Review
Biochemistry & Molecular Biology
Arif Luqman, Friedrich Goetz
Summary: After skin injury, wound healing progresses through four phases: hemostasis, inflammation, proliferation, and maturation. Skin microbiota play a significant role in wound healing, both negatively and positively, by influencing the release of certain hormones and neurotransmitters that impact the migration and re-epithelization of skin cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nina Dedic, Heather Dworak, Courtney Zeni, Grazia Rutigliano, Oliver D. Howes
Summary: TAAR1 has emerged as a promising therapeutic target for neuropsychiatric disorders due to its ability to modulate neurotransmission, particularly in regulating dopamine. Agonist compounds targeting TAAR1 have shown potential as treatments for schizophrenia and other disorders. Clinical trial data, along with preclinical findings, provide a rationale for further exploration and development of this new pharmacological class for treating related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov
Summary: Currently, the treatment of metabolic syndrome primarily focuses on pharmacological symptom relief and complex lifestyle changes. This study explores the role of trace amines and their receptor systems, particularly trace amine-associated receptor 1 (TAAR1), in the pathogenesis of metabolic syndrome and the regulation of insulin secretion in pancreatic islets. The findings suggest that TAAR1 agonists have a positive effect on the progression of metabolic syndrome and the development of related diseases. Additionally, the expression of TAARs and the deregulation of their functional associations were found to be different in patients with metabolic diseases compared to healthy donors, indicating their potential as therapeutic targets.
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Evgeniya V. Efimova, Saveliy R. Kuvarzin, Mikael S. Mor, Nataliia V. Katolikova, Taisiia S. Shemiakova, Valeria Razenkova, Maria Ptukha, Alena A. Kozlova, Ramilya Z. Murtazina, Daria Smirnova, Aleksandr A. Veshchitskii, Natalia S. Merkulyeva, Anna B. Volnova, Pavel E. Musienko, Dmitrii E. Korzhevskii, Evgeny A. Budygin, Raul R. Gainetdinov
Summary: Trace amine-associated receptors play important roles in regulating various brain functions, including the olfactory system, dopamine system, neuronal electrophysiological activity, and adult neurogenesis. Understanding their function and expression in the brain is significant for studying neuropsychiatric disorders and developing potential treatments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Michael W. Rudokas, John P. Post, Alejandra Sataray-Rodriguez, Rinzhin T. Sherpa, Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey
Summary: This study revealed that cAMP produced by stimulation of beta(2)-adrenoceptors was unable to reach the SERCA2 pump location, and this compartmentalized response is partly due to PDE2 and PDE3 activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, Michael E. Spurlock, John C. Kube, Xiang Z. Li, Stephen B. Smith
Summary: The study revealed that lubabegron fumarate is highly selective for the beta(3)-adrenergic receptor subtype and has minimal agonistic activity at the beta(2)-adrenergic receptor. Differences in mRNA expression levels of beta(1)-, beta(2)-, and beta(3)-AR were observed between subcutaneous and intramuscular adipose tissues. The response to beta-adrenergic ligands, especially agonists for the beta(1)- and beta(3)-receptor subtypes, was found to be lower in intramuscular adipose tissue compared to subcutaneous adipose tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Psychiatry
Adam Wysokinski, Elzbieta Kozlowska, Ewa Szczepocka, Anna Lucka, Justyna Agier, Ewa Brzezinska-Blaszczyk, Katarzyna Sobierajska
Summary: Schizophrenia patients exhibit a distinctive mRNA expression profile of dopamine and serotonin receptors in peripheral blood mononuclear cells. This expression is minimally affected by antipsychotic treatment, suggesting it may serve as a useful diagnostic biomarker for schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Michal Czerwinski, Anna Bednarska-Czerwinska, Nikola Zmarzly, Dariusz Boron, Marcin Oplawski, Beniamin Oskar Grabarek
Summary: This study compared the expression of biogenic amine-related genes and proteins in endometrioid endometrial cancer patients with a control group. It found that disturbances in signaling activated by histamine and dopamine receptors may potentially contribute to the progression of endometrioid endometrial cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Kucwaj-Brysz, Anna Dela, Sabina Podlewska, Marek Bednarski, Agata Siwek, Grzegorz Satala, Kinga Czarnota, Jadwiga Handzlik, Katarzyna Kiec-Kononowicz
Summary: Several studies have shown the reciprocal interactions between adrenergic and serotoninergic systems and their impact on anxiety pathogenesis. Finding chemical agents with a multifunctional pharmacodynamic profile may lead to effective therapy for CNS disorders. This study provides structural insights into hydantoin-arylpiperazine compounds and their serotonin/alpha-adrenergic activity, suggesting compounds 12 and 14 as potential candidates for anxiolytic agents.
Review
Biochemistry & Molecular Biology
Krzysztof Jozwiak, Anita Plazinska
Summary: Studies on different receptors belonging to class A of GPCRs reveal specific molecular mechanisms behind ligand directed signaling, including the role of important residues, the impact of ligand structural features on signaling, and the key interactions between ligands and receptors.
Article
Pharmacology & Pharmacy
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong
Summary: This study found that activation of AMPA receptors in the lateral habenula can reduce anxiety-like behaviors and increase dopamine and serotonin levels in the basolateral amygdala. Conversely, blocking AMPA receptors in the LHb may induce anxiety-like effects and decrease dopamine and serotonin levels in the BLA.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amni Al-Kachak, Ian Maze
Summary: Protein monoaminylation is a biochemical process that involves the covalent bonding of biogenic monoamines to specific protein substrates via Transglutaminase 2. It has been implicated in various biological processes and has recently been shown to regulate gene expression and contribute to neuronal plasticity and behavior. This review highlights recent advances in understanding the roles of protein monoaminylation as important chromatin regulators.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chintha Venkataramaiah, Bandila Lakshmi Priya, Wudayagiri Rajendra
Summary: The study found that a bioactive compound isolated from Celastrus paniculatus has neuroprotective potential against ketamine-induced schizophrenia by modulating the CNS monoamine neurotransmitter system and alleviating neurological dysfunction associated with monoaminergic abnormalities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Cell Biology
Marion Laudette, Karina Formoso, Frank Lezoualc'h
Summary: This article summarizes the pathophysiological roles of GRK2, GRK5, and Epac1 in the heart, focusing on how they interact under pathological conditions and contribute to the formation of scaffolded signaling systems.
Review
Biochemistry & Molecular Biology
Arif Luqman, Friedrich Goetz
Summary: After skin injury, wound healing progresses through four phases: hemostasis, inflammation, proliferation, and maturation. Skin microbiota play a significant role in wound healing, both negatively and positively, by influencing the release of certain hormones and neurotransmitters that impact the migration and re-epithelization of skin cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Majd Mohammad, Manli Na, Zhicheng Hu, Minh-Thu Nguyen, Pradeep Kumar Kopparapu, Anders Jarneborn, Anna Karlsson, Abukar Ali, Rille Pullerits, Friedrich Goetz, Tao Jin
Summary: The study demonstrates that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions. Lpp-deficient strains exhibit smaller lesion size and reduced bacterial loads in skin infections, indicating the crucial role of Lpp in promoting lesions and bacterial burden.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Microbiology
Samane Rahmdel, Friedrich Goetz
Summary: The outermost layer of the epidermis, the stratum corneum, is mainly composed of corneocytes which protect the body from desiccation. Despite being a hostile environment for microorganisms, the skin is colonized by commensal microbes.
Article
Microbiology
Sook-Ha Fan, Miki Matsuo, Li Huang, Paula M. Tribelli, Friedrich Gotz
Summary: CO2 and bicarbonate are essential for carboxylation reactions in bacteria, with two different dissolved inorganic carbon supply systems: MpsAB and CA. MpsAB has an advantage in species where CO2 diffusion is restricted, but coexpression of MpsAB and CA does not confer growth benefits under stress conditions. These findings contribute to understanding bacterial metabolism and potential antimicrobial targets, especially in pathogens like Staphylococcus.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Adela Finstrlova, Ivana Maslanova, Bob G. Blasdel Reuter, Jiri Doskar, Friedrich Goetz, Roman Pantucek
Summary: This study provides a comprehensive understanding of the interactions between phages and bacteria at the transcriptomic level, specifically focusing on the lytic action of Kayvirus and its molecular mechanisms. The results improve the knowledge of phage therapeutics and may contribute to the development of new antibacterial strategies.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biology
Minh Thiet Vu, Almando Geraldi, Hoang Dang Khoa Do, Arif Luqman, Hoang Danh Nguyen, Faiza Nur Fauzia, Fahmi Ikhlasul Amalludin, Aliffa Yusti Sadila, Nabilla Hapsari Wijaya, Heri Santoso, Yosephine Sri Wulan Manuhara, Le Minh Bui, Sucipto Hariyanto, Anjar Tri Wibowo
Summary: This study characterized the bacterial community associated with the roots of two plant species in coastal sand dune ecosystems in Indonesia. The findings demonstrated that the bacterial composition in the root is responsive to changes in soil mineral composition, especially Calcium, Titanium, Cuprum, and Zinc content. Some bacteria were also found to be sensitive to soil salinity levels. The study provided valuable information about the role of endophytic microbes in plant resistance against environmental pressures.
Article
Environmental Sciences
Nur Hidayatul Alami, Afan Hamzah, Bieby Voijant Tangahu, Idaa Warmadewanti, Ary Bachtiar Krishna Putra, Adi Setyo Purnomo, Edo Danilyan, Hellen Melati Putri, Citra Nesa Aqila, Aulia An Nisaa Dewi, Ayudia Pratiwi, Salsabilla Khairunisa Putri, Arif Luqman
Summary: This study investigates the microbiome profiles of crude oil contaminated soil and rhizosphere, showing that the microbiome profile of rhizosphere is similar to that of soil but with lower abundance of hydrocarbon-degrading genes. Most plants in the contaminated site are potential phytoremediators, but two abundant species have low potential. Traditional oil mining has negative environmental effects due to pollution with crude oil. The study aims to explore the microbiome profiles of contaminated soil and rhizosphere with naturalized plants, and provides insights into using indigenous hydrocarbon-degrading bacteria and naturalized plants as in-situ remediation agents.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Article
Multidisciplinary Sciences
Raphael Reher, Allegra T. Aron, Pavla Fajtova, Paolo Stincone, Berenike Wagner, Alicia Perez-Lorente, Chenxi Liu, Ido Y. Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L. Matos-Hernandez, Kelsey L. Alexander, Eduardo J. Caro-Diaz, C. Benjamin Naman, J. H. William Scanlan, Phil M. M. Hochban, Wibke E. Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A. Selim, Peter Sass, Heike Broetz-Oesterhelt, Chambers C. Hughes, Pieter C. Dorrestein, Anthony J. O'Donoghue, William H. Gerwick, Daniel Petras
Summary: The identity and biological activity of most metabolites are still unknown, and compound purification is a bottleneck for exploring their structures and pharmaceutical activities. Using a scalable native metabolomics approach, we identified a class of potentially bioactive metabolites and conducted structural elucidation and biological activity evaluation.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Laura Reinhardt, Dhana Thomy, Markus Lakemeyer, Linda Maria Westermann, Joaquin Ortega, Stephan A. Sieber, Peter Sass, Heike Broetz-Oesterhelt
Summary: Clp proteases are important targets for antibiotics and anticancer drugs. ADEP, an antibiotic, can deregulate the Clp protease system and accelerate protein degradation.
Article
Microbiology
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Droege, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Macek, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Broetz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Summary: Resistance to antibiotics is a growing problem and alternative antimicrobial therapies are needed. Cervimycin, a polyketide antibiotic, shows promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. This study identified the Clp system and the essential kinase WalK as mutational hotspots for cervimycin resistance in Staphylococcus aureus. Furthermore, cervimycin-resistant strains exhibited vancomycin-intermediate resistance phenotype, suggesting a role of cervimycin in perturbing the bacterial cell envelope.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Fabio Lino Gratani, Till Englert, Payal Nashier, Peter Sass, Laura Czech, Niels Neumann, Sofia Doello, Petra Mann, Rudolf Blobelt, Siegfried Alberti, Karl Forchhammer, Gert Bange, Katharina Hoefer, Boris Macek
Summary: Protein Ser/Thr kinases, such as the E. coli toxin YjjJ, play important roles in bacterial processes, including cell division and antibiotic tolerance. YjjJ acts as a Ser/Thr protein kinase and its main protein substrates are the ribosomal protein RpmE and the carbon storage regulator CsrA. YjjJ's activity affects ribosome assembly, cell division, and central carbon metabolism, but does not increase antibiotic tolerance like its homologue HipA. Interestingly, YjjJ overproduction can activate HipA and other kinases, suggesting cross talk between Ser/Thr kinases in E. coli.
Article
Environmental Sciences
Husna Nugrahapraja, Pramudya Wisnu Wicaksono Sugiyo, Balqis Qonita Putri, Ni'matuzahroh, Fatimah, Li Huang, Nourhane Hafza, Friedrich Gotz, Heri Santoso, Anjar Tri Wibowo, Arif Luqman
Summary: Microplastics are major pollutants in the environment and have been found in human food chains and bodies. This study examines the effect of microplastic contamination on the gut microbial composition in Indonesian populations. The results show that microplastic contamination does not significantly alter the overall gut microbial composition and abundance of gut-health-related genes, but certain types of microplastics correlate with specific bacterial taxa. Additionally, this study identifies the presence of genes encoding plastic-degrading enzymes in the human gut microbiome for the first time, suggesting an adaptation to microplastic contamination.
Article
Microbiology
Nourhane Hafza, Ningna Li, Arif Luqman, Friedrich Goetz
Summary: In this study, a SNAT protein was identified in the genus Staphylococcus, which catalyzes the acetylation of serotonin and tryptamine. The role of this protein in producing neuromodulators and its wide distribution in Staphylococcus strains were confirmed. The findings contribute to a better understanding of the interaction between Staphylococcus colonizers and the human nervous system.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Arif Luqman
Summary: The human microbiome and the host have reciprocal interactions. Recent studies have shown that microorganisms are capable of responding to host signaling molecules, such as hormones. There is a complex response of bacteria to hormone exposure, which affects various aspects of bacteria, including growth, metabolism, and virulence. The effects of hormones on bacteria seem to be species-specific, with catecholamines, also known as stress hormones, being the most studied. These hormones can either inhibit or enhance bacterial growth by acting as siderophores. Epinephrine and norepinephrine have also been reported to activate QseBC, a quorum sensing system in Gram-negative bacteria, ultimately enhancing pathogen virulence. Other hormones have also been reported to influence the composition and behavior of the human microbiome. Considering the complex response of bacteria to hormones, it is important to study the impact of hormones on bacteria when studying human health in relation to the human microbiome.
MICROBIAL PATHOGENESIS
(2023)
Article
Biotechnology & Applied Microbiology
Andri Frediansyah, Yosephine Sri Wulan Manuhara, Alfinda Novi Kristanti, Arif Luqman, Anjar Tri Wibowo
Summary: This study examined the effects of different culture media, agitation, and fungal elicitation on the production of violacein and deoxyviolacein in Janthinobacterium. The results showed that cultivation in minimal media and fungal elicitation enhanced the production of both pigments in Janthinobacterium.
FERMENTATION-BASEL
(2022)