Article
Chemistry, Physical
Zhe Yang, Shuwang Wu, Yun Gao, Dandan Kou, Kuan Lu, Can Chen, Yi Zhou, Dandan Zhou, Lei Chen, Jianxian Ge, Cang Li, Jianfeng Zeng, Mingyuan Gao
Summary: This study investigates the degradation of iron oxide nanoparticles under biologically relevant conditions, revealing that acidic environment, presence of bovine serum albumin, glutathione, and sodium citrate all have different effects on the degradation rate. The dissolution and aggregation of nanoparticles significantly impact their relaxivity, which has implications for their use as magnetic resonance imaging contrast agents.
Article
Chemistry, Physical
Jingpeng Li, Rumin Ma, Sisi Yao, Daochun Qin, Yun Lu, Yuhe Chen, Zehui Jiang, Dongjiang Yang
Summary: Plant-based flow microreactors with bamboo microchannels containing mesoporous TiO2-encapsulating ultrafine Pd nanoparticles were synthesized for continuous-flow hydrogenation. The design of the reactor enables high efficiency (>97%) and excellent stability (1,000 h) due to the abundant oxygen vacancies and open cavities provided by the TiO2 films, which facilitate the growth of Pd nanoparticles and improve their dispersion and catalytic activity. The optimized reactor shows promising potential for Pd-catalyzed hydrogenation in various conditions.
Article
Acoustics
Aniket Pradip Udepurkar, Wim Dermaut, Christian Clasen, Simon Kuhn
Summary: In this article, a new system combining an ultrasonic microreactor with a tubular reactor is introduced for the continuous production of polymer nanoparticles. The system demonstrates the continuous generation of cross-linked polymer nanoparticles using the monomer butyl methacrylate and the cross-linker ethylene glycol dimethacrylate. The article investigates the miniemulsion polymerization of a monomer-in-water miniemulsion in a batch system and then utilizes a coiled tubular reactor for the continuous polymerization. The study also examines the impact of monomer volume fraction and surfactant concentration on the synthesized nanoparticles. The system showcased in this research successfully synthesizes polymer particles ranging from 50 to 250 nm in size and achieves a high polymerization conversion.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Mechanics
Gesse Roure, Alexander Z. Zinchenko, Robert H. Davis
Summary: In this paper, a boundary-integral method is developed to simulate the motion of drops in microchannels with arbitrary geometries. The results show that scaling with maximum vs average velocities can accelerate the convergence of the simulation. Non-regular geometries can affect drop partitioning and introduce challenges when comparing results for different depths. Inertial effects on undisturbed flow are small for moderate Reynolds numbers.
Review
Chemistry, Multidisciplinary
Vikas Hakke, Shirish Sonawane, Sambandam Anandan, Shriram Sonawane, Muthupandian Ashokkumar
Summary: This review focuses on recent developments in synthesizing nanomaterials using process intensification, covering microreactor design, design principles, and fundamental mechanisms. Various examples from the literature discuss the advantages and disadvantages of microfluidics technology for nanomaterial synthesis.
Review
Chemistry, Physical
Claudia Carlucci
Summary: This article discusses the production of biodiesel using different catalytic methods, such as acids, bases, enzymes or supercritical fluids. Continuous flow processes and microreactors provide better control over experimental variables, increasing efficiency and safety. Additionally, combining other technologies such as microwave irradiation or ultrasounds allows for automation of the production process.
Article
Chemistry, Multidisciplinary
Yanpeng Dong, Xingyu Xiang, Zhongdong Wang, Chunying Zhu, Youguang Ma, Taotao Fu
Summary: In this study, the distribution of fluid flow, as well as the uniformity and stability of droplets, in asymmetrical parallelized microchannels were explored using a high-speed camera. The effects of pressure difference fluctuation at the T-junction, hydrodynamic resistance in microchannels, and shear-thinning property of fluids on flow distribution and droplet formation were revealed. The uniformity and stability of droplets in microdevices with different cavity settings were compared, and an optimal configuration was proposed. Prediction models for the flow distribution of shear-thinning fluids in asymmetrical parallelized microchannels were also established.
Article
Engineering, Chemical
Wei Du, Yingfeng Duan, Lina Wang, Dayu Liu
Summary: The liquid-liquid two-phase flow and size prediction of slug droplets in microchannels with varying orifice sizes downstream were assessed through experiments. Aqueous glycerol and mineral oil with surfactant were used as the dispersed and continuous phases, respectively. Three characteristic flow patterns were observed, and flow region changes with orifice size were documented. Universal flow pattern maps and slug droplet formation regions were established, and prediction correlations for droplet sizes were developed and validated experimentally.
Article
Engineering, Environmental
Yanpeng Dong, Hongwei Zhu, Xingyu Xiang, Zhongdong Wang, Asad Ullah, Sajawal Raza, Chunying Zhu, Wenyuan Fan, Bing Sun, Youguang Ma, Taotao Fu
Summary: The dynamics of viscoelastic droplet formation in T-shaped asymmetric parallel microchannels were investigated using a high-speed camera. The effects of fluid viscoelasticity and flow rates on droplet stability, uniformity, and flow distribution were explored. The results showed that the viscoelasticity influenced the different stages of droplet formation, and increasing the continuous phase flow rate improved stability and affected droplet uniformity. Prediction models for fluid flow distribution, droplet size, and formation period were established, and the breakup mode and satellite droplet size were also studied. The findings demonstrated the importance of fluid viscoelasticity and flow rates in droplet formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kardelen Kaya-Ozkiper, Keiran Mc Carogher, Anca Roibu, Simon Kuhn
Summary: The relationship between three-phase flow and single-oxygen-sensitized photo-oxidation is explored, with sustainability enhanced by continuous recycling. Microreactors have emerged as a promising platform for conducting photo-oxidations, providing green routes for significant chemical transformations. In this study, the sustainability of photo-oxidations is improved by a three-phase gas/liquid/liquid flow reaction in a photo-microreactor with continuous recycling, applied to a model reaction.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Thermodynamics
Misagh Tafakhori, Davood Kalantari, Pourya Biparva, S. M. Peyghambarzadeh
Summary: Research shows that under a concentration of 0.1 vol%, the heat exchange performance of the car radiator is improved by approximately 21%, which is the optimal working condition, while increasing the nanoparticle concentration leads to heat transfer deterioration.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Multidisciplinary
Marc Escriba-Gelonch, Jodie Bricout, Volker Hessel
Summary: The research applies circular economy principles to a flow chemistry process for synthesizing vitamin D-3, achieving efficient recycling of starting materials through a novel separation technique using acetonitrile. The study enhances material circularity metrics and demonstrates the potential for sustainable pharmaceutical production processes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Engineering, Chemical
V. V. Banakar, S. S. Sabnis, P. R. Gogate, A. Raha, Saurabh
Summary: Traditionally, chemical industries rely on batch or semi-continuous operations, but there is an increasing trend towards developing novel reactor designs and processes based on continuous flow. Micro and milli structured reactors are applied for continuous processing, but have limitations in handling solids. Power ultrasound is proposed as a solution for intensifying crystallization and chemical synthesis in microreactors. Ultrasound-assisted continuous processes or their combination with microreactors can bring significant intensification benefits.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Lennart Goepfert, Max Schoenen, Oliver Reisen, Eva Miriam Buhl, Benedikt Mues, Thomas Schmitz-Rode, Ioana Slabu
Summary: A modular millifluidic system for continuous flow synthesis of magnetic nanoparticles (MNPs) is presented in this study. By varying input parameters, MNPs with a diameter of about 10nm and low polydispersity index were successfully synthesized. The MNPs showed promising characteristics as MRI contrast agents, MPI tracers, and heating agents.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Materials Science, Ceramics
Renzhong Xue, Liuyang Zhao, Siyuan Chen, Hongxuan Chen, Mengru Cui, Xintao Bai, Tao Li, Dewei Liu, Haiyang Dai
Summary: The effects of A-site transition from Ca2+ to Cd2+ on the microstructure, morphology, and electrical properties of Ca(1-x)CdxCu(3)Ti(4)O(12) thin films were investigated. The films exhibited smooth and compact surfaces without cracks. The transition from Ca2+ to Cd2+ resulted in changes in grain size and electrical properties. In particular, the simultaneous occupancy of A sites by Ca2+ and Cd2+ improved the dielectric and nonlinear properties of Ca1-xCdxCu3Ti4O12 films.
CERAMICS INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Liang-Jie Tang, Gang Li, Mohammed Eslam, Pei-Wu Zhu, Sui-Dan Chen, Howard Ho-Wai Leung, Ou-Yang Huang, Grace Lai-Hung Wong, Yu-Jie Zhou, Morten Karsdal, Diana Julie Leeming, Pei Jiang, Cong Wang, Hai-Yang Yuan, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study developed a novel sequential algorithm based on PRO-C3 to identify liver inflammation and fibrosis in MAFLD patients. The algorithm performed well in high-risk patients and can be used to screen high-risk MAFLD patients for clinical trials and emerging pharmacotherapies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
Xiao-Jia Liu, Tian-Meng Lv, Sheng Sun, Jing-Yi Xu, Qi Guan, Jia-Hui Hao, Zhen-Chi Zhou, Sheng-Li Niu, Hui-Ming Hua
Summary: Researchers conducted a systematic phytochemical investigation on Garcinia nujiangensis and isolated four new compounds and four known compounds. One of the new compounds showed significant antiproliferative effects against HepG2 human cancer cells.
Article
Pharmacology & Pharmacy
Hong-Liu Jin, Xiao-Jia Liu, Xiao-Ying Feng, Wen-Ting Zhu, Sen-Ling Feng, Li-Ping Cao, Zhong-Wen Yuan
Summary: This study investigated the pharmacological effects and molecular mechanism of quercetin 7-rhamnoside (Q7R) in the treatment of cholestatic hepatitis induced by alpha-naphthylisothiocyanate (ANIT). The results showed that Q7R could decrease the level of CYP7A1, increase FXR and CYP27A1 levels, improve abnormal bile acid secretion, and alleviate inflammation by reducing TNF-alpha, IL-1 beta, PTGS1, PTGS2, NCOA2, and NF-kappa B levels. Therefore, Q7R has an effective therapeutic effect on ANIT-induced cholestatic hepatitis by regulating bile acid secretion and inhibiting inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Zhizhi Sheng, Zengwei Liu, Yinglai Hou, Haotian Jiang, Yuzhen Li, Guangyong Li, Xuetong Zhang
Summary: This article provides an overview of the fabrication methodologies, material choices, and properties of aerogel fibers, as well as highlights the nano-confining functionalization strategy and emerging applications. It also points out the existing challenges and opportunities in the development of aerogel fibers.
Review
Biochemistry & Molecular Biology
Wei Yu, Yufeng Jiang, Hui Xu, Yafeng Zhou
Summary: HFpEF is a disease without definitive and effective treatment, affecting more than 50% of HF patients. Gut microbiota (GMB) has been shown to be related to HFpEF. In HFpEF patients, the composition of GMB is significantly altered and tends towards dysbiosis. Metabolites of GMB mediate various pathophysiological mechanisms of HFpEF.
Editorial Material
Cardiac & Cardiovascular Systems
Wenjie Chen, Yufeng Jiang, Tan Chen, Yafeng Zhou
Summary: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a group of diseases with different pathological mechanisms, and it is uncertain whether the traditional treatment strategies for myocardial infarction in obstructive coronary artery disease (MI-CAD) are suitable for MINOCA patients. Properly designed prospective studies are needed to explore the pathophysiology and etiology of MINOCA in order to understand the effectiveness and safety of medical therapies for different types of MINOCA. Specific prospective randomized controlled trials are desired to assess the specificity, efficacy, and safety of different antiplatelet agents in MINOCA patients with different etiologies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Construction & Building Technology
Zhiming He, Fei Shi, Zicheng Lin, Chao Zhang, Yun Zhou, Feng Zhao
Summary: This study investigates the mechanical behavior of a viscoelastic damper (VED) under monotonic and cyclic loading, with a focus on the cyclic stability of VEDs' mechanical properties. The VED consists of 2 layers of elastomer compound sandwiched between 3 steel plates. Nine damper specimens are tested to examine the effects of strain amplitude, loading frequency, strain history, and high-cycle fatigue loading on the mechanical properties of VED. The experimental results demonstrate that VED has a high damping capacity, low frequency dependency, and significant sensitivity to strain amplitude and loading frequency in high-cycle fatigue performance.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Biodiversity Conservation
Lanjun Li, Xiaoyu Song, Dan Feng, Huaiyou Li, Xinkai Zhao, Pengfei Meng, Chong Fu, Long Wang, Ruoyu Jiao, Wanyin Wei, Nan Yang, Yu Liu
Summary: Investigating the impacts of climate change on soil desiccation in planted forests is important for water resource management and ecological restoration. This study conducted field experiments in planted forests with different tree ages and used Hydrus-1D models to simulate soil water dynamics. The results showed that future warming and drying climate would greatly increase soil desiccation in all plots. Precipitation and vapour pressure deficit played important roles in soil desiccation in different soil layers.
ECOLOGICAL INDICATORS
(2023)
Article
Biochemistry & Molecular Biology
Qiong Wu, Gaojie Yan, Linghua Tan, Weihua Zhu, Yunping Zhou
Summary: A total of 24 nitrogen-rich fused-ring energetic metal complexes were designed and studied. The structures were modified by introducing different metals and energetic groups, resulting in compounds with higher energy and lower sensitivity compared to a well-known high energy compound. The effects of different metals and small energetic groups on the structure and properties were investigated. The results showed that copper, NO2, and C(NO2)(3) increased the energy, while cobalt and NH2 helped reduce the sensitivity.
JOURNAL OF MOLECULAR MODELING
(2023)
Article
Chemistry, Multidisciplinary
Zeyuan Cao, Peiyi Li, Yuzhen Li, Manjin Zhang, Meng Hao, Wenwen Li, Xueli Mao, Lijie Mo, Chuan Yang, Xin Ding, Yi Yan Yang, Peiyan Yuan, Songtao Shi, Xiaoxing Kou
Summary: Extracellular vesicles (EVs) are lipid bilayer nanovesicles that can transport various substances and play important roles in cell communication and tissue homeostasis. In this study, it is shown that apoptotic mesenchymal stem cells (MSCs) can efficiently encapsulate nanoparticles into apoptotic vesicles (apoVs). The researchers also demonstrated that nano-bortezomib-apoVs have a synergistic effect on improving multiple myeloma (MM) and reducing side effects. Furthermore, they discovered that Rab7 regulates the encapsulation efficiency of nanoparticles in apoptotic MSCs.
Article
Chemistry, Multidisciplinary
Mingxiao Yin, Jingwen Dong, Cuicui Sun, Xiaojia Liu, Zhirui Liu, Lu Liu, Zean Kuang, Na Zhang, Dian Xiao, Xinbo Zhou, Hongbin Deng
Summary: The study identifies Raddeanin A (RA) as a potent immunogenic cell death (ICD) inducer that enhances antitumor immunity by inducing tumor cell immunogenicity and reprogramming the tumor microenvironment. RA directly binds to TDP-43 and induces its localization to mitochondria and mtDNA leakage, leading to upregulation of nuclear factor kappa B and type I interferon signaling and enhancing antigen cross-presentation and T cell activation.
Article
Immunology
Shuo Zhang, Yiran Chen, Xin Chen, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Li Wang, Mengtao Li
Summary: This interventional study evaluated the efficacy and safety of leflunomide in patients with refractory lupus nephritis (LN). The results showed that leflunomide can effectively reduce urine protein quantity, but the complete response rate decreased over time. Overall, leflunomide has the potential therapeutic effect and safety in treating refractory LN.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yunyun Zhou, Lingzhi Zhao, Juanjuan Peng, Xueshen Wang, Lulu Yang, Jian Wang, Keqiang Lu
Summary: Acute kidney injury (AKI) is a severe disease that often leads to chronic kidney disease (CKD). Efficient targeted drug delivery to the damaged kidney is crucial for AKI treatment. In this study, silica cross-linked micelles (SCLMs) were prepared to specifically target and accumulate in the injured renal tubules. The SCLMs showed selective localization in the damaged tubular cells and could be used for imaging the injured kidney. Atorvastatin-loaded SCLMs effectively improved renal function indexes in AKI and CKD, such as tubular necrosis, collagen deposition, and inflammation.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
Yanfang Zhang, Weixin Qiu, Yang Liu, Keke Wang, Wenyuan Li, Jihu Kang, Xiaoqing Qiu, Min Liu, Wenzhang Li, Jie Li
Summary: Inspired by the bilayer phospholipid molecular structure of cell membranes, a Cu(2)O/Sn photocathode modified with the bilayer surfactant DHAB was developed to achieve high CO2 permeability and suppress HER. The Cu2O/Sn/DHAB photocathode stabilizes the *OCHO intermediate and facilitates the production of HCOOH.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)