Review
Medicine, Research & Experimental
Zhangyang Bi, Wei Zhang, Xiaoyan Yan
Summary: ICA and ICT, the main active ingredients of Epimedium, have anti-inflammatory and immunomodulatory effects and hold promising clinical applications in the treatment of various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Chaoyang Zhao, Fen Wang, Bolin Tang, Jun Han, Xiang Li, Guo Lian, Xiaolong Li, Shisheng Hao
Summary: The study demonstrated that K-3-rh has the potential to reduce HSV-1-induced brain injury by decreasing the secretion of microglial pro-inflammatory factors, inducing apoptosis of microglial cells, and through the cytochrome C and caspase-3 pathway.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hernan Speisky, Maria Fernanda Arias-Sante, Jocelyn Fuentes
Summary: Recent research challenges the belief that the oxidation of flavonoids would result in a loss of their antioxidant properties. It has been found that the oxidation of quercetin and its analogue kaempferol leads to the formation of metabolites with significantly higher antioxidant potency than the precursors. The amplification of antioxidant properties is even greater for kaempferol, with a 100-fold increase compared to quercetin.
Article
Plant Sciences
Yrvinn Campos-Vidal, Alejandro Zamilpa, Enrique Jimenez-Ferrer, Antonio Ruperto Jimenez-Aparicio, Brenda Hildeliza Camacho-Diaz, Gabriela Trejo-Tapia, Daniel Tapia-Maruri, Nayeli Monterrosas-Brisson, Maribel Herrera-Ruiz
Summary: A mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from Malvaviscus arboreus flowers can prevent ethanol-induced gastric lesions and possess anti-inflammatory and antioxidant activities.
Article
Pharmacology & Pharmacy
Yanli Li, Jie Liu, Pawin Pongkorpsakol, Zhengguo Xiong, Li Li, Xuemei Jiang, Haixia Zhao, Ding Yuan, Changcheng Zhang, Yuhui Guo, Yaoyan Dun
Summary: This study explores the potential therapeutic effects of Icariin (ICA) on inflammation-associated intestinal barrier function impairment in aging. The results show that ICA can alleviate the down-regulation of tight junctions and reduce the expression of inflammatory cytokines. It is also found that ICA exerts its effects by suppressing oxidative stress and decreasing miR-122a expression. These findings suggest that ICA may have a protective effect on intestinal barrier function and could be a potential treatment for colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenjing Yang, Dengchao Xie, Yuqi Liang, Nanxi Chen, Bo Xiao, Lian Duan, Min Wang
Summary: Kaempferol loaded fibroin nanoparticles show promise as a therapeutic platform for anti-inflammatory treatments due to their ability to overcome the limitations of kaempferol and their favorable drug release properties and biocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min-you Qi, Ying-hao He, Yin Cheng, Qing Fang, Ru-yu Ma, Shao-jie Zhou, Jia-qi Hao
Summary: Icariin demonstrated significant renal protective effects in mice with diabetic nephropathy, reducing proteinuria, improving renal function indicators, enhancing antioxidant enzyme activities, and attenuating renal inflammation responses.
Review
Medicine, Research & Experimental
Allah Rakha, Nehal Umar, Roshina Rabail, Masood Sadiq Butt, Marek Kieliszek, Abdo Hassoun, Rana Muhammad Aadil
Summary: Chronic inflammation plays a crucial role in chronic diseases, and flavonoids in diet have the potential to regulate inflammation and display anti-inflammatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Ke Li, Xiu-Hua Yu, Anish R. Maskey, Ibrahim Musa, Zhen-Zheng Wang, Victor Garcia, Austin Guo, Nan Yang, Kamal Srivastava, David Dunkin, Jun-Xiong Li, Longgang Guo, Yung-Chi Cheng, Haoliang Yuan, Raj Tiwari, Xiu-Min Li
Summary: In this study, it was found that epimedium can inhibit the activity of CYP3A4 enzyme, thereby enhancing the anti-inflammatory effect of corticosteroids. The active compound of epimedium, kaempferol, was identified and shown to eliminate the production of interleukin and tumor necrosis factor in combination with corticosteroids. These findings reveal the mechanism of interaction between epimedium and corticosteroids.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Tiago Macedo, Federico Ferreres, David M. Pereira, Andreia P. Oliveira, Nelson G. M. Gomes, Angel Gil-Izquierdo, Patricia Valentao, Luisa Araujo, Paula B. Andrade
Summary: This study investigates the anti-inflammatory properties of Cassia sieberiana leaf extract, focusing on its chemical composition and potential therapeutic associations in African folk medicine practices. Results show that the extract inhibits key enzymes involved in the inflammatory response and reduces the levels of pro-inflammatory cytokines, supporting its traditional use in treating conditions such as arthritis and rheumatism.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuan Zhu, Xinlin Wang, Tianhao Ying, Xiaoli Li, Yidi Tang, Yanfang Wang, Tao Yu, Mengmeng Sun, Jianing Zhao, Yuan Du, Leiming Zhang
Summary: This study investigated the anti-sepsis effects and mechanisms of kaempferol in a lipopolysaccharide-induced sepsis model. The results demonstrated that kaempferol alleviated inflammatory response and stabilized the endothelial barrier in LPS-induced sepsis by regulating the SphK1/S1P signaling pathway. The study also revealed that kaempferol exhibited cell-specific effects on the regulation of SphK1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Jianing Zhao, Longbing Ling, Wei Zhu, Tianhao Ying, Tao Yu, Mengmeng Sun, Xuan Zhu, Yuan Du, Leiming Zhang
Summary: Atherosclerosis is a major cause of death globally. Targeting plaque inflammation by repolarizing macrophages from pro-inflammatory to anti-inflammatory state could be a promising strategy. This study discovered the potential of kaempferol as an anti-inflammatory drug and developed a macrophage biomimetic kaempferol delivery platform for effective treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Rheumatology
Dhivya Das, Ernest Choy
Summary: Non-inflammatory pain is common in patients with inflammatory arthritis, and one important cause is concomitant fibromyalgia. Fibromyalgia is common in RA patients, affecting 1 in 5 patients, and is associated with higher disease activity scores. European Alliance of Association for Rheumatology highlights that concomitant fibromyalgia is an important consideration in assessing difficult-to-treat RA.
Article
Dermatology
M. A. McAleer, I. Jakasa, N. Stefanovic, W. H. I. McLean, S. Kezic, A. D. Irvine
Summary: This study investigated the effects of topical corticosteroid treatment on infants with atopic dermatitis by measuring skin and blood biomarkers. The therapy significantly improved disease severity, although most immune markers did not reach healthy control levels. The results suggest that correcting systemic immune dysregulation through topical therapy may have long-term beneficial effects.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Grzegorz Chmielewski, Michal S. Majewski, Jakub Kuna, Mateusz Mikiewicz, Magdalena Krajewska-Wlodarczyk
Summary: Fatigue is a common symptom in various rheumatic diseases, affecting patients' quality of life and exacerbating disability. Its nature involves multiple factors, including physiological, psychological, and social aspects. Despite its significance, fatigue is often underestimated in clinical practice. Comprehensive assessment of the subjective components of fatigue is crucial for effective management of this symptom in inflammatory joint diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Yue Yu, Shanshan Zhu, Dongwei Wu, Lihua Li, Changren Zhou, Lu Lu
Article
Biochemistry & Molecular Biology
Dongwei Wu, Johanna Berg, Birte Arlt, Viola Roehrs, Munir A. Al-Zeer, Hedwig E. Deubzer, Jens Kurreck
Summary: This study developed a neuroblastoma three-dimensional model based on a human-derived environment, which can be used to test the cytotoxicity and tumor selectivity of new anticancer drugs. Compared to two-dimensional culture, this model has advantages in the width of the therapeutic window, demonstrating the value of studying anticancer drugs in human three-dimensional models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Dongwei Wu, Wuxiao Ding, Naohiro Kameta
Summary: By functionalizing organic nanotubes (ONTs) and hybridizing them with poly(ethylene glycol) (PEG) to construct nanocomposite hydrogels, researchers were able to enhance the mechanical strength and control the release properties of the hydrogels. The resulting mechanically enhanced nanocomposite hydrogels offer a novel approach for drug delivery, with the potential for various biomedical applications.
Article
Materials Science, Multidisciplinary
Shumin Pang, Dongwei Wu, Franz Kamutzki, Jens Kurreck, Aleksander Gurlo, Dorian A. H. Hanaor
Summary: The addition of small amounts of copper enhances the mechanical and biointegrative performance of bioceramics. 3D scaffolds made from copper-doped diopside were studied, and the results showed improved fracture toughness, antimicrobial activity, and in vitro angiogenesis with low levels of copper. However, excessive copper content led to cytotoxicity. Scaffolds with 0-1% copper substitution demonstrated favorable biocompatibility and cell proliferation.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Tadao Ohno
Summary: In this study, a combination therapy of an immune checkpoint inhibitor and an HMS-based cancer vaccine was proposed to enhance the therapeutic efficacy of the immune checkpoint inhibitor. The HMS-based cancer vaccine acts as an adjuvant to activate dendritic cells and present antigens. The results showed that the combination therapy reduced the required dose of the immune checkpoint inhibitor and increased the anti-tumor effect, along with increased CD4+ and CD8+ T cell populations.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Shumin Pang, Dongwei Wu, Aleksander Gurlo, Jens Kurreck, Dorian A. H. Hanaor
Summary: Additively manufactured hollow-strut bioceramic scaffolds offer a promising strategy for patient-tailored bone tissue engineering, providing pathways for nutrient and cell transport and promoting osseointegration and vascularization. This study presents a slurry based additive manufacturing approach for modified diopside bioceramics, producing hollow-strut scaffolds with diverse cross-sectional forms. Mechanical characterization showed that square outer cross-sections for hollow struts in woodpile scaffolds result in higher compressive strength compared to solid cylindrical strut scaffolds, despite lower density. Hollow struts in bioceramic scaffolds significantly enhance cell attachment and proliferation and have potential for new bone tissue formation. This work provides a controlled method for extrusion-based 3D printing of hollow strut scaffolds, enhancing functional and mechanical performance in bone tissue engineering scaffolds.
Article
Biochemistry & Molecular Biology
Yikun Mei, Dongwei Wu, Johanna Berg, Beatrice Tolksdorf, Viola Roehrs, Anke Kurreck, Thomas Hiller, Jens Kurreck
Summary: Lung cancer continues to be one of the most common and deadliest forms of cancer, especially in developing countries. The development of new treatment options is urgently needed, and human cancer models are essential for drug discovery. In this study, a non-small cell lung cancer model was generated using a perfusion system and bioprinting technique, allowing for easy testing of drug candidates. The results showed that the 3D model had higher drug resistance than traditional 2D cell cultures, and dynamic cultivation enhanced drug cytotoxicity. Further improvements are needed for in-depth drug characterization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Shumin Pang, Dongwei Wu, Haotian Yang, Franz Kamutzki, Jens Kurreck, Aleksander Gurlo, Dorian A. H. Hanaor
Summary: Effective scaffolds for bone-tissue-engineering should possess adequate mechanical and chemical performance, as well as osseointegrative, angiogenetic, and anti-bacterial modes of bioactivity. In this study, we used robocasting to additively manufacture square strut scaffolds made from strontium/copper co-substituted diopside. The scaffolds exhibited improved mechanical properties and showed excellent bioactivity and biocompatibility. The co-doped materials also demonstrated strong antimicrobial activity. These findings suggest that this system has great potential for developing high-performance bone substitutes.
BIOMATERIALS ADVANCES
(2023)
Review
Engineering, Manufacturing
Cijun Shuai, Desheng Li, Xiong Yao, Xia Li, Chengde Gao
Summary: Heterostructures are a new generation of materials/structures with dramatically different properties in heterogeneous zones. Additive manufacturing techniques have attracted attention in developing heterostructure due to their unique flexibility. This review summarizes the structural features, material systems, and synergistic effects of heterostructure. It also outlines the progress, advantages, properties, and applications of additive manufacturing in developing heterostructure, with a focus on biomedical applications such as bioscaffolds, vasculatures, biosensors, and biodetections. The future research directions and breakthroughs of heterostructure are also discussed.
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING
(2023)
Article
Materials Science, Biomaterials
Xueping Yu, Xiupeng Wang, Lue Sun, Atsushi Yamazaki, Xia Li
Summary: Radiotherapy (RT) has immune stimulation potency in cancer treatment, but its inhibitory effect on tumor growth and metastasis is limited. This study highlights the potential strategy of using SiO2@MnO2 nanoparticles (SM NPs) to regulate TME and enhance the effectiveness of RT and immunotherapy.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Biomaterials
Xueping Yu, Xiupeng Wang, Atsushi Yamazaki, Xia Li
Summary: Manganese-doped mesoporous silica nanoparticles (MM NPs) were used to regulate the tumor microenvironment (TME) and enhance the efficiency of chemotherapy and immunotherapy. The combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors showed synergistic efficiency in inhibiting tumor growth in a bilateral animal model. Additionally, Mn-doping endowed MSNs with six new regulatory functions for the TME.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Guowen Qian, Lemin Zhang, Xia Li, Cijun Shuai, Xiupeng Wang
Summary: Magnetite nanoparticles as drug carriers have precise drug targeting abilities but tend to aggregate in physiological environments. The Fe-MIL-88B-derived method of constructing Fe3O4-loaded mesoporous carbon systems provides a feasible solution to this issue and enables effective drug delivery. Fe-MIL-88B evenly distributes iron atoms through coordination bonds, and the mesoporous carbon generated after carbonization acts as a barrier against aggregation of Fe3O4 nanoparticles.
ACS APPLIED BIO MATERIALS
(2021)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)