Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amber F. MacDonald, Meaghan E. Harley-Troxell, Steven D. Newby, Madhu S. Dhar
Summary: This article summarizes the application of graphene-based materials in tissue engineering, with a focus on bone tissue engineering. It discusses the need for developing 3D graphene scaffolds and introduces the current manufacturing techniques and limitations.
Article
Engineering, Biomedical
Ashley L. Farris, Dennis Lambrechts, Yuxiao Zhou, Nicholas Y. Zhang, Naboneeta Sarkar, Megan C. Moorer, Alexandra N. Rindone, Ethan L. Nyberg, Alexander Perdomo-Pantoja, S. J. Burris, Kendall Free, Timothy F. Witham, Ryan C. Riddle, Warren L. Grayson
Summary: Oxygen delivery plays a crucial role in enhancing the therapeutic efficacy of cell transplants. In this study, researchers developed a novel scaffold material that effectively releases oxygen, leading to improved bone tissue regeneration mediated by adipose-derived stem cells.
Article
Cell & Tissue Engineering
Stefano Negri, Yiyun Wang, Takashi Sono, Qizhi Qin, Ginny Ching-Yun Hsu, Masnsen Cherief, Jiajia Xu, Seungyong Lee, Robert J. Tower, Victoria Yu, Abhi Piplani, Carolyn A. Meyers, Kristen Broderick, Min Lee, Aaron W. James
Summary: Research has shown that anti-DKK1 neutralizing antibodies can enhance the osteogenic differentiation of human adipose-derived stem cells, aiding in bone repair, and demonstrating potential beneficial effects in a mouse model.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guanzhou Zhou, Ailing Tian, Xin Yi, Lufeng Fan, Wenchong Shao, Han Wu, Nianfeng Sun
Summary: The study demonstrated that Ad-MSCs from primary cultures exhibit stem cell characteristics, and self-assembled nanopeptide hydrogel is a good tissue engineering material. In the 3D-printed tissue model, Ad-MSCs grew well and retained strong differentiation ability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Ling Ho, Chin-Jung Hsu, Che-Wei Wu, Ling-Hua Chang, Jhen-Wei Chen, Chung-Hwan Chen, Kui-Chou Huang, Je-Ken Chang, Shun-Cheng Wu, Pei-Lin Shao
Summary: This study investigated the effect of adipose-derived stem cell (ADSC)-secreted extracellular vesicles (EVs) on osteoblast function. The results showed that ADSC-EVs can enhance osteoblast proliferation and activity, and may regulate osteoblast function through autophagy or signaling pathways.
Article
Materials Science, Multidisciplinary
Xiping Jiang, Yunfan Kong, Mitchell Kuss, Joel Weisenburger, Hani Haider, Robert Harms, Wen Shi, Bo Liu, Wen Xue, Jianghu Dong, Jingwei Xie, Philipp Streubel, Bin Duan
Summary: This study presents a novel therapeutic method that combines three-dimensional (3D) bioprinting and melt electrospinning writing techniques to regenerate the tendon-to-bone interface. The use of 3D-bioprinted pre-differentiated autologous adipose-derived mesenchymal stem cells (ADMSC) generated biomimetic multilayered scaffolds that recapitulated the compositional and cellular structures of the interface. In vivo studies demonstrated the superior histological score and improved collagen organization of the scaffold with spatially differentiated autologous ADMSCs.
APPLIED MATERIALS TODAY
(2022)
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Huijuan Fu, Dequan Zhang, Jinshi Zeng, Qiang Fu, Zhaoyang Chen, Xuer Sun, Yi Yang, Shiyi Li, Minliang Chen
Summary: This study aimed to explore the in vivo application of a 3D-printed tissue-engineered skin substitute loaded with human adipose-derived stem cells (hADSCs) in wound healing. The newly designed biomaterial, composed of adipose tissue decellularized extracellular matrix (dECM) pre-gel, methacrylated gelatin (GelMA), and methacrylated hyaluronic acid (HAMA), was fabricated by 3D printing. The results showed that the 3D-printed skin substitute accelerated wound healing, promoting blood perfusion, re-epithelialization, collagen deposition, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Engineering, Biomedical
R. Tevlin, H. desJardins-Park, J. Huber, S. E. DiIorio, M. T. Longaker, D. C. Wan
Summary: Osteoarthritis is a global burden that affects joints and bones. Tissue engineering, specifically adipose-derived stromal cells, shows promise as a treatment option. Advancements in material science allow for improved engraftment of these cells and activation of biophysical signals through designed microstructures.
Article
Cell & Tissue Engineering
Jana C. Blum, Thilo L. Schenck, Alexandra Birt, Riccardo E. Giunta, Paul S. Wiggenhauser
Summary: In this study, the combination of cell-derived artificial extracellular matrix with 3D printed polycaprolactone scaffolds showed promising results in improving bioactivity and differentiation of human adipose derived stem cells. The ac/aoPCL scaffolds demonstrated good biocompatibility and enhanced chondrogenic and osteogenic differentiation potential.
JOURNAL OF TISSUE ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yiqiang Chang, Ansong Ping, Chunyu Chang, Volker M. Betz, Lin Cai, Bin Ren
Summary: This study investigated the effects of lactoferrin (LF) on the osteogenic differentiation of adipose-derived stem cells (ADSCs). The results showed that LF could promote the proliferation and osteogenic differentiation of ADSCs. LF concentration of 100 mu g/mL exhibited the most significant osteoinductive effect. LF could be used as an alternative to bone morphogenetic protein-2 (BMP-2) in bone tissue engineering to promote bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Ceramics
Xin Zhang, Jun Ma
Summary: In this study, porous scaffolds with photothermal effect were constructed by incorporating graphene nanoplatelets into apatite/gelatin composites. The mild photothermal treatment showed significant acceleration in the proliferation of MC3T3-E1 cells, suggesting the potential of graphene nanoplatelets in accelerating bone regeneration after photothermal treatment for malignant bone tumors.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Danli Zhu, Wanting Bao, Boxuan Wei, Hao Wei, Jinwu Wang, Guangdong Zhou, Xiansong Wang, Shanyu Guo
Summary: In this study, a strategy for the construction of vascularized tissue-engineered adipose tissue was proposed. By integrating a gas-foamed method (soil) and three-dimensional cell spheroids (seeds), adipose tissue regeneration was achieved. The prepared soil significantly enhanced the vascularization of the regenerated tissue, while optimizing the seed cells promoted adipogenesis. This study provides a solution for the regeneration of vascularized adipose tissue and establishes a general research model for the reconstruction of breast defects.
APPLIED MATERIALS TODAY
(2023)
Article
Engineering, Biomedical
Guang Yang, Bhushan Mahadik, Ji Young Choi, Justine R. Yu, Trevor Mollot, Bin Jiang, Xiaoming He, John P. Fisher
Summary: The study utilized a microfluidic approach to prepare collagen microbeads loaded with human bone marrow derived mesenchymal stem cells for creating engineered bone grafts. The cell-laden microbeads self-assembled into macro-tissues, enabling precise control over cell spatial distribution at the macroscale, offering flexibility for graft volume and architecture. The approach has the potential to create 3D engineered bone grafts with customized vasculature using modular tissue engineering and 3D printing.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
D. S. Abdullah Al Maruf, Krishnan Parthasarathi, Kai Cheng, Payal Mukherjee, David R. McKenzie, Jeremy M. Crook, Gordon G. Wallace, Jonathan R. Clark
Summary: This review focuses on the recent progresses in modulating the physiochemical properties and applications of biomaterials in bone tissue engineering (BTE) for mandibular segmental defect repair. BTE is an important strategy for reconstructing critical-sized bone defects and improving patients' quality of life.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Engineering, Environmental
Kezhong Wang, Yunfeng Chao, Zhiqi Chen, Sepidar Sayyar, Caiyun Wang, Gordon Wallace
Summary: A facile coaxial wet-spinning method was used to continuously produce hollow graphene fibers with high conductivity and flexibility. The resulting fibers exhibited outstanding electrochemical and mechanical properties, making them promising candidates for use in wearable supercapacitors and electronics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Polymer Science
Abdul Moqeet Hai, Zhilian Yue, Stephen Beirne, Gordon Wallace
Summary: Electrowriting combines 3D printing and electrospinning to produce complex structures with submicron resolutions. This study demonstrates the compatibility of water-based silk fibroin ink with electrowriting and explores the optimization of ink composition and process parameters. The electrowriting of hydrophilic silk fibroin has the potential to create material structures with biological properties similar to natural systems.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaoteng Jia, Xuenan Ma, Li Zhao, Meiying Xin, Yulei Hao, Peng Sun, Chenguang Wang, Danming Chao, Fangmeng Liu, Caiyun Wang, Geyu Lu, Gordon Wallace
Summary: Implanted rechargeable batteries with biodegradable properties are highly desirable, but limited by the lack of suitable electrode materials. In this study, we present a molecular engineering strategy to develop erodible poly(3,4-ethylenedioxythiophene) (PEDOT) with hydrolyzable carboxylic acid pendants. The compact rechargeable Zn battery with this material demonstrates high capacity and cycling stability, and shows complete biodegradation and biocompatibility in vivo. This strategy offers potential for developing implantable conducting polymers with predetermined degradation profiles and high energy storage capability.
Correction
Multidisciplinary Sciences
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayyar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yan Zhou, Xiaoteng Jia, Daxin Pang, Shan Jiang, Meihua Zhu, Geyu Lu, Yaping Tian, Caiyun Wang, Danming Chao, Gordon Wallace
Summary: The authors propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This patch eliminates the conventional interface impedance between the electrode and drug reservoir, reducing system complexity and size. The delivery dosage can be easily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode.
NATURE COMMUNICATIONS
(2023)
Article
Electrochemistry
Amruthalakshmi Vijayakumar, Yong Zhao, Kezhong Wang, Yunfeng Chao, Haiqun Chen, Caiyun Wang, Gordon G. G. Wallace
Summary: In this study, a scalable one-step glucose blowing method was used to prepare a porous N-doped carbon supported Cu nanoparticles (Cu-NC) composite catalyst for CO2 electroreduction. The Cu-NC catalyst showed efficient catalytic activity for CO2-to-C1 product (CO and formate) conversion, with a high efficiency of 69% at an overpotential of 590 mV. The excellent catalytic activity is attributed to the structure of the composite and the presence of N-species in the carbonaceous matrix.
Article
Medicine, Research & Experimental
Xiao Liu, Marius Berthel, Grishmi Rajbhandari, Ying Zhou, Philip M. Lewis, Zhilian Yue, Gordon G. Wallace
Summary: This research developed a collagen-based hybrid tissue repair patch that can integrate into surrounding tissue and control inflammatory responses for effective post-operative inflammation control. The patch enables simultaneous loading and release of multiple drugs with controllable ratios. The demonstration of co-encapsulation and release of anti-inflammatory dexamethasone and anti-epileptic phenytoin validates the dual drug delivery ability of this versatile composite material. The material's Young's modulus was increased to 20 KPa using a biocompatible riboflavin-induced UV light cross-linking strategy. This composite material has broad potential applications and warrants further research exploration.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Physical
Ruibo Zhong, Sepehr Talebian, Barbara B. Mendes, Gordon Wallace, Robert Langer, Joao Conde, Jinjun Shi
Summary: RNA-based therapeutics hold great promise in disease intervention, and hydrogels are attracting attention for controlled release of these therapeutics. Hydrogels offer advantages such as biodegradability, tunable physiochemical properties, and precise spatiotemporal control over RNA release.
Article
Biochemistry & Molecular Biology
Lingzhi Kang, Ying Zhou, Xifang Chen, Zhilian Yue, Xiao Liu, Chris Baker, Gordon G. Wallace
Summary: The development of biomimetic structures using integrated extracellular matrix (ECM) components provides a promising method for biomaterial fabrication. In this study, an artificial ECM consisting of collagen I, elastin (ELN), and hyaluronan (HA) was created. The electrochemically aligned collagen and ELN mimic the composition of the dermal matrix, while HA is incorporated into the matrices through adsorption and chemical immobilization. The resulting collagen/ELN/hyaluronic acid scaffold (CEH) recapitulates the compositional features of the native skin ECM and supports the proliferation, differentiation, and regeneration of skin cells.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Cell & Tissue Engineering
Tajanka Mladenovska, Peter F. Choong, Gordon G. Wallace, Cathal D. O'Connell
Summary: New developments in additive manufacturing and regenerative medicine have the potential to disrupt traditional therapy development and medical device manufacture. Regulators face challenges in adapting traditional regulatory frameworks for bespoke solutions and incorporating living cells in 3D bioprinting. This perspective discusses the regulatory challenges of 3D bioprinting in comparison to existing cell therapies and custom-made medical devices, including classification, risk, standardization, and quality control.
REGENERATIVE MEDICINE
(2023)
Article
Cell Biology
Hai Xin, Sara Romanazzo, Eva Tomaskovic-Crook, Timothy C. Mitchell, Jui Chien Hung, Steven G. Wise, Kai Cheng, D. S. Abdullah Al Maruf, Murray J. Stokan, Timothy G. H. Manzie, Krishnan Parthasarathi, Veronica K. Y. Cheung, Ruta Gupta, Mark Ly, Carlo Pulitano, Innes K. Wise, Jeremy M. Crook, Jonathan R. Clark
Summary: We have developed an ex vivo perfusion bioreactor system to preserve surgically resected periosteal flaps, demonstrating long-term cell viability and metabolism. This proof-of-concept study paves the way for innovative bone engineering approaches using autotransplanted periosteum to enhance in vivo bone repair.
Review
Polymer Science
Hai Xin, Eva Tomaskovic-Crook, D. S. Abdullah Al Maruf, Kai Cheng, James Wykes, Timothy G. H. Manzie, Steven G. Wise, Jeremy M. Crook, Jonathan R. Clark
Summary: This article provides an overview of the research on the use of periosteum for bone repair, including the anatomy and function of periosteum, culture of periosteal progenitor cells, periosteum-induced ossification, periosteum engineering, and scaffold vascularization.
Article
Biotechnology & Applied Microbiology
D. S. Abdullah Al Maruf, Kai Cheng, Hai Xin, Veronica K. Y. Cheung, Matthew Foley, Innes K. Wise, Will Lewin, Catriona Froggatt, James Wykes, Krishnan Parthasarathi, David Leinkram, Dale Howes, Natalka Suchowerska, David R. Mckenzie, Ruta Gupta, Jeremy M. Crook, Jonathan R. Clark
Summary: Autologous bone replacement is the preferred treatment for mandibular defects, but limitations exist. Bone tissue engineering could overcome these limitations. This study compares various bone substitutes with autologous bone, aiming to select a suitable option for future mandibular repair studies.
BIOENGINEERING-BASEL
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
