Journal
CLINICAL AND EXPERIMENTAL HYPERTENSION
Volume 42, Issue 3, Pages 205-212Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641963.2019.1601208
Keywords
Embryo; conceptuses size; fatty acid; preeclampsia; vitamin E
Funding
- Indian Council of Medical Research (ICMR), New Delhi, India [5/7/1069/13-RCH]
- 'INSPIRE fellowship' from the Department of Science and Technology, Government of India
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Background: Early (EOP) and late onset (LOP) preeclampsia are two subtypes of preeclampsia. This study examines the effect of maternal omega-3 fatty acids and vitamin E supplementation in a rat model of preeclampsia. Method: Pregnant Wistar rats were assigned to control; EOP; LOP; EOP+omega-3 fatty acid supplementation+vitamin E and LOP+omega-3 fatty acid supplementation+vitamin E. L-Nitroarginine methylester was used to induce preeclampsia. Blood Pressure (BP) was recorded during pregnancy and dams were dissected at d14 and d20 of gestation. Results: Animals from EOP and LOP groups demonstrated higher systolic and diastolic BP, lower weight gain, lower conceptuses size, lower conceptuses weight and fetal weight as compared to control. EOP and LOP groups showed higher percentage of fetal resorptions and embryotoxicity (deformities and hematomas). Conclusion: Supplementation reduced the diastolic BP, percentage of resorptions and embryotoxicity only in the LOP group, suggesting a need for differential supplementation regime for the two subtypes of preeclampsia.
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