Article
Endocrinology & Metabolism
Chin-Hsiao Tseng
Summary: This study compared the risk of gingival and periodontal diseases (GPD) between patients with type 2 diabetes mellitus who were ever users and never users of metformin. The results showed that long-term use of metformin was significantly associated with a reduced risk of GPD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jung-Hyun Park, Sun-Hyun Kim, Sun-Jong Kim, Jin-Woo Kim
Summary: This study investigated the association between the recovery from or development of periodontal disease (PD) and the risk of incident diabetes in a population. The results showed that individuals who recovered from PD had a lower risk of diabetes compared to those who had consistent PD, while individuals who developed PD had a higher risk of diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
A. C. Borsanelli, L. Viora, T. Parkin, D. F. Lappin, D. Bennett, G. King, I. S. Dutra, M. P. Riggio
Summary: This pilot study aimed to identify potential risk factors associated with bovine periodontitis development and found that the prevalence of periodontitis increases with age in cattle. Although the study did not detect a major influence of breed on the age-effect, periodontitis has a significant impact on oral health and productivity in older cattle.
Article
Oncology
Eun Hwa Kim, Sunghyun Nam, Chung Hyun Park, Yitak Kim, Myeongjee Lee, Joong Bae Ahn, Sang Joon Shin, Yu Rang Park, Hoi In Jung, Baek-Il Kim, Inkyung Jung, Han Sang Kim
Summary: This study aimed to investigate the association between chronic periodontitis and cancer risk. Using a large nationwide database, the study found that individuals with periodontitis had a higher risk of developing cancer compared to those without periodontitis. The study also identified significant associations between periodontitis and specific types of cancer, including stomach cancer, colon cancer, lung cancer, bladder cancer, thyroid cancer, and leukemia. However, there was no significant association between periodontitis and the development of secondary malignancy in cancer survivors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Shishir Rao, Yikuan Li, Milad Nazarzadeh, Dexter Canoy, Mohammad Mamouei, Abdelaali Hassaine, Gholamreza Salimi-Khorshidi, Kazem Rahimi
Summary: A study using deep learning modeling found a monotonic relationship between systolic blood pressure and risk of cardiovascular events in patients with diabetes, without evidence of a J-shaped relationship.
Review
Engineering, Biomedical
Barbara Lopes Freire, Lucas Guimaraes Abreu, Fernando Oliveira Costa, Luis Otavio Miranda Cota, Rafael Paschoal Esteves-Lima
Summary: The purpose of this study is to evaluate the impact of photobiomodulation adjunct to non-surgical periodontal treatment on individuals with type 2 diabetes mellitus (T2DM). The findings from eight studies showed that photobiomodulation adjunct to periodontal therapy in individuals with diabetes resulted in a greater reduction in probing depth and greater attachment gain compared to periodontal treatment alone. The included studies exhibited a low risk of bias.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Sina Kianersi, Yue Liu, Marta Guasch-Ferre, Susan Redline, Eva Schernhammer, Qi Sun, Tianyi Huang
Summary: Evening chronotype is associated with unhealthy lifestyle and increased risk of diabetes, but adjustment for factors like BMI, physical activity, and diet quality can attenuate some of this risk.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koji Mizutani, Hidehiro Shioyama, Takanori Matsuura, Risako Mikami, Kohei Takeda, Yuichi Izumi, Akira Aoki, Takanori Iwata
Summary: This study found that minimally invasive periodontal surgery using EMD in patients with and without diabetes mellitus can lead to similar levels of clinical attachment gain and bone fill. This is the first documented study of successful periodontal tissue regeneration in patients with diabetes mellitus.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Medicine, General & Internal
Rosana Costa, Blanca Rios-Carrasco, Luis Monteiro, Paula Lopez-Jarana, Filipa Carneiro, Marta Relvas
Summary: Gingivitis and periodontitis are chronic inflammatory diseases affecting the supporting tissues of the teeth, and their pathogenesis can be influenced by factors such as bacterial biofilms, smoking, drugs, and systemic diseases. This study aims to analyze the association between periodontal status and type 1 diabetes mellitus. The results show a confirmed association between type 1 diabetes mellitus and periodontal diseases, with higher prevalence and severity in diabetic patients compared to healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Article
Chemistry, Multidisciplinary
Jae-Hong Lee, Seong-Nyum Jeong
Summary: The study found an association between chronic periodontitis and acute respiratory infections, particularly with acute upper and lower respiratory infections.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Eun-Jung Rhee, Won-Young Lee
Summary: Studies have shown that comorbid depression in patients with diabetes increases the risk of cardiovascular disease and mortality. It is important to pay more attention to diabetic patients with depressive symptoms.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Physiology
Yan Yan, Min Mao, Yan-Qin Li, Yong-Ji Chen, He-Dong Yu, Wen-Zhong Xie, Qiao Huang, Wei-Dong Leng, Jie Xiong
Summary: Periodontitis is associated with an increased risk of heart failure, according to this study using data from the Third National Health and Nutrition Examination Survey.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Talal S. Alshihayb, Elizabeth A. Kaye, Yihong Zhao, Cataldo W. Leone, Brenda Heaton
Summary: Unmeasured confounding did not explain the observed associations between pre-existing diabetes and incident periodontitis. However, weak unmeasured confounding eliminated the observed associations between pre-existing periodontitis and incident diabetes. These findings clarify the bidirectional association between periodontitis and diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Alice A. Gibson, Emma Cox, Joanne Gale, Maria E. Craig, Joerg Eberhard, Shalinie King, Clara K. Chow, Stephen Colagiuri, Natasha Nassar
Summary: This study found that oral health status is associated with the risk of developing diabetes, highlighting the importance of oral health screening for diabetes prevention.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Environmental Sciences
Sheng-Wen Wu, Chun-Hung Su, Yung-Chuan Ho, Rosa Huang-Liu, Ching-Chi Tseng, Yun-Wei Chiang, Kun-Lin Yeh, Shiuan-Shinn Lee, Wen-Ying Chen, Chun-Jung Chen, Yi-Ching Li, Chien-Ying Lee, Yu-Hsiang Kuan
Summary: The study revealed that genotoxicity induced by 1-NP manifests as DNA damage, including micronucleus formation and DNA strand breaks, and can be quantitatively measured through a lactate dehydrogenase (LDH) assay.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Ping-Ho Pan, Chih-Cheng Wu, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: The study illustrates that gefitinib induces glioma cell apoptosis by activating ER stress and modulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Ping-Ho Pan, Jian-Ri Li, Yen-Chuan Ou, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In stroke patients, the occurrence of acute kidney injury (AKI) is associated with worse outcomes and increased mortality. This study in a rodent model demonstrated that intrastriatal collagenase injection led to neurological deficits, brain injury, and signs of kidney dysfunction, with glycerol showing potential in alleviating these effects. Increased levels of stress hormones in rats with intracerebral hemorrhage suggest that kidney dysfunction and structural integrity of the glomerulus are potential targets vulnerable to post-stroke injury.
Article
Environmental Sciences
Yun-Wei Chiang, Chun-Hung Su, Han-Yin Sun, Shih-Pin Chen, Chun-Jung Chen, Wen-Ying Chen, Chia-Che Chang, Chuan-Mu Chen, Yu-Hsiang Kuan
Summary: BPA, an estrogen-like compound, can enter the human body, affecting ARPE-19 cells and leading to cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: Elevation of intracellular cAMP levels through inhibition of phosphodiesterase using dipyridamole has shown to inhibit glioma cell proliferation, migration, and invasion. Dipyridamole induces apoptosis through Noxa-guided endoplasmic reticulum (ER) stress and impairs autophagic flux. YAP1 plays a role in the communication between ER stress and autophagy, promoting autophagy and protecting glioma cells from dipyridamole-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Tsun-Li Cheng, Zi-Yun Lin, Keng-Ying Liao, Wei-Chi Huang, Cian-Fen Jhuo, Pin-Ho Pan, Chun-Jung Chen, Yu-Hsiang Kuan, Wen-Ying Chen
Summary: This study investigated the potential of Magnesium lithospermate B (MLB) in combating muscle atrophy in mice with high-fat diet (HFD)-induced obesity. The results showed that MLB supplementation alleviated metabolic abnormalities and prevented muscle loss caused by obesity, likely through inhibiting muscle degradation pathways. This study also revealed changes in inflammatory markers and signaling pathways associated with muscle atrophy.
Article
Environmental Sciences
Ci-Wen Luo, Shih-Pin Chen, Chen-Yu Chiang, Wen-Jun Wu, Chun-Jung Chen, Wen-Ying Chen, Yu-Hsiang Kuan
Summary: Depression is a common mental disorder that affects more than 264 million people worldwide. This study found that moderate levels of UVB exposure can lower the risk of depression, while high levels of UVB exposure gradually increase the risk.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ci-Wen Luo, Yun-Wei Chiang, Han-Yin Sun, Kun-Lin Yeh, Min-Wei Lee, Wen-Jun Wu, Yu-Hsiang Kuan
Summary: By analyzing data from Taiwan's Longitudinal Health Insurance Database, the study found that compared with normal-tension glaucoma (NTG), primary open-angle glaucoma (POAG) has a higher risk associated with fine particulate matter (PM2.5) exposure, and PM2.5 has a concentration-dose effect.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In this study, the preventive effects of intrathecal bupivacaine administration against neuropathic pain were investigated. Bupivacaine attenuated pain behaviors and inflammatory alternations by suppressing microglia M1 polarization and pro-inflammatory cytokine expression. The Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappa B inflammatory axes were identified as key players in microglia polarization and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Li-Chiu Yang, Yu-Chao Chang, Kun-Lin Yeh, Fu-Mei Huang, Ni-Yu Su, Yu-Hsiang Kuan
Summary: This study investigated the protective mechanism of rutin in alleviating TEGDMA-induced toxicity in macrophages. Results showed that rutin substantially reduced cytotoxicity, apoptosis, and genotoxicity, and decreased oxidative stress and ROS generation caused by TEGDMA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Chien-Ying Lee, Yung-Chuan Ho, Shiuan-Shinn Lee, Yi-Ching Li, Mei-Yu Lai, Yu-Hsiang Kuan
Summary: This study aims to clarify the mechanisms underlying HEMA-induced cytotoxicity and apoptosis in macrophages. The results showed that HEMA induced concentration-dependent cell toxicity and mediated genotoxicity and apoptosis through mitochondrial dysfunction, intrinsic caspase pathway activation, and intracellular reactive oxygen species accumulation.
Article
Chemistry, Medicinal
Yin-Che Lu, Yu-Hsiang Kuan, Chih-Yi Lin, Yu-Ting Chou, Shan-Chun Chen, Guan-Lun Gao, Chiang Wei Hsu, Jyan-Gwo Joseph Su
Summary: This study reveals that alizarin, a natural red dye, is an unreported ligand of AhR and can induce the expression of CYP1A1 gene. The effects on nuclear localization and transcriptional activity further confirm the role of alizarin as an AhR agonist.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Fu-Mei Huang, Ci-Wen Luo, Shiuan-Shinn Lee, Yung-Chuan Ho, Yi-Ching Li, Yu-Chao Chang, Yu-Hsiang Kuan
Summary: Periodontal disease is often neglected and can lead to tooth loss and systemic diseases if its initial symptoms are overlooked. Patients with otitis media are at a higher risk of vestibular and balance dysfunction, resulting in vertigo. This study found that periodontal disease is a factor that causes dizziness.
Article
Health Care Sciences & Services
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Summary: The study found that comorbidities such as hypotension, sleep disturbances, peptic ulcers, and allergic rhinitis are more highly associated with NTG than POAG.
Article
Medicine, General & Internal
Kuang-Hua Huang, Wei-Yin Kuo, Yu-Hsiang Kuan, Yu-Chia Chang, Tung-Han Tsai, Chien-Ying Lee
Summary: This study found that older patients with Parkinson's disease (PD) who use antipsychotic drugs have a higher risk of pneumonia. Among the antipsychotics, haloperidol and clozapine were associated with increased pneumonia risk, while aripiprazole showed no significant risk.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
