Article
Oncology
Ritu R. Singh, Alison P. Klein, Neil R. Sharma, Eileen M. O'Reilly
Summary: This study investigates the incidence of pancreatic ductal adenocarcinoma (PDAC) in patients with non-biliary and non-alcoholic acute pancreatitis (AP), and compares the rates of early-stage diagnosis and surgical resection between patients with and without AP. The results show that the incidence of PDAC is relatively low, but patients with preceding AP are more likely to undergo surgical resection and have a trend towards earlier diagnosis.
Article
Gastroenterology & Hepatology
Wisam Sbeit, Mahmoud Salman, Abed Khalaileh, Ahmad Zoabi, Zakhar Bramnik, David Hovel, Mahmud Mahamid, Eran Israeli, Lior Katz, Reem Khoury, Nama Mubariki, Andrea Lisotti, Halim Awadie, Tawfik Khoury
Summary: This study compared the diagnostic accuracy of contrast-enhanced computed tomography (CECT) and endoscopic ultrasound (EUS) in local staging of pancreatic cancer. The results showed that EUS had a better diagnostic performance than CECT. Combining both techniques improved the sensitivity of local staging.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshihiro Konno, Yasuhiro Sugai, Masafumi Kanoto, Keisuke Suzuki, Toshitada Hiraka, Yuki Toyoguchi, Kazuho Niino
Summary: This study aimed to investigate intrapancreatic late enhancement (ILE) observed in the early stages of pancreatic adenocarcinoma (PAC). Among the enrolled patients, ILE was observed in 63% of cases and was found to be a significant indicator for early detection of PAC. Awareness of ILE improved lesion detection and increased interobserver agreement among radiologists.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Nuria Lluis, Mario Serradilla-Martin, Mar Achalandabaso, Francois Jehaes, Bobby V. M. Dasari, Sara Mambrilla-Herrero, Ernesto Sparrelid, Anita Balakrishnan, Frederik J. H. Hoogwater, Maria J. Amaral, Bodil Andersson, Frederik Berrevoet, Alexandre Doussot, Victor Lopez-Lopez, Mohammedsuror Alsammani, Olivier Detry, Carlos Domingo-del Pozo, Nikolaos Machairas, Damjan Pekli, Candido F. Alcazar-Lopez, Horacio Asbun, Bergthor Bjornsson, Thalis Christophides, Alberto Diez-Caballero, David Francart, Colin B. Noel, Donzilia Sousa-Silva, Enrique Toledo-Martinez, George N. Tzimas, Sheraz Yaqub, Francois Cauchy, Mikel Prieto-Calvo, Melroy A. D'Souza, Harry V. M. Spiers, Marius C. van den Heuvel, Ramon Charco, Mickael Lesurtel, Jose M. Ramia
Summary: This study aimed to characterize current surgical strategies and outcomes for intraductal papillary neoplasm of the bile duct (IPNB) in European centers. The results showed that achieving the desired outcome in IPNB surgery had a positive impact on patient survival.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Gaetan-Romain Joliat, Sergio Gaspar-Figueiredo, Ismail Labgaa, Dionisios Vrochides, Julie Perinel, Mustapha Adham, Nicolas Demartines, Markus Schaefer
Summary: This study found no association between statin treatment and overall survival or disease-free survival in patients with pancreatic ductal adenocarcinoma who underwent upfront pancreatoduodenectomy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Breanna C. Perlmutter, Mir Shanaz Hossain, Robert Naples, Chao Tu, Valery Vilchez, John McMichael, Katherine Tullio, Robert Simon, R. Matthew Walsh, Toms Augustin
Summary: Chemotherapy for pancreatic adenocarcinoma has improved significantly in recent years. Patients with hepatic artery lymph node involvement showed improved overall survival compared to those with stage IV disease, regardless of HALN status. Preoperative endoscopic ultrasound-guided biopsy is not necessary for patients with HALN positivity undergoing pancreatectomy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Hematology
Jia Ruan, Jasmine Zain, Brett Palmer, Borko Jovanovic, Xinlei Mi, Alok Swaroop, Jane N. Winter, Leo I. Gordon, Reem Karmali, Jonathan Moreira, Adam M. Petrich, Barbara Pro
Summary: This study evaluated the combination of romidepsin and lenalidomide as initial treatment for PTCL and found that it is feasible and effective, showing promising overall response rates and survival outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew T. Trout, Maisam Abu-El-Haija, Sudha A. Anupindi, Megan B. Marine, Michael Murati, Andrew S. Phelps, Mitchell A. Rees, Judy H. Squires, Kate M. Ellery, Cheryl E. Gariepy, Asim Maqbool, Brian A. McFerron, Emily R. Perito, Sarah J. Schwarzenberg, Bin Zhang, Dana K. Andersen, Mark E. Lowe, Aliye Uc
Summary: This study evaluated the interobserver agreement among experienced pediatric radiologists for imaging findings of chronic pancreatitis in children. The results showed fair to moderate agreement for most CT and MRI findings, highlighting challenges in the imaging diagnosis of pediatric chronic pancreatitis. Standardized and/or objective criteria are needed for improved diagnosis.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Oncology
Marcello Di Martino, Ye Xin Koh, Nicholas Syn, Ken Min Chin, Fernando Burdio, Patricia Sanchez Velazquez, Alberto Manzoni, Andrea Benedetti Cacciaguerra, Mikel Prieto, Francesco Lancellotti, Giuseppe Malleo, Giovanni Marchegiani, Roberto Salvia, Giovanni Vennarecci, Mohammad Abu Hilal, Benedetto Ielpo
Summary: This study compares the impact of novel prognostic scores with traditional ones in patients with distal cholangiocarcinoma. The results demonstrate that LNR15 is an independent predictor of disease-free survival, overall survival, early recurrence, local recurrence, and distant recurrence.
Article
Oncology
Katrina S. Pedersen, Nathan R. Foster, Michael J. Overman, Patrick M. Boland, Sunnie S. Kim, Kathryn A. Arrambide, Brandy L. Jaszewski, Tanios Bekaii-Saab, Rondell P. Graham, Jack Welch, Richard H. Wilson, Robert R. McWilliams
Summary: For patients with previously treated advanced small-bowel adenocarcinoma, the PD-1 inhibitor pembrolizumab did not achieve the anticipated response rate overall, but showed some responses in selected cohorts based on key biomarkers.
CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Yuan-Xing Gao, Zhi-Ming Zhao, Guo-Dong Zhao, Ming-Gen Hu, Xiang-Long Tan, Wan Yee Lau, Rong Liu
Summary: The risk factors, patterns, and long-term prognosis for early recurrence (ER) and late recurrence (LR) after pancreaticoduodenectomy (PD) in pancreatic ductal adenocarcinoma (PDAC) patients were studied. Patients who developed ER had worse prognosis compared to those with LR.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Nutrition & Dietetics
Alex Richard Costa Silva, Valdete Regina Guandalini, Taisa Sabrina Silva Pereira, Longgang Zhao, Michael D. Wirth, James R. Hebert, Gisele Aparecida Fernandes, Paulo Pimentel de Assumpcao, Monica Santiago Barbosa, Maria Paula Curado
Summary: This study evaluated the association between diet-related inflammation and gastric adenocarcinoma (GA). It found that a pro-inflammatory diet, measured by higher E-DII scores, was associated with an increased risk of GA in Brazil.
Article
Pathology
Sung Joo Kim, Se Jin Choi, Junmo Yang, Deokhoon Kim, Dong Wook Kim, Jae Ho Byun, Seung-Mo Hong
Summary: The clinical significance of pancreatic ductal adenocarcinomas (PDACs) with a large duct pattern (PLDP) has not been systematically evaluated. This study compared the clinicopathological, immunohistochemical, and mutational characteristics of PDACs with PLDP with conventional PDACs, and found that PLDP PDACs have unique histologic features, longer survival, and better prognosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ho Lee, Hong Il Ha, Jin-Young Jang, Jung Woo Lee, Jin-Young Choi, Seungmin Bang, Chang Hee Lee, Wan Bae Kim, Seung Soo Lee, Song Cheol Kim, Bo-Kyeong Kang, Jeong Min Lee
Summary: This prospective multicenter study aimed to evaluate the diagnostic performance of 80-kVp thin-section pancreatic CT in determining pancreatic ductal adenocarcinoma (PDAC) resectability according to the recent National Comprehensive Cancer Network (NCCN) guidelines. The study enrolled surgical resection candidates for PDAC from six tertiary referral hospitals, who underwent pancreatic CT using 80 kVp tube voltage with 1-mm reconstruction interval. The results showed that 80-kVp thin-section pancreatic CT had excellent diagnostic performance in assessing PDAC resectability.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Alessandra Arcelli, Federica Bertini, Silvia Strolin, Gabriella Macchia, Francesco Deodato, Savino Cilia, Salvatore Parisi, Aldo Sainato, Michele Fiore, Pietro Gabriele, Domenico Genovesi, Francesco Cellini, Alessandra Guido, Silvia Cammelli, Milly Buwenge, Emiliano Loi, Silvia Bisello, Matteo Renzulli, Rita Golfieri, Alessio G. Morganti, Lidia Strigari
Summary: This study generated a local failure risk map in resected pancreatic cancer patients and proposed new CTV contouring guidelines based on a combination of previous research results and a probabilistic approach, aiming to improve the precision and efficacy of radiotherapy.
Meeting Abstract
Oncology
Vincent Chung, Sant P. Chawla, Huan Dong, Semmie Kim, Ronald Lee Korn, Kian-Huat Lim, Marcus Smith Noel, Anne M. Noonan, Paul Eliezer Oberstein, Allyson J. Ocean, Shubham Pant, Vincent J. Picozzi, Philip Agop Philip, Alexander Rosemurgy, Benjamin R. Tan, Andrea Wang-Gillam, Steve Wong, Giuseppe Del Priore
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Bruno Bockorny, Teresa Macarulla, Valerya Semenisty, Erkut Borazanci, Jaime Feliu, Mariano Ponz-Sarvise, David Gutierrez Abad, Paul Oberstein, Angela Alistar, Andres Munoz, Ravit Geva, Carmen Guillen-Ponce, Mercedes Salgado Fernandez, Amnon Peled, Marya Chaney, Irit Gliko-Kabir, Liron Shemesh-Darvish, Debby Ickowicz, Ella Sorani, Shaul Kadosh, Abi Vainstein-Haras, Manuel Hidalgo
Summary: This study evaluated the efficacy of dual blockade of CXCR4 and PD1 with chemotherapy in PDAC, showing that the triple combination was safe, well tolerated, and exhibited signs of efficacy in a population with poor prognosis.
CLINICAL CANCER RESEARCH
(2021)
Meeting Abstract
Oncology
Paul Eliezer Oberstein, Osama E. Rahma, Nina Beri, Amy C. Stoll-D'Astice, Anne-Marie Duliege, Saloney Nazeer, Matthew Squires, Dafna Bar-Sagi, Brian M. Wolpin, Stephanie Dougan, Diane M. Simeone
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Kazuya Masuda, Adam Kornberg, Jonathan Miller, Sijie Lin, Nathan Suek, Theo Botella, Kerim A. Secener, Alyssa M. Bacarella, Liang Cheng, Matthew Ingham, Vilma Rosario, Ahmed M. Al-Mazrou, Steven A. Lee-Kong, Ravi P. Kiran, Marlon Stoeckius, Peter Smibert, Armando Del Portillo, Paul E. Oberstein, Peter A. Sims, Kelley S. Yan, Arnold Han
Summary: This study identified distinct subsets of T cells in colorectal cancer, including cytotoxic T cells associated with good outcomes (GZMK(+)KLRG1(+)) and dysfunctional cytotoxic T cells associated with poor outcomes (GNLY(+)CD103(+)). Additionally, CD38(+) Tregs were associated with bad outcomes and inhibitory effects on antitumor immunity. These findings suggest the potential utility of these T cell subsets in predicting outcomes and the possibility of novel therapies targeting specific T cell populations.
Article
Oncology
Cathy Eng, Emerson Y. Chen, Jane Rogers, Mark Lewis, Jonathan Strosberg, Ramya Thota, Smitha Krishnamurthi, Paul Oberstein, Rang Govindarajan, Gary Buchschacher, Sandip Patel, Davendra Sohal, Taymeyah Al-Toubah, Philip Philip, Arvind Dasari, Hagan Kennecke, Stacey Stein
Summary: Despite efforts to improve enrollment and diversity in clinical trials, less than 5% of cancer patients participate in trials, and COVID-19 has exacerbated existing barriers. Academic and community researchers have created a white paper with recommendations to enhance efficiency in trial activation and conduct, aiming to provide better access and care for cancer patients.
JCO ONCOLOGY PRACTICE
(2021)
Article
Oncology
Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh, Edgar Gonzalez, Brian J. Christmas, Valerie H. Narumi, Emily F. Davis-Marcisak, Gaurav Sharma, Emma Bigelow, Ajay Vaghasia, Anuj Gupta, Alyza Skaist, Michael Considine, Sarah J. Wheelan, Sathish Kumar Ganesan, Min Yu, Srinivasan Yegnasubramanian, Vered Stearns, Roisin M. Connolly, Daria A. Gaykalova, Luciane T. Kagohara, Elizabeth M. Jaffee, Elana J. Fertig, Evanthia T. Roussos Torres
Summary: This study comprehensively characterized the changes in the tumor microenvironment (TME) induced by entinostat, an oral histone deacetylase inhibitor, using single-cell RNA sequencing. The results showed that entinostat shifted the TME from a protumor to an antitumor signature, mainly through changes in myeloid cells. This study suggests that entinostat-induced alterations in myeloid cell types reduce immunosuppression and increase antitumor responses, thus improving the sensitivity to immune checkpoint inhibitors (ICIs).
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Jessica N. Everett, Shenin A. Dettwyler, Xiaohong Jing, Cody Stender, Madeleine Schmitter, Ariele Baptiste, Jennifer Chun, Emily A. Kawaler, Lauren G. Khanna, Seth A. Gross, Tamas A. Gonda, Nina Beri, Paul E. Oberstein, Diane M. Simeone
Summary: Integrating genetics into a multidisciplinary setting improves compliance with genetic testing for pancreatic ductal adenocarcinoma (PDAC) patients, reduces logistical barriers, and clarifies cancer risks for relatives.
Article
Biochemistry & Molecular Biology
Gehan Botrus, Denise Roe, Gayle S. Jameson, Pedro Luiz Serrano Uson Junior, Ronald Lee Korn, Lana Caldwell, Taylor Bargenquast, Max Miller, Erkut Hasan Borazanci
Summary: Recent research has shown promising results in personalizing treatment for metastatic pancreatic cancer with platinum-based chemotherapy and PARP inhibitors in patients with homologous recombination deficiency (HRD). However, new strategies are needed to overcome resistance. This study documents the cases of HRD pancreatic cancer patients treated with Mitomycin C (MMC), showing positive outcomes and manageable toxicities.
Article
Multidisciplinary Sciences
Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Summary: The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) plays a crucial role in tumor progression. In this study, single-cell RNA sequencing was performed on PDAC samples before and after chemotherapy. The results showed a heterogeneous mixture of cancer cell subtypes and distinct fibroblast and macrophage subpopulations. Interestingly, chemotherapy did not cause a shift towards a different cancer cell subtype, but rather impacted the ligand-receptor interactions, suggesting a potential role in promoting resistance to immunotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Caroline Y. Um, Brandilyn A. Peters, Hee Sun Choi, Paul Oberstein, Dia B. Beggs, Mykhaylo Usyk, Feng Wu, Richard B. Hayes, Susan M. Gapstur, Marjorie L. McCullough, Jiyoung Ahn
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Kelsey R. Monson, Brandilyn A. Peters, Mykhaylo Usyk, Caroline Y. Um, Paul E. Oberstein, Marjorie L. McCullough, Mark P. Purdue, Neal D. Freedman, Richard B. Hayes, Jiyoung Ahn
Summary: This study demonstrates that diets high in carbohydrates and glycemic index (GI) may influence the composition of the oral microbiome, with high carbohydrate intake associated with certain carcinogenic bacteria and decreased abundance of protective bacteria, and high GI intake associated with increased abundance of certain inflammation-related bacteria.
CANCER RESEARCH COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Agop Philip Philip, Nathan Bahary, Amit Mahipal, Anup Kasi, Caio Max Sao Pedro Rocha Lima, Angela Tatiana Alistar, Paul Eliezer Oberstein, Talia Golan, Vaibhav Sahai, Jean Philippe Metges, Jill Lacy, Christos Fountzilas, Charles D. Lopez, Michel Ducreux, Pascal Hammel, Mohamed E. Salem, David Lawrence Bajor, Al Bowen Benson, Marc E. Buyse, Eric Van Cutsem
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Rachael A. Safyan, Gulam Abbas Manji, Shing Mirn Lee, Rebecca Silva, Susan Elaine Bates, Ruth Aroon White, Jacob K. R. Jamison, Adam Joel Bass, Gary K. Schwartz, Paul Eliezer Oberstein, Tamas Gonda
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Manuel Hidalgo, Teresa Macarulla, Valerya Semenisty, Erkut Borazanci, Jaime Feliu, Mariano Ponz-Sarvise, David Gutierrez Abad, Paul Oberstein, Angela Alistar, Andres Munoz, Ravit Geva, Carmen Guillen-Ponce, Mercedes Salgado Fernandez, Amnon Peled, Marya Chaney, Irit Glicko-Kabir, Liron Shemesh-Darvish, Debby Ickowicz, Ella Sorani, Shaul E. Kadosh, Abi Vainstein-Haras, Bruno Bockorny
Article
Medicine, General & Internal
Gerald Falchook, Jeffrey Infante, Hendrik-Tobias Arkenau, Manish R. Patel, Emma Dean, Erkut Borazanci, Andrew Brenner, Natalie Cook, Juanita Lopez, Shubham Pant, Arthur Frankel, Peter Schmid, Kathleen Moore, William McCulloch, Katharine Grimmer, Marie O'Farrell, George Kemble, Howard Burris
Summary: The study aimed to determine the MTD and RP2D of oral FASN inhibitor TVB-2640 and evaluate its safety and efficacy in monotherapy and in combination with paclitaxel. Results showed potent FASN inhibition with manageable toxicity primarily affecting skin and eyes, supporting further investigation particularly in KRASMUT lung, ovarian, and breast cancer patients.