Article
Urology & Nephrology
Christine A. White, Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll
Summary: This study compared plasma iohexol and Tc-99m-DTPA GFR with varying sampling strategies to urinary inulin GFR and identified protocols with the greatest accuracy based on clinical characteristics. Delayed sampling in plasma iohexol protocols showed highest accuracy in low GFRs, while early sampling showed highest accuracy in high GFRs. Customization of GFR protocols based on anticipated GFR levels is crucial for accuracy.
KIDNEY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Shinhyeung Kwak, Jeong Yeon Kim, Heeyeon Cho
Summary: This retrospective study conducted at Samsung Medical Center in Seoul, South Korea, aimed to investigate the prevalence and risk factors of vancomycin-induced nephrotoxicity in non-ICU pediatric patients. The study found that a longer hospital stay, concomitant use of piperacillin-tazobactam, and a serum trough level of vancomycin above 24.35 mu g/mL were independently associated with VIN. The study suggests that measuring serum trough level of vancomycin can help clinicians prevent VIN in pediatric patients.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Article
Critical Care Medicine
Maxime Desgrouas, Hamid Merdji, Anne Bretagnol, Chantal Barin-Le Guellec, Jean-Michel Halimi, Stephan Ehrmann, Charlotte Salmon Gandonniere
Summary: Kinetic glomerular filtration rate equations are not accurate enough to estimate glomerular filtration rate in patients with shock. They can both under- or overestimate glomerular filtration rate, with a trend to overestimation. Applying corrective factors to creatinine concentration or volume of distribution did not improve accuracy sufficiently to make these formulas reliable.
CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Filippo Mariano, Consuelo De Biase, Zsuzsanna Hollo, Ilaria Deambrosis, Annalisa Davit, Alberto Mella, Daniela Bergamo, Stefano Maffei, Francesca Rumbolo, Alberto Papaleo, Maurizio Stella, Luigi Biancone
Summary: The study found that burn patients treated with CRRT had a long-term expectation of preserved renal function, but were more predisposed to microalbuminuria, diabetes, and the presence of risk factors for intercurrent comorbidities and chronic renal disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Urology & Nephrology
Pierre Delanaye, Etienne Cavalier, Hans Pottel, Thomas Stehle
Summary: Glomerular filtration rate (GFR) is estimated using equations based on serum biomarker concentration and demographic data. The 2009 creatinine-based CKD-EPI equation (CKD-EPI2009) was widely used until 2021 when it was recalibrated. However, both CKD-EPI2009 and the recalibrated version overestimate GFR in adults aged 18-30 years, with a particularly significant overestimation at age 18. Alternative equations like EKFC and EKFCCC provide better performance in diverse populations, with EKFCCC being a sex-free and race-free equation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment is associated with unfavorable outcomes following intracerebral hemorrhage, and there may be safety concerns for intensive blood pressure control in patients with renal impairment.
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Jun Wang, Menglei Zha, Hui Zhao, Wentong Yue, Decheng Wu, Kai Li
Summary: This research successfully synthesized a class of renal-clearable gadolinium nanoparticles and achieved the diagnosis of kidney dysfunction in a mice model with a damaged kidney through noninvasive magnetic resonance imaging. This provides a new tool for exploring translational strategies for kidney dysfunction.
ANALYTICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Nori J. L. Smeets, Oliver Hartmann, Janin Schulte, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study aimed to investigate the relationship between a novel GFR marker, PENK, and age in children, as well as its correlation with traditional markers. The study found that PENK levels were higher in young children and decreased to adult levels around two years of age. The correlation between PENK and mGFR was similar to the correlation between SCr-based eGFR and mGFR.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment may lead to unfavorable outcomes following intracerebral hemorrhage, and there is a significant interaction between decreased eGFR and treatment assignment in intensive blood pressure control therapy, raising safety concerns.
Article
Pediatrics
Nori J. L. Smeets, Esther M. M. Teunissen, Kim van der Velden, Maurice J. P. van der Burgh, Demi E. Linders, Elodie Teesselink, Dirk-Jan A. R. Moes, Camilla Tondel, Rob Ter Heine, Arno van Heijst, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study aimed to compare the prevalence of AKI and ARC in critically ill children using iohexol-based mGFR and SCr-based eGFR methods, and investigate the performance of different SCr-based eGFR methods. The results showed that AKI prevalence was higher and ARC prevalence was lower when using mGFR, and age- and sex-dependent equations had the highest accuracy for diagnosing AKI and ARC.
PEDIATRIC NEPHROLOGY
(2022)
Review
Immunology
Jianhua Yang, Yuanxiu Gan, Xuanyun Feng, Xiangyu Chen, Shu Wang, Junwei Gao
Summary: This study systematically reviewed and assessed the efficacy and safety of melatonin in preventing acute kidney injury (AKI). The results showed that melatonin did not have a significant effect on reducing the incidence of AKI. More well-designed clinical studies with larger sample size are needed in the future to verify these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Pierre Delanaye, Emmanuelle Vidal-Petiot, Thomas Stehle, Laurence Dubourg, Francois Gaillard, Gunnar Sterner, Christine A. White, Sandrine Lemoine, Vincent Audard, Dominique Prie, Etienne Cavalier, Marie Courbebaisse, Hans Pottel, Martin Flamant
Summary: This study evaluated the performance of different equations in correcting the early disappearance curve in the GFR range >90 ml/min per 1.73 m(2). The results showed that the BM and JBM equations had the best overall performance, especially with the lowest accuracy in the hyperfiltration range.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Zhicheng Jin, Rongrong Huang, Paul Christensen, Roger L. Bertholf, Xin Yi
Summary: This study aimed to establish a convenient laboratory test to evaluate the plasma clearance of iohexol in living kidney donors. Iohexol was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and automated data integration and result calculation were achieved using a custom Python script and a laboratory informatics system (LIS) vendor's direct media interface for automated result reporting.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Ivan Pavlov, Hangyong He, Bairbre McNicholas, Yonatan Perez, Elsa Tavernier, Matthew W. Trump, Julie A. Jackson, Wei Zhang, Daniel S. Rubin, Thomas Spiegel, Anthony Hung, Miguel Angel Ibarra Estrada, Oriol Roca, David L. Vines, David Cosgrave, Sara Mirza, John G. Laffey, Todd W. Rice, Stephan Ehrmann, Jie Li
Summary: Awake prone positioning (APP) can improve oxygenation in patients with acute respiratory failure due to COVID-19, but it does not reduce the intubation rate. Randomized controlled clinical studies are needed to confirm these findings due to the high heterogeneity and observational nature of the included studies.
Article
Pharmacology & Pharmacy
Alexandre Destere, Pierre Marquet, Charlotte Salmon Gandonniere, Anders Asberg, Veronique Loustaud-Ratti, Paul Carrier, Stephan Ehrmann, Chantal Barin-Le Guellec, Aurelie Premaud, Jean-Baptiste Woillard
Summary: This study investigates the use of a hybrid machine learning/population pharmacokinetic approach to improve individual iohexol clearance estimation. The results show that machine learning algorithms can correct the limited sampling-based MAP-BE clearance estimates, leading to a decrease in estimation error.
CLINICAL PHARMACOKINETICS
(2022)
Letter
Medicine, General & Internal
Jie Li, Ivan Pavlov, Stephan Ehrmann
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Critical Care Medicine
Laetitia Bodet-Contentin, Melanie Letourneur, Stephan Ehrmann
Summary: The study aimed to evaluate the feasibility and efficacy of virtual reality (VR) in reducing stress, anxiety, and fatigue, and increasing work disconnection among ICU caregivers during their breaktime. The results showed that VR was easy to use and resulted in a significant reduction in fatigue and increased disconnection from the work environment. However, no significant difference was observed for other parameters.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Thierry Boulain, Mai-Anh Nay, Pierre-Francois Dequin, Jean-Baptiste Lascarrou, Philippe Vignon, Toufik Kamel, Gregoire Mueller, Stephan Ehrmann
Summary: The purpose of this study was to assess the predictive performance of pulse oximetry (SpO2) in ruling out hypoxaemia and hyperoxia in critically ill patients. Prospective measurements of SpO2, arterial oxygenation (SaO2), and arterial partial pressure of oxygen (PaO2) were taken every 6 hours during the first 24 hours of intensive care unit admission. The study found that SpO2 had poor discriminative ability to rule out hypoxaemia and hyperoxia in this cohort of patients with circulatory failure.
AUSTRALIAN CRITICAL CARE
(2023)
Review
Critical Care Medicine
Jie Li, Jian Luo, Ivan Pavlov, Yonatan Perez, Wei Tan, Oriol Roca, Elsa Tavernier, Aileen Kharat, Bairbre McNicholas, Miguel Ibarra-Estrada, David L. Vines, Nicholas A. Bosch, Garrett Rampon, Steven Q. Simpson, Allan J. Walkey, Michael Fralick, Amol Verma, Fahad Razak, Tim Harris, John G. Laffey, Claude Guerin, Stephan Ehrmann
Summary: Awake prone positioning can reduce the need for intubation in patients with COVID-19-related acute hypoxaemic respiratory failure, particularly among those requiring advanced respiratory support or treated in the ICU.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Remi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, Frederic Pene, Maxens Decavele, Nicolas Terzi, Gwenael Prat, Charlotte Garret, Damien Contou, Arnaud Gacouin, Jeremy Bourenne, Christophe Girault, Christophe Vinsonneau, Jean Dellamonica, Guylaine Labro, Sebastien Jochmans, Alexandre Herbland, Jean-Pierre Quenot, Jerome Devaquet, Dalila Benzekri, Emmanuel Vivier, Saad Nseir, Gwenhael Colin, Didier Thevenin, Giacomo Grasselli, David Bougon, Mona Assefi, Claude Guerin, Thierry Lherm, Achille Kouatchet, Stephanie Ragot, Arnaud W. Thille
Summary: This study aimed to compare the efficacy of high-flow nasal oxygen (HFNO) alone and non-invasive ventilation (NIV) alternating with HFNO in immunocompromised patients with acute respiratory failure. The results showed no significant difference in mortality rate at day 28 between the two methods.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Anesthesiology
Laetitia Bodet-Contentin, Emilie Szymkowicz, Eric Delpierre, Delphine Chartier, Pierrick Gadrez, Gregoire Muller, Aurelie Renault, Stephan Ehrmann
Summary: This study demonstrates that the eye tracking technology device specifically designed for intensive care can be easily used by awake intubated patients with a short training time.
MINERVA ANESTESIOLOGICA
(2022)
Letter
Medicine, General & Internal
Ivan Pavlov, Miguel Ibarra-Estrada, Stephan Ehrmann
JAMA INTERNAL MEDICINE
(2022)
Letter
Critical Care Medicine
Benoit Painvin, Stephan Ehrmann, Arnaud W. Thille, Jean-Marc Tadie
ANNALS OF INTENSIVE CARE
(2022)
Article
Virology
Sandrine Le Guellec, Jeoffrey Pardessus, Elsa Bodier-Montagutelli, Guillaume L'Hostis, Emilie Dalloneau, Damien Piel, Hakim Chouky Samai, Antoine Guillon, Elvir Mujic, Emmanuelle Guillot-Combe, Stephan Ehrmann, Eric Morello, Jerome Gabard, Nathalie Heuze-Vourc'h, Cindy Fevre, Laurent Vecellio
Summary: Bacteriophages have the potential to treat lung infections in the context of antibiotic resistance, and nebulization during mechanical ventilation is an effective delivery method.
Article
Medicine, General & Internal
Stephan Ehrmann, Francois Barbier, Julien Demiselle, Jean-Pierre Quenot, Jean-Etienne Herbrecht, Damien Roux, Jean-Claude Lacherade, Mickael Landais, Philippe Seguin, David Schnell, Anne Veinstein, Philippe Gouin, Sigismond Lasocki, Qin Lu, Gaetan Beduneau, Martine Ferrandiere, Gaetan Plantefeve, Claire Dahyot-Fizelier, Nader Chebib, Emmanuelle Mercier, Nathalie Heuze-Vourc'h, Renaud Respaud, Nicolas Gregoire, Denis Garot, Mai-Anh Nay, Ferhat Meziani, Pascal Andreu, Raphael Clere-Jehl, Noemie Zucman, Marie-Ange Azais, Marjorie Saint-Martin, Charlotte Salmon Gandonniere, Dalila Benzekri, Hamid Merdji, Elsa Tavernier
Summary: A 3-day course of inhaled amikacin reduced the burden of ventilator-associated pneumonia in critically ill patients who had undergone mechanical ventilation for at least 3 days.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Laetitia Bodet-Contentin, Helene Messet-Charriere, Valerie Gissot, Aurelie Renault, Gregoire Muller, Aurelie Aubrey, Pierrick Gadrez, Elsa Tavernier, Stephan Ehrmann
Summary: The study evaluated an eye-tracking adapted comprehension test for ICU patients and found significant differences in comprehension capabilities among patients, which were related to age and educational level.
Article
Critical Care Medicine
Miguel Ibarra-Estrada, Jie Li, Ivan Pavlov, Yonatan Perez, Oriol Roca, Elsa Tavernier, Bairbre McNicholas, David Vines, Miguel Marin-Rosales, Alexandra Vargas-Obieta, Roxana Garcia-Salcido, Sara A. Aguirre-Diaz, Jose A. Lopez-Pulgarin, Quetzalcoatl Chavez-Pena, Julio C. Mijangos-Mendez, Guadalupe Aguirre-Avalos, Stephan Ehrmann, John G. Laffey
Summary: Awake prone positioning (APP) can reduce intubation rate and improve treatment success in COVID-19 patients. Longer duration of APP, increase in ROX index after APP, and decrease in lung ultrasound score are significantly associated with treatment success.
Article
Immunology
Damien Contou, Gwenhael Colin, Brendan Travert, Sebastien Jochmans, Marie Conrad, Jean-Baptiste Lascarrou, Benoit Painvin, Alexis Ferre, David Schnell, Beatrice La Combe, Remi Coudroy, Stephan Ehrmann, Jerome Rambaud, Arnaud Wiedemann, Pierre Asfar, Pierre Kalfon, Emmanuel Guerot, Sebastien Preau, Laurent Argaud, Florence Daviet, Jean Dellamonica, Audrey Dupont, Muriel Fartoukh, Toufik Kamel, Gaetan Beduneau, Florence Canoui-Poitrine, Emmanuelle Boutin, Gerard Lina, Armand Mekontso Dessap, Anne Tristan, Nicolas de Prost
Summary: This multicenter study retrospectively analyzed m-TSS patients in 43 hospitals in France, and found that none of the patients met the CDC criteria for confirmed m-TSS at ICU admission. Despite the need for vasopressor support and invasive mechanical ventilation, no patients required limb amputation or died.
CLINICAL INFECTIOUS DISEASES
(2022)