Article
Pharmacology & Pharmacy
Sili Zheng, Zhiyong Li, Jie Song, Pin Wang, Jian Xu, Wenjun Hu, Yi Shi, Qi Qi, Zhuwei Miao, Yunfeng Guan, Chaoyu Miao
Summary: METRNL is a newly identified endothelial substance that regulates vascular health and disease by determining the level of circulating METRNL and regulating endothelial function. It has potential as a therapeutic target against endothelial dysfunction and atherosclerosis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Endocrinology & Metabolism
Yanyun Zhao, Yue Zhou, Min Xiao, Yajing Huang, Mengmeng Qi, Zili Kong, Jingwei Chi, Kui Che, Wenshan Lv, Bingzi Dong, Yangang Wang
Summary: This study compared serum levels of pancreatic polypeptide (PP), insulin, C-peptide, and glucagon in different glucose tolerance stages. The results showed that IGR and T2DM patients have enhanced postprandial PP secretion, mainly affected by BMI and blood glucose levels.
JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Ran Liu, Shilin Guan, Zhongai Gao, Jingyu Wang, Jie Xu, Zhaohu Hao, Yi Zhang, Shaohua Yang, Zhenhong Guo, Juhong Yang, Hailin Shao, Baocheng Chang
Summary: In the prediabetic stage of IGT, high concentrations of insulin and glucose regulate the secretory function of glomerular endothelial cells in opposite ways by modulating the expression of miRNA-21, potentially leading to renal tubule ischemia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Motonori Sato, Yoshifumi Tamura, Takashi Nakagata, Yuki Someya, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The prevalence of impaired glucose tolerance (IGT) was higher in young underweight Japanese women compared to normal weight women, with those with IGT showing impaired early-phase insulin secretion, lower fitness levels, and reduced whole-body and adipose tissue insulin sensitivity levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Xin Zhang, Yankun Yue, Shaobo Liu, Xiangfeng Cong, Wenjuan Wang, Jianhong Li
Summary: This study investigates the relationship between BMI and the risk of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in Chinese adults. The results show that obesity is an important risk factor for IGT and IFG in China, and the risk of IGT increases during the overweight stage.
Article
Endocrinology & Metabolism
Kathryn J. Potter, Quitterie Reynaud, Valerie Boudreau, Florence Racine, Francois Tremblay, Annick Lavoie, Maite Carricart, Genevieve Mailhot, Isabelle Durieu, Peter A. Senior, Remi Rabasa-Lhoret
Summary: Patients meeting both criteria of indeterminate glycemia and impaired glucose tolerance have an increased risk of developing diabetes, suggesting the need for closer monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Immunology
Shuren Guo, Xiaohuan Mao, Jun Liu
Summary: CTRPs family members play critical roles in the development and progression of AS by influencing inflammatory response, modulating glucose and lipid metabolism, regulating endothelial functions, and the proliferation of vascular smooth muscle cells (VSMCs).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Food Science & Technology
Yutaka Inoue, Lianne Cormanes, Kana Yoshimura, Aiko Sano, Yumiko Hori, Ryuichiro Suzuki, Ikuo Kanamoto
Summary: This study investigated the impact of consuming apples on postprandial blood glucose and insulin levels in individuals with normal versus impaired glucose tolerance. The findings suggest that consuming an apple before a meal can help regulate blood glucose and insulin levels in both normal individuals and those with impaired glucose tolerance.
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Review
Biochemistry & Molecular Biology
Masato Kajikawa, Yukihito Higashi
Summary: Obesity is closely related to cardiovascular diseases. It affects endothelial function through complications such as oxidative stress, insulin resistance, and inflammation. Various measures and methods have shown an association between obesity and endothelial function. Understanding the mechanisms of obesity-induced endothelial dysfunction is crucial for preventing and treating cardiovascular events.
Article
Biochemistry & Molecular Biology
Xiao-Wei Jia, Dong-Liang Fang, Xin-Yi Shi, Tao Lu, Chun Yang, Yan Gao
Summary: Inducible beige adipocytes may have beneficial effects on improving impaired glucose metabolism and enhancing energy expenditure, even in the absence of interscapular brown adipose tissue (iBAT). Data shows that beige adipocytes could partly contribute to the improvement of impaired glucose metabolism and enhancing glucose uptake in iBAT-removal animal models. Additionally, inducible beige adipocytes may have different mechanisms to improve glucose metabolism and enhance energy expenditure when iBAT is lacking.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Physiology
Hongli Zeng, Xiangsheng Cai, Zhenyang Qiu, Yuchan Liang, Lu Huang
Summary: The study aimed to investigate the effects of quinoa on glucose and lipid metabolism, and the prognosis in people with impaired glucose tolerance. The results showed that adding quinoa to staple food intake significantly reduced postprandial blood glucose, improved lipid metabolism and insulin resistance, and delayed the progression of diabetes in people with impaired glucose tolerance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Hitoe Mori, Hirokazu Takahashi, Keiichiro Mine, Ken Higashimoto, Kanako Inoue, Motoyasu Kojima, Shigetaka Kuroki, Takahisa Eguchi, Yasuhiro Ono, Sadataka Inuzuka, Hidenobu Soejima, Seiho Nagafuchi, Keizo Anzai
Summary: The TYK2 promoter variant is associated with impaired insulin secretion and lower insulin resistance in type 2 diabetes, indicating that patients with this variant may require careful monitoring and appropriate treatment such as insulin injections.
Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Alessia Riccio, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study found that deteriorated glucose homeostasis in women is associated with greater fat accumulation and worsening insulin sensitivity compared to men.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Hazem M. El-Ashmawy, Azza M. Ahmed
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2018)
Article
Gastroenterology & Hepatology
Hazem M. El-Ashmawy, Azza M. Ahmed
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2019)
Article
Endocrinology & Metabolism
Hazem M. EL-Ashmawy, Fayrouz O. Selim, Thoraya A. M. Hosny, Hosam N. Almassry
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2019)
Article
Endocrinology & Metabolism
Fawzy A. F. El-Messallamy, Hazem M. El-Ashmawy, Arafa M. El Shabrawy, Samia E. Radwan
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2019)
Article
Cardiac & Cardiovascular Systems
Hazem M. El-Ashmawy, Hisham S. Roshdy, Zizi Saad, Azza M. Ahmed
JOURNAL OF THE SAUDI HEART ASSOCIATION
(2019)