Article
Biochemistry & Molecular Biology
Liying Zhang, Gao He, Yang Yu, Yu Zhang, Xiang Li, Shige Wang
Summary: In this study, a multifunctional hydrogel with photothermal conversion capability, biocompatibility, and degradation ability was successfully prepared. Additionally, the hydrogel has the potential to induce osteogenesis and showed good biocompatibility and photothermal conversion properties in both cell and animal experiments.
Article
Chemistry, Multidisciplinary
Song Yi Lee, JiHye Park, Da In Jeong, ChaeRim Hwang, Junmin Lee, KangJu Lee, Han -Jun Kim, Hyun-Jong Cho
Summary: This study developed a hyaluronic acid-based hydrogel reactor that can be formed into a gel with a single syringe injection for multiple therapies against breast cancer. The hydrogel system provides sustained therapeutic functions and high safety profiles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Juan Yue, Peng Miao, Li Li, Ruhong Yan, Wen-Fei Dong, Qian Mei
Summary: Hydrogel has been widely used in tumor therapy due to its excellent biocompatibility and degradability. In this study, an injectable hydrogel was proposed by the Schiff base reaction between HA-CHO and carbon dots (CDs), which can realize both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. The CD@ Hydrogel showed outstanding biosafety and high antitumor effect after laser irradiation, providing a simple and efficient strategy for cancer phototherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Hang Wu, Qi Jiang, Keyi Luo, Chunping Zhu, Mengmeng Xie, Shige Wang, Zhewei Fei, Jiulong Zhao
Summary: This study presents a novel nanoenzyme-based theranostic nanoplatform for combined photothermal therapy (PTT) and photodynamic therapy (PDT), showing enhanced photothermal conversion efficiency under NIR irradiation and the ability to produce reactive oxygen species under 660 nm NIR laser irradiation. The findings suggest the potential of theranostic nanoenzymes for translational medicine.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Wen Zeng, Chunping Liu, Shuntao Wang, Ziqi Wang, Qinqin Huang
Summary: This study demonstrated that SFO-based nanozymes hold great promise as a catalytic, radiosensitizing anti-tumor therapy.
FRONTIERS IN ONCOLOGY
(2021)
Retraction
Biotechnology & Applied Microbiology
Ji-jun Fu, Ming- yue Chen, Jie-xia Li, Jun- hua Zhou, Sheng-nan Xie, Ping Yuan, Bo Tang, Cheng- cheng Liu
Summary: The article has been retracted. Please refer to the Retraction Notice for more details: https://doi.org/10.1186/s12951-021-00780-0.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jingyu Gu, Xinpei Liu, Zhongfang Ji, Mengling Shen, Minqian Zhu, Yuanyuan Ren, Li Guo, Kai Yang, Teng Liu, Xuan Yi
Summary: In this study, DMXAA, a vasodestructive agent with cGAS-STING stimulation capacity, was integrated with polyethylene glycol grafted poly (lactic-co-glycolic) acid co-polymer (PLGA-PEG) to form PLGA-PEG/DMXAA (PPD) nanoparticles, which induced tumor-specific vascular destruction and allowed for multiple synergistic therapies of cancer. PPD could induce blood clot formation in the tumor, mediate photothermal therapy, and promote oxygen release for enhanced radiotherapy. Additionally, PPD-mediated therapies could induce tumor starvation therapy and trigger systemic anti-tumor immunity by activating the cGAS-STING pathway. Together with anti-PD-L1, PPD-mediated therapies effectively eliminated primary tumors, distant tumors, metastasis, and recurrence, providing a practical strategy for cancer therapy.
Review
Chemistry, Multidisciplinary
Filipa A. L. S. Silva, Hui-Ping Chang, Jean Anne C. Incorvia, Maria J. Oliveira, Bruno Sarmento, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: Photothermal therapy (PTT) and magnetic hyperthermia therapy (MHT) using 2D nanomaterials (2DnMat) show promising potential for alternative cancer and bacterial infection treatments. The unique properties of 2DnMat, including high surface area, near-infrared absorption, responsiveness to external stimuli, and surface functionalization possibilities, make them ideal platforms for PTT and MHT. Although significant progress has been made in in vitro and in vivo studies, challenges such as improving drug conjugation, understanding in vivo biodegradation, and refining evaluation criteria still need to be addressed.
Article
Pharmacology & Pharmacy
Tianming Cui, Shukai Li, Shengfu Chen, Ying Liang, Haotian Sun, Longgang Wang
Summary: A new drug delivery system G5MEK7C(n)-ICG with a stealth layer was prepared to overcome the biological toxicity and reduce therapeutic efficacy of dendrimers and indocyanine green. The system exhibited excellent biocompatibility, photothermal conversion effect, and tumor inhibition rate in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Panchanathan Manivasagan, Sekar Ashokkumar, Ala Manohar, Ara Joe, Hyo-Won Han, Sun-Hwa Seo, Thavasyappan Thambi, Hai-Sang Duong, Nagendra Kumar Kaushik, Ki Hyeon Kim, Eun Ha Choi, Eue-Soon Jang
Summary: Novel calcium ion-doped magnesium ferrite nanoparticles have been developed as efficient and biocompatible photothermal therapeutic materials for cancer treatment, with their high near-infrared absorption, short treatment period, strong cytotoxicity to cancer cells under laser irradiation, and minimal damage to healthy cells.
Article
Materials Science, Multidisciplinary
Zhonghang Yu, Youling He, Weiwei Feng, Yan Wang, Xinyu Zhang, Zhichao Zheng, Lihong Wu, Gang Wu, Huade Zheng
Summary: A new near infrared biocompatible photothermal therapeutic (PTT) agent BPD-BBTD was synthesized, along with a new type of photothermal gel BPD-BBTD-NPs@PDA-PAM hydmgels, exhibiting high photothermal conversion efficiency and strong ability in killing cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiuying Liu, Yu Zhang, Hang Wu, Jingwen Tang, Jiao Zhou, Jiulong Zhao, Shige Wang
Summary: A methacrylic gelatin/oxidized dextran/montmorillonite-strontium/polypyrrole (GOMP) hydrogel with a dual network structure was synthesized. The hydrogel demonstrated sustained release of doxorubicin (DOX) due to the network structure. The inclusion of polypyrrole provided conductivity and photo-thermal conversion capacity to the hydrogel, resulting in a high photothermal conversion efficiency of 31.61% under 808 nm laser radiation. The GOMP hydrogel exhibited good swelling properties in solvents and showed excellent biocompatibility and biodegradability in vitro and in vivo. Furthermore, the in vitro and in vivo experiments demonstrated synergistic effects of DOX-loaded GOMP hydrogel on tumor cell apoptosis through chemotherapy and photothermal therapy, while the inclusion of montmorillonite-strontium (MMT-Sr) improved the mechanical properties and promoted bone regeneration. The multifunctional GOMP hydrogel shows great potential for osteosarcoma treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Shuaiqi Gan, Yongzhi Wu, Xu Zhang, Zheng Zheng, Min Zhang, Li Long, Jinfeng Liao, Wenchuan Chen
Summary: Phototherapeutic agent-based phototherapies have been proven to be safe for the treatment of malignant tumors. The main modalities include photothermal therapy and photodynamic therapy. However, the phototoxicity of these therapies limits their clinical application. To improve therapeutic performance and minimize side effects, researchers have focused on developing hydrogel-based phototherapy.
Article
Nanoscience & Nanotechnology
Camila M. Otero, Guillermina Boggan Simal, Magali F. Scocozza, Aldo Rubert, Claudia A. Grillo, Luciana Hannibal, Gabriel Lavorato, Maria Ana Huergo, Daniel H. Murgida, Carolina Vericat
Summary: This study presents a post-synthesis optimization and characterization method for biocompatible gold nanotriangles (Au NTs), which can be efficiently separated from spherical gold nanoparticles using depletion forces. The study also analyzes the cytotoxic effects of surface sulfide species and residual presence of surfactant and demonstrates the successful application of Au NTs in photothermal conversion.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Environmental
Da In Jeong, Sungyun Kim, Song Yi Lee, Han-Jun Kim, Junmin Lee, KangJu Lee, Hyun-Jong Cho
Summary: A glucose deprivation, hydroxyl radical generation, photothermal ablation, and ferroptosis induction-installed injectable hydrogel reactor was designed for multiple therapy of localized breast cancer. Iron sulfate and glucose oxidase were incorporated into the hydrogel to achieve cancer cell starvation, H2O2 production, hydroxyl radical generation, and photothermal therapy. The HC-based hydrogel network was locally injected for treatment, and its rheological properties were tuned for immediate and uniform gelation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)