell differentiation. The surface charge and size of the nanocomplex were found to affect the immune response. Furthermore, vaccination with the positively charged nanocomplex was shown to increase specific antibody and memory T-cell responses.
MATERIALS TODAY BIO
(2022)
Article
Gastroenterology & Hepatology
Chao Zhang, Jiesheng Li, Yongqian Cheng, Fanping Meng, Jin-Wen Song, Xing Fan, Hongtao Fan, Jing Li, Yu-Long Fu, Ming-Ju Zhou, Wei Hu, Si-Yu Wang, Yuan-Jie Fu, Ji-Yuan Zhang, Ruo-Nan Xu, Ming Shi, Xueda Hu, Zemin Zhang, Xianwen Ren, Fu-Sheng Wang
Summary: In this study, the comprehensive immune responses in different phases of HBV infection were analyzed using single-cell RNA sequencing. The results showed that both immune active and acute recovery phases were characterized by high levels of exhausted CD8+ T cells in the liver. Significant cell-cell interactions were observed between these exhausted T cells and regulatory CD4+ T cells, as well as between T cells and macrophages. Specific subsets of CD8+ T cells were expanded during the acute recovery phase, providing a potential marker for viral resolution. This study provides important insights into the immunopathogenesis of HBV and the development of effective therapeutic strategies.
Article
Multidisciplinary Sciences
Yali Chen, Juan Liu, Xiaomin Zhang, Ha Zhu, Yujia Wang, Zhiqing Li, Yanfang Liu, Shuo Liu, Shuxun Liu, Nan Li, Kun Chen, Xuetao Cao
Summary: RNA-RBP interaction plays a crucial role in immune regulation and is associated with various immune disorders. This study demonstrates that lncRNA-GM can polarize TH17 differentiation while inhibiting iTreg differentiation by reducing Foxo1 activity. The findings provide mechanistic insights into the interaction between lncRNA and transcription factors in determining T cell subset differentiation during T cell-mediated autoimmune diseases.
Article
Fisheries
Yuan Li, Bingxi Li, Yanjian Yang, Liting Wu, Shengli Fu, Zheng Guo, Jianmin Ye
Summary: The study cloned the CD27 molecule of Nile tilapia and identified its important roles in T cell-dependent response and B cell differentiation. The expression levels of OnCD27 varied in different B cell subsets, indicating its specific roles in regulating B cell functions.
Review
Immunology
Peiyu Zheng, Yongqing Dou, Qinying Wang
Summary: Chronic hepatitis B virus (HBV) infection poses a major threat to global public health, despite increasing vaccination rates. The outcome of HBV infection depends on the interaction between viral replication and host immune response. While innate immunity plays an initial role, long-term immunity is lacking due to HBV's ability to evade detection. Therefore, adaptive immunity involving T cells and B cells is crucial in controlling and clearing HBV infections. However, the persistence of HBV leads to immune tolerance and makes achieving a functional cure challenging.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shihong Zhong, Qiong Li, Chunhua Wen, Yifan Li, Yang Zhou, Zihan Jin, Guofu Ye, Yanda Zhao, Jinlin Hou, Yongyin Li, Libo Tang
Summary: The objective of this study was to investigate the role of B cells in IFN-alpha-mediated anti-HBV cellular immunity. The results showed that B cell depletion impaired the function of T cells and delayed HBV clearance. IFN-alpha treatment enhanced the response of HBV-specific CD8+ T cells, but this effect was lost in B cell-deficient models. These findings suggest that IFN-alpha orchestrates protective HBV-specific cellular immunity in a B cell-dependent manner.
ANTIVIRAL RESEARCH
(2022)
Article
Veterinary Sciences
Ze Zhang, Jiaxi Cai, Shanshan Hao, Chenfei Li, Jiajing Chen, Tongtong Li, Xiuli Feng
Summary: This study found that BP5 can promote B cell differentiation and increase the percentages of activated and differentiated B cells in immunized mice. RNA sequencing technology revealed that BP5 induced enrichment of various biological functions and stimulated five significant enrichment pathways in B cells. Furthermore, differential expression of transcription factors was observed in B cells following BP5 immunization.
VETERINARY RESEARCH
(2022)
Article
Immunology
Joseena Iype, Moumita Datta, Ahmad Khadour, Rudolf Uebelhart, Antonella Nicolo, Tim Rollenske, Marcus Duehren-von Minden, Hedda Wardemann, Palash C. Maity, Hassan Jumaa
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Palash C. Maity, Mayas Bilal, Marvyn T. Koning, Marc Young, Cornelis A. M. van Bergen, Valerio Renna, Antonella Nicolo, Moumita Datta, Eva Gentner-Goebel, Rob S. Barendse, Sebastiaan F. Somers, Ruben A. L. de Groen, Joost S. P. Vermaat, Daniela Steinbrecher, Christof Schneider, Eugen Tausch, Tamara Bittolo, Riccardo Bomben, Andrea Nicola Mazzarello, Giovanni del Poeta, Wilma G. M. Kroes, J. Tom van Wezel, Katharina Imkeller, Christian E. Busse, Massimo Degano, Tamam Bakchoul, Axel Ronald Schulz, Henrik Mei, Paolo Ghia, Konstantia Kotta, Kostas Stamatopoulos, Hedda Wardemann, Antonella Zucchetto, Nicholas Chiorazzi, Valter Gattei, Stephan Stilgenbauer, Hendrik Veelken, Hassan Jumaa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Lionel Rohner, Ramona Reinhart, Joseena Iype, Sofia Bachmann, Thomas Kaufmann, Michaela Fux
SCIENTIFIC REPORTS
(2020)
Article
Allergy
Joseena Iype, Andrea Odermatt, Sofia Bachmann, Mazarine Coeudevez, Michaela Fux
Summary: In allergic subjects, basophils exhibit increased sensitivity towards IL-33 and IL-1 beta, resulting in enhanced inflammatory mediator release and activation of signaling pathways. This enhanced responsiveness is mediated through IL-3-induced IL-1RI surface expression, leading to differences in cytokine release between allergic and healthy donors.
Review
Cell Biology
Joseena Iype, Michaela Fux
Summary: This study focuses on the role of eosinophils and basophils in allergic diseases, suggesting their potential interaction and influence on each other in allergic inflammations.
Article
Rheumatology
Matthias B. Moor, Franziska Suter-Riniker, Michael P. Horn, Daniel Aeberli, Jennifer Amsler, Burkhard Moller, Linet M. Njue, Cesare Medri, Anne Angelillo-Scherrer, Luca Borradori, Susanne Radonjic-Hoesli, S. Morteza Seyed Jafari, Andrew Chan, Robert Hoepner, Vera Ulrike Bacher, Laila-Yasmin Mani, Joseena Mariam Iype, Cedric Hirzel, Britta Maurer, Daniel Sidler
Summary: The study investigated immune responses to SARS-CoV-2 mRNA vaccines in patients receiving CD20-targeted B-cell-depleting therapies. Results showed blunted immune responses in these patients, indicating potential challenges in vaccination strategies for this population.
LANCET RHEUMATOLOGY
(2021)
Article
Cell Biology
Andrea Harzschel, Lixia Li, Peter W. Krenn, Eva Szenes-Nagy, Geoffroy Andrieux, Elisabeth Bayer, Dietmar Pfeifer, Laura Polcik, Ursula Denk, Jan P. Hopner, Elif Karabatak, Danielle-Justine Danner, Simone Tangermann, Lukas Kenner, Hassan Jumaa, Richard Greil, Melanie Borries, Raphael Ruppert, Palash C. Maity, Tanja Nicole Hartmann
Summary: The lack of Kindlin-3 leads to a reduction in the number of B cells, especially late immature, mature, and recirculating B cells in the bone marrow, as well as a decrease in marginal zone B cells and an increase in follicular B cells in the spleen.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Oncology
Antonella Nicolo, Alexandra Theresa Linder, Hassan Jumaa, Palash Chandra Maity
Summary: Advanced GWAS studies identified valuable prognostic markers in CLL and BCL, while genetic manipulations facilitated preclinical models to validate mutations. Acquired mutations in BCR components are recognized as important biomarkers for precision diagnostics and therapy. The proposed model suggests that augmented BCR signaling creates a conducive platform for the appearance of transforming mutations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Rheumatology
Daniel Sidler, Alexander Born, Simeon Schietzel, Michael P. Horn, Daniel Aeberli, Jennifer Amsler, Burkhard Moller, Linet M. Njue, Cesare Medri, Anne Angelillo-Scherrer, Luca Borradori, S. Morteza Seyed Jafari, Susanne Radonjic-Hoesli, Andrew Chan, Robert Hoepner, Ulrike Bacher, Laila-Yasmin Mani, Joseena Mariam Iype, Franziska Suter-Riniker, Cornelia Staehelin, Michael Nagler, Cedric Hirzel, Britta Maurer, Matthias B. Moor
Summary: This study reveals that the decay rates of immunity are comparable between patients receiving anti-CD20 therapies and healthy volunteers. However, in most patients who did not respond to two doses of the vaccine, a third dose of SARS-CoV-2 vaccine resulted in inefficient humoral or cell-mediated immune responses, indicating the need for individually tailored vaccination strategies in this population.
Editorial Material
Immunology
Godehard A. Scholz, Michaela Fux, Lisa Christ, Joseena Iype, Yara Banz, Peter M. Villiger
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Joseena Iype, Lionel Rohner, Sofia Bachmann, Tanja Rahel Hermann, Nikolay Pavlov, Christophe von Garnier, Michaela Fux
Summary: This study identified CD25 as a unique marker on blood basophils of patients with stable phase of allergic asthma, showing significantly increased expression compared to healthy individuals. The expression of CD25 on blood basophils positively correlated with FeNO levels. Importantly, ex vivo allergen stimulation did not affect CD25 expression on blood basophils of patients with stable-phase allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Andrea N. Mazzarello, Eva Gentner-Goebel, Marcus Duehren-von Minden, Tatyana N. Tarasenko, Antonella Nicolo, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R. Rai, Jan A. Burger, Peter J. McGuire, Palash C. Maity, Hassan Jumaa, Nicholas Chiorazzi
Summary: This study found that IgM plays a critical and selective role in BCR signaling and B cell fate decisions in chronic lymphocytic leukemia (CLL), which may open up new avenues for CLL therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)