Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 40, Pages 9415-9418Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201900903
Keywords
1,2-diketones; isocyanides; magnesium aldimines; organomagnesium halides; Weinreb amides
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Funding
- Ludwig-Maximilians-Universitat Munchen
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The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and alpha-hydroxy ketones.
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