Synthesis and properties of 1-[(adamantan-1-yl)methyl]-3-pyrazolyl ureas

Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability

(2018) Vladimir Burmistrov et al.   BIOORGANIC CHEMISTRY

Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines

(2017) Yanmin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and pharmacological evaluation of new anti-inflammatory compounds

(2016) Amanda F. Cidade et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N′-Diarylurea Derivatives

(2016) Dianxi Zhu et al.   MOLECULES

1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors

(2015) Vladimir Burmistrov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments

(2015) G. M. Butov et al.   Chemistry of Heterocyclic Compounds

Synthesis and antiviral activity of some new bis-1,3-thiazole derivatives

(2015) Kamal M. Dawood et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2

(2015) Kurt G. Pike et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs

(2014) Syuhei Nakao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

(2014) Samet Mert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

(2014) Ke Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of 5-Amino-1H-pyrazole-4- carboxamide Derivatives as Potential Antitumor Agents

(2014) Baowei Yang et al.   Letters in Drug Design & Discovery

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

(2013) E. Jeffrey North et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors

(2013) Sung Hee Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transformations of naproxen into pyrazolecarboxamides: search for potent anti-inflammatory, analgesic and ulcerogenic agents

(2013) Abdullah G. El-Sehemi et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis and biological evaluation of 4-(1-(4(sulphanilamide)phenyl)-3-(methyl)-1H-pyrazol-5-yl)dine urea and N-acyl derivatives as a soluble epoxide hydrolase inhibitors

(2013) Vijaykumar D. Nimbarte et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

(2013) S. Bhavanarushi et al.   MEDICINAL CHEMISTRY RESEARCH

Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

(2012) Rajâa Boulahjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

(2011) Sung Hee Hwang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

(2011) Martin W. Rowbottom et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

(2009) Martina Decker et al.   ARCHIVES OF TOXICOLOGY

Eicosanoids and renal damage in cardiometabolic syndrome

(2008) John D Imig   Expert Opinion on Drug Metabolism & Toxicology