Article
Endocrinology & Metabolism
Kripa Shankar, Salil Varshney, Deepali Gupta, Bharath K. K. Mani, Sherri Osborne-Lawrence, Nathan P. P. Metzger, Corine P. P. Richard, Jeffrey M. M. Zigman
Summary: Recurrent episodes of insulin-induced hypoglycemia can lead to hypoglycemia-associated autonomic failure (HAAF), a major cause of morbidity in diabetes. The molecular pathways underlying HAAF are not fully understood, but previous research has suggested a role for ghrelin. This study investigates the impact of attenuated ghrelin release on HAAF.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Marianne Lerbok Bergmann, Simon Veedfald, Jens Juul Holst, Dorte Worm
Summary: This study evaluated counterregulatory responses during postprandial hypoglycemia in patients with postbariatric hypoglycemia who underwent Rouxen-Y gastric bypass surgery. The findings showed that individuals with postbariatric hypoglycemia had minor increases in counterregulatory hormones during postprandial hypoglycemia, but larger hormone responses occurred when glucose levels were lowered during treatment with sitagliptin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Sevasti Gaspari, Gwenael Labouebe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
Summary: In this study, Tmem117 in vasopressin neurons is identified as a physiological regulator of glucagon secretion in response to hypoglycemia. Tmem117 inactivation increases ER stress, ROS production, and intracellular calcium levels, leading to elevated vasopressin production and secretion.
Article
Endocrinology & Metabolism
Clare J. Lee, Jeanne M. Clark, Josephine M. Egan, Olga D. Carlson, Michael Schweitzer, Susan Langan, Todd Brown
Summary: The study compared meal-stimulated hormonal responses in patients with postbariatric surgery hypoglycemia (PBH) after sleeve gastrectomy (SG) and after Roux-en-Y gastric bypass (RYGB). The results showed significant differences in glucagon and GLP-1 responses between the two groups, while insulin and GIP responses were similar.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Longlong Tu, Makoto Fukuda, Qingchun Tong, Yong Xu
Summary: This review discusses the role of the brain in glucose homeostasis, particularly in the contexts of hypoglycemia and diabetes, emphasizing the potential roles played by non-neuronal cells and extracellular matrix, as well as the ionic mechanisms by which glucose-sensing neurons sense fluctuations of ambient glucose levels.
CELL AND BIOSCIENCE
(2022)
Article
Endocrinology & Metabolism
Anne-Sophie Sejling, Peili Wang, Wanling Zhu, Rawad Farhat, Nicholas Knight, Daniel Appadurai, Owen Chan
Summary: Repeated activation of noradrenergic receptors in the ventromedial hypothalamus increases local lactate levels, leading to a blunted counterregulatory hormone response to hypoglycemia.
Article
Medicine, General & Internal
Lara Ribeiro-Parenti, Hounayda El Jindi, Alexandra Willemetz, Matthieu Siebert, Nathalie Kapel, Johanne Le Beyec, Andre Bado, Maude Le Gall
Summary: One anastomosis gastric bypass (OAGB) is as effective as Roux-en-Y gastric bypass (RYGB) in improving metabolism and weight loss. Shortening the biliopancreatic limb of OAGB can improve metabolic parameters without significantly affecting weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo
Summary: Roux-en Y gastric bypass surgery and sleeve gastrectomy alter postprandial glucose metabolism, increasing the risk of hypoglycemia. After surgery, there is a reduced hepatic glucose production response during insulin-induced hypoglycemia. However, the counterregulatory response to hypoglycemia is similar among individuals with surgery and without surgery.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Louise L. Stentebjerg, Lene R. Madsen, Rene K. Stoving, Lise Lotte T. Andersen, Christina A. Vinter, Claus B. Juhl, Dorte M. Jensen
Summary: This study aimed to investigate glucose metabolism during pregnancy in women who had undergone Roux-en-Y gastric bypass (RYGB). The study found that women with RYGB were more susceptible to hypoglycemia and hyperglycemia compared with control participants. Further research is needed to explore the association between hypoglycemia and fetal growth restriction in women with RYGB.
Article
Endocrinology & Metabolism
Antonio Ferreira, Katja A. Schonenberger, Natascha Potoczna, Andreas Vogt, Philipp A. Gerber, Jorg Zehetner, Daniel Giachino, Philipp Nett, Joanna Gawinecka, Luca Cossu, Daniel G. Fuster, Chiara Dalla Man, Andrea Facchinetti, Andreas Melmer, Christos T. Nakas, Matthias Hepprich, Marc Y. Donath, David Herzig, Lia Bally
Summary: The aim of this study was to investigate the effect of empagliflozin on glucose dynamics in individuals suffering from postbariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB). The results showed that empagliflozin reduced glucose excursions but had no significant effect on hypoglycemia.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Tal Schiller, Alena Kirzhner, Taiba Zornitzki, Lee Cohen, Yael Winter Shafran, Viviana Ostrovsky, Hilla Knobler, Edi Vaisbuch
Summary: Post-bariatric surgery hypoglycemia (PBH) is a serious and relatively common complication of bariatric surgery, which is often underdiagnosed due to lack of awareness. PBH can have a profound impact on health and quality of life. Data on the natural history and management of PBH during pregnancy are limited.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Medicine, Research & Experimental
Shana O. Warner, Yufei Dai, Nicole Sheanon, Michael V. Yao, Rebecca L. Cason, Shahriar Arbabi, Shailendra B. Patel, Diana Lindquist, Jason J. Winnick
Summary: Fasting increases the risk of hypoglycemia in individuals with type 1 diabetes, and it also negatively affects insulin-induced hypoglycemia responses in healthy individuals.
Article
Endocrinology & Metabolism
Daniel Lee, Jonathan M. Dreyfuss, Amanda Sheehan, Alexa Puleio, Christopher M. Mulla, Mary Elizabeth Patti
Summary: The study found that patients with post-bariatric hypoglycemia experience higher glycemic variability and frequency of low sensor glucose values compared to healthy controls, especially at night.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Summary: The study demonstrates that bariatric surgery, specifically Vertical Sleeve Gastrectomy (VSG), improves diabetes by enhancing beta-cell function and intra-islet connectivity, potentially through changes in circulating GLP-1 levels.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Martha Campbell-Thompson, Elizabeth A. Butterworth, J. Lucas Boatwright, Malavika A. Nair, Lith H. Nasif, Kamal Nasif, Andy Y. Revell, Alberto Riva, Clayton E. Mathews, Ivan C. Gerling, Desmond A. Schatz, Mark A. Atkinson
Summary: The dysregulation of glucagon secretion in type 1 diabetes involves the sympathetic nervous system and noradrenalin degradation pathways. The study found that sympathetic innervation at islets and intrinsic adrenergic signaling pathways could be novel targets for improving glucagon secretion in T1D patients.
SCIENTIFIC REPORTS
(2021)