Journal
CHEMBIOCHEM
Volume 20, Issue 19, Pages 2432-2441Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201900191
Keywords
biosensors; imaging agents; nanostructures; Raman spectroscopy; surface plasmon resonance
Funding
- Ministry of Education-Singapore [MOE2015-T2-1-112, RG49/16]
- China Scholarship Council [201706320290]
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Surface-enhanced Raman scattering (SERS), with greatly amplified fingerprint spectra, holds great promise in biochemical and biomedical research. In particular, the possibility of exciting a library of SERS probes and differentially detecting them simultaneously has stimulated widespread interest in multiplexed biodetection. Herein, recent progress in developing SERS-active plasmonic nanostructures for cellular and intracellular detection is summarized. The development of nanosensors with tailored plasmonic and multifunctional properties for profiling molecular and pathological processes is highlighted. Future challenges towards the routine use of SERS technology in quantitative bioanalysis and clinical diagnostics are further discussed.
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