Toxicology of Trastuzumab: An Insight into Mechanisms of Cardiotoxicity

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes

(2017) Liqun Zhao et al.   Scientific Reports

ErbB2 signaling at the crossing between heart failure and cancer

(2016) Zarha Vermeulen et al.   BASIC RESEARCH IN CARDIOLOGY

Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes

(2016) Nishant Mohan et al.   MOLECULAR CANCER THERAPEUTICS

Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity

(2015) Sasha E Stanton et al.   BMC CANCER

Influence of the HER2 Ile655Val polymorphism on trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients

(2015) Celia Gómez Peña et al.   Pharmacogenetics and Genomics

Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids

(2015) Cristina E. Rodríguez et al.   PLoS One

The anthracycline–trastuzumab interaction: a lesson in not jumping to confusion

(2015) Michael S. Ewer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1)

(2014) J Diessner et al.   Cell Death & Disease

The role of iron in anthracycline cardiotoxicity

(2014) Elena Gammella et al.   Frontiers in Pharmacology

Cardiotoxicity of novel HER2-targeted therapies

(2013) Mehmet A.N. Sendur et al.   CURRENT MEDICAL RESEARCH AND OPINION

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Trastuzumab-induced cardiotoxicity in early breast cancer patients: a retrospective study of possible risk and protective factors

(2013) Alberto Farolfi et al.   HEART

The role of autophagy in doxorubicin-induced cardiotoxicity

(2013) Amie J. Dirks-Naylor   LIFE SCIENCES

Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice

(2013) M. Khair ElZarrad et al.   PLoS One

Role of renal function on the development of cardiotoxicity associated with trastuzumab-based adjuvant chemotherapy for early breast cancer

(2012) Giulia Russo et al.   Internal and Emergency Medicine

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab

(2012) Andreas S. Barth et al.   Stem Cells Translational Medicine

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors

(2011) C. Serrano et al.   ANNALS OF ONCOLOGY

Baseline diastolic dysfunction as a predictive factor of trastuzumab-mediated cardiotoxicity after adjuvant anthracycline therapy in breast cancer

(2011) Alexandre Cochet et al.   BREAST CANCER RESEARCH AND TREATMENT

The Vulnerability of the Heart As a Pluricellular Paracrine Organ

(2010) Gilles W. De Keulenaer et al.   CIRCULATION RESEARCH

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Resistance to Trastuzumab in Breast Cancer

(2009) P. R. Pohlmann et al.   CLINICAL CANCER RESEARCH

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure

(2008) Lihe Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY