Article
Oncology
Gabriela Oses, Tanny Daniela Barreto, Carla Cases, Diego Munoz-Guglielmetti, Gabriela Antelo, Meritxell Molla
Summary: This retrospective study compares hypofractionated boost and normofractionated boost in terms of skin toxicity and local control in breast cancer patients. The results show no significant differences between the two groups in terms of acute and chronic skin toxicity, as well as local control.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Imjai Chitapanarux, Wannapha Nobnop, Wimrak Onchan, Pitchayaponne Klunklin, Thongtra Nanna, Chomporn Sitathanee, Sutthisak Kulpisitthicharoen, Patumrat Sripan
Summary: This study investigated the acute toxicities on skin and hematologic function in breast cancer patients who received hypofractionated whole breast irradiation with or without regional nodal irradiation. It was found that the whole body integral dose and the incidence of acute toxicities were higher in patients receiving regional nodal irradiation, but there was no statistically significant difference in the occurrence of grade 2 or more acute toxicities between the two groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ting Yu, Yankang Li, Tao Sun, Min Xu, Wei Wang, Qian Shao, Yingjie Zhang, Jianbin Li, Jinming Yu
Summary: This study compared the dosimetric difference of hypofractionated whole-breast irradiation with sequential boost and simultaneous integrated boost in supine and prone positions, finding that prone SIB-HFWBI may be more suitable for postoperative radiotherapy in early-stage breast cancer patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Martin C. Tom, Sarah Mc Sittenfeld, Chirag Shah, Kristine Bauer-Nilsen, Rahul Tendulkar, Sheen Cherian, Zahraa Al-Hilli, Douglas Arthur, Abram Recht, Frank Vicini
Summary: This study aimed to evaluate the time trends and factors associated with the use of radiation tumor bed boost (TBB) following breast-conserving surgery for early stage breast cancer patients. The utilization of TBB decreased over time, especially for patients receiving conventional whole-breast irradiation, while increasing for those receiving hypofractionated whole-breast irradiation. Fractionation regimen played a critical role in the changing practice patterns of TBB over time.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Gerd Fastner, Roland Reitsamer, Christoph Gaisberger, Wolfgang Hitzl, Bartosz Urbanski, Dawid Murawa, Christiane Matuschek, Wilfried Budach, Antonella Ciabattoni, Juliann Reiland, Marie Molnar, Cristiana Vidali, Claudia Schumacher, Felix Sedlmayer
Summary: Intraoperative electron radiation therapy (IOERT) combined with moderate hypofractionation schedule has been shown to effectively reduce local recurrence rates in patients with invasive breast cancer after breast conserving surgery. The HIOB trial demonstrated low five-year local recurrence rates and minimal toxicity, making it a viable treatment option for these patients.
Article
Oncology
Birgitte V. Offersen, Jan Alsner, Hanne M. Nielsen, Erik H. Jakobsen, Mette H. Nielsen, Lars Stenbygaard, Anders N. Pedersen, Mette S. Thomsen, Esben Yates, Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mirjana Josipovic, Maj-Britt Jensen, Jens Overgaard
Summary: External-beam PBI is noninferior to WBI in terms of breast induration for patients with low-risk breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Brigid E. Hickey, Margot Lehman
Summary: The study suggests that partial breast irradiation (PBI)/accelerated partial breast irradiation (APBI) may result in slightly reduced local recurrence-free survival, but similar overall survival compared to whole breast radiotherapy (WBRT), with little to no difference in other oncological outcomes. However, PBI/APBI may lead to worse cosmetic outcomes.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
X. Li, J. Sanz, N. Argudo, M. Vernet-Tomas, N. Rodriguez, L. Torrent, E. Fernandez-Velilla, O. Pera, Y. Huang, P. Nicolau, M. Jimenez, M. Segura, M. Algara
Summary: The study results show that in breast cancer treatment, IORT as PBI has better tolerance and quality of life for patients, while as IORT + WBI, patients experienced some mild acute toxicity reactions.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Maria Cristina Leonardi, Chiara Fausta Cormio, Samuele Frassoni, Samantha Dicuonzo, Cristiana Fodor, Mattia Intra, Maria Alessia Zerella, Anna Morra, Federica Cattani, Stefania Comi, Nicola Fusco, Mattia Zaffaroni, Viviana Galimberti, Paolo Veronesi, Silvia Dellapasqua, Francesca De Lorenzi, Giovanni Battista Ivaldi, Vincenzo Bagnardi, Roberto Orecchia, Damaris Patricia Rojas, Barbara Alicja Jereczek-Fossa
Summary: The study evaluated the outcome of intraoperative electron boost and hypofractionated whole breast irradiation for breast cancer in young women. The treatment achieved excellent local control but resulted in tumor bed fibrosis.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Mutlay Sayan, Zeinab Abou Yehia, Imraan Jan, Apar Gupta, Irina Vergalasova, Marc Reviello, Shicha Kumar, Bruce Haffty, Nisha Ohri
Summary: This study evaluated the changes in lumpectomy cavity volume during hypofractionated radiation and suggested the dosimetric benefits of adaptive boost planning in reducing normal tissue exposure in breast cancer patients.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Ioannis M. Koukourakis, Marianthi Panteliadou, Axiotis G. Giakzidis, Christos Nanos, Ioannis Abatzoglou, Alexandra Giatromanolaki, Michael I. Koukourakis
Summary: Long-term results of HypoAR in breast-conserving surgery patients shows it is a safe and effective treatment, with minimal early radiation toxicity but late toxicities including breast edema and arm lymphedema. Positive surgical margins, extracapsular node invasion, and HER2-enriched/triple-negative phenotypes are associated with a higher risk of locoregional relapse.
Review
Oncology
Camil Ciprian Mirestean, Roxana Irina Iancu, Dragos Petru Teodor Iancu
Summary: Breast cancer is a common cancer among women worldwide and is often treated with radiotherapy. By improving radiotherapy techniques and heart protection methods, the risk of cardiac toxicity from hypo-fractionated breast irradiation can be reduced.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hans Van Hulle, Eline Desaunois, Vincent Vakaet, Leen Paelinck, Max Schoepen, Giselle Post, Annick Van Greveling, Bruno Speleers, Marc Mareel, Wilfried De Neve, Chris Monten, Pieter Deseyne, Liv Veldeman
Summary: The study found that the differences in physician-assessed toxicity and photographic analysis between simultaneous integrated boost (SIB) and sequential boost (SEB) at two years were very small and not significant, indicating that SIB does not lead to an excess in toxicity or worse cosmetic outcome.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Alicia Le Bras, Yazid Belkacemi, Celine Bourgier, Isabelle Gabelle-Flandin, Adeline Petit, Philippe Guilbert, Julien Geffrelot, Severine Racadot, Eleonor Rivin Del Campo, Chantal Hanzen, Claire Charra Brunaud, Guillaume Auzac, Thomas Lacornerie, Jerome Lemonnier, Eric Lartigau, Isabelle Durand-Zaleski
Summary: This study evaluates the cost-effectiveness and national budget impact of accelerated partial breast irradiation (APBI) versus standard or hypofractionated whole breast irradiation (WBI) in low-risk breast cancer patients in France. The results show that APBI is cost-saving and there is no significant difference in quality-adjusted life years (QALYs) compared to WBI.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Oliver J. Ott, Wilhelm Stillkrieg, Ulrike Lambrecht, Claudia Schweizer, Allison Lamrani, Tim-Oliver Sauer, Vratislav Strnad, Christoph Bert, Carolin C. Hack, Rainer W. Fietkau, Matthias W. Beckmann
Summary: Compared to whole-breast irradiation, partial-breast irradiation reduces radiation doses to healthy tissues and should be recommended to suitable patients to minimize risks of secondary tumors and major cardiac events.
Article
Otorhinolaryngology
Stefano Ursino, Elisa Calistri, Francesca De Felice, Pierluigi Bonomo, Isacco Desideri, Pierfrancesco Franco, Francesca Arcadipane, Caterina Colosimo, Rosario Mazzola, Marta Maddalo, Alessandra Gonnelli, Giulia Malfatti, Riccardo Morganti, Daniela Musio, Fabiola Paiar
Summary: This study aimed to investigate changes in M.D. Anderson Dysphagia Inventory (MDADI) scores in patients with naso- and oropharynx cancer after radiochemotherapy using IMRT with sparing of swallowing organs at risk (SWOARs). The results showed a slight decline in MDADI scores after treatment in the optimal group, and a significant and clinically meaningful improvement in the adequate/poor group. Therefore, dose optimization to SWOARs can minimize treatment-related symptoms in patients with optimal deglutition-related quality of life and help those with adequate/poor deglutition-related quality of life recover from cancer dysphagia.
Article
Oncology
Livia Marrazzo, Icro Meattini, Gabriele Simontacchi, Lorenzo Livi, Stefania Pallotta
Summary: Multiple phase 3 trials have shown that partial breast irradiation is not inferior to whole breast irradiation in terms of local control and has similar or reduced toxicity. The 5-fraction regimen has gained interest, especially during the COVID-19 pandemic. The APBI-IMRT-Florence trial schedule of 30 Gy in 5 fractions appears to be a safe and effective option for patients with early breast cancer.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Marco Tagliamento, Alessandra Gennari, Matteo Lambertini, Ramon Salazar, Nadia Harbeck, Lucia Del Mastro, Juan Aguilar-Company, Mark Bower, Rachel Sharkey, Alessia Dalla Pria, Andrea Plaja, Amanda Jackson, Jasmine Handford, Ailsa Sita-Lumsden, Clara Martinez-Vila, Marta Matas, Ana Miguel Rodriguez, Bruno Vincenzi, Giuseppe Tonini, Alexia Bertuzzi, Joan Brunet, Paolo Pedrazzoli, Francesca D'Avanzo, Federica Biello, Alasdair Sinclair, Alvin J. X. Lee, Sabrina Rossi, Gianpiero Rizzo, Oriol Mirallas, Isabel Pimentel, Maria Iglesias, Ana Sanchez de Torre, Annalisa Guida, Rossana Berardi, Alberto Zambelli, Carlo Tondini, Marco Filetti, Francesca Mazzoni, Uma Mukherjee, Nikolaos Diamantis, Alessandro Parisi, Avinash Aujayeb, Aleix Prat, Michela Libertini, Salvatore Grisanti, Maura Rossi, Federica Zoratto, Daniele Generali, Cristina Saura, Gary H. Lyman, Nicole M. Kuderer, David J. Pinato, Alessio Cortellini
Summary: Although breast cancer patients have lower mortality rates from COVID-19, it is important to evaluate the impact of the pandemic in different phases and the effectiveness of vaccination to inform clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Giulio Francolini, Giulio Frosini, Vanessa Di Cataldo, Beatrice Detti, Maria Grazia Carnevale, Marco Banini, Anna Peruzzi, Viola Salvestrini, Luca Visani, Emanuela Olmetto, Carlotta Becherini, Andrea Allegra, Luca Burchini, Vieri Scotti, Monica Mangoni, Icro Meattini, Isacco Desideri, Lorenzo Livi
Summary: This study aimed to explore predictive factors of fitness to taxane chemotherapy in older adult patients. Data from patients aged 70 years old and above were collected, and it was found that G8 score is an important predictor for tolerability of taxane chemotherapy.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Oncology
Icro Meattini, Rejane de Oliveira Franco, Viola Salvestrini, Tarek Hijal
Summary: Breast cancer is the most common cancer in women worldwide, and significant progress has been made in understanding its biology and pathology. A personalized conservative approach is currently used based on individual patient risk. Partial-breast irradiation has been developed to reduce treatment morbidity while maintaining the ability to decrease local recurrences. However, there are still questions to be answered and a one-treatment-fits-all approach is not appropriate for this heterogeneous disease.
Article
Oncology
Carl Sars, Helena Sackey, Jan Frisell, Paul W. Dickman, Fredrik Karlsson, Isabelle Kindts, Gustavo Nader Marta, Ruffo Freitas-Junior, Tove Filtenborg Tvedskov, Loay Kassem, Ahmed S. Ali, Hanna Ihalainen, Mathias Neron, Michalis Kontos, Orit Kaidar-Person, Icro Meattini, Anne Brecht Francken, Frederieke van Duijnhoven, Ingvild Ona Moberg, Tanja Marinko, Attila Kollar, Mahbubl Ahmed, Dennis Remoundos, Jenny Banks, Reshma Jagsi, Lesly A. Dossett, Ebba K. Lindqvist
Summary: Phyllodes tumors of the breast are rare fibroepithelial lesions classified as benign, borderline or malignant. Current clinical practice in managing these tumors shows considerable variation, indicating a need for education and further research to establish appropriate surgical margins, follow-up time, and a multidisciplinary approach.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Elisa Scola, Guido Del Vecchio, Giorgio Busto, Andrea Bianchi, Ilaria Desideri, Davide Gadda, Sara Mancini, Edoardo Carlesi, Marco Moretti, Isacco Desideri, Giovanni Muscas, Alessandro Della Puppa, Enrico Fainardi
Summary: The non-enhancing peritumoral area (NEPA) is defined as the hyperintense region in T2-weighted and fluid-attenuated inversion recovery (FLAIR) images surrounding a brain tumor. NEPA analyses using conventional and advanced MRI techniques have shown promise in the differential diagnosis of brain tumors and predicting prognosis and treatment response. An update on this topic is needed due to the rapid technological advancements in advanced MRI imaging.
Editorial Material
Oncology
Elisa Agostinetto, Evandro de Azambuja, Matteo Lambertini
Article
Biology
Elze Prokurotaite, Margherita Condorelli, Julie Dechene, Jason Bouziotis, Matteo Lambertini, Isabelle Demeestere
Summary: This study aimed to evaluate the impact of breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) on ovarian reserve in young women and assess the performance of fertility preservation (FP). The results showed that neither BC nor gBRCA PV significantly affected ovarian reserve and FP efficacy.
Review
Oncology
Graziana Scavone, Silvia Ottonello, Eva Blondeaux, Luca Arecco, Paola Scaruffi, Sara Stigliani, Barbara Cardinali, Roberto Borea, Michele Paudice, Valerio G. Vellone, Margherita Condorelli, Isabelle Demeestere, Matteo Lambertini
Summary: CDK4/6 inhibitors combined with endocrine therapy are the standard treatment for HR+/HER2- advanced breast cancer patients. However, limited data is available on the potential gonadotoxicity of these inhibitors. This review summarizes the role of the CDK4/6 complex in ovarian tissue and the potential impact of CDK4/6 inhibition on ovarian physiological processes.
Letter
Oncology
C. Massarotti, S. Stigliani, I. Gazzo, M. Lambertini, P. Anserini
Article
Radiology, Nuclear Medicine & Medical Imaging
Eleonora Bicci, Cosimo Nardi, Leonardo Calamandrei, Eleonora Barcali, Michele Pietragalla, Linda Calistri, Isacco Desideri, Francesco Mungai, Luigi Bonasera, Vittorio Miele
Summary: Texture analysis on MRI images can differentiate inflammation, fibrosis, and residual cancer in patients with naso-oropharynx carcinoma after radiochemotherapy. Two features (Energy and Grey Level Non-Uniformity) on T1 images and five features on ADC maps were found to be statistically significant for distinguishing positive and negative patients. The reduction in feature values correlated with a good response to therapy.
Review
Chemistry, Multidisciplinary
Ilaria Morelli, Carlotta Becherini, Marco Banini, Marianna Valzano, Niccolo Bertini, Mauro Loi, Giulio Francolini, Icro Meattini, Viola Salvestrini, Pierluigi Bonomo, Lorenzo Livi, Isacco Desideri
Summary: This review evaluates the role of radiomic features from conventional imaging in assessing the HPV status of OPSCC patients. The study finds that radiomic models can play a complementary role in determining HPV status, with MRI and CT-based models showing comparable efficacy.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Jonas Willmann, L. Appelt, Panagiotis Balermpas, G. Baumert, Dirk de Ruysscher, Morten Hoyer, Coen Hurkmans, Orit Kaidar-Person, Icro Meattini, Maximilian Niyazi, Philip Poortmans, Nick Reynaert, Stephanie Tandini-Lang, Yvette van der Linden, Carsten Nieder, Nicolaus Andratschke
Summary: This study investigated the patterns of care for re-irradiation internationally and found significant heterogeneity across anatomical regions, highlighting the need for high-quality evidence from prospective studies to guide treatment decisions and establish safe cumulative dose constraints.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulio Francolini, Maria Grazia Carnevale, Vanessa Di Cataldo, Mauro Loi, Beatrice Detti, Carolina Orsatti, Luisa Caprara, Niccolo Bertini, Victoria Lorenzetti, Emanuela Olmetto, Carlotta Becherini, Luca Visani, Viola Salvestrini, Gabriele Simontacchi, Daniela Greto, Pierluigi Bonomo, Raffaela Doro, Laura Masi, Isacco Desideri, Icro Meattini, Sergio Serni, Lorenzo Livi
Summary: This study retrospectively collected data from 101 patients with locally recurrent prostate cancer who underwent re-irradiation. The results showed that CyberknifeR rSBRT had promising oncological outcomes and low toxicity in this patient cohort.
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)