Journal
DEVELOPMENTAL CELL
Volume 49, Issue 4, Pages 499-500Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2019.05.005
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Funding
- NEI NIH HHS [R01 EY010199] Funding Source: Medline
- NIGMS NIH HHS [R01 GM120196] Funding Source: Medline
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Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of Developmental Cell, Zhang and colleagues (2019) show autophagy-mediated regulation of EGFR signaling cell autonomously controls intestinal stem cell proliferation, with implications for human colorectal cancer development.
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